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The Nanomedicine

Feng Wan, Tommy Nylander, Camilla Foged, Mingshi Yang, Stefania G Baldursdottir, Hanne M Nielsen
Understanding the interaction between inhaled nanoparticles and pulmonary surfactant is a prerequisite for predicting the fate of inhaled nanoparticles. Here, we introduce a quartz crystal microbalance with dissipation monitoring (QCM-D)-based methodology to reveal the extent and nature of the biophysical interactions of polymer- and lipid-based nanoparticles with pulmonary surfactant. By fitting the QCM-D data to the Langmuir adsorption equation, we determined the kinetics and equilibrium parameters [i.e., maximal adsorption (Δmmax ), equilibrium constant (Ka ), adsorption rate constant (ka ) and desorption rate constant (kd )] of polymeric nanoparticles adsorption onto the pulmonary surfactant (e...
March 1, 2019: Journal of Colloid and Interface Science
Qiang Zeng, Yali Liu, Yonggui Song, Bingwei Feng, Pengfei Xu, Baixi Shan, Zhou Liao, Kuangyi Liu, Youbao Zhong, Lai Chen, Dan Su
Poly (l-glutamic acid)-Combretastatin A4 conjugate (PLG-CA4) is a novel nano-anticancer drug. For macromolecule conjugate nanomedicine, its pharmacology mechanism is closely related to the pharmacokinetic profiles in vivo. It is a great significance that evaluates this polymer drug combined by covalently bound via studying the pharmacokinetics and distribution characteristics. Therefore, it is urgent to develop a simple, accurate and practical analytical method for such conjugated polymers combined by covalently bound...
March 5, 2019: Journal of Pharmaceutical and Biomedical Analysis
Malcolm Lim, Simon Puttick, Zachary H Houston, Kristofer J Thurecht, Priyakshi Kalita-de Croft, Stephen Mahler, Stephen E Rose, Rosalind L Jeffree, Roberta Mazzieri, Riccardo Dolcetti, Sunil R Lakhani, Jodi M Saunus
Brain metastases are the most prevalent of intracranial malignancies. They are associated with a very poor prognosis and near 100% mortality. This has been the case for decades, largely because we lack effective therapeutics to augment surgery and radiotherapy. Notwithstanding improvements in the precision and efficacy of these life-prolonging treatments, with no reliable options for adjunct systemic therapy, brain recurrences are virtually inevitable. The factors limiting intracranial efficacy of existing agents are both physiological and molecular in nature...
March 14, 2019: International Journal of Molecular Sciences
Jingang Li, Eric H Hill, Linhan Lin, Yuebing Zheng
Recent advances in chemical sciences have enabled the tailorable synthesis of colloidal particles with variable composition, size, shape and properties. Building superstructures with colloidal particles as building blocks is appealing for the fabrication of functional metamaterials and nanodevices. Optical nano-printing provides a versatile platform to print various particles into arbitrary configurations with nanometric precision. In this review, we summarize recent progress in optical nano-printing of colloidal particles and its related applications...
March 15, 2019: ACS Nano
Yuxiang Tang, Yihui Li, Si Li, Hang Hu, Yuxin Wu, Chen Xiao, Zhiqin Chu, Zifu Li, Xiangliang Yang
Tumor penetration is the bottleneck for current cancer nanomedicine, limiting the ultimate antitumor efficacy in the clinic. Herein, by exploiting the well-known instability of indocyanine green (ICG), we report the preparation of near infrared (NIR) light responsive nanoparticles (NP) for enhanced tumor penetration. ICG crosslinks hydroxyethyl starch (HES) and doxorubicin (DOX) conjugates (HES-SS-DOX) via noncovalent interactions, facilitating the formation of ICG@HES-SS-DOX NP. The light triggered degradation of ICG leads to the dissociation of such NP, and the resulting HES-SS-DOX has been shown to penetrate deeper in both H22 tumor spheroids and tumor bearing mice, due to the photothermal effect of ICG...
March 15, 2019: Nanoscale
Indrani Pal, Dipita Bhattacharyya, Rajiv Kumar Kar, D Zarena, Anirban Bhunia, Hanudatta S Atreya
The recent rise of multidrug resistant microbial strains requires development of new and novel therapeutic alternatives. In this study, we present a novel antibacterial system that comprises of modified naturally abundant antimicrobial peptides in conjugation with silver nanoparticles. Further, we propose a simple route to incorporate a cysteine residue either at the N- or C-terminal of the parent peptide. Tagging a cysteine residue at the terminals not only enhances the binding propensity of the resultant peptide with the silver nanoparticle, but also increases its antimicrobial property against several pathogenic bacterial strains including K...
March 14, 2019: Scientific Reports
Teresa Musumeci, Angela Bonaccorso, Giovanni Puglisi
Epilepsy is the fourth most common global neurological problem, which can be considered a spectrum disorder because of its various causes, seizure types, its ability to vary in severity and the impact from person to person, as well as its range of co-existing conditions. The approaches to drug therapy of epilepsy are directed at the control of symptoms by chronic administration of antiepileptic drugs (AEDs). These AEDs are administered orally or intravenously but alternative routes of administration are needed to overcome some important limits...
March 13, 2019: Pharmaceutics
Marta Truffi, Serena Mazzucchelli, Arianna Bonizzi, Luca Sorrentino, Raffaele Allevi, Renzo Vanna, Carlo Morasso, Fabio Corsi
Cancer-associated fibroblasts (CAF) are the most abundant cells of the tumor stroma and they critically influence cancer growth through control of the surrounding tumor microenvironment (TME). CAF-orchestrated reactive stroma, composed of pro-tumorigenic cytokines and growth factors, matrix components, neovessels, and deregulated immune cells, is associated with poor prognosis in multiple carcinomas, including breast cancer. Therefore, beyond cancer cells killing, researchers are currently focusing on TME as strategy to fight breast cancer...
March 13, 2019: International Journal of Molecular Sciences
Caterina Minelli, Dorota Bartczak, Ruud Peters, Jenny Rissler, Anna Undas, Aneta Sikora, Eva Sjostrom, Heidi Goenaga-Infante, Alexander G Shard
Measuring the number concentration of colloidal nanoparticles is critical for assessing reproducibility, compliance with regulation and performing risk assessments of nanoparticle-enabled products. For nanomedicines, their number concentration directly relates to their dose. However, the lack of relevant reference materials and established traceable measurement approaches make the validation of methods for nanoparticle number concentration difficult. Furthermore, commercial products often exhibit agglomeration, but guidelines for dealing with non-ideal samples are scarce...
March 14, 2019: Langmuir: the ACS Journal of Surfaces and Colloids
Qilong Wang, Ping Zhang, Zhongmin Li, Xiangru Feng, Chengyue Lv, Huaiyu Zhang, Haihua Xiao, Jianxun Ding, Xuesi Chen
Hepatoma is one of the most severe malignancies usually with poor prognosis, and many patients are insensitive to the existing therapeutic agents, including the drugs for chemotherapy and molecular targeted therapy. Currently, researchers are committed to developing the advanced formulations with controlled drug delivery to improve the efficacy of hepatoma therapy. Numerous inoculated, induced, and genetically engineered hepatoma rodent models are now available for formulation screening. However, animal models of hepatoma cannot accurately represent human hepatoma in terms of histological characteristics, metastatic pathways, and post-treatment responses...
2019: Theranostics
Longguang Tang, Zhen Yang, Zijian Zhou, Ying Ma, Dale O Kiesewetter, Zhantong Wang, Wenpei Fan, Shoujun Zhu, Mingru Zhang, Rui Tian, Lixin Lang, Gang Niu, Xianzhong Zhang, Xiaoyuan Chen
It remains a major challenge to achieve precise on-demand drug release. Here, we developed a modular nanomedicine integrated with logic-gated system enabling programmable drug release for on-demand chemotherapy. Methods: We employed two different logical AND gates consisting of four interrelated moieties to construct the nanovesicles, denoted as v-A-CED2 , containing oxidation-responsive nanovesicles (v), radical generators (A), and Edman linker conjugated prodrugs (CED2 ). The first AND logic gate is connected in parallel by mild hyperthermia ( I ) and acidic pH ( II ), which executes NIR laser triggered prodrug-to-drug transformation through Edman degradation...
2019: Theranostics
Rémi Rosière, Thierry Berghmans, Paul De Vuyst, Karim Amighi, Nathalie Wauthoz
Despite new treatment modalities, including targeted therapies and checkpoint inhibitors, cytotoxic chemotherapy remains central in the care of patients with lung tumors. Use of the pulmonary route to deliver chemotherapy has been proved to be feasible and safe in phase I, Ib/IIa and II trials for lung tumors, with the administration of drug doses to the lungs without prior distribution in the organism. The severe systemic toxicities commonly observed with conventional systemic chemotherapy are consequently reduced...
March 7, 2019: Cancers
Ruihao Yang, Mengmeng Hou, Ya Gao, Lei Zhang, Zhigang Xu, Yuejun Kang, Peng Xue
Hollow mesoporous structures with interior cavities and expanded surface area have attracted considerable interest as drug delivery systems. In this study, a multifunctional nanotheranostic agent was developed by conjugating indocyanine green (ICG) and loading doxorubicin (DOX) onto the surfaces or within the cavities of hollow mesoporous Prussian blue (HMPB) nanoparticles, known as HMPB@PEI/ICG/DOX or simply HPID NPs, which were investigated as phototheranostic agents for in vivo fluorescence imaging and light-induced chemotherapy, photothermal therapy (PTT) and photodynamic therapy (PDT)...
March 13, 2019: Nanoscale
Juan Aparicio-Blanco, Ignacio A Romero, David K Male, Karla Slowing, Luis Garcia, Ana I Torres-Suárez
Diseases affecting the central nervous system (CNS) should be regarded as a major health challenge due to the current lack of effective treatments given the hindrance to brain drug delivery imposed by the blood-brain barrier (BBB). Since efficient brain drug delivery should not solely rely on passive targeting, active targeting of nanomedicines into the CNS is being explored. The present study is devoted to the development of lipid nanocapsules (LNCs) decorated with non-psychotropic cannabinoids as pioneering non-immunogenic brain targeting molecules and to the evaluation of their brain targeting ability both in vitro and in vivo...
March 13, 2019: Molecular Pharmaceutics
Junyang Huang, Bart de Nijs, Sean Cormier, Kamil Sokolowski, David-Benjamin Grys, Charlie A Readman, Steven J Barrow, Oren A Scherman, Jeremy J Baumberg
External-stimuli controlled reversible formation of radical species is of great interest for synthetic and supramolecular chemistry, molecular machinery, as well as emerging technologies ranging from (photo)catalysis and photovoltaics to nanomedicine. Here we show a novel hybrid colloidal system for light-driven reversible reduction of chemical species that, on their own, do not respond to light. This is achieved by the unique combination of photo-sensitive plasmonic aggregates and temperature-responsive inorganic species generating radicals that can be finally accepted and stabilised by non-photo-responsive organic molecules...
March 13, 2019: Faraday Discussions
Miguel Mireles, Jordi Morales-Dalmau, Johannes D Johansson, Ernesto E Vidal-Rosas, Clara Vilches, Mar Martínez-Lozano, Vanesa Sanz, Ignacio de Miguel, Oriol Casanovas, Romain Quidant, Turgut Durduran
Owing to their unique combination of chemical and physical properties, inorganic nanoparticles show a great deal of potential as suitable agents for early diagnostics and less invasive therapies. Yet, their translation to the clinic has been hindered, in part, by the lack of non-invasive methods to quantify their concentration in vivo while also assessing their effect on the tissue physiology. In this work, we demonstrate that diffuse optical techniques, employing near-infrared light, have the potential to address this need in the case of gold nanoparticles which support localized surface plasmons...
March 12, 2019: Nanoscale
Yan Xu, Hao Ren, Jiwei Liu, Yonglu Wang, Zhengjie Meng, Zhanjie He, Wenjun Miao, Guoguang Chen, Xueming Li
Clinical chemotherapy for cancer is limited by the physiological barrier of tumors, resulting in low drug delivery to tumors, poor efficacy of drugs and inability to block tumor metastasis. Here we developed an intelligent switchable nitric oxide (NO)-releasing nanoparticle, IPH-NO, which loads a photosensitizer (IR780) and the chemotherapy drug paclitaxel (PTX) into NO donor-S-nitrosated human serum albumin (HSA-NO). NO exhibits two effects based on its concentration: enhancement of chemotherapy by increasing the enhanced permeability and retention (EPR) effect at low concentrations and direct killing of cancer cells at high concentrations...
March 11, 2019: Nanoscale
Amy Barton Pai
Intravenous (IV) iron is widely used to provide supplementation when oral iron is ineffective or not tolerated. All commercially available intravenous iron formulations are comprised of iron oxyhydroxide cores coated with carbohydrates of varying structure and branch characteristics. The diameter of the iron-carbohydrate complexes ranges from 5-100 nm and meets criteria for nanoparticles. Clinical use of IV iron formulations entered clinical practice beginning of the late 1950s, which preceded the nanomedicine exploration frontier...
January 14, 2019: Metal Ions in Life Sciences
M Ibrahim Khot, Helen Andrew, Hafdis S Svavarsdottir, Gemma Armstrong, Aaron J Quyn, David G Jayne
Oncologic thermal ablation involves the use of hyperthermic temperatures to damage and treat solid cancers. Thermal ablation is being investigated as a method of treatment in colorectal cancers and has the potential to complement conventional anticancer treatments in managing local recurrence and metastatic disease. Photothermal therapy utilizes photosensitive agents to generate local heat and induce thermal ablation. There is growing interest in developing nanotechnology platforms to deliver such photosensitive agents...
February 14, 2019: Clinical Colorectal Cancer
Archana George, Priyanka A Shah, Pranav S Shrivastav
Nanomedicines are now considered as the new-generation medication in the current era mainly because of their features related to nano size. The efficacy of many drugs in their micro/macro formulations is shown to have poor bioavailability and pharmacokinetics after oral administration. To overcome this predicament, use of natural/synthetic biodegradable polymeric nanoparticles (NPs) have gained prominence in the field of nanomedicine for targeted drug delivery to improve biocompatibility, bioavailability, safety, enhanced permeability, better retention time and lower toxicity...
March 6, 2019: International Journal of Pharmaceutics
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