Chee-Keng Mok, Yan Ling Ng, Bintou Ahmadou Ahidjo, Zhen Qin Aw, Huixin Chen, Yi Hao Wong, Regina Ching Hua Lee, Marcus Wing Choy Loe, Jing Liu, Kai Sen Tan, Parveen Kaur, De Yun Wang, Erwei Hao, Xiaotao Hou, Yong Wah Tan, Jiagang Deng, Justin Jang Hann Chu
The COVID-19 pandemic has brought about unprecedented medical and healthcare challenges worldwide. With the continual emergence and spread of new COVID-19 variants, four drug compound libraries were interrogated for their antiviral activities against SARS-CoV-2. Here, we show that the drug screen has resulted in 121 promising anti-SARS-CoV-2 compounds, of which seven were further shortlisted for hit validation: citicoline, pravastatin sodium, tenofovir alafenamide, imatinib mesylate, calcitriol, dexlansoprazole, and prochlorperazine dimaleate...
March 12, 2023: Pharmaceutics