Michael D L Johnson, Usir S Younis, Sanjay V Menghani, Kenneth J Addison, Michael Whalen, Aprile L Pilon, Anne E Cress, Francesca Polverino, Casey E Romanoski, Monica Kraft, Fernando D Martinez, Stefano Guerra, Julie G Ledford
Rationale CC16 (club cell secretory protein) is a pneumoprotein produced predominantly by pulmonary club cells. Circulating CC16 is associated with protection from the inception and progression of the two most common obstructive lung diseases (asthma and chronic obstructive pulmonary disease). Objectives Although exact mechanisms remain elusive, studies consistently suggest a causal role of CC16 in mediating antiinflammatory and antioxidant functions in the lung. We sought to determine any novel receptor systems that could participate in CC16's role in obstructive lung diseases...
June 1, 2021: American Journal of Respiratory and Critical Care Medicine