Angela L Hughson, Gary Hannon, Noah A Salama, Tara G Vrooman, Caroline A Stockwell, Bradley N Mills, Jesse Garrett-Larsen, Haoming Qiu, Roula Katerji, Lauren Benoodt, Carl J Johnston, Joseph D Murphy, Emma Kruger, Jian Ye, Nicholas W Gavras, David C Keeley, Shuyang S Qin, Maggie L Lesch, Jason B Muhitch, Tanzy M T Love, Laura M Calvi, Edith M Lord, Nadia Luheshi, Jim Elyes, David C Linehan, Scott A Gerber
UNLABELLED: The immunosuppressive milieu in pancreatic cancer (PC) is a significant hurdle to treatments, resulting in survival statistics that have barely changed in 5 decades. Here we present a combination treatment consisting of stereotactic body radiation therapy (SBRT) and IL-12 mRNA lipid nanoparticles delivered directly to pancreatic murine tumors. This treatment was effective against primary and metastatic models, achieving cures in both settings. IL-12 protein concentrations were transient and localized primarily to the tumor...
November 2, 2023: bioRxiv