Mengzhuang Gou, Shujuan Pan, Jinghui Tong, Yanfang Zhou, Jiarui Han, Ting Xie, Ting Yu, Wei Feng, Yanli Li, Song Chen, Yimin Cui, Baopeng Tian, M D Shuping Tan, Zhiren Wang, Xingguang Luo, Chiang-Shan R Li, Ping Zhang, Junchao Huang, L Elliot Hong, Yunlong Tan, Li Tian
MicroRNA (miR)-181b-5p is considered to be involved in the pathogenesis of schizophrenia, and one of its regulatory target genes BCL-2 (B-cell lymphoma 2) is suggested to associate with cognition of schizophrenia. Cognitive deficit is a core trait of schizophrenia. However, it remains unclear whether miR-181b-5p affects cognition and its possible pathway in schizophrenia. We hypothesized that miR-181b-5p affects cognition by targeting BCL-2 mRNA and downregulating BCL-2 protein expression in schizophrenia patients...
February 14, 2021: Journal of Psychiatric Research