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REVIEW
Jean-Marie Bruzzese
Asthma is a significant worldwide concern among adolescents. Adolescents experience key cognitive and psychosocial developmental changes that they must negotiate as they transition from children to adults. Several of these changes have implications for their ability to effectively manage their asthma. When health care professionals (HCPs) understand these pivotal changes and their role in asthma management, they are better able to work with adolescents and help them become effective asthma self-managers. Therefore, this article reviews the cognitive changes that render adolescents ready to care for their asthma, as well as the following psychosocial changes that may hinder or facilitate self-management: independence from caregivers, reliance on peers, identity development, the role of social media in adolescents' lives, and risk-taking behaviors...
September 2024: Pediatric Allergy, Immunology, and Pulmonology
#2
JOURNAL ARTICLE
Sefika Ilknur Kokcu Karadag, Burak Sariaydin, Ayşegül Sariaydin, Recep Sancak
Background: In the past two decades, the prevalence of asthma, eczema, and allergic rhinitis has increased among school-aged children in the Central Black Sea region of Turkey. This increase is consistent with national and international data, reflecting the impact and temporal changes of allergic diseases on the community. A similar increasing trend is also observed worldwide. This study aims to contribute to the development of health policies related to allergic diseases among Turkish children in the Central Black Sea region...
September 2024: Pediatric Allergy, Immunology, and Pulmonology
#3
EDITORIAL
Scott Bickel, Ronald Morton
No abstract text is available yet for this article.
September 2024: Pediatric Allergy, Immunology, and Pulmonology
#4
JOURNAL ARTICLE
Jean-Marie Bruzzese
No abstract text is available yet for this article.
September 2024: Pediatric Allergy, Immunology, and Pulmonology
#5
JOURNAL ARTICLE
Russell J Hopp, Andrew Huang
A 16-year-old Caucasian male with previously diagnosed eosinophilic esophagitis (EoE) 4 years before his initial visit to an allergist-immunologist, scheduled due to severe dysphagia and recurrent food impaction. He had been off EoE therapy for 1 year. After resuming inhaled fluticasone and a proton pump inhibitor (PPI), esophagogastroduodenoscopy (EGD) was immediately scheduled. The dates of the original EGD procedures with the histological summary and EoE therapy are reported in the Table 1. The fourth endoscopy revealed near normal histology, with rare candida staining (Table 1)...
September 2024: Pediatric Allergy, Immunology, and Pulmonology
#6
JOURNAL ARTICLE
Megan M Wyatt, Chrystal M Paulos
Cancer remains one of the most complex challenges in modern medicine, with intricate relationships between immune responses and tumor development. This article examines a groundbreaking study by Fesneau, Thevin and colleagues, published in Nature Immunology. This elegant body of work explores the link between chronic inflammation and cancer, particularly focusing on Th17 cells involved in intestinal cancer initiation. Th17 cells, known for their dual roles in immunity, can promote or inhibit tumor growth depending on their environment...
September 18, 2024: Cancer Research
#7
JOURNAL ARTICLE
Chengying Cui, Haojie Zhang, Congcong Yang, Mingwei Yin, Xinkun Teng, Miaomiao Yang, Dejie Kong, Jinzhi Zhang, Weidong Peng, Zhimin Chu, Jingjing Wang, Yating Sun, Liping Kang, Bin Lyu, Qian Gao, Mingqing Wu, Yongqiang Wang, Yang Li
Currently, only 20-40% of cancer patients benefit from immune checkpoint inhibitors. Understanding the mechanisms underlying the immunosuppressive tumor microenvironment (TME) and characterizing dynamic changes in the immunological landscape during treatment are critical for improving responsiveness to immunotherapy. Here, we identified JNK signaling in cancer-associated fibroblasts (CAFs) as a regulator of the immunosuppressive tumor microenvironment. Single-cell RNA sequencing of bladder cancer treated with a JNK inhibitor revealed enhanced cytotoxicity and effector functions of CD8+ T cells...
September 18, 2024: Cancer Research
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JOURNAL ARTICLE
Justin C Jagodinsky, Jessica M Vera, Won Jong Jin, Amanda G Shea, Paul A Clark, Raghava N Sriramaneni, Thomas C Havighurst, Ishan Chakravarthy, Raad H Allawi, KyungMann Kim, Paul M Harari, Paul M Sondel, Michael A Newton, Marka R Crittenden, Michael J Gough, Jessica R Miller, Irene M Ong, Zachary S Morris
Radiation therapy (RT) activates multiple immunologic effects in the tumor microenvironment (TME), with diverse dose-response relationships observed. We hypothesized that, in contrast with homogeneous RT, a heterogeneous RT dose would simultaneously optimize activation of multiple immunogenic effects in a single TME, resulting in a more effective antitumor immune response. Using high-dose-rate brachytherapy, we treated mice bearing syngeneic tumors with a single fraction of heterogeneous RT at a dose ranging from 2 to 30 gray...
September 18, 2024: Science Translational Medicine
#9
JOURNAL ARTICLE
Benoît Manfroi, Bui Thi Cuc, Aurélien Sokal, Alexis Vandenberghe, Sarah Temmam, Mikaël Attia, Mohamed El Behi, Francesco Camaglia, Ngan Thu Nguyen, Jelka Pohar, Layale Salem-Wehbe, Valentine Pottez-Jouatte, Sibyline Borzakian, Narcisse Elenga, Caroline Galeotti, Guillaume Morelle, Camille de Truchis de Lays, Michaela Semeraro, Anne-Sophie Romain, Mélodie Aubart, Naim Ouldali, Florence Mahuteau-Betzer, Claire Beauvineau, Elsa Amouyal, Romain Berthaud, Célia Crétolle, Marc Duval Arnould, Albert Faye, Mathie Lorrot, Grégoire Benoist, Nelly Briand, Marie Courbebaisse, Roland Martin, Peter Van Endert, Jean-Sébastien Hulot, Anne Blanchard, Eric Tartour, Maria Leite-de-Moraes, Guillaume Lezmi, Mickael Ménager, Marine Luka, Claude-Agnès Reynaud, Jean-Claude Weill, Laetitia Languille, Marc Michel, Pascal Chappert, Thierry Mora, Aleksandra M Walczak, Marc Eloit, Petra Bacher, Alexander Scheffold, Matthieu Mahévas, Isabelle Sermet-Gaudelus, Simon Fillatreau
The development of the human immune system lasts for several years after birth. The impact of this maturation phase on the quality of adaptive immunity and the acquisition of immunological memory after infection at a young age remains incompletely defined. Here, using an antigen-reactive T cell (ARTE) assay and multidimensional flow cytometry, we profiled circulating severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-reactive CD3+ CD4+ CD154+ T cells in children and adults before infection, during infection, and 11 months after infection, stratifying children into separate age groups and adults according to disease severity...
September 18, 2024: Science Translational Medicine
#10
JOURNAL ARTICLE
Yuepeng Zhang, Fabian Otte, Marcel Stoeckle, Alexander Thielen, Martin Däumer, Rolf Kaiser, Katharina Kusejko, Karin J Metzner, Thomas Klimkait
Even during extended periods of effective immunological control, a substantial dynamic of the viral genome can be observed in different cellular compartments in HIV-1 positive individuals, indicating the persistence of active viral reservoirs. To obtain further insights, we studied changes in the proviral as well as in the viral HIV-1 envelope (Env) sequence along with transcriptional, translational and viral outgrowth activity as indicators for viral dynamics and genomic intactness. Our study identified distinct reservoir patterns that either represented highly sequence-diverse HIV-1 populations or only a single / few persisting virus variants...
September 2024: PLoS Pathogens
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JOURNAL ARTICLE
Iivo Hetemäki, Joona Sarkkinen, Huai Hui Wong, Nelli Heikkilä, Saila Laakso, Simo Miettinen, Mikko I Mäyränpää, Outi Mäkitie, T Petteri Arstila, Eliisa Kekäläinen
Mucosal-associated invariant T cells (MAIT) are innate-like lymphocytes enriched in mucosal organs where they contribute to antimicrobial defense. APECED is an inborn error of immunity characterized by immune dysregulation and chronic mucocutaneous candidiasis. Reduction in the frequency of circulating MAITs has been reported in many inborn errors of immunity, but only in a few of them, the functional competence of MAITs has been assessed. Here, we show in a cohort of 24 patients with APECED, that the proportion of circulating MAITs was reduced compared with healthy age and sex-matched controls (1...
September 18, 2024: European Journal of Immunology
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JOURNAL ARTICLE
Alexandra A Aybar-Torres, Lennon A Saldarriaga, Ann T Pham, Amir M Emtiazjoo, Ashish K Sharma, Andrew J Bryant, Lei Jin
The significance of STING1 gene in tissue inflammation and cancer immunotherapy has been increasingly recognized. Intriguingly, common human STING1 alleles R71H-G230A-R293Q ( HAQ ) and G230A-R293Q ( AQ ) are carried by ~60% of East Asians and ~40% of Africans, respectively. Here, we examine the modulatory effects of HAQ, AQ alleles on STING-associated vasculopathy with onset in infancy (SAVI), an autosomal dominant, fatal inflammatory disease caused by gain-of-function human STING1 mutations. CD4 T cellpenia is evident in SAVI patients and mouse models...
September 18, 2024: ELife
#13
JOURNAL ARTICLE
Bing Ma, Suchitra Kamle, Takayuki Sadanaga, Chang-Min Lee, Joyce H Lee, Daniel C Yee, Zhou Zhu, Edwin K Silverman, Dawn L DeMeo, Augustine M K Choi, Chun Geun Lee, Jack A Elias
Innate immune responses such as phagocytosis are critically linked to the generation of adaptive immune responses against the neoantigens in cancer and the efferocytosis that is essential for homeostasis in diseases characterized by lung injury, inflammation, and remodeling as in chronic obstructive pulmonary disease (COPD). Chitinase 3-like-1 (CHI3L1) is induced in many cancers where it inhibits adaptive immune responses by stimulating immune checkpoint molecules (ICPs) and portends a poor prognosis. CHI3L1 is also induced in COPD where it regulates epithelial cell death...
September 18, 2024: Journal of Immunology
#14
JOURNAL ARTICLE
Zhiyuan Niu, Mengjun Wang, Yangchun Yan, Xinru Jin, Linwei Ning, Bingqian Xu, Yanfeng Wang, Yuekai Hao, Zhixia Luo, Changjiang Guo, Lingtong Zhi, Wuling Zhu
The human-derived NK-92 cell-based CAR-NK therapy exhibits inconsistency with overall suboptimal efficacy and rapid in vivo clearance of CAR-NK92 cells in cancer patients. Analysis indicates that although pre-existing IgM in healthy individuals (n = 10) strongly recognizes both NK-92 and CAR-NK92 cells, IgG and IgE do not. However, only a subset of cancer patients (3/8) exhibit strong IgM recognition of these cells, with some (2/8) showing pre-existing IgG recognition. These results suggest a natural immunoreactivity between NK-92 and CAR-NK92 cells and pre-existing human Abs...
September 18, 2024: Journal of Immunology
#15
JOURNAL ARTICLE
Kumiko Kuwaba, Masashi Kusubata, Maki Saito, Kazunori Mizuno
The mood status of fatigue can impact daily activities. Dietary collagen peptides have been reported to be beneficial for health conditions. A randomized, double-blinded, placebo-controlled, parallel-group study investigated the effects of collagen peptides on mood status including fatigue, physical condition, and immunological status. The participants who were healthy but easily fatigued consumed active food containing collagen peptides (10 g/day) ( n = 33) or placebo food ( n = 33) for eight weeks...
September 18, 2024: Journal of Dietary Supplements
#16
REVIEW
Sudheer Salana, Vishal Verma
In recent decades, several cell-based and acellular methods have been developed to evaluate ambient particulate matter (PM) toxicity. Although cell-based methods provide a more comprehensive assessment of PM toxicity, their results are difficult to comprehend due to the diversity in cellular endpoints, cell types, and assays and the interference of PM chemical components with some of the assays' techniques. In this review, we attempt to clarify some of these issues. We first discuss the morphological and immunological differences among various macrophage and epithelial cells, belonging to the respiratory systems of human and murine species, used in the in vitro studies evaluating PM toxicity...
September 18, 2024: Environmental Science. Processes & Impacts
#17
JOURNAL ARTICLE
Zhongben Tang, Meiqiu Chen, Chen Chen, Chao Fan, Jiaxian Huang
INTRODUCTION: Myasthenia gravis (MG) is an autoimmune disorder. Microvesicle-derived miRNAs have been implicated in autoimmune diseases. However, the role of microvesicle-derived miR-29a-3p in MG remains poorly understood. This study aimed to investigate the therapeutic effect and mechanism of miR-29a-3p derived from stem cell microvesicles (MVs) on experimental autoimmune myasthenia gravis (EAMG) rats. METHODS: EAMG was induced in rats by injection of the subunit of the rat nicotinic anti-acetylcholine receptor (AChR) R97-116 peptide...
September 18, 2024: Immunological Investigations
#18
JOURNAL ARTICLE
Xiaomeng Li, Qingqing Ma, Yuan Huang, Linlin Cheng, Yongmei Liu, Haolong Li, Haoting Zhan, Fengchun Zhang, Yudong Liu, Yongzhe Li
OBJECTIVES: The mitochondrial function in anti-MDA5 and TIF1-γ-positive dermatomyositis (DM) is relatively unknown. This study attempted to explore mitochondrial mass within the peripheral lymphocyte subsets of anti-MDA5 and TIF1-γ-positive DM. METHODS: This cross-sectional study enrolled 109 DM patients and 32 healthy controls (HCs). The mitochondrial mass of peripheral lymphocyte subsets was analyzed via flow cytometry using median fluorescence intensity assessment...
September 18, 2024: Immunological Investigations
#19
JOURNAL ARTICLE
Xiaoying Zhou, Diane Dunham, Sayantani B Sindher, Andrew Long, Andrea Fernandes, Iris Chang, Amal Assa'ad, Jacqueline Pongracic, Jonathan M Spergel, Jonathan Tam, Stephen Tilles, Julie Wang, Scott D Boyd, R Sharon Chinthrajah, Kari C Nadeau
BACKGROUND: Omalizumab (XOLAIR®)-assisted multi-food oral immunotherapy (mOIT) has been shown to safely, effectively, and rapidly desensitize patients with multiple food allergies. In our clinical trial (NCT02626611) on omalizumab-assisted mOIT, different desensitization outcomes (success or failure of desensitization) were observed following a period of either continued or discontinued mOIT. However, the association between the immunological changes induced by omalizumab-assisted mOIT and desensitization outcomes has not yet been fully elucidated...
September 18, 2024: Allergy
#20
JOURNAL ARTICLE
Brad H Rovin, Pierre M Ronco, Jack F M Wetzels, Sharon G Adler, Isabelle Ayoub, Philippe Zaoui, Seung Hyeok Han, Jaideep S Dudani, Houston N Gilbert, Uptal D Patel, Paul T Manser, Julia Jauch-Lembach, Nicola Faulhaber, Rainer Boxhammer, Stefan Härtle, Ben Sprangers
INTRODUCTION: Primary membranous nephropathy (PMN) is most often caused by autoantibodies to phospholipase A2 receptor (PLA2R). M-PLACE (NCT04145440) is an open-label, phase 1b/2a study that assessed the safety and efficacy of the fully human anti-CD38 monoclonal antibody felzartamab in high-risk anti-PLA2R+ PMN. METHODS: Patients with newly diagnosed or relapsed PMN (cohort 1 [C1]; n = 18) or PMN refractory to immunosuppressive therapy (IST) (cohort 2 [C2]; n = 13) received 9 infusions of felzartamab 16 mg/kg in the 24-week treatment period, followed by a 28-week follow-up...
September 2024: KI Reports
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