Ester Ponzetto, Quentin Delhez, Maarten Hoppenbrouwers, Nicolas De Schryver, Nicolas Serck, Thierry Dugernier, Marie-Céline Duray, Benjamin Gressens, Marco Vinetti, Gregorius J Sips, Jeroen van Kampen, Corine H GeurtsvanKessel, Sander van Boheemen
Macacine alphaherpesvirus 1, also known as herpes B virus (BV), is an alphaherpesvirus endemic to several macaque species, capable of causing zoonotic infections in humans, with high mortality rates. Evidence of reactivation in humans has rarely been reported. Here we depict a case of BV reactivation after 54 years, leading to severe meningoencephalitis. This case supports the use of antiviral prophylaxis in patients surviving a confirmed BV central nervous system infection. We sequenced DNA from BV obtained from the patient's cerebrospinal fluid...
October 16, 2023: American Journal of Tropical Medicine and Hygiene