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Cancer, Oncology, Carcinoma

Lingxiao Pan, Changsheng Ye, Lun Chen, Wei Tang, Xiaoshen Zhang, Jin Gao, Rui Wu, Xigang Ye, Weige Tan, Minghui Wan, Wenbo Zheng
BACKGROUND: Nipple-sparing mastectomy combined with breast reconstruction helps to optimize the contour of the breast after mastectomy. However, the indications for nipple-sparing mastectomy are still controversial. Local radiation to the nipple-areola complex may play some roles in improving the oncological safety of this procedure. METHODS: From January 2014 to December 2017, 41 consecutive patients who underwent nipple-sparing mastectomy combined with Intrabeam intraoperative radiotherapy to the nipple-areola complex flap and breast reconstruction were enrolled in this prospective study...
March 19, 2019: Breast Cancer: the Journal of the Japanese Breast Cancer Society
Vincent Balaya, Fabrice Lécuru, Laurent Magaud, Charlotte Ngô, Cyrille Huchon, Anne Sophie Bats, Patrice Mathevet
OBJECTIVE: The aim of this study was to determine the predictive factors of postoperative morbidity of patients who have undergone a radical trachelectomy (RT) for early-stage cervical cancer and to assess the oncologic outcomes. METHODS: We retrospectively analysed the data of 2 prospective trials on sentinel node biopsy for cervical cancer (SENTICOL I and II). Patients having a RT for early-stage cervical cancer with negative sentinel lymph node and safe margins, were included...
May 2019: Journal of Gynecologic Oncology
Corinne Calo, John O Elliott, Aine Clements, Gary Reid, Kellie Rath
OBJECTIVE: Completion of radiation therapy (RT) within 60 days has been proposed as a national quality measure for patients with carcinoma of the cervix as protracted RT has been associated with worse oncologic outcomes. The objective of this study was to compare compliance rates based on location of RT administration. METHODS: This was a retrospective chart review of patients diagnosed with cervical cancer between January of 2000 to December of 2016 who were planned to undergo primary treatment with sensitizing chemotherapy and RT...
March 2019: Gynecologic Oncology
Lucio Gordan, Marlo Blazer, Vishal Saundankar, Denise Kazzaz, Susan Weidner, Michael Eaddy
OBJECTIVES: The site of cancer care delivery has been shown to be associated with the total cost of care. The magnitude of this effect in patients receiving expensive immuno-oncology (I-O) therapies has not been evaluated. We evaluated cost differentials between community-based and hospital-based outpatient clinics among patients receiving I-O therapies. STUDY DESIGN: This was a retrospective analysis utilizing Truven MarketScan Commercial and Supplemental Medicare claims databases...
March 1, 2019: American Journal of Managed Care
Gianluca Franceschini, Alba Di Leone, Daniela Terribile, Martin Alessandro Sanchez, Riccardo Masetti
Aim of this paper is to allows to analyze a topic of great relevance and media interest such as the role of prophylactic mastectomy in healthy women with BRCA mutation proposing to the surgeons some useful informations for decision-making. Less than 15% of all breast cancers are associated with germline genetic mutations. The majority of hereditary breast tumors are due to mutations in BRCA1 and BRCA2 genes that are responsible for only one third of hereditary cases. The risk estimates are extremely heterogeneous with a mean cumulative lifetime breast cancer risk of approximately 72% in BRCA1 and 69% in BRCA2 by age 80...
2019: Annali Italiani di Chirurgia
Alexandre Bozec, Dorian Culié, Gilles Poissonnet, Olivier Dassonville
PURPOSE OF REVIEW: The objective of this review article is to discuss the current role of surgery as the primary treatment modality in patients with head and neck squamous cell carcinoma (HNSCC). RECENT FINDINGS: HNSCC represents one of the cancer locations where the primary treatment modality is the most under discussion. Indeed, the respective roles of primary surgical resection followed, as necessary, by adjuvant radiotherapy or definitive chemoradiotherapy remain controversial...
March 8, 2019: Current Opinion in Oncology
Wen-Kuei Chang, Ming-Ying Lee, Ying-Hsuan Tai, Yi-Min Kuo, Mei-Yung Tsou, Kuang-Yi Chang
BACKGROUND: Few studies have investigated the association between epidural analgesia (EA) and oncologic outcomes in patients following hepatocellular carcinoma (HCC) resection. METHODS: This retrospective study was conducted at a single medical center using electronic medical records. Patients with non-metastatic primary HCC undergoing tumor resection between January 2005 and December 2011 were classified into two groups based on their use of EA or intravenous analgesia...
March 7, 2019: Journal of the Chinese Medical Association: JCMA
Isabel Armas, Mariana Brandão, Inês Guerreiro, Inês Guerreiro, João Lobo, Carla Freitas, João Pinto-de-Sousa, Joaquim Abreu de Sousa
Intestinal lipomatosis is rare and often asymptomatic but can present with intestinal obstruction. Occasionally, metastatic breast cancer is identified in the ovary before a breast primary is discovered. We report the case of a 50-year-old woman diagnosed with synchronous intestinal obstruction due to lipomatosis, and incidental ovarian metastases from breast cancer. The patient presented with a 12-day history of nausea, diffuse abdominal pain, and constipation. An abdominal x-ray showed air-fluid levels, and computed tomography documented small bowel distention...
January 2019: Autopsy & Case Reports
E Shelley Hwang, Terry Hyslop, Thomas Lynch, Elizabeth Frank, Donna Pinto, Desiree Basila, Deborah Collyar, Antonia Bennett, Celia Kaplan, Shoshana Rosenberg, Alastair Thompson, Anna Weiss, Ann Partridge
INTRODUCTION: Ductal carcinoma in situ (DCIS) is a non-invasive non-obligate precursor of invasive breast cancer. With guideline concordant care (GCC), DCIS outcomes are at least as favourable as some other early stage cancer types such as prostate cancer, for which active surveillance (AS) is a standard of care option. However, AS has not yet been tested in relation to DCIS. The goal of the COMET (Comparison of Operative versus Monitoring and Endocrine Therapy) trial for low-risk DCIS is to gather evidence to help future patients consider the range of treatment choices for low-risk DCIS, from standard therapies to AS...
March 12, 2019: BMJ Open
John R Sims, Lauren E Yue, Rebecca A Ho, Azita S Khorsandi, Margaret Brandwein-Weber, Mark L Urken
Thyroid carcinoma can infiltrate the aerodigestive tract. Invasion via the common party wall of the tracheoesophageal groove (TEG) is rare. A review of patients with thyroid cancer invading the aerodigestive tract was performed. We describe three cases of invasive thyroid cancer presenting 4 to 6 years after the initial thyroidectomy. Original pathology showed positive margins near the recurrent laryngeal nerve and TEG. A partial tracheal resection with a stair-step reconstruction was performed in one case; the other cases required total laryngopharyngectomy...
March 12, 2019: Laryngoscope
Giovanni Lughezzani, Marco Paciotti, Vittorio Fasulo, Paolo Casale, Alberto Saita
PURPOSE OF REVIEW: The relationship between gender and kidney cancer incidence/outcomes has been largely evaluated and may significantly impact the management of patients diagnosed with these tumors. We reviewed and summarized the most relevant recent publications reporting about this clinically meaningful relationship. RECENT FINDINGS: The incidence of kidney cancer is higher in men than in women. Male gender is clearly associated with more aggressive histological characteristics both in terms of tumor stage and grade...
March 6, 2019: Current Opinion in Urology
C Murray, D Sivajohanathan, T P Hanna, S Bradshaw, N Solish, B Moran, R Hekkenberg, A C Wei, T Petrella
Objective: The purpose of the present work was to develop evidence-based indications for Mohs micrographic surgery in patients with a diagnosis of skin cancer. Methods: The guideline was developed by Cancer Care Ontario's Program in Evidence-Based Care, together with the Melanoma Disease Site Group and the Surgical Oncology Program, through a systematic review of relevant literature, patient- and caregiver-specific consultation, and internal and external reviews...
February 2019: Current Oncology
Ryusuke Murakami, Noriomi Matsumura, Hirofumi Michimae, Hiroshi Tanabe, Mayu Yunokawa, Haruko Iwase, Motoi Sasagawa, Toshiaki Nakamura, Osamu Tokuyama, Masashi Takano, Toru Sugiyama, Takashi Sawasaki, Seiji Isonishi, Kazuhiro Takehara, Hidekatsu Nakai, Aikou Okamoto, Masaki Mandai, Ikuo Konishi
OBJECTIVE: Recently, we established new histopathological subtypes of high-grade serous ovarian cancer (HGSOC) that include the mesenchymal transition (MT) type, the immune reactive (IR) type, the solid and proliferative (SP) type and the papillo-glandular (PG) type. Furthermore, we identified that the mesenchymal transcriptome subtype might be sensitive to taxane. We investigated whether these different histopathological subtypes of HGSOC require individualized chemotherapy for optimal treatment...
March 7, 2019: Gynecologic Oncology
Carlo Sposito, Alessandro Cucchetti, Vincenzo Mazzaferro
Hepatocellular carcinoma (HCC) as an indication to liver transplant (LT) started as palliative treatment, then moved to potentially curative anti-cancer therapy and more recently entered the era of competition with non-cancer indications, consequent to the need of the society to target equal distribution of the limited resource of donated organs among different indications. Nowadays HCC is a leading indication to LT, currently representing up to 50% of the indications in most transplant Centers. The risk of post-transplant death and the causes of mortality significantly vary along the post-transplant follow-up...
March 9, 2019: Digestive Diseases and Sciences
Alexandre Bozec, Philippe Schultz, Jocelyn Gal, Emmanuel Chamorey, Yann Chateau, Olivier Dassonville, Gilles Poissonnet, François Demard, Frédéric Peyrade, Esma Saada, Karen Benezery, Axel Leysalle, Laure Santini, Lila Messaoudi, Nicolas Fakhry
OBJECTIVES: The purposes of this study were to assess the evolution of quality of life (QoL) in patients with head and neck squamous cell carcinoma (HNSCC) undergoing oncologic surgery and to determine the predictive factors of post-therapeutic QoL. METHODS: All HNSCC patients who underwent primary surgery, between 2012 and 2014, were enrolled in this prospective multicentric study. Patients completed the EORTC QLQ-C30 and QLQ-H&N35 questionnaires before surgery and at 6 months after treatment...
March 2019: Surgical Oncology
Heng Yu, Lei Tao, Liang Zhou, Ming Zhang, Haitao Wu, Xiaoming Li, Xiaoling Chen, Cai Li, Ming Xie, Lei Cheng
Primary subglottic carcinoma is rare and surgery is the most common therapeutic strategy for Chinese patients with this disease. To retrospectively evaluate surgically treated primary subglottic carcinoma treated with surgery. Patients with primary subglottic carcinoma who initially underwent surgery from 2005-2010 were grouped by surgical procedures with or without laryngeal function preservation and reviewed. Of 1815 patients with laryngeal cancer, 23 had a subglottic origin. Of these, 21 initially underwent surgery; 12 had 'early' (stage I/II) disease, and nine had 'advanced' (stage III/IV) disease...
March 8, 2019: Acta Oto-laryngologica
Germán Calderillo-Ruiz, Roberto Herrera-Goepfert, Consuelo Díaz-Romero, Berenice Carbajal-López, Horacio López-Basave
BACKGROUND: Gallbladder epidermoid carcinoma is rare and more common in women over 55 years of age. AIM: To report the features of 15 patients with gallbladder epidermoid carcinoma. MATERIAL AND METHODS: Review of medical records of patients with gallbladder cancer in an oncology service. RESULTS: Of 207 patients with gallbladder cancer, 15patients aged 53-72years, 93% women had an epidermoid component in their cancer...
December 2018: Revista Médica de Chile
Beat Foerster, David D'Andrea, Mohammad Abufaraj, Stephan Broenimann, Pierre I Karakiewicz, Morgan Rouprêt, Paolo Gontero, Seth P Lerner, Shahrokh F Shariat, Francesco Soria
PURPOSE: To assess the oncologic impact of adjuvant endocavitary instillation after kidney-sparing surgery (KSS) in the treatment of upper tract urothelial carcinoma (UTUC). METHODS: A meta-analysis of the available literature was performed using PUBMED and MEDLINE on June 2018. No time or language restrictions were applied. All included participants were substratified into 2 groups: Ta/T1 UTUC and upper tract (UT) carcinoma in situ. Subjects with higher stage disease, involvement of the bladder, or urethra were excluded...
March 4, 2019: Urologic Oncology
Germana Rappa, Caterina Puglisi, Mark F Santos, Stefano Forte, Lorenzo Memeo, Aurelio Lorico
The diagnostic approach to thyroid cancer is one of the most challenging issues in oncology of the endocrine system because of its high incidence (3.8% of all new cancer cases in the US) and the difficulty to distinguish benign from malignant non-functional thyroid nodules and establish the cervical lymph node involvement during staging. Routine diagnosis of thyroid nodules usually relies on a fine-needle aspirate biopsy, which is invasive and often inaccurate. Therefore, there is an urgent need to identify novel, accurate, and non-invasive diagnostic procedures...
March 5, 2019: International Journal of Molecular Sciences
K K Shahedah, S H How, A R Jamalludin, M T Mohd Faiz, Y C Kuan, C K Ong
BACKGROUND: Depression is a recognized complication of lung cancer underreported in developing countries such as Malaysia. Treating and identifying depression in cancer patients increases survival and quality of life. Our objectives are to study prevalence of depressive symptoms in newly diagnosed lung carcinoma, and examine the relationship of depressive symptoms with other influencing risk factors. METHODS: A 2-year, cross sectional study February 2015-February 2017, was conducted at Hospital Tengku Ampuan Afzan, and Penang General Hospital...
December 20, 2018: Tuberculosis and Respiratory Diseases
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