Qi-Xin Xu, Manoj Madhavan, Shu-Wen Wei, Wang-Qing Zhang, Lei Lu, Ke-Zhi Wang, Moldovan Genna, Yong Song, Yu Zhao, Huan-Ting Shao, Jin-Wen Kang, Asgerally T Fazleabas, Ripla Arora, Ren-Wei Su
In mammals, the endometrium undergoes dynamic changes in response to estrogen and progesterone to prepare for blastocyst implantation. Two distinct types of endometrial epithelial cells, the luminal (LE) and glandular (GE) epithelial cells play different functional roles during this physiological process. Previously, we have reported that Notch signaling plays multiple roles in embryo implantation, decidualization, and postpartum repair. Here, using the uterine epithelial-specific Ltf-iCre, we showed that Notch1 signaling over-activation in the endometrial epithelium caused dysfunction of the epithelium during the estrous cycle, resulting in hyper-proliferation...
July 2023: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology