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https://read.qxmd.com/read/30858598/aromatic-19-f-13-c-trosy-a-background-free-approach-to-probe-biomolecular-structure-function-and-dynamics
#1
Andras Boeszoermenyi, Sandeep Chhabra, Abhinav Dubey, Denitsa L Radeva, Nikola T Burdzhiev, Christo D Chanev, Ognyan I Petrov, Vladimir M Gelev, Meng Zhang, Clemens Anklin, Helena Kovacs, Gerhard Wagner, Ilya Kuprov, Koh Takeuchi, Haribabu Arthanari
Atomic-level information about the structure and dynamics of biomolecules is critical for an understanding of their function. Nuclear magnetic resonance (NMR) spectroscopy provides unique insights into the dynamic nature of biomolecules and their interactions, capturing transient conformers and their features. However, relaxation-induced line broadening and signal overlap make it challenging to apply NMR spectroscopy to large biological systems. Here we took advantage of the high sensitivity and broad chemical shift range of 19 F nuclei and leveraged the remarkable relaxation properties of the aromatic 19 F-13 C spin pair to disperse 19 F resonances in a two-dimensional transverse relaxation-optimized spectroscopy spectrum...
March 11, 2019: Nature Methods
https://read.qxmd.com/read/30848618/azimuthal-anisotropy-of-heavy-flavor-decay-electrons-in-p-pb-collisions-at-sqrt-s_-nn-5-02-tev
#2
S Acharya, D Adamová, J Adolfsson, M M Aggarwal, G Aglieri Rinella, M Agnello, N Agrawal, Z Ahammed, S U Ahn, S Aiola, A Akindinov, M Al-Turany, S N Alam, D S D Albuquerque, D Aleksandrov, B Alessandro, R Alfaro Molina, Y Ali, A Alici, A Alkin, J Alme, T Alt, L Altenkamper, I Altsybeev, M N Anaam, C Andrei, D Andreou, H A Andrews, A Andronic, M Angeletti, V Anguelov, C Anson, T Antičić, F Antinori, P Antonioli, R Anwar, N Apadula, L Aphecetche, H Appelshäuser, S Arcelli, R Arnaldi, O W Arnold, I C Arsene, M Arslandok, A Augustinus, R Averbeck, M D Azmi, A Badalà, Y W Baek, S Bagnasco, R Bailhache, R Bala, A Baldisseri, M Ball, R C Baral, A M Barbano, R Barbera, F Barile, L Barioglio, G G Barnaföldi, L S Barnby, V Barret, P Bartalini, K Barth, E Bartsch, N Bastid, S Basu, G Batigne, B Batyunya, P C Batzing, J L Bazo Alba, I G Bearden, H Beck, C Bedda, N K Behera, I Belikov, F Bellini, H Bello Martinez, R Bellwied, L G E Beltran, V Belyaev, G Bencedi, S Beole, A Bercuci, Y Berdnikov, D Berenyi, R A Bertens, D Berzano, L Betev, P P Bhaduri, A Bhasin, I R Bhat, H Bhatt, B Bhattacharjee, J Bhom, A Bianchi, L Bianchi, N Bianchi, J Bielčík, J Bielčíková, A Bilandzic, G Biro, R Biswas, S Biswas, J T Blair, D Blau, C Blume, G Boca, F Bock, A Bogdanov, L Boldizsár, M Bombara, G Bonomi, M Bonora, H Borel, A Borissov, M Borri, E Botta, C Bourjau, L Bratrud, P Braun-Munzinger, M Bregant, T A Broker, M Broz, E J Brucken, E Bruna, G E Bruno, D Budnikov, H Buesching, S Bufalino, P Buhler, P Buncic, O Busch, Z Buthelezi, J B Butt, J T Buxton, J Cabala, D Caffarri, H Caines, A Caliva, E Calvo Villar, R S Camacho, P Camerini, A A Capon, F Carena, W Carena, F Carnesecchi, J Castillo Castellanos, A J Castro, E A R Casula, C Ceballos Sanchez, S Chandra, B Chang, W Chang, S Chapeland, M Chartier, S Chattopadhyay, S Chattopadhyay, A Chauvin, C Cheshkov, B Cheynis, V Chibante Barroso, D D Chinellato, S Cho, P Chochula, T Chowdhury, P Christakoglou, C H Christensen, P Christiansen, T Chujo, S U Chung, C Cicalo, L Cifarelli, F Cindolo, J Cleymans, F Colamaria, D Colella, A Collu, M Colocci, M Concas, G Conesa Balbastre, Z Conesa Del Valle, J G Contreras, T M Cormier, Y Corrales Morales, P Cortese, M R Cosentino, F Costa, S Costanza, J Crkovská, P Crochet, E Cuautle, L Cunqueiro, T Dahms, A Dainese, S Dani, M C Danisch, A Danu, D Das, I Das, S Das, A Dash, S Dash, S De, A De Caro, G de Cataldo, C de Conti, J de Cuveland, A De Falco, D De Gruttola, N De Marco, S De Pasquale, R D De Souza, H F Degenhardt, A Deisting, A Deloff, S Delsanto, C Deplano, P Dhankher, D Di Bari, A Di Mauro, B Di Ruzza, R A Diaz, T Dietel, P Dillenseger, Y Ding, R Divià, Ø Djuvsland, A Dobrin, D Domenicis Gimenez, B Dönigus, O Dordic, L V R Doremalen, A K Dubey, A Dubla, L Ducroux, S Dudi, A K Duggal, M Dukhishyam, P Dupieux, R J Ehlers, D Elia, E Endress, H Engel, E Epple, B Erazmus, F Erhardt, M R Ersdal, B Espagnon, G Eulisse, J Eum, D Evans, S Evdokimov, L Fabbietti, M Faggin, J Faivre, A Fantoni, M Fasel, L Feldkamp, A Feliciello, G Feofilov, A Fernández Téllez, A Ferretti, A Festanti, V J G Feuillard, J Figiel, M A S Figueredo, S Filchagin, D Finogeev, F M Fionda, G Fiorenza, F Flor, M Floris, S Foertsch, P Foka, S Fokin, E Fragiacomo, A Francescon, A Francisco, U Frankenfeld, G G Fronze, U Fuchs, C Furget, A Furs, M Fusco Girard, J J Gaardhøje, M Gagliardi, A M Gago, K Gajdosova, M Gallio, C D Galvan, P Ganoti, C Garabatos, E Garcia-Solis, K Garg, C Gargiulo, P Gasik, E F Gauger, M B Gay Ducati, M Germain, J Ghosh, P Ghosh, S K Ghosh, P Gianotti, P Giubellino, P Giubilato, P Glässel, D M Goméz Coral, A Gomez Ramirez, V Gonzalez, P González-Zamora, S Gorbunov, L Görlich, S Gotovac, V Grabski, L K Graczykowski, K L Graham, L Greiner, A Grelli, C Grigoras, V Grigoriev, A Grigoryan, S Grigoryan, J M Gronefeld, F Grosa, J F Grosse-Oetringhaus, R Grosso, R Guernane, B Guerzoni, M Guittiere, K Gulbrandsen, T Gunji, A Gupta, R Gupta, I B Guzman, R Haake, M K Habib, C Hadjidakis, H Hamagaki, G Hamar, M Hamid, J C Hamon, R Hannigan, M R Haque, A Harlenderova, J W Harris, A Harton, H Hassan, D Hatzifotiadou, S Hayashi, S T Heckel, E Hellbär, H Helstrup, A Herghelegiu, E G Hernandez, G Herrera Corral, F Herrmann, K F Hetland, T E Hilden, H Hillemanns, C Hills, B Hippolyte, B Hohlweger, D Horak, S Hornung, R Hosokawa, J Hota, P Hristov, C Huang, C Hughes, P Huhn, T J Humanic, H Hushnud, N Hussain, T Hussain, D Hutter, D S Hwang, J P Iddon, S A Iga Buitron, R Ilkaev, M Inaba, M Ippolitov, M S Islam, M Ivanov, V Ivanov, V Izucheev, B Jacak, N Jacazio, P M Jacobs, M B Jadhav, S Jadlovska, J Jadlovsky, S Jaelani, C Jahnke, M J Jakubowska, M A Janik, C Jena, M Jercic, O Jevons, R T Jimenez Bustamante, M Jin, P G Jones, A Jusko, P Kalinak, A Kalweit, J H Kang, V Kaplin, S Kar, A Karasu Uysal, O Karavichev, T Karavicheva, P Karczmarczyk, E Karpechev, U Kebschull, R Keidel, D L D Keijdener, M Keil, B Ketzer, Z Khabanova, A M Khan, S Khan, S A Khan, A Khanzadeev, Y Kharlov, A Khatun, A Khuntia, M M Kielbowicz, B Kileng, B Kim, D Kim, D J Kim, E J Kim, H Kim, J S Kim, J Kim, M Kim, S Kim, T Kim, T Kim, S Kirsch, I Kisel, S Kiselev, A Kisiel, J L Klay, C Klein, J Klein, C Klein-Bösing, S Klewin, A Kluge, M L Knichel, A G Knospe, C Kobdaj, M Kofarago, M K Köhler, T Kollegger, N Kondratyeva, E Kondratyuk, A Konevskikh, P J Konopka, M Konyushikhin, O Kovalenko, V Kovalenko, M Kowalski, I Králik, A Kravčáková, L Kreis, M Krivda, F Krizek, M Krüger, E Kryshen, M Krzewicki, A M Kubera, V Kučera, C Kuhn, P G Kuijer, J Kumar, L Kumar, S Kumar, S Kundu, P Kurashvili, A Kurepin, A B Kurepin, A Kuryakin, S Kushpil, J Kvapil, M J Kweon, Y Kwon, S L La Pointe, P La Rocca, Y S Lai, I Lakomov, R Langoy, K Lapidus, A Lardeux, P Larionov, E Laudi, R Lavicka, R Lea, L Leardini, S Lee, F Lehas, S Lehner, J Lehrbach, R C Lemmon, I León Monzón, P Lévai, X Li, X L Li, J Lien, R Lietava, B Lim, S Lindal, V Lindenstruth, S W Lindsay, C Lippmann, M A Lisa, V Litichevskyi, A Liu, H M Ljunggren, W J Llope, D F Lodato, V Loginov, C Loizides, P Loncar, X Lopez, E López Torres, A Lowe, P Luettig, J R Luhder, M Lunardon, G Luparello, M Lupi, A Maevskaya, M Mager, S M Mahmood, A Maire, R D Majka, M Malaev, Q W Malik, L Malinina, D Mal'Kevich, P Malzacher, A Mamonov, V Manko, F Manso, V Manzari, Y Mao, M Marchisone, J Mareš, G V Margagliotti, A Margotti, J Margutti, A Marín, C Markert, M Marquard, N A Martin, P Martinengo, J L Martinez, M I Martínez, G Martínez García, M Martinez Pedreira, S Masciocchi, M Masera, A Masoni, L Massacrier, E Masson, A Mastroserio, A M Mathis, P F T Matuoka, A Matyja, C Mayer, M Mazzilli, M A Mazzoni, F Meddi, Y Melikyan, A Menchaca-Rocha, E Meninno, J Mercado Pérez, M Meres, C S Meza, S Mhlanga, Y Miake, L Micheletti, M M Mieskolainen, D L Mihaylov, K Mikhaylov, A Mischke, A N Mishra, D Miśkowiec, J Mitra, C M Mitu, N Mohammadi, A P Mohanty, B Mohanty, M Mohisin Khan, D A Moreira De Godoy, L A P Moreno, S Moretto, A Morreale, A Morsch, T Mrnjavac, V Muccifora, E Mudnic, D Mühlheim, S Muhuri, M Mukherjee, J D Mulligan, M G Munhoz, K Münning, M I A Munoz, R H Munzer, H Murakami, S Murray, L Musa, J Musinsky, C J Myers, J W Myrcha, B Naik, R Nair, B K Nandi, R Nania, E Nappi, A Narayan, M U Naru, A F Nassirpour, H Natal da Luz, C Nattrass, S R Navarro, K Nayak, R Nayak, T K Nayak, S Nazarenko, R A Negrao De Oliveira, L Nellen, S V Nesbo, G Neskovic, F Ng, M Nicassio, J Niedziela, B S Nielsen, S Nikolaev, S Nikulin, V Nikulin, F Noferini, P Nomokonov, G Nooren, J C C Noris, J Norman, A Nyanin, J Nystrand, H Oh, A Ohlson, J Oleniacz, A C Oliveira Da Silva, M H Oliver, J Onderwaater, C Oppedisano, R Orava, M Oravec, A Ortiz Velasquez, A Oskarsson, J Otwinowski, K Oyama, Y Pachmayer, V Pacik, D Pagano, G Paić, P Palni, J Pan, A K Pandey, S Panebianco, V Papikyan, P Pareek, J Park, J E Parkkila, S Parmar, A Passfeld, S P Pathak, R N Patra, B Paul, H Pei, T Peitzmann, X Peng, L G Pereira, H Pereira Da Costa, D Peresunko, E Perez Lezama, V Peskov, Y Pestov, V Petráček, M Petrovici, C Petta, R P Pezzi, S Piano, M Pikna, P Pillot, L O D L Pimentel, O Pinazza, L Pinsky, S Pisano, D B Piyarathna, M Płoskoń, M Planinic, F Pliquett, J Pluta, S Pochybova, P L M Podesta-Lerma, M G Poghosyan, B Polichtchouk, N Poljak, W Poonsawat, A Pop, H Poppenborg, S Porteboeuf-Houssais, V Pozdniakov, S K Prasad, R Preghenella, F Prino, C A Pruneau, I Pshenichnov, M Puccio, V Punin, J Putschke, S Raha, S Rajput, J Rak, A Rakotozafindrabe, L Ramello, F Rami, R Raniwala, S Raniwala, S S Räsänen, B T Rascanu, V Ratza, I Ravasenga, K F Read, K Redlich, A Rehman, P Reichelt, F Reidt, X Ren, R Renfordt, A Reshetin, J-P Revol, K Reygers, V Riabov, T Richert, M Richter, P Riedler, W Riegler, F Riggi, C Ristea, S P Rode, M Rodríguez Cahuantzi, K Røed, R Rogalev, E Rogochaya, D Rohr, D Röhrich, P S Rokita, F Ronchetti, E D Rosas, K Roslon, P Rosnet, A Rossi, A Rotondi, F Roukoutakis, C Roy, P Roy, O V Rueda, R Rui, B Rumyantsev, A Rustamov, E Ryabinkin, Y Ryabov, A Rybicki, S Saarinen, S Sadhu, S Sadovsky, K Šafařík, S K Saha, B Sahoo, P Sahoo, R Sahoo, S Sahoo, P K Sahu, J Saini, S Sakai, M A Saleh, S Sambyal, V Samsonov, A Sandoval, A Sarkar, D Sarkar, N Sarkar, P Sarma, M H P Sas, E Scapparone, F Scarlassara, B Schaefer, H S Scheid, C Schiaua, R Schicker, C Schmidt, H R Schmidt, M O Schmidt, M Schmidt, N V Schmidt, J Schukraft, Y Schutz, K Schwarz, K Schweda, G Scioli, E Scomparin, M Šefčík, J E Seger, Y Sekiguchi, D Sekihata, I Selyuzhenkov, S Senyukov, E Serradilla, P Sett, A Sevcenco, A Shabanov, A Shabetai, R Shahoyan, W Shaikh, A Shangaraev, A Sharma, A Sharma, M Sharma, N Sharma, A I Sheikh, K Shigaki, M Shimomura, S Shirinkin, Q Shou, K Shtejer, Y Sibiriak, S Siddhanta, K M Sielewicz, T Siemiarczuk, D Silvermyr, G Simatovic, G Simonetti, R Singaraju, R Singh, R Singh, V Singhal, T Sinha, B Sitar, M Sitta, T B Skaali, M Slupecki, N Smirnov, R J M Snellings, T W Snellman, J Song, F Soramel, S Sorensen, F Sozzi, I Sputowska, J Stachel, I Stan, P Stankus, E Stenlund, D Stocco, M M Storetvedt, P Strmen, A A P Suaide, T Sugitate, C Suire, M Suleymanov, M Suljic, R Sultanov, M Šumbera, S Sumowidagdo, K Suzuki, S Swain, A Szabo, I Szarka, U Tabassam, J Takahashi, G J Tambave, N Tanaka, M Tarhini, M Tariq, M G Tarzila, A Tauro, G Tejeda Muñoz, A Telesca, C Terrevoli, B Teyssier, D Thakur, S Thakur, D Thomas, F Thoresen, R Tieulent, A Tikhonov, A R Timmins, A Toia, N Topilskaya, M Toppi, F Torales-Acosta, S R Torres, S Tripathy, S Trogolo, G Trombetta, L Tropp, V Trubnikov, W H Trzaska, T P Trzcinski, B A Trzeciak, T Tsuji, A Tumkin, R Turrisi, T S Tveter, K Ullaland, E N Umaka, A Uras, G L Usai, A Utrobicic, M Vala, J W Van Hoorne, M van Leeuwen, P Vande Vyvre, D Varga, A Vargas, M Vargyas, R Varma, M Vasileiou, A Vasiliev, A Vauthier, O Vázquez Doce, V Vechernin, A M Veen, E Vercellin, S Vergara Limón, L Vermunt, R Vernet, R Vértesi, L Vickovic, J Viinikainen, Z Vilakazi, O Villalobos Baillie, A Villatoro Tello, A Vinogradov, T Virgili, V Vislavicius, A Vodopyanov, M A Völkl, K Voloshin, S A Voloshin, G Volpe, B von Haller, I Vorobyev, D Voscek, D Vranic, J Vrláková, B Wagner, H Wang, M Wang, Y Watanabe, M Weber, S G Weber, A Wegrzynek, D F Weiser, S C Wenzel, J P Wessels, U Westerhoff, A M Whitehead, J Wiechula, J Wikne, G Wilk, J Wilkinson, G A Willems, M C S Williams, E Willsher, B Windelband, W E Witt, R Xu, S Yalcin, K Yamakawa, S Yano, Z Yin, H Yokoyama, I-K Yoo, J H Yoon, V Yurchenko, V Zaccolo, A Zaman, C Zampolli, H J C Zanoli, N Zardoshti, A Zarochentsev, P Závada, N Zaviyalov, H Zbroszczyk, M Zhalov, X Zhang, Y Zhang, Z Zhang, C Zhao, V Zherebchevskii, N Zhigareva, D Zhou, Y Zhou, Z Zhou, H Zhu, J Zhu, Y Zhu, A Zichichi, M B Zimmermann, G Zinovjev, J Zmeskal, S Zou
Angular correlations between heavy-flavor decay electrons and charged particles at midrapidity (|η|<0.8) are measured in p-Pb collisions at sqrt[s_{NN}]=5.02  TeV. The analysis is carried out for the 0%-20% (high) and 60%-100% (low) multiplicity ranges. The jet contribution in the correlation distribution from high-multiplicity events is removed by subtracting the distribution from low-multiplicity events. An azimuthal modulation remains after removing the jet contribution, similar to previous observations in two-particle angular correlation measurements for light-flavor hadrons...
February 22, 2019: Physical Review Letters
https://read.qxmd.com/read/30814273/azadirachtin-inhibits-amyloid-formation-disaggregates-pre-formed-fibrils-and-protects-pancreatic-%C3%AE-cells-from-human-islet-amyloid-polypeptide-amylin-induced-cytotoxicity
#3
Richa Dubey, Ketaki Patil, Sarath Chandra Dantu, Devika M Sardesai, Parnika Bhatia, Nikita Malik, Jhankar D Acharya, Soham Sarkar, Soumadwip Ghosh, Rajarshi Chakrabarti, Shilpy Sharma, Ashutosh Kumar
The human islet amyloid polypeptide (hIAPP) or amylin is the major constituent of amyloidogenic aggregates found in pancreatic islets of type 2 diabetic patients that have been associated with b-cell dysfunction and/or death associated with type 2 diabetes mellitus (T2DM). Therefore, developing and/or identifying inhibitors of hIAPP aggregation pathway and/or compound that can mediate disaggregation of pre-formed aggregates holds promise as a medical intervention for T2DM management. In the current study, the anti-amyloidogenic potential of Azadirachtin (AZD) - a secondary metabolite isolated from traditional medicinal plant Neem ( Azadirachta indica ) - was investigated by using a combination of biophysical and cellular assays...
February 27, 2019: Biochemical Journal
https://read.qxmd.com/read/30807723/re-evaluation-of-asynchronous-asexual-development-of-cystoisospora-canis-in-intestines-of-dogs
#4
J P Dubey, D S Lindsay
The coccidian parasite Cystoisospora canis (syn. Isospora canis) can cause clinical disease in dogs. Three generation of schizonts have been reported in the small intestine of dogs before oocysts are excreted 9-11 days post inoculation (PI). Here, we re-evaluated asexual development of C. canis in 2 dogs necropsied 10 days after oral inoculation with 100,000 C. canis oocysts; both dogs had excreted oocysts 9 days PI. Asexual and sexual stages were seen in the lamina propria throughout the small intestine. Merozoites of different sizes were present, often in the same vacuole...
February 2019: Journal of Parasitology
https://read.qxmd.com/read/30807718/confirmation-of-sarcocystis-jamaicensis-sarcocysts-in-ifn-%C3%AE-gene-knockout-mice-orally-inoculated-with-sporocysts-from-a-red-tailed-hawk-buteo-jamaicensis
#5
J P Dubey, Camila K Cerqueira-Cézar, Fernando H A Murata, J D Mowery, D Scott, A Rosypal von Dohlen, David S Lindsay
Here, we report confirmation of sarcocysts of Sarcocystis jamaicensis in an experimental intermediate host, IFN-γ gene knockout (KO) mice orally inoculated sporocysts from its natural definitive host, a red-tailed hawk ( Buteo jamaicensis) (RTH). A RTH submitted to the Carolina Raptor Center, Huntersville, North Carolina, was euthanized because it could not be rehabilitated and released. Fully sporulated sporocysts from intestinal scrapings of the RTH were orally fed to 2 laboratory-reared outbred Swiss Webster mice (SW; Mus musculus) and to 2 KO mice...
February 2019: Journal of Parasitology
https://read.qxmd.com/read/30745476/safety-and-immunogenicity-of-two-doses-of-a-quadrivalent-meningococcal-polysaccharide-diphtheria-toxoid-conjugate-vaccine-in-indian-and-russian-children-aged-9-to-17-months
#6
Bakul Javadekar, Apurba Ghosh, Rajeev Zachariah Kompithra, Shally Awasthi, Olga Perminova, Viktor Romanenko, Vera Rodnikova, Susanna Kharit, Yael Thollot, Valerie Bosch-Castells, Alexander Goldstein, Himanshu Dubey
OBJECTIVE: Evaluation of tolerability, safety and immunogenicity of a two-dose series of a quadrivalent meningococcal polysaccharide diptheria toxoid conjugate (ACYW-D) vaccine in Indian and Russian infants/toddlers. DESIGN: Open-label, single-arm, phase III multi-national trial. STUDY PARTICIPANTS: 300 children aged 9-17 months, previously unvaccinated against meningococcal disease from four sites each in India (n=200) and the Russian Federation (n=100)...
December 15, 2018: Indian Pediatrics
https://read.qxmd.com/read/30718305/substrate-assisted-mechanism-of-catalytic-hydrolysis-of-misaminoacylated-trna-required-for-protein-synthesis-fidelity
#7
Mykola Ilchenko, Mariia Rybak, Alex Rayevsky, Oksana Kovalenko, Igor Dubey, Michael Tukalo
D-aminoacyl-tRNA-deacylase (DTD) prevents the incorporation of D-amino acids into proteins during translation by hydrolyzing the ester bond between mistakenly attached amino acids and tRNAs. Despite extensive study of this proofreading enzyme, the precise catalytic mechanism remains unknown. Here, a combination of biochemical and computational investigations has enabled the discovery of a new substrate-assisted mechanism of D-Tyr-tRNATyr hydrolysis by Thermus thermophilus DTD. Several functional elements of the substrate, misacylated tRNA, participate in the catalysis...
February 4, 2019: Biochemical Journal
https://read.qxmd.com/read/30705747/vilnius-declaration-on-chronic-respiratory-diseases-multisectoral-care-pathways-embedding-guided-self-management-mhealth-and-air-pollution-in-chronic-respiratory-diseases
#8
REVIEW
A Valiulis, J Bousquet, A Veryga, U Suprun, D Sergeenko, S Cebotari, D Borelli, S Pietikainen, J Banys, I Agache, N E Billo, A Bush, I Chkhaidze, L Dubey, W J Fokkens, J Grigg, T Haahtela, K Julge, O Katilov, N Khaltaev, M Odemyr, S Palkonen, R Savli, A Utkus, V Vilc, T Alasevicius, A Bedbrook, M Bewick, J Chorostowska-Wynimko, E Danila, A Hadjipanayis, R Karseladze, V Kvedariene, E Lesinskas, L Münter, B Samolinski, S Sargsyan, B Sitkauskiene, D Somekh, L Vaideliene, A Valiulis, P W Hellings
Background: Over 1 billion people suffer from chronic respiratory diseases such as asthma, COPD, rhinitis and rhinosinusitis. They cause an enormous burden and are considered as major non-communicable diseases. Many patients are still uncontrolled and the cost of inaction is unacceptable. A meeting was held in Vilnius, Lithuania (March 23, 2018) under the patronage of the Ministry of Health and several scientific societies to propose multisectoral care pathways embedding guided self-management, mHealth and air pollution in selected chronic respiratory diseases (rhinitis, chronic rhinosinusitis, asthma and COPD)...
2019: Clinical and Translational Allergy
https://read.qxmd.com/read/30607121/incidence-of-spinal-disease-and-role-of-spinal-radiotherapy-in-multiple-myeloma
#9
A M Sharma, M Sackett, D Bueddefeld, P Lambert, A Dubey, V Wadhwa, R Kotb, N Ahmed
Background: Spinal disease (spd) in multiple myeloma (mm) can be a major source of morbidity in newly diagnosed patients and long-term survivors. We retrospectively assessed the incidence of spinal disease in patients newly diagnosed with myeloma, its effect on survival, and the possible effect of spinal radiation therapy (rt). Methods: Patients diagnosed with mm between 2010 and 2014 were identified through the provincial cancer registry. Plain radiography, computed tomography, and magnetic resonance imaging were reviewed to detect and document the type of spd...
December 2018: Current Oncology
https://read.qxmd.com/read/30557123/exposure-of-alaska-brown-bears-ursus-arctos-to-bacterial-viral-and-parasitic-agents-varies-spatiotemporally-and-may-be-influenced-by-age
#10
Andrew M Ramey, Christopher A Cleveland, Grant V Hilderbrand, Kyle Joly, David D Gustine, Buck Mangipane, William B Leacock, Anthony P Crupi, Dolores E Hill, Jitender P Dubey, Michael J Yabsley
We collected blood and serum from 155 brown bears ( Ursus arctos) inhabiting five locations in Alaska during 2013-16 and tested samples for evidence of prior exposure to a suite of bacterial, viral, and parasitic agents. Antibody seroprevalence among Alaska brown bears was estimated to be 15% for Brucella spp., 10% for Francisella tularensis, 7% for Leptospira spp., 18% for canine adenovirus type 1 (CAV-1), 5% for canine distemper virus (CDV), 5% for canine parvovirus, 5% for influenza A virus (IAV), and 44% for Toxoplasma gondii...
December 17, 2018: Journal of Wildlife Diseases
https://read.qxmd.com/read/30532494/a-bibliometric-analysis-of-global-research-on-toxoplasmosis-in-the-web-of-science
#11
Mahdi Fakhar, Masoud Soosaraei, Ali Akbar Khasseh, Reza Zolfaghari Emameh, Hajar Ziaei Hezarjaribi
Aim: This study was designed to evaluate the network productions and research collaborations on toxoplasmosis worldwide. Materials and Methods: A bibliometric research was carried out using the Web of Science (WOS) database. The analysis unit was the original research articles about toxoplasmosis published between 2000 and 2016 (17 years). Results: Totally, 6,550 articles about toxoplasmosis were indexed in the WOS with the following information: (A) 18,410 researchers played a role in drafting the articles; (B) 33 different countries have contributed in the toxoplasmosis studies; (C) the USA was ranked at the first place with 2,162 publications about toxoplasmosis; and (D) "Dubey JP" was compiled and participated in 401 articles from the USA, as the highest number and main core of publications in the toxoplasmosis network...
November 2018: Veterinary World
https://read.qxmd.com/read/30488222/amisulpride-prevents-nausea-and-vomiting-associated-with-highly-emetogenic-chemotherapy-a-randomised-double-blind-placebo-controlled-dose-ranging-trial
#12
J Herrstedt, Y Summers, K Jordan, J von Pawel, A H Jakobsen, M Ewertz, S Chan, J D Naik, M Karthaus, S Dubey, R Davis, G M Fox
PURPOSE: Chemotherapy-induced nausea and vomiting (CINV) remain significant clinical problems, especially in the delayed phase (24-120 h after chemotherapy). Amisulpride is a dopamine D2 /D3 -receptor antagonist previously shown to be an effective intravenous antiemetic. We conducted a randomised, double-blind study to characterise the dose response of oral amisulpride in delayed phase CINV. METHODS: Chemotherapy-naïve patients receiving cisplatin ≥ 70 mg/m2 or an anthracycline-cyclophosphamide regimen for breast cancer received, on day 1, 20 mg amisulpride and 8-16 mg ondansetron intravenously followed, once daily on days 2-4, by 10, 20 or 40 mg oral amisulpride or placebo...
November 28, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://read.qxmd.com/read/30301915/functional-analysis-of-polyketide-synthase-genes-in-the-biocontrol-fungus-clonostachys-rosea
#13
Umma Fatema, Anders Broberg, Dan Funck Jensen, Magnus Karlsson, Mukesh Dubey
Clonostachys rosea is a mycoparasitic fungus used for biological control of plant diseases. Its genome contains 31 genes putatively encoding for polyketide synthases (PKSs), 75% of which are arranged in biosynthetic gene clusters. Gene expression analysis during C. rosea interactions with the fungal plant pathogens Botrytis cinerea and Fusarium graminearum showed common and species-specific induction of PKS genes. Our data showed a culture media dependent correlation between PKS gene expression and degree of antagonism in C...
October 9, 2018: Scientific Reports
https://read.qxmd.com/read/30298952/il-6-mediates-er-expansion-during-hyperpolarization-of-alternatively-activated-macrophages
#14
Ehab A Ayaub, Karun Tandon, Manreet Padwal, Jewel Imani, Hemisha Patel, Anisha Dubey, Olivia Mekhael, Chandak Upagupta, Anmar Ayoub, Anna Dvorkin-Gheva, James Murphy, Philipp S Kolb, Sarka Lhotak, Jeffrey G Dickhout, Rick C Austin, Martin Rj Kolb, Carl D Richards, Kjetil Ask
Although recent evidence has shown that IL-6 is involved in enhanced alternative activation of macrophages toward a pro-fibrotic phenotype, the mechanisms leading to their increased secretory capacity are not fully understood. Here, we investigated the effect of IL-6 on endoplasmic reticulum (ER) expansion and alternative activation of macrophages in vitro. An essential mediator in this ER expansion process is the IRE1 pathway, which possesses a kinase and endoribonuclease domain to cleave XBP1 into a spliced bioactive molecule...
October 9, 2018: Immunology and Cell Biology
https://read.qxmd.com/read/30282957/correlation-between-diabetes-mellitus-and-knee-osteoarthritis-a-dry-to-wet-lab-approach
#15
Navneet Kumar Dubey, Dina Nur Anggraini Ningrum, Rajni Dubey, Yue-Hua Deng, Yu-Chuan Li, Peter D Wang, Joseph R Wang, Shabbir Syed-Abdul, Win-Ping Deng
Recent years have witnessed an increased prevalence of knee osteoarthritis (KOA) among diabetes mellitus (DM) patients-conditions which might share common risk factors such as obesity and advanced aging. Therefore, we conducted dry-to-wet lab research approaches to assess the correlation of type 1 DM (T1DM) and type 2 DM (T2DM) with KOA among all age and genders of Taiwanese population. The strength of association (odds ratio: OR) was analyzed using a phenome-wide association study portal. Populations of 37,353 T1DM and 1,218,254 T2DM were included...
October 3, 2018: International Journal of Molecular Sciences
https://read.qxmd.com/read/30280350/nanocarrier-based-combination-chemotherapy-for-resistant-tumor-development-characterization-and-ex-vivo-cytotoxicity-assessment
#16
Sarjana Raikwar, Sonal Vyas, Rajeev Sharma, Nishi Mody, Surbhi Dubey, Suresh P Vyas
A folic acid-conjugated paclitaxel (PTX)-doxorubicin (DOX)-loaded nanostructured lipid carrier(s) (FA-PTX-DOX NLCs) were prepared by using emulsion-evaporation method and extensively characterized for particle size, polydispersity index, zeta potential, and % entrapment efficiency which were found to be 196 ± 2.5 nm, 0.214 ± 0.04, +23.4 ± 0.3 mV and 88.3 ± 0.2% (PTX), and 89.6 ± 0.5% (DOX) respectively. In vitro drug release study of optimized formulation was carried out using dialysis tube method...
October 2, 2018: AAPS PharmSciTech
https://read.qxmd.com/read/30258024/area-postrema-syndrome-frequency-criteria-and-severity-in-aqp4-igg-positive-nmosd
#17
Eslam Shosha, Divyanshu Dubey, Jacqueline Palace, Ichiro Nakashima, Anu Jacob, Kazuo Fujihara, Toshiyuki Takahashi, Daniel Whittam, Maria Isabel Leite, Tatsuro Misu, Takai Yoshiki, Silvia Messina, Liene Elsone, Masoud Majed, Eoin Flanagan, Avi Gadoth, Carey Huebert, Jessica Sagen, Benjamin M Greenberg, Michael Levy, Aditya Banerjee, Brian Weinshenker, Sean J Pittock
OBJECTIVE: To define the frequency, duration, and severity of intractable nausea, vomiting, or hiccups in aquaporin-4-immunoglobulin G (AQP4-IgG)-positive neuromyelitis optica spectrum disorder (NMOSD) and propose diagnostic criteria and a severity scale for area postrema syndrome (APS). METHODS: An International NMOSD database was interrogated for frequency of APS. Patients with AQP4-IgG-positive NMOSD completed an APS symptom questionnaire. Nausea and vomiting severity was derived from the Pregnancy-Unique Quantification of Emesis and Nausea (PUQE) score...
October 23, 2018: Neurology
https://read.qxmd.com/read/30120590/histopathological-morphological-and-molecular-characterization-of-sarcocystis-species-in-elk-cervus-elaphus-from-pennsylvania-usa
#18
Camila K Cerqueira-Cézar, Peter C Thompson, Fernando H A Murata, Joseph Mowery, Justin D Brown, Jeremy Banfield, Benjamin M Rosenthal, Jitender P Dubey
Sarcocystis sarcocysts are common in many species of domestic and wild animals. Here, we report sarcocystosis in muscles from 91 free range elk (Cervus elaphus) from Pennsylvania, USA, tested by histopathology, transmission electron microscopy (TEM), and DNA sequencing. Sarcocysts were detected in hematoxylin and eosin (HE)-stained sections from 83 of 91 (91.2%) elk, including 83/91 (91.2%) tongues and 15/17 (88.2%) hearts. With respect to age, sarcocysts were found in 0/5 calves, 8/9 (88.8%) yearlings, and 75/77 (97...
October 2018: Parasitology Research
https://read.qxmd.com/read/30104114/non-interference-of-bovine-human-reassortant-pentavalent-rotavirus-vaccine-rotasiil%C3%A2-with-the-immunogenicity-of-infant-vaccines-in-comparison-with-a-licensed-rotavirus-vaccine
#19
Sajjad Desai, Niraj Rathi, Anand Kawade, Padmasani Venkatramanan, Ritabrata Kundu, Sanjay K Lalwani, A P Dubey, J Venkateswara Rao, D Narayanappa, Radha Ghildiyal, Nithya J Gogtay, P Venugopal, Sonali Palkar, Renuka Munshi, Ashish Bavdekar, Sanjay Juvekar, Nupur Ganguly, Prabal Niyogi, Kheya Ghosh Uttam, Alpana Kondekar, Dipti Kumbhar, Smilu Mohanlal, Mukesh C Agarwal, Parvan Shetty, Kalpana Antony, Bhagwat Gunale, Abhijeet Dharmadhikari, Jagdish Deshpande, Uma Nalavade, Deepa Sharma, Anurag Bansal, Yuxiao Tang, Jorge Flores, Prasad S Kulkarni
BACKGROUND: A newly developed bovine-human reassortant pentavalent vaccine (BRV-PV, ROTASIIL®) was tested for its potential effect on the immunogenicity of concomitantly administered EPI vaccines in infants in a randomized controlled study in India. METHODS: In this Phase III, multicenter, open label, randomized, controlled study, three doses of BRV-PV or two doses of Rotarix® and one dose of placebo were given to healthy infants at 6, 10, and 14 weeks of age...
September 5, 2018: Vaccine
https://read.qxmd.com/read/30076629/lgi1-and-caspr2-neurological-autoimmunity-in-children
#20
A Sebastian López-Chiriboga, Christopher Klein, Anastasia Zekeridou, Andrew McKeon, Divyanshu Dubey, Eoin P Flanagan, Vanda A Lennon, Jan-Mendelt Tillema, Elaine C Wirrell, Marc C Patterson, Avi Gadoth, J Gregory Aaen, J Nicholas Brenton, Jonathan D Bui, Amanda Moen, Catherine Otten, Amanda Piquet, Sean J Pittock
The clinical phenotype of leucine-rich glioma-inactivated protein 1 (LGI1) and contactin-associated proteinlike 2 (CASPR2) autoimmunity is well defined in adults. Data for children are limited (<10 cases). Among 13,319 pediatric patients serologically tested for autoimmune neurological disorders (2010-2017), 264 were seropositive for voltage-gated potassium channel-complex-IgG (radioimmunoprecipitation). Only 13 (4.9%) were positive by transfected cell-binding assay for LGI1-IgG (n = 7), CASPR2-IgG (n = 3), or both (n = 3)...
September 2018: Annals of Neurology
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