keyword
https://read.qxmd.com/read/38537162/advancing-bone-targeted-drug-delivery-leveraging-biological-factors-and-nanoparticle-designs-to-improve-therapeutic-efficacy
#1
JOURNAL ARTICLE
Baixue Xiao, Marian A Ackun-Farmmer, Emmanuela Adjei-Sowah, Yuxuan Liu, Indika Chandrasiri, Danielle S W Benoit
Designing targeted drug delivery systems to effectively treat bone diseases ranging from osteoporosis to nonunion bone defects remains a significant challenge. Previously, nanoparticles (NPs) self-assembled from diblock copolymers of poly(styrene- alt -maleic anhydride)- b -poly(styrene) (PSMA- b -PS) delivering a Wnt agonist were shown to effectively target bone and improve healing via the introduction of a peptide with high affinity to tartrate-resistant acid phosphatase (TRAP), an enzyme deposited by the osteoclasts during bone remodeling...
March 27, 2024: ACS Biomaterials Science & Engineering
https://read.qxmd.com/read/38537079/amino-acid-supplementation-confers-protection-to-red-blood-cells-prior-to-plasmodium-falciparum-bystander-stress
#2
JOURNAL ARTICLE
Heather Colvin Binns, Elmira Alipour, Cameron E Sherlock, Dinah S Nahid, John F Whitesides, Anderson O'Brien Cox, Cristina M Furdui, Glen S Marrs, Daniel B Kim-Shapiro, Regina Joice Cordy
Malaria is a highly oxidative parasitic disease in which anemia is the most common clinical symptom. A major contributor to malarial anemia pathogenesis is the destruction of bystander, uninfected red blood cells (RBCs). Metabolic fluctuations are known to occur in the plasma of individuals with acute malaria, emphasizing the role of metabolic changes in disease progression and severity. Here, we report that conditioned media from Plasmodium falciparum culture induces oxidative stress in uninfected, catalase-depleted RBCs...
March 27, 2024: Blood Advances
https://read.qxmd.com/read/38537065/a-multicenter-study-of-venetoclax-based-treatment-for-patients-with-richter-transformation-of-chronic-lymphocytic-leukemia
#3
JOURNAL ARTICLE
Paul Joseph Hampel, Mahesh Swaminathan, Kerry A Rogers, Erin M Parry, Jan A Burger, Matthew S Davids, Wei Ding, Alessandra Ferrajoli, Jonathan Mitry Hyak, Nitin Jain, Saad S Kenderian, Yucai Wang, William G Wierda, Jennifer A Woyach, Sameer A Parikh, Philip A Thompson
Patients with chronic lymphocytic leukemia (CLL) who develop Richter transformation (RT) have a poor prognosis when treated with chemoimmunotherapy regimens used for de novo diffuse large B-cell lymphoma. Venetoclax, a BCL2 inhibitor, has single agent efficacy in patients with RT and is potentially synergistic with chemoimmunotherapy. In this multicenter, retrospective study, we evaluated 62 patients with RT who received venetoclax-based treatment outside of a clinical trial, in combination with a Bruton tyrosine kinase inhibitor (BTKi; n=28), R-CHOP (n=13), or intensive chemoimmunotherapy other than R-CHOP (n=21)...
March 27, 2024: Blood Advances
https://read.qxmd.com/read/38537062/late-cytomegalovirus-disease-after-hematopoietic-cell-transplantation-significance-of-novel-transplantation-techniques
#4
JOURNAL ARTICLE
Alicja Sadowska-Klasa, Sezen Özkök, Hu Xie, Wendy M Leisenring, Danniel Zamora, Sachiko Seo, Jordan Sheldon, Stephanie J Lee, Keith R Jerome, Margaret L Green, Michael J Boeckh
Pre-emptive therapy (PET) and letermovir prophylaxis are effective in preventing CMV disease within the first 100 days after allogeneic hematopoietic cell transplantation (HCT) but are associated with late-onset CMV disease. We retrospectively examined the clinical manifestations, risk factors, prevention algorithm, and outcome of late CMV disease in CMV seropositive day 100 survivors transplanted between 2001-2017 (PET cohort) and 2018-2021 (letermovir cohort). There were 187 episodes of late CMV disease among 2469 day 100 survivors and the estimated cumulative incidence of first late CMV disease was 6...
March 27, 2024: Blood Advances
https://read.qxmd.com/read/38537061/cost-effectiveness-of-bevacizumab-therapy-in-the-care-of-patients-with-hereditary-hemorrhagic-telangiectasia
#5
JOURNAL ARTICLE
Daniel Wang, Satoko Ito, Christina Waldron, Ayesha Butt, Ellen Zhang, Harlan Krumholz, Hanny Al-Samkari, George Goshua
No FDA or EMA approved therapies exist for bleeding due to hereditary hemorrhagic telangiectasia (HHT), the second-most-common inherited bleeding disorder worldwide. The current standard-of-care (SOC) includes iron and red cell supplementation, alongside the necessary hemostatic procedures, none of which target underlying disease pathogenesis. Recent evidence has demonstrated that bleeding pathophysiology is amenable to systemic antiangiogenic therapy with the anti-VEGF bevacizumab. Despite its high cost, the addition of longitudinal bevacizumab to the current SOC may reduce overall healthcare resource utilization and improve patient quality-of-life...
March 27, 2024: Blood Advances
https://read.qxmd.com/read/38536944/ancestral-%C3%AE-globin-gene-haplotypes-modify-%C3%AE-thalassemia-severity-in-a-mouse-model
#6
JOURNAL ARTICLE
Christophe Lechauve, Julia Keith, Alfonso G Fernandez, Eugene Khandros, Kalin Mayberry, Thiyagaraj Mayuranathan, Lance E Palmer, Xiaohui Qiu, Heather Sheppard, Rahul Telange, Hans-Martin Herz, Mitchell J Weiss
No abstract text is available yet for this article.
March 27, 2024: Blood Advances
https://read.qxmd.com/read/38536941/identification-of-novel-nup98-fusion-partners-and-co-mutations-in-acute-myeloid-leukemia-an-adult-cohort-study
#7
JOURNAL ARTICLE
James S Heald, Aleix Méndez López, Miguel L Pato, Neus Ruiz-Xiville, Marta Cabezón, Lurdes Zamora, Susana Vives, Rosa Coll Jorda, Clara Maluquer Artigal, Isabel Granada, Francesc Sole, Manel Esteller, María Berdasco
No abstract text is available yet for this article.
March 27, 2024: Blood Advances
https://read.qxmd.com/read/38536939/anticoagulation-and-antiplatelet-use-among-patients-with-von-willebrand-disease-and-cardiac-disease
#8
JOURNAL ARTICLE
Lauren E Merz, Duaa AbdelHameid, Dareen M Kanaan, Subrina Farah, Peter Manzo, Nathan T Connell
No abstract text is available yet for this article.
March 27, 2024: Blood Advances
https://read.qxmd.com/read/38536906/tet2-is-a-tumor-suppressor-in-the-pre-leukemic-phase-of-t-cell-acute-lymphoblastic-leukemia
#9
JOURNAL ARTICLE
Stien De Coninck, Juliette Roels, Beatrice Lintermans, Sara T'Sas, Tom Taghon, David J Curtis, Tim Pieters, Steven Goossens, Pieter Van Vlierberghe
TET2-mediated DNA demethylation plays a pivotal role in regulating pre-leukemic clonal expansion in acute myeloid leukemia (AML), where TET2 mutations are also linked to AML progression. However, its function in other types of leukemias, including T-cell acute lymphoblastic leukemia (T-ALL), remains unclear. Here, we used two different T-ALL mouse models to study the possible tumor suppressor role of Tet2 in pre-leukemic T-ALL. Overexpression of Tet2 resulted in a mild but significant increase in T-ALL latency in the immature CD2-Lmo2tg T-ALL mouse model, but no effect on survival was observed in the mature Lck-Cretg/+ Ptenfl/lf T-ALL mouse model...
March 27, 2024: Blood Advances
https://read.qxmd.com/read/38536645/recent-advances-in-understanding-the-biology-of-follicular-lymphoma
#10
REVIEW
Momoko Nishikori
Follicular lymphoma (FL), the most common indolent B-cell lymphoma, develops over decades before manifesting as overt disease. BCL2 overexpression by t(14;18) confers a survival advantage to B cells during the germinal center reaction, and abnormalities in epigenetic modifier genes lead to desynchronization of gene expression changes in germinal center B cells. Studies in mouse models have shown that BCL2 overexpression and epigenetic deregulation in B cells cooperatively promote lymphomagenesis. The immune microenvironment also plays an essential role in the biology of FL, and many molecular prognostic indicators based on the immune microenvironment have been proposed...
March 27, 2024: International Journal of Hematology
https://read.qxmd.com/read/38536644/hereditary-ttp-upshaw-schulman-syndrome-the-ductus-arteriosus-controls-newborn-survival
#11
REVIEW
Yoshihiro Fujimura
Hereditary TTP (hTTP), termed Upshaw-Schulman syndrome, is an ultra-rare disorder caused by a severe deficiency of plasma ADAMTS13 activity that allows circulation of ultra-large von Willebrand factor (UL-VWF) multimers. The greatest risk for hTTP is in their first days after birth, when 35-50% of patients will have severe hemolysis, jaundice, and thrombocytopenia. It is often fatal without effective treatment. In utero, fetal blood flowing from the pulmonary artery through the ductus arteriosus (DA) to the aorta is under low-shear-force...
March 27, 2024: International Journal of Hematology
https://read.qxmd.com/read/38536638/sublethal-concentrations-of-cadmium-and-lead-effects-on-hemato-biochemical-parameters-and-tissue-accumulation-in-wallagu-attu
#12
JOURNAL ARTICLE
Rim El Amouri, Javed Ahmed Ujan, Asif Raza, Alia Mushtaq, Muhammad Qamar Saeed, Samrah Masud, Syed Sikandar Habib, Marija Milošević, Salim S Al-Rejaie, Mohamed Mohany
The exposure of fish to heavy metals can significantly impact physiological processes and potentially lead to adverse health effects. This study assesses the effects of exposure to Cd and Pb sublethal concentrations in water on Wallagu attu. A total of 48 fish with an average body weight of 145.5 ± 26 g were distributed among three groups (control, Cd-treated, and Pb-treated) within 60 L fiberglass tanks. They were exposed to 30% sublethal concentrations of Cd and Pb for durations of 1, 15, and 30 days...
March 27, 2024: Biological Trace Element Research
https://read.qxmd.com/read/38536576/bruton-tyrosine-kinase-inhibition-an-effective-strategy-to-manage-waldenstr%C3%A3-m-macroglobulinemia
#13
REVIEW
Reema K Tawfiq, Jithma P Abeykoon, Prashant Kapoor
PURPOSE OF REVIEW: The treatment of Waldenström macroglobulinemia (WM) has evolved over the past decade. With the seminal discoveries of MYD88 and CXCR warts, hypogammaglobulinemia, infections, and myelokathexis (WHIM) mutations in WM cells, our understanding of the disease biology and treatment has improved. The development of a new class of agents, Bruton tyrosine kinase inhibitors (BTKi), has substantially impacted the treatment paradigm of WM. Herein, we review the current and emerging BTKi and the evidence for their use in WM...
March 27, 2024: Current Hematologic Malignancy Reports
https://read.qxmd.com/read/38536476/herombopag-for-the-treatment-of-persistent-thrombocytopenia-following-hematopoietic-stem-cell-transplantation
#14
JOURNAL ARTICLE
Miao Zhou, Tongyu Li, Ping Zhang, Yanli Lai, Lixia Sheng, Guifang Ouyang
Allogeneic hematopoietic stem cell transplantation (Allo-HSCT) stands as a pivotal treatment for hematologic malignancies, often considered the sole effective treatment option. A frequent complication following allo-HSCT is poor graft function (PGF), with one of its primary manifestations being persistent thrombocytopenia (PT), comprising prolonged isolated thrombocytopenia (PIT) and secondary failure of platelet recovery (SFPR). Conventional treatment methods have had poor efficacy and a high transplantation-associated mortality rate...
March 27, 2024: Annals of Hematology
https://read.qxmd.com/read/38536399/characteristics-of-enterococcus-species-bloodstream-infections-among-adults-with-and-without-onco-hematological-malignancies-experiences-from-the-national-center-of-hungary
#15
JOURNAL ARTICLE
Bence Marosi, Béla Kádár, Anna Bruzsa, Laura Kocsis, Katalin Kamotsay, János Sinkó, Bálint Gergely Szabó, Botond Lakatos
INTRODUCTION: Over the past decade, enterococcal bloodstream infection (BSI) shows increasing incidence globally among the elderly and in patients with comorbidities. In this study, we aimed to assess microbiological and clinical characteristics and long-term outcomes of BSIs caused by Enterococcus spp. in adult patients with and without active onco-hematological malignancies hospitalized at a national referral institute. METHODS: A prospective analysis of consecutive enterococcal BSI cases was conducted in the National Institute of Hematology and Infectious Diseases (Budapest, Hungary) between December 2019 and April 2022...
March 27, 2024: European Journal of Microbiology & Immunology
https://read.qxmd.com/read/38536200/incidence-risk-factors-and-outcome-of-asymptomatic-central-nervous-system-involvement-in-adult-patients-with-acute-myeloid-leukemia
#16
JOURNAL ARTICLE
Marijana Virijevic, Nada Kraguljac-Kurtovic, Mirjana Mitrovic, Ljubomir Jakovic, Zoran Bukumuric, Nikola Pantic, Nikica Sabljic, Zlatko Pravdic, Mirjana Cvetkovic, Vesna Knezevic, Tijana Dragovic-Ivancevic, Irena Djunić, Jovan Rajic, Violeta Milosevic, Milena Todorovic-Balint, Ana Vidovic, Nada Suvajdzic-Vukovic
Examination of central nervous system (CNS) involvement is not routine diagnostic practice in adult patients with acute myeloid leukemia (AML). Therefore, many asymptomatic patients with CNS involvement might go undetected. The effect of CNS involvement on the AML disease course is not well defined, with conflicting results regarding clinical outcome. This study aimed to determine the incidence of asymptomatic CNS involvement in AML estimated by multiparametric flow cytometry of cerebrospinal fluid (MFC-CSF) at diagnosis, the related potential risk factors, and prognosis...
March 2024: Hematological Oncology
https://read.qxmd.com/read/38536023/tim3-and-ctla4-immune-checkpoint-polymorphisms-are-associated-with-acute-myeloid-leukemia-in-saudi-arabia
#17
JOURNAL ARTICLE
Mashael Alqahtani, Ali Aljuaimlani, Jameel Al-Tamimi, Suliman Alomar, Lamjed Mansour
BACKGROUND: Immune checkpoints are receptors on the surface of T cells that function crucially in suppressing the immune response, and they are implicated in autoimmunity and cancer diseases. AIM: The present study aimed to investigate the relationship between functional single nucleotide polymorphisms (SNPs) of two immune checkpoint molecules, CTLA-4 and TIM-3, and acute myeloid leukemia (AML) in a Saudi population. METHODS: Two SNPs in CTLA-4 (rs231775, A > G) and TIM-3 (rs10515746, A > C) were genotyped in 229 subjects, including 98 patients and 131 healthy controls, from the Saudi population using TaqMan assay methods...
December 2024: Hematology (Amsterdam, Netherlands)
https://read.qxmd.com/read/38535931/safety-of-oral-carica-papaya-l-leaf-10-ethanolic-extract-for-acute-and-chronic-toxicity-tests-in-sprague-dawley-rats
#18
JOURNAL ARTICLE
Weerakit Taychaworaditsakul, Chalermpong Saenjum, Nongkran Lumjuan, Kriangkrai Chawansuntati, Suphunwadee Sawong, Kanjana Jaijoy, Mingkwan Na Takuathung, Seewaboon Sireeratawong
Carica papaya L. leaves, traditionally utilized in dietary supplements and pharmaceuticals, exhibit a broad spectrum of potentially therapeutic properties, including anti-inflammatory, antimalarial, and wound healing properties. This study examined the acute and chronic toxicity of 10% ethanolic-extracted C. papaya leaf in Sprague Dawley rats. The acute toxicity assessment was a single oral dose of 5000 mg/kg body weight, while the chronic toxicity assessment included daily oral doses of 100, 400, 1000, and 5000 mg/kg over 180 days...
March 1, 2024: Toxics
https://read.qxmd.com/read/38535788/assessment-of-the-impact-of-humic-acids-on-intestinal-microbiota-gut-integrity-ileum-morphometry-and-cellular-immunity-of-turkey-poults-fed-an-aflatoxin-b-1-contaminated-diet
#19
JOURNAL ARTICLE
Jesús A Maguey-González, Jing Liu, Guolong Zhang, Juan D Latorre, Juan O Hernández-Ramírez, María de Jesús Nava-Ramírez, Roberto Senas-Cuesta, Sergio Gómez-Rosales, María de Lourdes Ángeles, Andressa Stein, Bruno Solís-Cruz, Daniel Hernández-Patlán, Rubén Merino-Guzmán, Xochitl Hernandez-Velasco, Inkar Castellanos-Huerta, Santiago Uribe-Diaz, Alma Vázquez-Durán, Abraham Méndez-Albores, Victor M Petrone-Garcia, Guillermo Tellez, Billy M Hargis, Guillermo Téllez-Isaías
A recent study published data on the growth performance, relative weights of the organs of the gastrointestinal tract, liver histology, serum biochemistry, and hematological parameters for turkey poults fed an experimental diet contaminated with aflatoxin B1 (AFB1 ) and humic acids (HA) extracted from vermicompost. The negative effects of AFB1 (250 ng AFB1 /g of feed) were significantly reduced by HA supplementation (0.25% w / w ), suggesting that HA might be utilized to ameliorate the negative impact of AFB1 from contaminated diets...
February 29, 2024: Toxins
https://read.qxmd.com/read/38535413/effect-of-a-cross-training-and-resistance-exercise-routine-on-il-15-in-adults-with-type-b-acute-lymphoblastic-leukemia-during-the-induction-phase-randomized-pilot-study
#20
JOURNAL ARTICLE
Adán Germán Gallardo Rodríguez, Irma Olarte Carrillo, Adolfo Martínez Tovar, Rafael Cerón Maldonado, Emmanuel Martínez Moreno, Christian Omar Ramos Peñafiel
IL-15 is a proinflammatory myokine essential for activating NK cells and CD8+ T lymphocytes, and its overexpression has been related to reducing overall survivorship in patients with acute lymphoblastic leukemia (ALL). Physical exercise has been shown to be safe, feasible, and beneficial in hematological cancers. Exercise requires the activation of muscles that secrete cytokines, such as IL-15, causing immune mobilization. The objective was to compare the outcomes of two training routines on IL-15 and survival prognosis in adult patients diagnosed with ALL...
December 21, 2023: Journal of Functional Morphology and Kinesiology
keyword
keyword
1828
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.