Ana Dácil Marrero, Casimiro Cárdenas, Laura Castilla, Juan Ortega-Vidal, Ana R Quesada, Beatriz Martínez-Poveda, Miguel Ángel Medina
Extra virgin olive oil (EVOO), a staple of the Mediterranean diet, is rich in phenolic compounds recognized for their potent bioactive effects, including anticancer and anti-inflammatory properties. However, its effects on vascular health remain relatively unexplored. In this study, we examined the impact of a "picual" EVOO extract from Jaén, Spain, on endothelial cells. Proteomic analysis revealed the modulation of angiogenesis-related processes. In subsequent in vitro experiments, the EVOO extract inhibited endothelial cell migration, adhesion, invasion, ECM degradation, and tube formation while inducing apoptosis...
May 29, 2024: Journal of Agricultural and Food Chemistry