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https://read.qxmd.com/read/30768161/a-14-day-esomeprazole-and-amoxicillin-containing-high-dose-dual-therapy-regimen-achieves-a-high-eradication-rate-as-first-line-anti-helicobacter-pylori-treatment-in-taiwan-a-prospective-randomized-trial
#1
Wei-Chen Tai, Chih-Ming Liang, Chung-Mou Kuo, Pao-Yuan Huang, Cheng-Kun Wu, Shih-Cheng Yang, Yuan-Hung Kuo, Ming-Tsung Lin, Chen-Hsiang Lee, Chien-Ning Hsu, Keng-Liang Wu, Tsung-Hui Hu, Seng-Kee Chuah
BACKGROUND: The first-line eradication rate of standard triple therapy for Helicobacter pylori infection has declined to <80%, and alternative therapies with >90% success rates are needed. Inconsistent eradication rates were reported for proton pump inhibitor- and amoxicillin-containing high-dose dual therapy. OBJECTIVES: We performed a prospective, randomized controlled study to assess the efficacy of esomeprazole- and amoxicillin-containing high-dose dual therapy and investigated the influencing clinical factors...
February 14, 2019: Journal of Antimicrobial Chemotherapy
https://read.qxmd.com/read/30764765/helicobacter-pylori-infection-as-a-risk-factor-for-serum-bilirubin-change-and-less-favourable-lipid-profiles-a-hospital-based-health-examination-survey
#2
Miao-Miao Zhao, Jeremy Krebs, Xi Cao, Jing Cui, Dong-Ning Chen, Yu Li, Lin Hua, Jim Mann, Jin-Kui Yang
BACKGROUND: Helicobacter pylori infection is associated with several extragastric conditions including dyslipidemia and metabolic syndrome. This study aimed to investigate additional metabolic parameters associated with H. pylori infection in a Chinese population. METHODS: Using a case-control approach we studied 617 subjects with 13 C-urea breath test (13 C-UBT) values ≥10‰ who were defined as being positive for H. pylori (cases), while 617 sex and age- matched subjects with 13 C-UBT values ≤1‰ were defined as H...
February 14, 2019: BMC Infectious Diseases
https://read.qxmd.com/read/30762742/high-dose-dual-therapy-versus-bismuth-quadruple-therapy-for-helicobacter-pylori-eradication-treatment-a-systematic-review-and-meta-analysis
#3
Xue Yang, Jin-Xia Wang, Sheng-Xi Han, Cai-Ping Gao
AIM: The aim of this study was to perform a systematic review and meta-analysis on high-dose dual therapy (HDDT) versus bismuth quadruple therapy (BQT) for Helicobacter pylori infection. METHODS: Comparing HDDT to BQT were identified from PubMed, EMBASE, Cochrane library, CNKI, and Wanfang databases in Chinese up to March 2018. Statistical analyses were conducted using Review Manager 5.3 to compare the efficacy and side effects of these 2 therapies for H pylori infection...
February 2019: Medicine (Baltimore)
https://read.qxmd.com/read/30761584/machine-learning-model-to-predict-recurrent-ulcer-bleeding-in-patients-with-history-of-idiopathic-gastroduodenal-ulcer-bleeding
#4
Grace Lai-Hung Wong, Andy Jinhua Ma, Huiqi Deng, Jessica Yuet-Ling Ching, Vincent Wai-Sun Wong, Yee-Kit Tse, Terry Cheuk-Fung Yip, Louis Ho-Shing Lau, Henry Hin-Wai Liu, Chi-Man Leung, Steven Woon-Choy Tsang, Chun-Wing Chan, James Yun-Wong Lau, Pong-Chi Yuen, Francis Ka-Leung Chan
BACKGROUND: Patients with a history of Helicobacter pylori-negative idiopathic bleeding ulcers have an increased risk of recurring ulcer complications. AIM: To build a machine learning model to identify patients at high risk for recurrent ulcer bleeding. METHODS: Data from a retrospective cohort of 22 854 patients (training cohort) diagnosed with peptic ulcer disease in 2007-2016 were analysed to build a model (IPU-ML) to predict recurrent ulcer bleeding...
February 13, 2019: Alimentary Pharmacology & Therapeutics
https://read.qxmd.com/read/30753327/gwas-analysis-reveals-a-significant-contribution-of-psca-to-the-risk-of-heliobacter-pylori-induced-gastric-atrophy
#5
Asahi Hishida, Tomotaka Ugai, Ryosuke Fujii, Masahiro Nakatochi, Michael C Wu, Hidemi Ito, Isao Oze, Tajika Masahiro, Niwa Yasumasa, Takeshi Nishiyama, Hiroko Nakagawa-Senda, Sadao Suzuki, Teruhide Koyama, Daisuke Matsui, Yoshiyuki Watanabe, Takahisa Kawaguchi, Fumihiko Matsuda, Yukihide Momozawa, Michiaki Kubo, Mariko Naito, Keitaro Matsuo, Kenji Wakai
Although recent genome-wide association studies (GWASs) have identified genetic variants associated with Helicobacter pylori (HP)-induced gastric cancer, few studies have examined the genetic traits associated with the risk of HP-induced gastric precancerous conditions. This study aimed to elucidate genetic variants associated with these conditions using a genome-wide approach. Data from four sites of the J-MICC Study were used in the discovery phase (Stage I); two datasets from the HERPACC2 Study were used in the replication phases (Stages II and III), and SKAT (SNP-set Kernel Association Test) and single variant-based GWASs were conducted for the risks of gastric atrophy (GA) and severe GA defined by serum pepsinogen (PG) levels, and PG1 and PG1/2 ratios...
February 8, 2019: Carcinogenesis
https://read.qxmd.com/read/30746681/n-acetylcysteine-as-an-adjuvant-therapy-for-helicobacter-pylori-eradication
#6
REVIEW
Luís Eduardo S Fontes, Ana Luiza C Martimbianco, Carolina Zanin, Rachel Riera
BACKGROUND: Helicobacter pylori (H pylori) is one of the most common pathogens to establish and cause infection in human beings, affecting about 50% of the world's population. Prevalence may be as high as 83% in Latin American countries and as low as 17% in North America. Approximately 20% of infected people will manifest disease; people at high risk include those who live in low- and middle-income countries with poor sanitary conditions, since the mechanism of transmission seems to be oral-oral or faecal-oral (mostly during infancy)...
February 12, 2019: Cochrane Database of Systematic Reviews
https://read.qxmd.com/read/30742638/correlation-between-macrophage-migration-inhibitory-factor-and-autophagy-in-helicobacter-pylori-associated-gastric-carcinogenesis
#7
Kichul Yoon, Nayoung Kim, Youngmi Park, Bo Kyung Kim, Ji Hyun Park, Cheol Min Shin, Dong Ho Lee, Young-Joon Surh
The role of macrophage migration inhibitory factor (MIF) and autophagy in gastric cancer is not clear. We determined H. pylori infection status of the subjects and investigated the expression of MIF and autophagy markers (Atg5, LC3A and LC3B) in human gastric tissue at baseline. Then H. pylori eradication was done for H. pylori positive patients and MIF and Atg5 levels were investigated on each follow-up for both H. pylori-eradicated and H. pylori negative patients. Baseline tissue mRNA expression of MIF, Atg5, LC3A and LC3B was measured by real-time PCR in 453 patients (control 165, gastric dysplasia 82, and gastric cancer 206)...
2019: PloS One
https://read.qxmd.com/read/30737531/association-between-atrial-fibrillation-and-helicobacter-pylori
#8
REVIEW
Cecilia Tetta, Amalia Ioanna Moula, Francesco Matteucci, Orlando Parise, Bart Maesen, Daniel Johnson, Mark La Meir, Sandro Gelsomino
The connection between atrial fibrillation (AF) and H. pylori (HP) infection is still matter of debate. We performed a systematic review and metanalysis of studies reporting the association between AF and HF. A systematic review of all available reports in literature of the incidence of HP infection in AF and comparing this incidence with subjects without AF were analysed. Risk ratio and 95% confidence interval (CI) and risk difference with standard error (SE) were the main statistics indexes. Six retrospective studies including a total of 2921 were included at the end of the selection process...
February 8, 2019: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://read.qxmd.com/read/30734341/fdg-pet-ct-as-a-diagnostic-and-prognostic-tool-for-the-evaluation-of-marginal-zone-lymphoma
#9
Iuliana Vaxman, Hanna Bernstine, Geffen Kleinstern, Natav Hendin, Shai Shimony, Liran Domachevsky, Ronit Gurion, David Groshar, Pia Raanani, Anat Gafter-Gvili
We evaluated the role of 18-Fluoro-2-deoxy-D-glucose positron emission tomography ([18F] FDG-PET) with computed tomography (CT) (PET/CT) as a diagnostic and prognostic tool in newly diagnosed marginal zone lymphoma (MZL) patients. This is a retrospective cohort study of patients with newly diagnosed MZL, treated with immunotherapy, chemotherapy regimens, surgery or helicobacter pylori eradication between 2008 and 2016 in a single tertiary center. Only patients who had a pre-treatment PET/CT (P-PET/CT) were included...
February 8, 2019: Hematological Oncology
https://read.qxmd.com/read/30732192/comparison-the-cost-efficacy-of-furazolidone-based-versus-clarithromycin-based-quadruple-therapy-in-initial-treatment-of-helicobacter-pylori-infection-in-a-variable-clarithromycin-drug-resistant-region-a-single-center-prospective-randomized-open-label-study
#10
Dong-Min Yi, Tao-Tao Yang, Shuai-Heng Chao, Ya-Xin Li, Ying-Lei Zhou, Hai-Hui Zhang, Ling Lan, Yu-Wei Zhang, Xue-Mei Wang, Yan-Rui Zhang, Jian Li, Song-Ze Ding
Helicobacter pylori (Hp) drug resistant rate to clarithromycin (CLA) has increased to 20% to 50%, which cause concerns regarding its effectiveness in eradicating Hp, we aim to evaluate the cost-effectiveness of CLA-based versus furazolidone (FZD)-based quadruple therapy, and assess factors that affect anti-Hp efficacy.One hundred eighty-five patients were enrolled in this single-center, prospective, randomized, open-label study. In FZD group, 92 patients were treated with FZD plus esomeprazole, bismuth potassium citrate, and amoxicillin for 14 days...
February 2019: Medicine (Baltimore)
https://read.qxmd.com/read/30732157/helicobacter-pylori-infection-and-risk-of-salmonella-infection
#11
Rasha I Salama, Mohamed H Emara, Hanan M Mostafa, Sherief Abd-Elsalam, Sherein Mohamed Alnabawy, Samah A Elshweikh, Mariam Salah Zaghloul
Helicobacter pylori (H pylori) infection is the most frequent infection worldwide and it has been postulated that it predisposes to multiple enteric pathogens and diarrheal diseases. Salmonella infection is common in tropical and under developed communities and is associated with wide range of diseases from gastroenteritis to typhoid fever. This study aimed at detecting the impact of H pylori infection on the incidence of salmonella infections.The study participants were sampled from cohorts of patients in four university hospitals in different Egyptian Governorates...
February 2019: Medicine (Baltimore)
https://read.qxmd.com/read/30724729/comparison-of-new-and-classical-point-mutations-associated-with-clarithromycin-resistance-in-helicobacter-pylori-strains-isolated-from-dyspeptic-patients-and-their-effects-on-phenotypic-clarithromycin-resistance
#12
Bekir Kocazeybek, Merve Kutlu Sakli, Pelin Yuksel, Mehmet Demirci, Reyhan Caliskan, Tevhide Ziver Sarp, Suat Saribas, Suleyman Demiryas, Fatma Kalayci, Huseyin Cakan, Hayriye Kirkoyun Uysal, Nesrin Gareayaghi, Sevgi Ergin, Yusuf Ziya Erzin, Kadir Bal, İhsan Tascı, Hrisi Bahar Tokman
PURPOSE: We aimed to investigate the presence of three recently identified point mutations (A2115G, G2141A and A2144T) of the 23 S rRNA gene and compare them with the three most frequently encountered point mutations (A2142G, A2142C and A2143G) in Helicobacter pylori strains in Turkey. METHODOLOGY: A total of 63 patients (mean 47.08±12.27) were included. The E-test method (for clarithromycin) was used for the clarithromycin antimicrobial susceptibility test of isolated H...
February 6, 2019: Journal of Medical Microbiology
https://read.qxmd.com/read/30722796/the-evaluation-of-nasal-mucociliary-clearance-in-patients-with-helicobacter-pylori-infection
#13
S Üstün Bezgin, T Çakabay, K Irak, M Koçyiğit, B Serin Keskineğe, S Giran Örtekin
OBJECTIVE: This study aimed to examine nasal mucociliary clearance time in patients with Helicobacter pylori infection. METHODS: Fifty patients who were newly diagnosed with H pylori infection using gastric biopsy in the gastroenterology out-patient clinic, and 50 age- and gender-matched healthy adults who were admitted to the otorhinolaryngology out-patient clinic, were included in this study. After an otorhinolaryngological examination (anterior rhinoscopy and nasal endoscopic examination), the nasal mucociliary clearance time of each subject was calculated using the saccharine test...
February 6, 2019: Journal of Laryngology and Otology
https://read.qxmd.com/read/30705518/eradication-therapy-for-helicobacter-pylori-infection-improves-nutrition-status-in-japanese-hemodialysis-patients-a-pilot-study
#14
Hitomi Ichikawa, Mitsushige Sugimoto, Yukitoshi Sakao, Shu Sahara, Naro Ohashi, Koji Sano, Shigeru Tadokoro, Hisanori Azekura, Akira Shimomura, Fuyuki Yamashita, Daiki Sugiyama, Ken Fukuta, Takahisa Furuta, Akihiko Kato, Ken Sugimoto, Hideo Yasuda
Plasma ghrelin level is influenced by Helicobacter pylori ( H. pylori ) status and the severity of gastric mucosal atrophy, and the ghrelin level is associated with nutrition status in hemodialysis patients. Here, we investigated the efficacy of H. pylori eradication therapy in improving nutrition status in relation to the ghrelin level in H. pylori -positive hemodialysis patients. Of H. pylori -positive patients receiving hemodialysis at 8 dialysis center, 21 patients underwent gastroduodenoscopy for evaluation of the severity of gastric atrophy, and nutrition markers and plasma ghrelin levels before and 1 year after H...
January 2019: Journal of Clinical Biochemistry and Nutrition
https://read.qxmd.com/read/30701937/evaluation-of-the-efficacy-and-safety-of-the-hybrid-scheme-for-eradication-therapy-of-helicobacter-pylori-infection
#15
G L Yurenev, E V Partzvania-Vinogradova, D N Andreev, D T Dicheva, I V Maiev
AIM: The aim is to conduct a comprehensive comparative study of the efficacy and safety of the hybrid scheme of eradication therapy (ET) in patients with peptic ulcer of the stomach or duodenum associated with Helicobacter pylori. MATERIALS AND METHODS: Materials and methods. In a prospective, randomized comparative study, 180 patients were divided into three equal groups of 60 people, depending on the prescribed 10-day ET regimen. Group 1 - the standard triple scheme (omeprazole, amoxicillin and clarithromycin); group 2 - four-component therapy with preparations of bismuth (omeprazole, tetracycline, metronidazole, bismuth tricalium dicitrate); group 3 - hybrid scheme (first 5 days: omeprazole and amoxicillin, the next 5 days: omeprazole, amoxicillin, clarithromycin, metronidazole)...
August 27, 2018: Terapevticheskiĭ Arkhiv
https://read.qxmd.com/read/30701936/efficacy-and-safety-of-the-use-of-rebamipide-in-the-scheme-of-triple-eradication-therapy-of-helicobacter-pylori-infection-a-prospective-randomized-comparative-study
#16
D N Andreev, I V Maev, D T Dicheva, A A Samsonov, E V Partzvania-Vinogradova
AIM: To evaluate the effectiveness and safety of the use of rebamipide as part of the triple eradication therapy (ET) scheme of Helicobacter pylori infection. MATERIALS AND METHODS: A prospective, randomized comparative study included 94 patients with uncomplicated H. pylori-associated stomach / duodenal ulcer. In the process of randomization, patients are divided into three groups depending on the intended therapy. The first group (n=36) received a classical triple scheme of the first-line ET (omeprazole 20 mg twice a day, amoxicillin 1000 mg twice a day, clarithromycin 500 mg twice a day) for 10 days...
August 27, 2018: Terapevticheskiĭ Arkhiv
https://read.qxmd.com/read/30701869/the-prevalence-of-helicobacter-pylori-infection-among-urban-population
#17
T V Zhestkova, M A Butov, S V Papkov
AIM: Determination of the prevalence of Helicobacter pylori infection (H. pylori) among the urban population. MATERIALS AND METHODS: 655 people (638 adults and 17 children) were examined using the immunoassay method of quantitative detection of IgG class antibodies. RESULTS: High infection of adult residents of Ryazan H. pylori - 64,4% is established. The greatest prevalence of H. pylori infection was observed in individuals 41 to 80 years of age (66,9%)...
April 19, 2018: Terapevticheskiĭ Arkhiv
https://read.qxmd.com/read/30701820/case-of-thrombosis-of-the-portal-vein-and-its-branches-in-a-patient-seropositive-for-borrelia-antigens
#18
E V Reznik, M P Prushkovskaya, E D Presnova, N A Novikova, R A Ivaschenko, E I Dedov, A E Nikitin, I G Nikitin
Borreliosis after sucking ticks is an acute problem in the world. People do not go to doctors after that often, which leads to the development of various complications. Thrombosis of veins of various localization can be one of them. Thrombosis of the portal vein represents a significant problem too with high morbidity and mortality. The risk factors for splanchnic vein thrombosis include infections, but its relationship with borreliosis has not been studied. А 34-year-old man with chronic helicobacter-associated gastritis and gallstones was hospitalized due to development during the last 11 days of epigastric pain and fever to 38...
November 22, 2018: Terapevticheskiĭ Arkhiv
https://read.qxmd.com/read/30700483/prevalence-and-determinants-of-serological-evidence-of-atrophic-gastritis-among-arab-and-jewish-residents-of-jerusalem-a-cross-sectional-study
#19
Khitam Muhsen, Ronit Sinnreich, Dafna Merom, Gany Beer-Davidson, Hisham Nassar, Dani Cohen, Jeremy D Kark
OBJECTIVE: Understanding the correlates of premalignant gastric lesions is essential for gastric cancer prevention. We examined the prevalence and correlates of serological evidence of atrophic gastritis, a premalignant gastric condition, using serum pepsinogens (PGs) in two populations with differing trends in gastric cancer incidence. METHODS: In a cross-sectional study, using ELISA we measured serum PGI and PGII concentrations (Biohit, Finland), Helicobacter pylori serum IgG and cytotoxin-associated gene A (CagA) antigen IgG antibodies in archived sera of 692 Jews and 952 Arabs aged 25-78 years, randomly selected from Israel's population registry in age-sex and population strata...
January 29, 2019: BMJ Open
https://read.qxmd.com/read/30700447/body-mass-index-and-risk-of-intestinal-metaplasia-a-cohort-study
#20
Seungho Ryu, Kyungeun Kim, Yoosoo Chang, Jiin Ahn, Hyo-Joon Yang, Ju Young Jung, Seokkyun Kim, Chong Il Sohn
BACKGROUND: We examined the association between body mass index (BMI) and development of endoscopic intestinal metaplasia (IM). METHODS: This retrospective cohort study included 142,832 Korean adults free of endoscopic IM and atrophic gastritis (AG) who underwent upper endoscopy at baseline and subsequent visits and were followed for up to 5 years. A parametric proportional hazards model was used to estimate the adjusted hazard ratio with 95% confidence interval (CI) for incident IM...
January 30, 2019: Cancer Epidemiology, Biomarkers & Prevention
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