Tiarnan D L Keenan, Clare Bailey, Maria Abraham, Christine Orndahl, Supriya Menezes, Sunil Bellur, Thilaka Arunachalam, Cathy Kangale-Whitney, Sowmya Srinivas, Ayesha Karamat, Muneeswar Nittala, Denise Cunningham, Brett G Jeffrey, Henry E Wiley, Alisa T Thavikulwat, SriniVas Sadda, Catherine A Cukras, Emily Y Chew, Wai T Wong
IMPORTANCE: Existing therapies to slow geographic atrophy (GA) enlargement in age-related macular degeneration (AMD) have relatively modest anatomic efficacy, require intravitreal administration, and increase the risk of neovascular AMD. Additional therapeutic approaches are desirable. OBJECTIVE: To evaluate the safety and possible anatomic efficacy of oral minocycline, a microglial inhibitor, for the treatment of GA in AMD. DESIGN, SETTING, AND PARTICIPANTS: This was a phase 2, prospective, single-arm, 45-month, nonrandomized controlled trial conducted from December 2016 to April 2023...
March 14, 2024: JAMA Ophthalmology