Simon J Cleary, Yurim Seo, Jennifer J Tian, Nicholas Kwaan, David P Bulkley, Arthur E H Bentlage, Gestur Vidarsson, Éric Boilard, Rolf Spirig, James C Zimring, Mark R Looney
UNLABELLED: Antibodies can initiate lung injury in a variety of disease states such as autoimmunity, transfusion reactions, or after organ transplantation, but the key factors determining in vivo pathogenicity of injury-inducing antibodies are unclear. A previously overlooked step in complement activation by IgG antibodies has been elucidated involving interactions between IgG Fc domains that enable assembly of IgG hexamers, which can optimally activate the complement cascade. Here, we tested the in vivo relevance of IgG hexamers in a complement-dependent alloantibody model of acute lung injury...
January 27, 2024: bioRxiv