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JOURNAL ARTICLE
Lisa Young, Lu Ban, Yong Chen, Patrick F Fogarty
OBJECTIVES: To describe people with hemophilia B (PWHB) in the US who experience bleeds despite factor replacement therapy and to quantify the associated burden from the third-party payer perspective. STUDY DESIGN: Observational study of adult male PWHB treated with factor IX replacement therapy identified from the PharMetrics Plus claims data from 2010 to 2019. METHODS: Patients with medically recorded bleeds (MRBs) were identified using diagnostic codes...
May 1, 2024: American Journal of Managed Care
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JOURNAL ARTICLE
David P VanEenenaam, Stefano Cardin, Daniel Yang, Elizabeth O'Brien, Wallis T Muhly, Wudbhav N Sankar
INTRODUCTION: Adequate pain control and early mobilization are critical in the postoperative period after periacetabular osteotomy (PAO). Regional anesthesia can reduce postoperative pain, but certain techniques can increase the risk of postoperative motor block and delayed functional recovery. Continuous lumbar epidurals can provide excellent analgesia but also create challenges with early ambulation. Recently, suprainguinal fascia iliaca (SIFI) single-shot blocks have been shown to provide effective analgesia in PAO patients...
May 14, 2024: Journal of the American Academy of Orthopaedic Surgeons
#43
JOURNAL ARTICLE
Jaime H X Lin, Lixia Ge, Huiling Liew, Elaine Tan, Jeremy Hoe, Enming Yong, Zhiwen Loh, Tiffany Chew, Mohd F M Farhan, Zhang Li, Donna Tan, Yi Bing Loh, Julia Zhu, Pauline Ang, Claris Shi, Dexter Yak Seng Chan, Chelsea Law, Nadiah Raman, Joseph Molina, Gary Ang, Hui Yan Koo, Kai Qiang Low, Julia Choo, Cin Yee Tan, Jo Ann Lim, James Siow, Shaun Wy Chan, Sadhana Chandraskear, Daniel Chew, Zhiwen Joseph Lo
Diabetic Foot in Primary and Tertiary (DEFINITE) Care is an inter-institutional, multidisciplinary team (MDT) program for patients with diabetic foot ulcers (DFU) within a healthcare cluster in Singapore. This is one of our subgroup analyses within DEFINITE Care, assessing clinical outcomes of lower extremity amputation prevention program (LEAPP), a multidisciplinary diabetic foot clinic, and non-LEAPP patients within the program. From June 2020 to June 2022, 2798 patients within the DEFINITE cohort completed a minimum of 12-month follow up...
May 15, 2024: International Journal of Lower Extremity Wounds
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JOURNAL ARTICLE
Yoav S Zvi, Shoran Tamura, Jonathan Rubin, Zeynep Seref-Ferlengez, Eli Kamara
INTRODUCTION: The Kellgren and Lawrence (KL) classification for knee osteoarthritis estimates disease severity. Its utility in predicting patient-reported outcomes (PROs) after primary total knee arthroplasty (pTKA) has been suggested. We hypothesized that patients who had higher preoperative KL grades would demonstrate greater improvements in PROs after pTKA. METHODS: This was a retrospective review of patients who underwent pTKA between 2016 and 2021. Two observers graded preoperative radiographs (KL1/2, KL3, and KL4)...
May 1, 2024: Journal of the American Academy of Orthopaedic Surgeons. Global Research & Reviews
#45
JOURNAL ARTICLE
Xingfu Li, Xinhan Li, Yamei Xu, Gang Fu, Hong Huang
AIMS: The aim of this retrospective clinical study was to compare the 5-year radiological and clinical outcomes of patients undergoing immediate implantation with or without the modified socket-shield technique. MATERIALS AND METHODS: Patients who underwent anterior tooth replacement via the modified socket-shield technique (MSST) or the conventional immediate implantation technique (CIIT) between 2016 and 2017 were included. The labial bone thickness was assessed at different measurement levels (0, 2, 4 and 6 mm apical to the implant shoulder (IS)) postoperatively (T1), 6 months postoperatively (T2) and 5 years postoperatively (T3)...
May 15, 2024: Clinical Oral Implants Research
#46
JOURNAL ARTICLE
Jean-Michel Halimi, Pantelis Sarafidis, Michel Azizi, Grzegorz Bilo, Thilo Burkard, Michael Bursztyn, Miguel Camafort, Neil Chapman, Santina Cottone, Tine de Backer, Jaap Deinum, Philippe Delmotte, Maria Dorobantu, Michalis Doumas, Rainer Dusing, Béatrice Duly-Bouhanick, Jean-Pierre Fauvel, Pierre Fesler, Zbigniew Gaciong, Eugenia Gkaliagkousi, Daniel Gordin, Guido Grassi, Charalampos Grassos, Dominique Guerrot, Justine Huart, Raffaele Izzo, Fernando Jaén Águila, Zoltán Járai, Thomas Kahan, Ilkka Kantola, Eva Kociánová, Florian P Limbourg, Marilucy Lopez-Sublet, Francesca Mallamaci, Athanasios Manolis, Maria Marketou, Gert Mayer, Alberto Mazza, Iain M MacIntyre, Jean-Jacques Mourad, Maria Lorenza Muiesan, Edgar Nasr, Peter Nilsson, Anna Oliveras, Olivier Ormezzano, Vitor Paixão-Dias, Ioannis Papadakis, Dimitris Papadopoulos, Sabine Perl, Jorge Polónia, Roberto Pontremoli, Giacomo Pucci, Nicolás Roberto Robles, Sébastien Rubin, Luis Miguel Ruilope, Lars Christian Rump, Sahrai Saeed, Elias Sanidas, Riccardo Sarzani, Roland Schmieder, François Silhol, Sekib Sokolovic, Marit Solbu, Miroslav Soucek, George Stergiou, Isabella Sudano, Ramzi Tabbalat, Istemihan Tengiz, Helen Triantafyllidi, Konstontinos Tsioufis, Jan Václavík, Markus van der Giet, Patricia Van der Niepen, Franco Veglio, Reto M Venzin, Margus Viigimaa, Thomas Weber, Jiri Widimsky, Grégoire Wuerzner, Parounak Zelveian, Pantelis Zebekakis, Stephan Lueders, Alexandre Persu, Reinhold Kreutz, Liffert Vogt
OBJECTIVE: Real-life management of hypertensive patients with chronic kidney disease (CKD) is unclear. METHODS: A survey was conducted in 2023 by the European Society of Hypertension (ESH) to assess management of CKD patients referred to ESH-Hypertension Excellence Centres (ESH-ECs) at first referral visit. The questionnaire contained 64 questions with which ESH-ECs representatives were asked to estimate preexisting CKD management quality. RESULTS: Overall, 88 ESH-ECs from 27 countries participated (fully completed surveys: 66/88 [75...
May 14, 2024: Journal of Hypertension
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JOURNAL ARTICLE
Jaclyn M Martindale, Victor M Ringheanu, Kelly A Pring, Sandra Norona, Kimberly Wiseman, Roy E Strowd, Leah Chapman, Joseph Rigdon, Stephen R Rapp, Eric A Storch, Edward Ip, Jonathan W Mink
INTRODUCTION: Persistent Tic Disorders such as Tourette Syndrome are common neurodevelopmental disorders that are highly stigmatized. Many individuals with Persistent Tic Disorders experience peer rejection, loneliness, and self-stigma. Experiencing stigmatization during childhood can influence the persistence of moderate-to-severe tics later in life. Additionally, these factors have been associated with increased suicidal ideation, suicide attempts, and psychiatric symptom severity. There is a need for interventions to reduce stigma and stigmatization in Persistent Tic Disorders...
2024: Frontiers in Psychology
#48
JOURNAL ARTICLE
Lisa S van Tol, Hanneke J A Smaling, Sarah I M Janus, Monique A A Caljouw, Wilco P Achterberg
BACKGROUND: COVID-19 infection prevention measures can negatively impact nursing home residents' well-being. Society has been concerned about the imbalance between infection prevention and residents' well-being, and about nursing home residents' autonomy in COVID-19 policymaking. OBJECTIVE: This study explores consensus among nursing home staff about which measures they found to be most important in contributing to preventing infections and to maintaining well-being of residents during COVID-19 outbreaks...
December 2023: International journal of nursing studies advances
#49
JOURNAL ARTICLE
Sunil Pradhan, Ruchika Tandon
OBJECTIVES: For this observational study, we evaluated the clinical profile of Parkinsonian features in multiple system atrophy (MSA), as there is no clarity about the specifics of these features in this disease compared to progressive supranuclear palsy (PSP) and Parkinson's disease (PD). MATERIALS AND METHODS: Here, we selected 57 patients with MSA based on standard criteria and grouped them into two categories - Parkinsonian variant of MSA (MSA-P) and cerebellar variant of MSA (MSA-C)...
2024: Journal of Neurosciences in Rural Practice
#50
Mari Armstrong-Hough, Amanda J Gupta, Joseph Ggita, Joan Nangendo, Achilles Katamba, J Lucian Davis
BACKGROUND: HIV status awareness and linkage to care are critical for ending the HIV epidemic and preventing tuberculosis (TB). Among household contacts of persons with TB, HIV greatly increases the risk of incident TB and death. However, almost half of household contacts in routine settings decline HIV test offers during routine contact investigation. We evaluated a brief social-behavioral norming intervention to increase acceptance of HIV testing during household TB contact investigation...
May 3, 2024: medRxiv
#51
JOURNAL ARTICLE
Doron Garfinkel, Yuval Levy
OBJECTIVES: To evaluate polypharmacy in older people to determine whether the number of medications de-prescribed correlates with the extent of improvement in quality of life (QoL) and clinical outcomes. DESIGN: A prospective longitudinal cohort study of polypharmacy in people living in a community in Israel. SETTING: Participants aged 65 years or older who took at least six prescription drugs followed up for at least 3 years (range 3-10 years) after poly-de-prescription (PDP) recommendations...
2024: Frontiers in Medicine
#52
JOURNAL ARTICLE
Alexander T D Grünwald, Susmita Roy, Renée Lampe
BACKGROUND: Spinal deformations, except for acute injuries, are among the most frequent reasons for visiting an orthopaedic specialist and musculoskeletal treatment in adults and adolescents. Data on the morphology and anatomical structures of the spine are therefore of interest to orthopaedics, physicians, and medical scientists alike, in the broad field from diagnosis to therapy and in research. METHODS: Along the course of developing supplementary methods that do not require the use of ionizing radiation in the assessment of scoliosis, twenty CT scans from females and males with various severity of spinal deformations and body shape have been analysed with respect to the transverse distances between the vertebral body and the spinous process end tip and the skin, respectively, at thoracic and lumbar vertebral levels...
May 14, 2024: BMC Medical Imaging
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JOURNAL ARTICLE
Jeffrey T Anderson, Christina Toolan, Emily Coker, Hannah Singer, Derek Pham, Nicholas Jackson, Catherine Lord, Rujuta B Wilson
BACKGROUND: Organized physical activity programs have been shown to provide wide benefits to participants, though there are relatively few studies examining the impact of these programs for individuals with developmental disabilities. This pilot study was conducted to determine the feasibility and impact of an undergraduate-led dance intervention program for children and adolescents with developmental disabilities. We evaluated the impact of the dance program on motor ability and social skills...
May 14, 2024: BMC Sports Science, Medicine and Rehabilitation
#54
JOURNAL ARTICLE
Yunhyung Choi, Jae Hee Lee
Plasma N-terminal prohormone of brain natriuretic peptide (NT-proBNP) level is primarily used as a biomarker for left ventricular (LV) dysfunction. It is influenced by various conditions, such as myocardial strain and situations affecting the clearance of NT-proBNP, including sepsis and shock. In this study, we investigated the appropriateness of NT-proBNP as a prognostic factor for septic shock. Patients with septic shock who visited the emergency department of the Ewha Womans' University Mokdong Hospital between January 1, 2018, and December 31, 2020, were classified into the survival group (those who survived in the hospital and were discharged) and the death group (those who died in the hospital)...
May 14, 2024: Scientific Reports
#55
JOURNAL ARTICLE
Sehrish Karim, Amna Rehana Siddiqui, Nurose Karim, Nousheen Akber Pradhan, Iqbal Azam, Muhammad Farrukh Qazi
BACKGROUND: Rotavirus (RV) induced diarrhea led to hospitalization and mortality prior to the introduction of the rotavirus vaccine (RVV). The estimated RVV coverage was 86% in children less than one year of age in Pakistan. OBJECTIVES: To determine the difference in the number of diarrheal episodes among children who received and who did not receive RVV, along with the parental and physician's perspectives on the barriers toward RV immunization in children aged less than 1 year in Karachi, Pakistan...
May 13, 2024: Vaccine
#56
JOURNAL ARTICLE
Onyeche Oche, Logan T Murry, Michelle S Keller, Joshua M Pevnick, Jeffrey L Schnipper, An T Nguyen, EunJi Michelle Ko, Korey A Kennelty
BACKGROUND: The PHARMacist Discharge Care (PHARM-DC) intervention is a pharmacist-led Transitions of Care (TOC) program intended to reduce 30-day hospital readmissions and emergency department visits which has been implemented at two hospitals in the United States. The objectives of this study were to: 1) explore perspectives surrounding the PHARM-DC program from healthcare providers, leaders, and administrators at both institutions, and 2) identify factors which may contribute to intervention success and sustainability...
April 23, 2024: Research in Social & Administrative Pharmacy: RSAP
#57
JOURNAL ARTICLE
Alexander Saucedo, Mamaram Ceesay, Sanjana Ravi, Kelsey Mumford, Miriam Alvarez, Jeny Gharty, Lorie M Harper, Alison G Cahill
BACKGROUND: Nationwide, obstetric clinics modified prenatal care to include telehealth visits in response to the COVID-19 pandemic, enabling the opportunity to investigate its impact on patient outcomes. We hypothesized that use of prenatal telehealth visits would increase the number of prenatal visits, decrease the frequency of urgent triage/emergency department (ED) visits, and improve perinatal outcomes. OBJECTIVE: To determine the impact of telehealth on number of obstetric prenatal visits and urgent triage/ED visits amidst the COVID-19 pandemic...
May 14, 2024: American Journal of Perinatology
#58
JOURNAL ARTICLE
Ayşe Polat, Zübeyde Demircioğlu, Hüseyin Küçükali
During the COVID-19 pandemic, Türkiye implemented a distinctive contact tracing approach involving in-person home visits by medical professionals to individuals who tested positive for the virus. This study examines the experiences of health professionals involved in contact tracing, exploring how they reappropriated their professional subjectivity and agency during their deployment in this role. It is an interpretive phenomenological qualitative study. We conducted 21 semi-structured in-depth interviews, subsequently carried out two separate focus group interviews with an additional 31 participants from various districts in Istanbul...
May 3, 2024: Social Science & Medicine
#59
JOURNAL ARTICLE
Mar Masiá, José A García, Javier García-Abellán, Sergio Padilla, Marta Fernández-González, Vanesa Agulló, Maria José Gosalbes, Sonia Ruíz-Pérez, Paula Mascarell, Angela Botella, Félix Gutiérrez
BACKGROUND: The relationship of microbiota composition dynamics and the progression of subclinical atherosclerosis in people with HIV (PWH) remains unknown. METHODS: 96-week, prospective, longitudinal study in virologically-suppressed PWH. Carotid intima-media thickness (cIMT) measurements and stool samples were obtained at baseline, 48-week and 96-week visits. cIMT progression was defined as an increase >10% and/or detection of new carotid plaque. To profile the gut microbiome, amplification and sequencing of 16S ribosomal-RNA (V3-V4 variable regions) were carried out following the Illumina protocol...
May 14, 2024: Journal of Infectious Diseases
#60
JOURNAL ARTICLE
Isabel S Moore, Kelly J Ashford, Richard Mullen, Holly S R Jones, Molly McCarthy-Ryan
The aim was to examine the effect of focus of attention cues on foot angle for retraining movement purposes. Twenty (females: 8) rearfoot-striking recreational runners (mass: 72.5 ± 11.8 kg; height: 1.73 ± 0.09 m; age: 32.9 ± 11.3 years) were randomly assigned to an internal focus (IF) ( n = 10) or external focus (EF) ( n = 10) verbal cue group. Participants performed 5 × 6 minute blocks of treadmill running (control run, 3 × cued running, retention run) at a self-selected running velocity (9...
May 14, 2024: Journal of Sports Sciences
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