Jie Liu, Xiajie Huang, Hongjie Su, Jie Yu, Xinyu Nie, Kaibing Liu, Wencong Qin, Yongxin Zhao, Yongfeng Su, Xiaocong Kuang, Di Chen, William W Lu, Yan Chen, Qikai Hua
PURPOSE: Management of severe diabetic foot ulcers (DFUs) remains challenging. Tibial cortex transverse transport (TTT) facilitates healing and limb salvage in patients with recalcitrant DFUs. However, the underlying mechanism is largely unknown, necessitating the establishment of an animal model and mechanism exploration. METHODS: Severe DFUs were induced in rats, then assigned to TTT, sham, or control groups (n=16/group). The TTT group underwent a tibial corticotomy, with 6 days each of medial and lateral transport; the sham group had a corticotomy without transport...
2024: Journal of Inflammation Research