keyword
https://read.qxmd.com/read/38534235/low-cost-arduino-reverse-transcriptase-loop-mediated-isothermal-amplification-rt-lamp-for-sensitive-nucleic-acid-detection
#1
JOURNAL ARTICLE
Bruno Dias Camargo, Mateus Cassaboni Stracke, Heloisa Bruna Soligo Sanchuki, Viviane Klassen de Oliveira, Hellen Cristina Ancelmo, Dayanne Mozaner Bordin, Fabricio Klerynton Marchini, Emilson Ribeiro Viana, Lucas Blanes
This work presents a low-cost transcription loop-mediated isothermal amplification (RT-LAMP) instrument for nucleic acid detection, employing an Arduino Nano microcontroller. The cooling system includes customized printed circuit boards (PCBs) that serve as electrical resistors and incorporate fans. An aluminum block is designed to accommodate eight vials. The system also includes two PCB heaters-one for sample heating and the other for vial lid heating to prevent condensation. The color detection system comprises a TCS3200 color 8-sensor array coupled to one side of the aluminum heater body and a white 8-LED array coupled to the other side, controlled by two Multiplexer/Demultiplexer devices...
February 29, 2024: Biosensors
https://read.qxmd.com/read/38529311/malaria-biochemical-physiological-diagnostic-and-therapeutic-updates
#2
JOURNAL ARTICLE
Enas El Saftawy, Mohamed F Farag, Hossam H Gebreil, Mohamed Abdelfatah, Basma Emad Aboulhoda, Mansour Alghamdi, Emad A Albadawi, Marwa Ali Abd Elkhalek
BACKGROUND: Malaria has been appraised as a significant vector-borne parasitic disease with grave morbidity and high-rate mortality. Several challenges have been confronting the efficient diagnosis and treatment of malaria. METHOD: Google Scholar, PubMed, Web of Science, and the Egyptian Knowledge Bank (EKB) were all used to gather articles. RESULTS: Diverse biochemical and physiological indices can mirror complicated malaria e.g., hypoglycemia, dyslipidemia, elevated renal and hepatic functions in addition to the lower antioxidant capacity that does not only destroy the parasite but also induces endothelial damage...
2024: PeerJ
https://read.qxmd.com/read/38527538/agriculture-and-environmental-management-through-nanotechnology-eco-friendly-nanomaterial-synthesis-for-soil-plant-systems-food-safety-and-sustainability
#3
REVIEW
Abdul Wahab, Murad Muhammad, Shahid Ullah, Gholamreza Abdi, Ghulam Mujtaba Shah, Wajid Zaman, Asma Ayaz
Through the advancement of nanotechnology, agricultural and food systems are undergoing strategic enhancements, offering innovative solutions to complex problems. This scholarly essay thoroughly examines nanotechnological innovations and their implications within these critical industries. Traditional practices are undergoing radical transformation as nanomaterials emerge as novel agents in roles traditionally filled by fertilizers, pesticides, and biosensors. Micronutrient management and preservation techniques are further enhanced, indicating a shift towards more nutrient-dense and longevity-oriented food production...
March 23, 2024: Science of the Total Environment
https://read.qxmd.com/read/38526507/an-electrochemical-biosensor-for-staphylococcus-aureus-detection-based-on-a-multilevel-surface-3d-micro-nanostructure
#4
JOURNAL ARTICLE
Caiyun Wang, Rui Yang, Guangtong Wang, Shaoqin Liu
Detection of pathogens is one of the key concerns for hospitals, the food industry, water suppliers, or other environmental engineering practices because pathogens can cause a wide range of infectious risks. Staphylococcus aureus ( S. aureus ) is one of the most common pathogens that are hazardous to human health and its existence is an important index to the safety of food, environmental sanitation, or medical products. In this study, we prepared an electrode with designed surface multilevel 3D micro/nano protrusions for facile and efficient S...
March 25, 2024: Analyst
https://read.qxmd.com/read/38495975/an-innovative-transportable-immune-device-for-the-recognition-of-%C3%AE-synuclein-using-kcc-1-npr-cs-2-modified-silver-nano-ink-integration-of-pen-on-paper-technology-with-biosensing-toward-early-stage-diagnosis-of-parkinson-s-disease
#5
JOURNAL ARTICLE
Arezoo Saadati, Hossein Navay Baghban, Mohammad Hasanzadeh, Nasrin Shadjou
Parkinson's disease (PD), the second most frequent neurodegenerative illness, is a neurological ailment that produces unintentional or uncontrolled body movements, which should be diagnosed in its early stages to hinder the progression. Monitoring the concentration of α-synuclein (α-Syn) in body fluids can be one of the most efficient ways for PD early detection. In this work, a paper-based electrochemical immunosensor was designed for α-Syn bio-assay in human plasma samples based on encapsulation of the biotinylated antibody on novel dendritic fibrous nanosilica ((KCC-1- nPr -CS2 )-Ab)...
March 14, 2024: RSC Advances
https://read.qxmd.com/read/38495121/mir-21-responsive-nanocarrier-targeting-ovarian-cancer-cells
#6
JOURNAL ARTICLE
Liting Han, Tao Song, Xinyu Wang, Yan Luo, Chuanqi Gu, Xin Li, Jinda Wen, Zhibin Wen, Xiaolong Shi
In recent years, DNA origami-based nanocarriers have been extensively utilized for efficient cancer therapy. However, developing a nanocarrier capable of effectively protecting cargos such as RNA remains a challenge. In this study, we designed a compact and controllable DNA tubular origami (DTO) measuring 120 nm in length and 18 nm in width. The DTO exhibited appropriate structural characteristics for encapsulating and safeguarding cargo. Inside the DTO, we incorporated 20 connecting points to facilitate the delivery of cargoes to various ovarian and normal epithelial cell lines...
December 2024: Computational and Structural Biotechnology Journal
https://read.qxmd.com/read/38479000/detection-of-tetanus-toxoid-with-iron-magnetic-nanobioprobe
#7
JOURNAL ARTICLE
Farzaneh Karkhaneh, Ziba Sadr, Ahmad Molaeirad, Adeleh Divsalar
Diagnosis of diseases with low facilities, speed, accuracy and sensitivity is an important matter in treatment. Bioprobes based on iron oxide nanoparticles are a good candidate for early detection of deadly and infectious diseases such as tetanus due to their high reactivity, biocompatibility, low production cost and sample separation under a magnetic field. In this study, silane groups were coated on surface of iron oxide nanoparticles using tetraethoxysilane (TEOS) hydrolysis. Also, NH2 groups were generated on the surface of silanized nanoparticles using 3-aminopropyl triethoxy silane (APTES)...
March 13, 2024: Biomedical Physics & Engineering Express
https://read.qxmd.com/read/38473509/ni-ws-2-wc-composite-nanosheets-as-an-efficient-catalyst-for-photoelectrochemical-hydrogen-peroxide-sensing-and-hydrogen-evolution
#8
JOURNAL ARTICLE
Yanping Liu, Yixin Zhu, Leqin Chen, Yujia Li, Lanfang Wang
It is highly attractive to develop a photoelectrochemical (PEC) sensing platform based on a non-noble-metal nano array architecture. In this paper, a PEC hydrogen peroxide (H2 O2 ) biosensor based on Ni/WS2 /WC heterostructures was synthesized by a facile hydrothermal synthesis method and melamine carbonization process. The morphology, structural and composition and light absorption properties of the Ni/WS2 /WC catalyst were investigated by scanning electron microscopy (SEM), X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS) and UV-visible spectrophotometer...
February 23, 2024: Materials
https://read.qxmd.com/read/38470728/functionalized-zno-based-nanocomposites-for-diverse-biological-applications-current-trends-and-future-perspectives
#9
REVIEW
Ioanna-Aglaia Vagena, Maria-Anna Gatou, Giorgos Theocharous, Pavlos Pantelis, Maria Gazouli, Natassa Pippa, Vassilis G Gorgoulis, Evangelia A Pavlatou, Nefeli Lagopati
The wide array of structures and characteristics found in ZnO-based nanostructures offers them a versatile range of uses. Over the past decade, significant attention has been drawn to the possible applications of these materials in the biomedical field, owing to their distinctive electronic, optical, catalytic, and antimicrobial attributes, alongside their exceptional biocompatibility and surface chemistry. With environmental degradation and an aging population contributing to escalating healthcare needs and costs, particularly in developing nations, there's a growing demand for more effective and affordable biomedical devices with innovative functionalities...
February 21, 2024: Nanomaterials
https://read.qxmd.com/read/38460624/bio-study-modeling-of-natural-nanomolecules-as-a-nanocarrier-surface-for-antioxidant-and-glucose-biosensor
#10
JOURNAL ARTICLE
Samar M Zanata, Nagi M El-Shafai, Amr M Beltagi, Sultan Alshehri, Mohamed El-Sherbini, Ibrahim M El-Mehasseb
The nature of nano molecules as a self-assembled nanocomposite surface depends on the nanoparticles of sodium butyrate, cellulose, and pycnogenol; the synthesis is achieved via precipitation and grinding methods. The excellent functionalized surface of nanocomposite (NCP) enables the loading of the selected drugs, where the efficiency of the NCP surface arrived at 92.2 %. The electrochemical behavior emphasized the success of a functionalized NCP surface for incorporation with drugs for the drug delivery system, the results of cytotoxicity detect the effect of NCP on the mouse normal liver (BNL) cells, where the high and low concentrations on the BNL cells have a safe dose...
March 7, 2024: International Journal of Biological Macromolecules
https://read.qxmd.com/read/38456771/phospholipid-membranes-as-chemically-and-functionally-tunable-materials
#11
JOURNAL ARTICLE
Daniel Huster, Sudipta Maiti, Andreas Herrmann
The sheet-like lipid bilayer is the fundamental structural component of all cell membranes. Its building blocks are phospholipids and cholesterol. Their amphiphilic structure spontaneously leads to the formation of a bilayer in aqueous environment. Lipids are not just structural elements. Individual lipid species, the lipid membrane structure, and lipid dynamics influence and regulate membrane protein function. An exciting field is emerging where the membrane-associated material properties of different bilayer systems are used in designing innovative solutions for widespread applications across various fields, such as the food industry, cosmetics, nano- and biomedicine, drug storage and delivery, biotechnology, nano- and biosensors, and computing...
March 8, 2024: Advanced Materials
https://read.qxmd.com/read/38451239/flexible-nanohybrid-substrates-utilizing-gold-nanocubes-nano-mica-platelets-with-3d-lightning-rod-effect-for-highly-efficient-bacterial-biosensors-based-on-surface-enhanced-raman-scattering
#12
JOURNAL ARTICLE
Yan-Feng Chen, Ming-Chang Lu, Chia-Jung Lee, Chih-Wei Chiu
In this study, gold nanocubes (AuNCs) were quickly synthesized using the seed-mediated growth method and reduced onto the surface of two-dimensional (2D) delaminated nano mica platelets (NMPs), enabling the development of AuNCs/NMPs nanohybrids with a 3D lightning-rod effect. First, the growth-solution amount can be changed to easily adjust the AuNCs average-particle size within a range of 30-70 nm. The use of the cationic surfactant cetyltrimethylammonium chloride as a protective agent allowed the surface of AuNCs and nanohybrids to be positively charged...
March 7, 2024: Journal of Materials Chemistry. B, Materials for Biology and Medicine
https://read.qxmd.com/read/38440679/unlocking-the-future-of-smart-food-packaging-biosensors-iot-and-nano-materials
#13
REVIEW
Aboli R Bhatlawande, Pravin U Ghatge, Gopal U Shinde, R K Anushree, Sagar D Patil
This review examines how biosensors, the Internet of Things (IoT), and nano materials can revolutionize food packaging. It highlights the limitations of traditional packaging, particularly concerning barrier properties and food quality monitoring. The paper aims to provide specific insights into the potential of these technologies. Biosensors enable real-time monitoring and spoilage detection, ensuring safer products, while IoT enhances traceability and transparency in the supply chain, leading to reduced material waste, energy waste, and operational inefficiencies, ultimately improving efficiency...
April 2024: Food Science and Biotechnology
https://read.qxmd.com/read/38427687/developments-and-trends-of-nanotechnology-application-in-sepsis-a-comprehensive-review-based-on-knowledge-visualization-analysis
#14
REVIEW
Jiaji Fu, Wentai Cai, Shangwen Pan, Lang Chen, Xiaowei Fang, You Shang, Jiqian Xu
Sepsis, a common life-threatening clinical condition, continues to have high morbidity and mortality rates, despite advancements in management. In response, significant research efforts have been directed toward developing effective strategies. Within this scope, nanotechnology has emerged as a particularly promising field, attracting significant interest for its potential to enhance disease diagnosis and treatment. While several reviews have highlighted the use of nanoparticles in sepsis, comprehensive studies that summarize and analyze the hotspots and research trends are lacking...
March 1, 2024: ACS Nano
https://read.qxmd.com/read/38417285/digital-monitoring-of-the-microchannel-filling-flow-dynamics-using-a-non-contactless-smartphone-based-nano-liter-precision-flow-velocity-meter
#15
JOURNAL ARTICLE
Weiming Xu, Abdulkadir Yasin Atik, Levent Beker, Hatice Ceylan Koydemir
Microfluidic systems find widespread applications in diagnostics, biological research, chemistry, and engineering studies. Among their many critical parameters, flow rate plays a pivotal role in maintaining the functionality of microfluidic systems, including droplet-based microfluidic devices and those used in cell culture. It also significantly influences microfluidic mixing processes. Although various flow rate measurement devices have been developed, the challenge remains in accurately measuring flow rates within customized channels...
February 13, 2024: Biosensors & Bioelectronics
https://read.qxmd.com/read/38412037/sea-anemone-like-nanomachine-based-on-dna-strand-displacement-composed-of-three-boolean-logic-gates-diversified-input-for-intracellular-multitarget-detection
#16
JOURNAL ARTICLE
Yuting Li, Peng Zhou, Zhenxin Wang, Yiping Ren, Xu Zhu, Jin Wang, Hanrong Yan, Lei Hua, Fenglei Gao
Efficient and accurate acquisition of cellular biomolecular information is crucial for exploring cell fate, achieving early diagnosis, and the effective treatment of various diseases. However, current DNA biosensors are mostly limited to single-target detection, with few complex logic circuits for comprehensive analysis of three or more targets. Herein, we designed a sea anemone-like DNA nanomachine based on DNA strand displacement composed of three logic gates (YES-AND-YES) and delivered into the cells using gold nano bipyramid carriers...
February 27, 2024: Analytical Chemistry
https://read.qxmd.com/read/38407063/smart-contact-lenses-for-healthcare-monitoring-and-therapy
#17
REVIEW
Xiaohu Liu, Ying Ye, Yuancai Ge, Jia Qu, Bo Liedberg, Qingwen Zhang, Yi Wang
The eye contains a wealth of physiological information and offers a suitable environment for noninvasive monitoring of diseases via smart contact lens sensors. Although extensive research efforts recently have been undertaken to develop smart contact lens sensors, they are still in an early stage of being utilized as an intelligent wearable sensing platform for monitoring various biophysical/chemical conditions. In this review, we provide a general introduction to smart contact lenses that have been developed for disease monitoring and therapy...
February 26, 2024: ACS Nano
https://read.qxmd.com/read/38402725/two-birds-with-one-stone-dual-mode-immunoassay-constructed-using-a-novel-emitter-ethylene-glycol-induced-perylene-diimide-and-a-multifunctional-ans-probe
#18
JOURNAL ARTICLE
Wenjing Lai, Shijie Yan, Mingzhe Jiang, Zhina Li, Min Wang, Chulei Zhao, Chaoyun Ma, Zhong Wei, Chenglin Hong
Perylene diimide (PDI) is a readily reducible electron-deficient dye that exhibits strong photoluminescent properties, providing new opportunities for synthesizing novel electrochemiluminescence (ECL) emitters. In this study, ethylene glycol (EG) was used to induce the self-assembly of PDI supramolecules for the preparation of ultrathin EG-PDI nanosheets characterized by low crystallinity and weak stacking interaction. Notably, EG-PDI integrates luminescent and catalytic functions into one device, accelerating the interfacial electron transfer and the faster charge transfer kinetics of EG-PDI with K2 S2 O8 ...
February 22, 2024: Biosensors & Bioelectronics
https://read.qxmd.com/read/38394703/toward-nano-sized-imprinted-norepinephrine-derived-biopolymer-as-artificial-receptors-for-detecting-igg1-by-surface-plasmon-resonance
#19
JOURNAL ARTICLE
Francesca Torrini, Giovanni Ferraro, Emiliano Fratini, Pasquale Palladino, Simona Scarano, Maria Minunni
Bio-based nanostructured molecularly imprinted polymers (nano-MIPs), also known as 'plastibodies', have a real potential to be used as alternatives to natural antibodies. These nanostructures have recently gained significant attention for diagnostic and therapeutic purposes. In this context, we have developed polynorepinephrine (PNE)-based nano-MIPs using an eco-friendly one-pot process for the sensitive and selective detection of a model biomolecule, immunoglobulin IgG1. We first investigated non-imprinted nanostructures (nano-NIPs) based on polydopamine as reference material, using DLS, SEM, and UV-Vis spectroscopy...
February 15, 2024: Biosensors & Bioelectronics
https://read.qxmd.com/read/38393630/recent-advances-in-the-role-of-different-nanoparticles-in-the-various-biosensors-for-the-detection-of-the-chikungunya-virus
#20
REVIEW
Seyed Abbas Shahrtash, Zahraa Sabah Ghnim, Mohammad Ghaheri, Javid Adabi, Mohammad Amir Hassanzadeh, Saman Yasamineh, Hamed Afkhami, Amir Hossein Kheirkhah, Omid Gholizadeh, Hesam Zendehdel Moghadam
Humans contract the Chikungunya virus (CHIKV), an alphavirus transmitted by mosquitoes that induces acute and chronic musculoskeletal discomfort and fever. Millions of cases of the disease have been attributed to CHIKV in the Indian Ocean region since 2004, and the virus has since spread to Europe, the Middle East, and the Pacific. The exponential proliferation of CHIKV in recent times underscores the critical nature of implementing preventative measures and exploring potential control strategies. The principal laboratory test employed to diagnose infection in serum samples collected over six days after the onset of symptoms is the detection of CHIKV or viral RNA...
February 23, 2024: Molecular Biotechnology
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