keyword
https://read.qxmd.com/read/38471431/association-between-obstructive-coronary-disease-and-diabetic-retinopathy-cross-sectional-study-of-coronary-angiotomography-and-multimodal-retinal-imaging
#21
JOURNAL ARTICLE
Andre Chateaubriand Campos, Eduardo Gomes Lima, Peter Karl Jacobsen, Louis Arnould, Simao Lottenberg, Renata Martins Maia, Livia Silva Conci, Tomas Minelli, Andrea Morato, Roberto Nery Dantas-Jr, Cesar Higa Nomura, Pedro Rissoli, Sergio Gianotti Pimentel, Carlos Vicente Serrano Junior
AIMS: To investigate the association between diabetic retinopathy (DR) and coronary artery disease (CAD) using coronary angiotomography (CCTA) and multimodal retinal imaging (MMRI) with ultra-widefield retinography and optical coherence tomography angiography and structural domain. METHODS: Single-center, cross-sectional, single-blind. Patients with diabetes who had undergone CCTA underwent MMRI. Uni and multivariate analysis were used to assess the association between CAD and DR and to identify variables independently associated with DR...
March 6, 2024: Journal of Diabetes and its Complications
https://read.qxmd.com/read/38466054/the-role-of-preoperative-ct-perfusion-imaging-in-assessing-colorectal-cancer-angiogenesis-and-its-clinical-value
#22
JOURNAL ARTICLE
Wei Zhou, Xingwen Wang
PURPOSE: Angiogenesis, the formation of new blood vessels, plays a crucial role in tumor growth and metastasis. Understanding the vascular characteristics of colorectal cancer through preoperative computed tomography (CT) perfusion parameters can provide valuable insights into the tumor's aggressiveness and potential for spread. Additionally, exploring the correlation between these parameters and serum tumor marker levels may offer a comprehensive perspective on the disease's biological behavior...
March 8, 2024: Alternative Therapies in Health and Medicine
https://read.qxmd.com/read/38465502/precision-culture-scaling-to-establish-high-throughput-vasculogenesis-models
#23
JOURNAL ARTICLE
Nicholas R Dennison, Maximilian Fusenig, Lisa Grönnert, Manfred F Maitz, Maria Alejandra Ramirez Martinez, Manja Wobus, Uwe Freudenberg, Martin Bornhäuser, Jens Friedrichs, Peter D Westenskow, Carsten Werner
Hydrogel-based 3D cell cultures can recapitulate (patho)physiological phenomena ex vivo. However, due to their complex multifactorial regulation, adapting these tissue and disease models for high-throughput screening workflows remains challenging. In this study, a new Precision Culture Scaling (PCS-X) methodology combines statistical techniques (Design of Experiment and Multiple Linear Regression) with automated, parallelized experiments and analyses to customize hydrogel-based vasculogenesis cultures using human umbilical vein endothelial cells and retinal microvascular endothelial cells...
March 11, 2024: Advanced Healthcare Materials
https://read.qxmd.com/read/38463523/downregulation-of-carbonic-anhydrase-ix-expression-in-mouse-xenograft-nasopharyngeal-carcinoma-model-via-doxorubicin-nanobubble-combined-with-ultrasound
#24
JOURNAL ARTICLE
Rong Li, Liugui Lu, Zhaoxi Huang, Yong Gao
The purpose of this study was to investigate whether doxorubicin nanobubbles (DOX-NB) combined with diagnostic ultrasound (DUS) irradiation could downregulate the expression of carbonic anhydrase IX (CAIX) in mouse xenograft nasopharyngeal carcinoma (NPC) model. In this study, the prepared DOX-NB was round and well dispersed. The average diameter of DOX-NB was 250.9 ± 50.8 nm, with an average polydispersity of 0.321 ± 0.05. The cumulative release of DOX in the DOX-NB + DUS group was significantly higher compared with that of the DOX-NB group ( p < 0...
2024: Open Medicine (Warsaw, Poland)
https://read.qxmd.com/read/38458836/retinal-changes-in-multiple-sclerosis-an-optical-coherence-tomography-and-angiography-study
#25
JOURNAL ARTICLE
S Mrabet, Y Falfoul, M Bouassida, A Souissi, K El Matri, A Gharbi, A Chebil, I Kacem, L El Matri, R Gouider
BACKGROUND: Multiple sclerosis (MS) is an autoimmune demyelinating disease of the central nervous system with neuroaxonal damage. It is the principal driver of non-traumatic disability in young adults. Visual symptoms are common and optic neuritis (ON) may be the revealing feature in up to 30% of cases. Structural optical coherence tomography (OCT) represents a biomarker of central nervous system neurodegeneration in MS. OCT-angiography (OCT-A) is a noninvasive tool allowing the study of retinal vasculature and the detection of microvascular damage in neuro-retinal diseases...
March 7, 2024: Revue Neurologique
https://read.qxmd.com/read/38456233/optical-coherence-tomography-angiography-in-vogt-koyanagi-harada-patients-a-systematic-review-and-meta-analysis
#26
REVIEW
Ruyu Liang, Jiawei Geng, Hai Jiang, Siyan Jin, Xia Wang, Xiaoli Liu
PURPOSE: To describe the choroidal retinal microvascular system in Vogt-Koyanagi-Harada (VKH) subjects and furnish additional proof for the early authentication and treatment of VKH suffers. METHODS: From the beginning to July 2023, a comprehensive search for issued articles on optical coherence tomography angiography (OCTA) among VKH sufferers was implemented in Embase, PubMed, and Web of Science databases. This meta-analysis included 9 eligible studies. Primary endpoints included four kinds of vascular densities, such as superficial capillaris plexus (SCP), deep capillaris plexus (DCP), and choriocapillary (CC)...
March 8, 2024: Current Eye Research
https://read.qxmd.com/read/38455822/lipoprotein-ratios-correlations-with-glycated-hemoglobin-among-type-2-diabetes-mellitus-patients
#27
JOURNAL ARTICLE
Prabhat Lnu, Jagriti Lnu, Ayan Banerjee, Akash Bansal, Javin B Gogoi
Introduction Diabetes mellitus (DM) has become a common disorder in India, and can be even considered as an epidemic in most developing countries. It usually adds a big burden on the economy through its macro and microvascular complications which often require hospitalisation. Glycated hemoglobin (HbA1c) is considered a well-established test to track long-term glycemic control, and hence can be used for both diagnosis and prognosis of disease. On the other hand, lipid profile is a significant marker of cardiovascular risks...
February 2024: Curēus
https://read.qxmd.com/read/38454847/optical-coherence-tomography-angiography-for-the-assessment-of-retinal-microvasculature-characteristics-in-preterm-born-children-a-systematic-review-and-meta-analysis
#28
JOURNAL ARTICLE
Qi Zhou, Bo Deng, Xiaohong Xiang, Yuting Liu, Yingqing Lei, Fang Wang, Hongbin Lv
This study aimed to evaluate the usefulness of optical coherence tomography angiography (OCTA) in assessing retinal microvascular structural changes in preterm-born children and compare them with those in term-born children. The Web of Science Library, Cochrane Library, PubMed, Embase, CNKI, Wanfang, VIP, and Sino Med databases were searched systematically to extract studies published till April 25, 2023. Two independent reviewers searched all the literature and completed the data extraction and quality assessment...
March 8, 2024: Indian Journal of Ophthalmology
https://read.qxmd.com/read/38447883/epac-inhibitor-suppresses-angiogenesis-and-tumor-growth-of-triple-negative-breast-cancer
#29
JOURNAL ARTICLE
Zishuo Li, Qiao Liu, Yuhao Cai, Na Ye, Zinan He, Yuying Yao, Yi Ding, Pingyuan Wang, Cuiling Qi, Lingyun Zheng, Lijing Wang, Jia Zhou, Qian-Qian Zhang
AIMS: Exchange protein directly activated by cAMP 1 (EPAC1), a major isoform of guanine nucleotide exchange factors, is highly expressed in vascular endothelia cells and regulates angiogenesis in the retina. High intratumor microvascular densities (MVD) resulting from angiogenesis is responsible for breast cancer development. Downregulation of EPAC1 in tumor cell reduces triple-negative breast cancer (TNBC)-induced angiogenesis. However, whether Epac1 expressed in vascular endothelial cells contributes to angiogenesis and tumor development of TNBC remains elusive...
March 4, 2024: Biochimica et Biophysica Acta. Molecular Basis of Disease
https://read.qxmd.com/read/38446750/association-between-albuminuria-and-retinal-microvascular-parameters-measured-with-swept-source-optical-coherence-tomography-angiography-in-patients-with-diabetic-retinopathy
#30
JOURNAL ARTICLE
Jin Sug Kim, Eung Suk Kim, Hyeon Seok Hwang, Kyung Hwan Jeong, Seung-Young Yu, Kiyoung Kim
PURPOSE: To evaluate the relationship between urine albumin excretion (UAE) and retinal microvascular parameters assessed using swept-source optical coherence tomography angiography (SS-OCTA) in patients with diabetic retinopathy (DR). METHODS: This retrospective cross-sectional study included 180 patients with diabetes and 50 age-matched controls. Patients with diabetes were grouped according to the five-stage DR severity, combined with the presence of albuminuria...
2024: PloS One
https://read.qxmd.com/read/38444830/microvascular-disease-not-type-2-diabetes-is-associated-with-increased-cortical-porosity-a-study-of-cortical-bone-microstructure-and-intracortical-vessel-characteristics
#31
JOURNAL ARTICLE
Maximilian T Löffler, Po-Hung Wu, Amir M Pirmoazen, Gabby B Joseph, Jay M Stewart, Isra Saeed, Jing Liu, Anne L Schafer, Ann V Schwartz, Thomas M Link, Galateia J Kazakia
INTRODUCTION: Fracture risk is elevated in type 2 diabetes (T2D) despite normal or even high bone mineral density (BMD). Microvascular disease (MVD) is a diabetic complication, but also associated with other diseases, for example chronic kidney disease. We hypothesize that increased fracture risk in T2D could be due to increased cortical porosity (Ct.Po) driven by expansion of the vascular network in MVD. The purpose of this study was to investigate associations of T2D and MVD with cortical microstructure and intracortical vessel parameters...
March 2024: Bone Reports
https://read.qxmd.com/read/38441857/effect-of-intraorbital-mechanical-compression-on-retinal-microvascular-perfusion-in-quiescent-thyroid-associated-ophthalmopathy-based-on-ocular-biomechanics-measured-by-corvis-st
#32
JOURNAL ARTICLE
Wei Fang, Ziyun Zhou, Zhenbin Qian, Mengdi Wang, Fangjun Bao, Lijun Shen
INTRODUCTION: To analyze the correlation between orbital compliance and retinal vessel density (VD) based on dynamic Scheimpflug analyzer (Corvis ST) and optical coherence tomographic angiography (OCT-A). METHODS: In this prospective observational study, 65 eyes of 44 patients with thyroid-associated ophthalmopathy (TAO) in quiescent stage were included (15 males and 29 females). The whole eye movement (WEM) was detected by Corvis ST. The superficial capillary plexus VD (SCP-VD) and deep capillary plexus VD (DCP-VD) were obtained by scanning the 3 × 3 mm area around the fovea using OCT-A, while the peripapillary vessel density (ppVD) was obtained by scanning the 4...
March 5, 2024: Ophthalmology and Therapy
https://read.qxmd.com/read/38440967/evaluation-of-the-diagnostic-utility-of-mcam-1-cd146-in-a-group-of-common-gynecological-cancers-a-case-control-study
#33
JOURNAL ARTICLE
Amit Kumar, Ujjawal Khurana, Rashmi Chowdhary, Ajay Halder, Neelkamal Kapoor
OBJECTIVE: MCAM-1 (CD146) is an endothelial cell adhesion molecule belonging to the immunoglobulin superfamily. Recent studies have identified CD146 expression as a critical marker for tumor progression, migration, and metastasis in various malignancies. This study aimed to evaluate CD146 immunohistochemical expression in various gynecological cancers. MATERIALS AND METHODS: This study was conducted in a tertiary medical center in central India. A total of 49 gynecological cancer cases and 16 site-matched controls were included...
March 4, 2024: Turkish Journal of Obstetrics and Gynecology
https://read.qxmd.com/read/38440901/characterization-of-vascular-niche-in-systemic-sclerosis-by-spatial-proteomics
#34
JOURNAL ARTICLE
Aleix Rius Rigau, Yi-Nan Li, Alexandru-Emil Matei, Andrea-Hermina Györfi, Peter-Martin Bruch, Sarah Koziel, Veda Devakumar, Armando Gabrielli, Alexander Kreuter, Jiucun Wang, Sascha Dietrich, Georg Schett, Jörg H W Distler, Minrui Liang
BACKGROUND: Systemic sclerosis (SSc) is a connective tissue disease that can serve as a model to study vascular changes in response to inflammation, autoimmunity, and fibrotic remodeling. Although microvascular changes are the earliest histopathologic manifestation of SSc, the vascular pathophysiology remains poorly understood. OBJECTIVE: We applied spatial proteomic approaches to deconvolute the heterogeneity of vascular cells at the single-cell level in situ and characterize cellular alterations of the vascular niches of patients with SSc...
March 5, 2024: Circulation Research
https://read.qxmd.com/read/38436165/nailfold-capillaroscopy-abnormalities-and-pulmonary-hypertension-in-mixed-connective-tissue-disease-and-systemic-sclerosis-patients
#35
JOURNAL ARTICLE
A Munteanu, N R Kundnani, A Caraba
OBJECTIVE: Pulmonary arterial hypertension (PAH) represents an important vascular complication of mixed connective tissue disease (MCTD) and systemic sclerosis (SSc). Microvascular involvement in these diseases can be investigated by means of nailfold capillaroscopy (NFC). Microvascular involvement detected in the nailfold bed is the mirror of the microvascular damage occurring in the entire body, further indicating the involvement of the target organs. The aim of this study was to evaluate the microvascular involvement in MCTD patients with or without PAH, compared to that found in SSc patients with or without PAH...
February 2024: European Review for Medical and Pharmacological Sciences
https://read.qxmd.com/read/38433711/retinal-vascular-density-as-a-potential-biomarker-of-diabetic-cerebral-small-vessel-disease
#36
JOURNAL ARTICLE
Yinqiong Huang, Siyun Wang, Chi Cai, Xinwei Huang, Yan Chen, Xiaohong Wu, Yiping Zhang, Yan Zhang, Xiahong Lin
AIM: The retina and brain share similar anatomical and physiological features. Thus, retinal imaging by optical coherence tomography angiography (OCTA) might be a potential tool for the early diagnosis of diabetic cerebral small vessel disease (CSVD). In this study, we aimed to evaluate retinal vascular density (VD) in diabetic CSVD by OCTA imaging and explore the associations between retinal VD and cerebral magnetic resonance imaging (MRI) markers and cognitive function. METHODS: In total, 131 patients were enrolled, including CSVD (n = 43) and non-CSVD groups (n = 88)...
March 4, 2024: Diabetes, Obesity & Metabolism
https://read.qxmd.com/read/38428559/macular-neural-and-microvascular-alterations-in-type-2-diabetes-without-retinopathy-a-ss-oct-study
#37
JOURNAL ARTICLE
Yining Dai, Dongping Zheng, Juwei Zhao, Kailu Wang, Binzhe Fu, Zhiling Xu, Sheng Wang, Chenxi Li, Guohong Zhou
PURPOSE: To identify specific markers indicative of macular neural and microvascular alterations in individuals with Type 2 Diabetes Mellitus (T2DM) without clinically observable retinopathy. DESIGN: Prospective cross-sectional study. METHODS: Using the PLEX Elite 9000, all eyes underwent swept-source optical coherence tomography (SS-OCT) angiography. Quantitative analysis of acquired images compared macular neural and microvascular alterations in T2DM patients without retinopathy to age-matched controls...
February 28, 2024: American Journal of Ophthalmology
https://read.qxmd.com/read/38426742/statin-administration-ameliorates-ischemia-induced-overactive-bladder-with-improvement-of-blood-flow-and-anti-inflammatory-effects-in-rats
#38
JOURNAL ARTICLE
Yuichi Ishizuka, Yohei Satake, Shingo Kimura, Shinichi Yamashita, Naoki Kawamorita, Akihiro Ito
AIMS: Statins are widely used to treat dyslipidemia and have been shown to reduce the risk of ischemic heart disease and cerebrovascular disease. The effects of statins on ischemia-induced overactive bladder (OAB) and the associated mechanisms were investigated in a rat model of chronic pelvic ischemia. METHODS: A pelvic ischemia model was created by iliac arterial injury (AI) and a high-fat diet using male Sprague-Dawley rats. Rats were assigned to 3 groups: control group, AI group, and AI + statin group...
March 1, 2024: Neurourology and Urodynamics
https://read.qxmd.com/read/38424650/eye-signs-as-a-novel-risk-predictor-in-pulmonary-arterial-hypertension-associated-with-systemic-lupus-erythematosus
#39
JOURNAL ARTICLE
Jianbin Li, Jiangbiao Xiong, Pengcheng Liu, Yilin Peng, Shuang Cai, Xia Fang, Shujiao Yu, Jun Zhao, Rui Wu
OBJECTIVE: To investigate the role of eye signs in predicting poor outcomes in systemic lupus erythematosus (SLE) patients with pulmonary arterial hypertension (PAH). METHODS: This prospective observational study recruited patients diagnosed with SLE-PAH from Jan. 2021 to Dec. 2021 at the First Affiliated Hospital of Nanchang University; those with other potential causes of PAH were excluded. The evaluation of various parameters, such as N-terminal prohormone of brain natriuretic peptide (NT-proBNP), 6-minute walking distance (6MWD), World Health Organization functional class (WHO-FC), echocardiography, and risk stratification based on the 2015 European Society of Cardiology (ESC)/European Respiratory Society (ERS) Guidelines, was conducted at intervals of every 1-3 months, and a 6-month follow-up period was observed...
February 29, 2024: Advances in Rheumatology
https://read.qxmd.com/read/38422358/choroidal-macrovascular-and-capillary-alterations-in-eyes-with-idiopathic-epiretinal-membranes
#40
JOURNAL ARTICLE
Ahmet M Hondur, Yavuz Kemal Aribas
PURPOSE: To evaluate the choroidal vascular alterations and effect of surgical treatment in the setting of idiopathic epiretinal membranes. METHODS: The structure of the choroid was studied in 33 patients with unilateral idiopathic epiretinal membrane using optical coherence tomography with enhanced depth imaging and optical coherence tomography angiography. Eyes with epiretinal membrane underwent 25-gauge vitrectomy with epiretinal membrane and internal limiting membrane peeling...
2024: Arquivos Brasileiros de Oftalmologia
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