Daniel Weidinger, Julian Jacobsen, Desiree Alisch, Hendrik Uebner, Natalie Heinen, Lea Greune, Saskia Westhoven, Kaschin Jamal Jameel, Juliane Kronsbein, Stephanie Pfaender, Christian Taube, Sebastian Reuter, Marcus Peters, Hanns Hatt, Jürgen Knobloch
BACKGROUND: Therapeutic options for steroid-resistant non-type 2 inflammation in obstructive lung diseases are limited. Bronchial epithelial cells are key in the pathogenesis by releasing the central proinflammatory cytokine interleukine-8 (IL-8). Olfactory receptors (ORs) are expressed in various cell types. This study examined the drug target potential of ORs by investigating their impact on associated pathophysiological processes in lung epithelial cells. METHODS: Experiments were performed in the A549 cell line and in primary human bronchial epithelial cells...
March 30, 2024: European Journal of Cell Biology