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Shuting Li, Liefeng Hu, Dapeng Li, Xin Wang, Panpan Zhang, Jun Wang, Guoqing Yan, Rupei Tang
This work described the preparation of two type nanogels based on the crosslinking between carboxymethyl chitosan (CMCS) and two different crosslink agents, an acid-labile cyclic ortho ester compound with dual epoxy end groups (OEDe) or corresponding non-sensitive ethyleneglycol diglycidyl ether (EGDE). The particle size, zeta potential, and micromorphology were characterized by dynamic light scattering and electron microscopy, respectively. Nanogels' stability was also investigated at physiological environments...
February 13, 2019: International Journal of Biological Macromolecules
Federico Baltar, Daniele De Corte, Blair Thomson, Taichi Yokokawa
Extracellular enzymatic activity (EEA) is performed by cell-associated and cell-free (i.e., "dissolved") enzymes. This cell-free fraction is operationally defined as passing through a 0.22 μm filter. The contribution of cell-free to total EEA is comparable to the cell-associated counterpart, so it is critical to understand what controls the relative importance of cell-free versus cell-associated EEA. However, attempts to tease apart the contribution of EEAs in the so-called dissolved fraction (<0...
April 10, 2019: Science of the Total Environment
Parisa Eslami, Filippo Rossi, Stefano Fedeli
Considering nanogels, we have focused our attention on hybrid nanosystems for drug delivery and biomedical purposes. The distinctive strength of these structures is the capability to join the properties of nanosystems with the polymeric structures, where versatility is strongly demanded for biomedical applications. Alongside with the therapeutic effect, a non-secondary requirement of the nanosystem is indeed its biocompatibility. The importance to fulfill this aim is not only driven by the priority to reduce, as much as possible, the inflammatory or the immune response of the organism, but also by the need to improve circulation lifetime, biodistribution, and bioavailability of the carried drugs...
February 7, 2019: Pharmaceutics
Majid Atarian, Ahmad Rajaei, Meisam Tabatabaei, Afshin Mohsenifar, Hojatolah Bodaghi
The aim of this study was to obtain a stable sunflower oil-in-water (O/W) Pickering emulsion stabilized by chitosan (CS)-stearic acid (SA) nanogels and to compare the oxidative stability of the sunflower Pickering emulsion stabilized by CS-SA nanogels with sunflower oil emulsion stabilized by Tween 80. The results of the scanning electron microscopy revealed that by increasing the SA to CS ratio, the uniformity of particles was increased. Also, the results showed that the emulsions with pH of 8, SA to CS ratio of 0...
April 15, 2019: Carbohydrate Polymers
Pengpeng Deng, Jing Sun, Juanjuan Chen, Xueqing Zou, Liqiong Liao
Photo-switchable dual-color fluorescent nanogels were fabricated via nanoprecipitation in aqueous solution. The spiropyran-modified β-cyclodextrin (β-CD-SP) and 4-amino-7-nitro-1,2,3-benzoxadiazole (NBDNH2 ) were encapsulated into nanogels in the presence of 1,6-hexamethylene diisocyanate (HMDI). In the nanogels, spiropyran moiety acted as fluorescence molecule acceptors under the irradiation of UV or visible light to quench or recover the fluorescence of the NBDNH2 to achieve reversible dual-color fluorescence...
April 15, 2019: Carbohydrate Polymers
Hongying Su, Xiaodong Han, Lihua He, Lihua Deng, Kun Yu, Hai Jiang, Changqiang Wu, Qingming Jia, Shaoyun Shan
Magnetic hybrid nanogels composed of magnetic nanoparticles and polymer hydrogel matrix have drawn much attention because of their unique superparamagnetic properties and biocompatibility as biomaterials. In this study, a facile method was developed for the preparation of iron oxide nanoparticle-loaded magnetic dextran nanogel as magnetic resonance imaging (MRI) probe. Water soluble superparamagnetic iron oxide nanocrystals (Fe3 O4 ) was pre-synthesized and physically doped into a Schiff base-containing dextran nanogel formed using W/O microemulsion as nanoreactor...
February 1, 2019: International Journal of Biological Macromolecules
Xie Han, Yuhong Liu, Guotao Liu, Jing Luo, Sheng Hua Liu, Wenbo Zhao, Jun Yin
A tetraphenylethene (TPE) derivative substituted with a sulfonyl-based naphthalimide unit (TPE-Np) was designed and synthesized. Its optical properties in solution and in the solid state were investigated. Photophysical properties indicated that the target molecule, TPE-Np, possessed aggregation-induced emission (AIE) behavior, although the linkage between TPE and the naphthalimide unit was nonconjugated. Additionally, it exhibited an unexpected, highly reversible mechanochromism in the solid state, which was attributed to the change in manner of aggregation between crystalline and amorphous states...
January 31, 2019: Chemistry, An Asian Journal
Jing Chen, Hua He, Chao Deng, Lichen Yin, Zhiyuan Zhong
Metastasis poses a long-standing treatment challenge for many cancers including breast cancer. Once spreading out, cell-selective delivery of drug appears especially critical. Here, we report on epidermal growth factor receptor and CD44 dual-targeted hyaluronic acid nanogels (EGFR/CD44-NGs) that afford enhanced targetability and protein therapy for metastatic 4T1 breast cancer in vivo. Flow cytometry in CD44 and EGFR-positive 4T1 metastatic breast cancer cells showed over 6-fold higher cellular uptake of EGFR/CD44-NGs than mono-targeting CD44-NGs...
January 27, 2019: International Journal of Pharmaceutics
Prashant Sahu, Sushil K Kashaw, Samaresh Sau, Varun Kushwah, Sanyog Jain, Ram K Agrawal, Arun K Iyer
The current research is focused to develop and investigate the toxicity and penetration potential of biocompatible chitosan nanogel encapsulating capecitabine by ionic interaction mechanism exhibiting pH triggered transdermal targeting. The nanogel (CPNL) was synthesized by ion gelation mechanism using Pluronic F 127 and surface decoration by Transcutol as non-ionic penetration enhancer. The CPNL possesses fine morphology and nano size range when evaluated by TEM, SEM and DLS analysis with cationic charge and slightly acidic pH assayed by zeta potential and pH analysis...
January 27, 2019: International Journal of Biological Macromolecules
Yu-Qing Xie, Hacer Arik, Lixia Wei, Yiran Zheng, Heikyung Suh, Darrell J Irvine, Li Tang
Interleukin-2 (IL-2) is a potent T-cell mitogen that can adjuvant anti-cancer adoptive T-cell transfer (ACT) immunotherapy by promoting T-cell engraftment. However, the clinical applications of IL-2 in combination with ACT are greatly hindered by the severe adverse effects such as vascular leak syndrome (VLS). Here, we developed a synthetic delivery strategy for IL-2 via backpacking redox-responsive IL-2/Fc nanogels (NGs) to the plasma membrane of adoptively transferred T-cells. The NGs prepared by traceless chemical cross-linking of cytokine proteins selectively released the cargos in response to T-cell receptor activation upon antigen recognition in tumors...
January 30, 2019: Biomaterials Science
Huan Peng, Xiaobin Huang, Andrea Melle, Marcel Karperien, Andrij Pich
HYPOTHESIS: Facile approaches for the development of new tailored drug carriers are of high importance for the controlled administration of drugs. Herein we report a method for the synthesis of water-soluble reactive copolymers with well-defined architectures for fabrication of redox-sensitive degradable prodrug nanogels for intracellular drug release. EXPERIMENTS: Primary amine-functionalized statistical copolymers were obtained by hydrolysis of poly(N-vinylpyrrolidone-co-N-vinylformamide) copolymers which were synthesized via Reversible Addition-Fragmentation chain-Transfer (RAFT) polymerization...
January 14, 2019: Journal of Colloid and Interface Science
Anil M Pethe, Khushwant S Yadav
A single outcome in a biological procedure at the time of cancer therapy is due to multiple changes happening simultaneously. Hence to mimic such complex biological processes, an understanding of stimuli responsiveness is needed to sense specific changes and respond in a predictable manner. Such responses due to polymers may take place either simultaneously at the site or in a sequential manner from preparation to transporting pathways to cellular compartments. The present review comprehends the stimuli-responsive polymers and multi-responsiveness with respect to cancer therapy...
December 2019: Artificial Cells, Nanomedicine, and Biotechnology
Kruti S Soni, Divya Thomas, Thomas Caffrey, Kamiya Mehla, Fan Lei, Kelly A O'Connell, Satish Sagar, Subodh M Lele, Michael A Hollingsworth, Prakash Radhakrishnan, Tatiana K Bronich
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers. A combination of Cisplatin (CDDP) and Gemcitabine (Gem) treatment has shown favorable clinical results for metastatic disease; both are limited by toxicities and non-targeted delivery. More than 80% of the PDAC aberrantly expresses Sialyl Tn (STn) antigen due to the loss of function of COSMC, a specific chaperone for the activity of core 1 β3-galactosyltransferase or C1GalT. Here, we report the development of polymeric nanogels (NGs) loaded with CDDP and coated with an anti-STn antigen specific antibody (TKH2 mAb) for the targeted treatment of PDAC...
January 25, 2019: Journal of Pharmacology and Experimental Therapeutics
William B Liechty, Rebekah L Scheuerle, Julia E Vela Ramirez, Nicholas A Peppas
The design of intracellular drug delivery vehicles demands an in-depth understanding of their internalization and function upon entering the cell to tailor the physicochemical characteristics of these platforms and achieve efficacious treatments. Polymeric cationic systems have been broadly accepted to be membrane disruptive thus being beneficial for drug delivery inside the cell. However, if excessive destabilization takes place, it can lead to adverse effects. One of the strategies used to modulate the cationic charge is the incorporation of hydrophobic moieties, thus increasing the hydrophobic content...
January 2019: Bioengineering & Translational Medicine
Yongjing Li, Jiaxun Wan, Fang Wang, Jia Guo, Changchun Wang
The clinical applications of particulate drug delivery systems have demonstrated limited treatment outcomes, which is largely attributable to the elimination of such systems by the immune system, especially in the liver. Inspired by the mechanism of nanomaterial clearance by the liver, we designed a new anticancer auxiliary delivery system by introducing norepinephrine loaded poly(acrylic acid) nanogels as angiotonics. The auxilliary system effectively decreased the liver uptake of nanodrugs by increasing the liver blood flow rate...
January 24, 2019: Biomaterials Science
João Basso, Ana Miranda, Sandra Nunes, Tânia Cova, João Sousa, Carla Vitorino, Alberto Pais
Chemotherapy is commonly associated with limited effectiveness and unwanted side effects in normal cells and tissues, due to the lack of specificity of therapeutic agents to cancer cells when systemically administered. In brain tumors, the existence of both physiological barriers that protect tumor cells and complex resistance mechanisms to anticancer drugs are additional obstacles that hamper a successful course of chemotherapy, thus resulting in high treatment failure rates. Several potential surrogate therapies have been developed so far...
July 19, 2018: Gels
G Roshan Deen, Xian Jun Loh
Stimuli-responsive, smart, intelligent, or environmentally sensitive polymers respond to changes in external stimuli such as pH, temperature, ionic strength, surfactants, pressure, light, biomolecules, and magnetic field. These materials are developed in various network architectures such as block copolymers, crosslinked hydrogels, nanogels, inter-penetrating networks, and dendrimers. Stimuli-responsive cationic polymers and hydrogels are an interesting class of "smart" materials that respond reversibly to changes in external pH...
February 1, 2018: Gels
Ying Qu, Bingyang Chu, Xiawei Wei, Minyi Lei, Danrong Hu, Ruoyu Zha, Lin Zhong, Mengyao Wang, Fangfang Wang, Zhiyong Qian
At present, chemotherapy remains to be one of the most important therapeutic approaches for malignant tumors. The tumor microenvironment(TME)-responsive intelligent drug delivery systems are still the hot research topics in delivering chemotherapeutic drugs. Camptothecin (CPT) possesses very strong antitumor activities, but its clinical application is hindered by its poor water-solubility and serious toxic side effects. Herein, a new intelligent and TME-responsive P(CPT-MAA) prodrug nanogel was developed for delivering CPT and reducing its side effects...
January 19, 2019: Journal of Controlled Release: Official Journal of the Controlled Release Society
Fatemeh Nikoomanesh, Shahla Roudbarmohammadi, Mehdi Khoobi, Farnoosh Haghighi, Maryam Roudbary
The evolution of drug resistance of Candida species to conventional antifungal agents has been a major medical challenge worldwide; attempt to use the potential antifungal agents with appropriate therapy efficacy and minimum effects is considerably growing. This study was conducted to evaluate the use of nanogel as a nanocarrier for pharmaceutical application of farnesol. The nanogels were synthetized using alginate (AL) and chitosan (CS) polymers containing 300 µM of farnesol in the nano-range 42-70 nm size...
December 2019: Artificial Cells, Nanomedicine, and Biotechnology
Qing Wu, Zhigang He, Xia Wang, Qi Zhang, Qingcong Wei, Sunqiang Ma, Cheng Ma, Jiyu Li, Qigang Wang
As the first line of innate immune cells to migrate towards tumour tissue, neutrophils, can immediately kill abnormal cells and activate long-term specific adaptive immune responses. Therefore, the enzymes mediated elevation of reactive oxygen species (ROS) bioinspired by neutrophils can be a promising strategy in cancer immunotherapy. Here, we design a core-shell supramolecular hybrid nanogel via the surface phosphatase triggered self-assembly of oligopeptides around iron oxide nanoparticles to simulate productive neutrophil lysosomes...
January 16, 2019: Nature Communications
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