Yu-Biao Liu, Jie-Ru Hong, Nan Jiang, Ling Jin, Wen-Jing Zhong, Chen-Yu Zhang, Hui-Hui Yang, Jia-Xi Duan, Yong Zhou
Chronic obstructive pulmonary disease (COPD) is a major cause of morbidity, mortality, and healthcare use worldwide with heterogeneous pathogenesis. Mitochondria, the powerhouses in cells responsible for oxidative phosphorylation and energy production, play essential roles in intracellular material metabolism, natural immunity, and cell death regulation. Therefore, it is crucial to address the urgent need for fine-tuning the regulation of mitochondrial quality to combat COPD effectively. Mitochondrial quality control (MQC) mainly refers to the selective removal of damaged or aging mitochondria and the generation of new mitochondria, which involves mitochondrial biogenesis, mitochondrial dynamics, mitophagy, etc...
December 15, 2023: Laboratory Investigation; a Journal of Technical Methods and Pathology