keyword
https://read.qxmd.com/read/38464335/cushing-s-syndrome-caused-by-adrenocortical-oncocytoma-a-case-report
#21
Chengren Gou, Qingsong Jian, Maoqiang Tian, Jinghai Li, Yi Zhang, Zhenyu Guo
Adrenal cortical eosinophilic adenoma usually presents as non-functional adrenal tumor but may lead to Cushing's syndrome in patients. The present article reports a patient with Cushing's syndrome caused by right adrenocortical oncocytoma. The patient was treated in Urology Department of Wuchuan People's Hospital (Zunyi, China) in November 2022 because of hirsutism, weight gain and hypertension. A laparoscopic right adrenal tumor resection was performed using an abdominal approach. Following surgery, blood pressure and heart rate of the patient fluctuated within a healthy range and menstruation returned to normal...
April 2024: Oncology Letters
https://read.qxmd.com/read/38462154/apds-patients-with-immune-complex-vasculitis-and-resolution-with-leniolisib
#22
JOURNAL ARTICLE
Mohammad-Ali Doroudchi, Alexis V Stephens, Ziwei Wang, Jaspreet Dhami, Manish J Butte
Activated phosphoinositide 3-kinase delta syndrome (APDS) is an inborn error of immunity with heterogeneous clinical manifestations of infections, immune dysregulation, autoimmunity; lymphoproliferation; and malignancy. Immune complex-mediated vasculitides have not yet been described in APDS patients. Here we offer a case series of three patients with APDS who have refractory IgA vasculitis (also called Henoch-Schönlein purpura), a form of immune complex-mediated vasculitis that activates complement and attracts neutrophils, macrophages and eosinophils to cause local tissue injury...
March 8, 2024: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://read.qxmd.com/read/38461469/clinical-and-atopic-features-of-patients-with-primary-eosinophilic-colitis-an-italian-multicentre-study
#23
JOURNAL ARTICLE
Carlo Maria Rossi, Marco Vincenzo Lenti, Stefania Merli, Antonio Lo Bello, Aurelio Mauro, Andrea Anderloni, Davide Giuseppe Ribaldone, Elisa Marabotto, Marta Vernero, Shirin Djahandideh Sheijani, Daria Maniero, Alessandro Vanoli, Catherine Klersy, Edoardo Vincenzo Savarino, Antonio Di Sabatino
Eosinophilic colitis (EC) is the rarest among primary eosinophilic gastrointestinal disorders (EGID). EC is underdiagnosed due to its blurred and proteiform clinical manifestations. To explore the clinical and atopic characteristic of EC adult patients, the diagnostic delay, and relapse-associated factors, by comparison with patients with eosinophilic esophagitis (EoE) and irritable bowel syndrome (IBS). EC patients followed-up at four clinics were included, and clinical, histopathological, and laboratory data were retrieved...
March 10, 2024: Internal and Emergency Medicine
https://read.qxmd.com/read/38457562/association-of-white-blood-cell-parameters-with-metabolic-syndrome-a-systematic-review-and-meta-analysis-of-168-000-patients
#24
JOURNAL ARTICLE
Aysal Mahmood, Hoorain Haider, Saba Samad, Danisha Kumar, Aimen Perwaiz, Rabeea Mushtaq, Abraish Ali, Muhammad Zain Farooq, Hadi Farhat
BACKGROUND: Leukocyte parameters are predicted to be affected in patients with metabolic syndrome (MetS). We conducted a systematic review and meta-analysis to study the association between white blood cell parameters (WBC) in people with and without MetS. METHODS: PubMed, EMBASE, Scopus and Cochrane Library databases were searched according to the study protocol. The standardized mean difference (SMD) and 95% confidence intervals (CI) of leukocyte markers between individuals with and without MetS were pooled using an inverse variance model...
March 8, 2024: Medicine (Baltimore)
https://read.qxmd.com/read/38457550/a-case-of-empty-sella-syndrome-with-adrenal-insufficiency-masked-by-prednisolone-after-administration-of-immune-checkpoint-inhibitors
#25
JOURNAL ARTICLE
Yuichiro Iwamoto, Fuminori Tatsumi, Mana Ohnishi, Yukino Katakura, Tomohiko Kimura, Masashi Shimoda, Shuhei Nakanishi, Tomoatsu Mune, Hideaki Kaneto
INTRODUCTION: The use of immune checkpoint inhibitors (ICIs) is gradually increasing; ICIs produce a variety of immune-related adverse events (irAEs), especially ICI-induced hypoadrenocorticism, which can be a lethal complication if treatment is delayed. PATIENT CONCERNS: A 63-year-old man received chemotherapy with pembrolizumab for nonsmall cell lung cancer. He developed drug-induced interstitial pneumonia 366 days after receiving pembrolizumab and was treated with prednisolone...
March 8, 2024: Medicine (Baltimore)
https://read.qxmd.com/read/38457125/biologic-therapy-in-rare-eosinophil-associated-disorders-remaining-questions-and-translational-research-opportunities
#26
JOURNAL ARTICLE
Paneez Khoury, Florence Roufosse, Fei Li Kuang, Steven J Ackerman, Praveen Akuthota, Bruce S Bochner, Mats W Johansson, Sameer K Mathur, Princess U Ogbogu, Lisa A Spencer, Michael E Wechsler, Nives Zimmermann, Amy D Klion
Rare eosinophil-associated disorders (EADs), including hypereosinophilic syndrome, eosinophilic granulomatosis with polyangiitis and eosinophilic gastrointestinal disorders, are a heterogeneous group of conditions characterized by blood and/or tissue hypereosinophilia and eosinophil-related clinical manifestations. Although the recent availability of biologic therapies that directly and indirectly target eosinophils has the potential to dramatically improve treatment options for all EADs, clinical trials addressing their safety and efficacy in rare EADs have been relatively few...
March 8, 2024: Journal of Leukocyte Biology
https://read.qxmd.com/read/38456078/an-occurrence-of-eosinophilic-folliculitis-and-alopecia-associated-with-a-sustained-complete-response-to-mogamulizumab-in-s%C3%A3-zary-syndrome-a-case-report
#27
Jean-Matthieu L'Orphelin
Mogamulizumab is a monoclonal antibody that binds to C-C chemokine receptor 4 (CCR4), initiating antibody-dependent cellular cytotoxicity. CCR4 is highly expressed in the cutaneous T-cell lymphoma subtypes mycosis fungoides and Sézary syndrome (SS), and mogamulizumab has been shown to be effective in patients with these conditions who were refractory to at least one prior systemic treatment. One of the more common adverse events encountered with mogamulizumab is rash, which may mimic disease progression and lead to premature discontinuation...
2024: Therapeutic Advances in Hematology
https://read.qxmd.com/read/38425288/exosomal-mir-223-promotes-ards-by-targeting-insulin-like-growth-factor-1-receptor-a-cell-communication-study
#28
JOURNAL ARTICLE
Miaomiao Li, Lilei Zhuang, Tao Jiang, Li Sun
BACKGROUND: Acute respiratory distress syndrome (ARDS) is a respiratory failure syndrome characterized by hypoxemia and changes in the respiratory system. ARDS is the most common cause of death in COVID-19 deaths was ARDS. In this study, we explored the role of miR-223 in exosomes in ARDS. METHODS: Exosomes were purified from the supernatants of macrophages. qPCR was used to detect relative mRNA levels. A luciferase reporter assay was performed to verify the miRNA target genes...
2024: Experimental Lung Research
https://read.qxmd.com/read/38422019/pathogenic-gata2-genetic-variants-utilize-an-obligate-enhancer-mechanism-to-distort-a-multilineage-differentiation-program
#29
JOURNAL ARTICLE
Koichi R Katsumura, Peng Liu, Jeong-Ah Kim, Charu Mehta, Emery H Bresnick
Mutations in genes encoding transcription factors inactivate or generate ectopic activities to instigate pathogenesis. By disrupting hematopoietic stem/progenitor cells, GATA2 germline variants create a bone marrow failure and leukemia predisposition, GATA2 deficiency syndrome, yet mechanisms underlying the complex phenotypic constellation are unresolved. We used a GATA2-deficient progenitor rescue system to analyze how genetic variation influences GATA2 functions. Pathogenic variants impaired, without abrogating, GATA2-dependent transcriptional regulation...
March 5, 2024: Proceedings of the National Academy of Sciences of the United States of America
https://read.qxmd.com/read/38417937/mercaptopurine-induced-sweet-s-syndrome
#30
JOURNAL ARTICLE
Natalie Commins, Deloshaan Subhaharan, Andrew Dettrick, Desmond Patrick
Sweet's syndrome is an acute febrile neutrophilic dermatosis. Drug-induced Sweet's syndrome typically occurs soon after drug administration, with rapid resolution of symptoms with cessation of the offending agent. We report a man in his early 40s who presented with fever and widespread erythematous rash on a background of recently diagnosed mild stricturing ileal Crohn's disease. He was commenced on 6-mercaptopurine 12 days before presentation. Skin biopsy demonstrated diffuse infiltration of neutrophils in the upper dermis, dermal oedema, eosinophils and fibrin deposition...
February 27, 2024: BMJ Case Reports
https://read.qxmd.com/read/38415838/a-prospective-observational-study-validating-the-cet-score-as-a-screening-tool-in-suspected-dress-syndrome
#31
JOURNAL ARTICLE
Sukhdeep Singh, Keshavamurthy Vinay, Anuradha Bishnoi, Davinder Parsad, Muthu Sendhil Kumaran
BACKGROUND: Drug reaction with eosinophilia and systemic symptoms (DRESS) is an idiosyncratic severe cutaneous adverse reaction that may be potentially life-threatening. Recently, a simple scoring system for the early screening of DRESS patients was derived by combining hsCRP levels, the eosinophil count, and the total body surface area (CET score). The objectives of this study were validating the CET score, and calculating its lead time advantage and cost-benefits compared to RegiSCAR scoring...
February 28, 2024: International Journal of Dermatology
https://read.qxmd.com/read/38407323/a-rare-manifestation-of-igg4-related-disease-and-secondary-hypereosinophilic-syndrome-a-case-report
#32
JOURNAL ARTICLE
Miyoshi Takeuchi, Masumi Shojima, Shumei Matsueda, Hiroshi Nagae, Mika Kuroiwa, Aya Fujita, Mitsuhiro Kawano, Dai Inoue, Takahiro Komori, Mai Takeuchi, Koichi Ooshima, Yusuke Kuroki, Ritsuko Katafuchi
We report a case of IgG4-related disease with marked eosinophilia. A 79-year-old woman was admitted due to diarrhea, and weight loss. Cervical lymphadenopathy, bilateral submandibular glands swelling, anemia (Hb8.5g/dl), hypereosinophilia (9,750/μL), and elevated serum creatinine (1.57 mg/dL), pancreatic amylase (191 IU/L), and IgG4 (3,380 mg/dL) were found. Diffusion-weighted image on MRI showed high intensity signals inside of both the pancreas and the kidney. The echogram of submandibular glands revealed cobblestone pattern...
February 26, 2024: Modern rheumatology case reports
https://read.qxmd.com/read/38406046/a-case-of-bullous-sweet-s-syndrome-associated-with-esophageal-adenocarcinoma
#33
Adriana G Bagos-Estevez, Sarah Moore, Leslie Turner, Brooke Baldwin
Sweet's syndrome (SS), or acute febrile neutrophilic dermatosis, characteristically presents with fever, dermal neutrophilic infiltrates, and neutrophilia. It typically manifests as tender erythematous plaques; however, various variants are documented, including bullous. Malignancy-associated Sweet's syndrome (MASS) can present as a paraneoplastic syndrome in those with established cancers or with undiagnosed malignancies. We present a 72-year-old male with a three-day history of a progressive bullous, erythematous papular rash starting on his right forearm and spreading to his extremities, trunk, palms, and soles...
January 2024: Curēus
https://read.qxmd.com/read/38401465/morita-baylis-hillman-adduct-2-3-hydroxy-1-methyl-2-oxoindolin-3-il-acrylonitrile-cisacn-ameliorates-the-pulmonary-allergic-inflammation-in-caras-model-by-increasing-ifn-%C3%AE-il-4-ratio-towards-the-th1-immune-response
#34
JOURNAL ARTICLE
Larissa Adilis Maria Paiva Ferreira, Laércia Karla Diega Paiva Ferreira, Raquel Fragoso Pereira Cavalcanti, Francisco Allysson de Assis Ferreira Gadelha, Louise Mangueira de Lima, Adriano Francisco Alves, Cláudio Gabriel Lima Júnior, Marcia Regina Piuvezam
Combined allergic rhinitis and asthma syndrome (CARAS) is an airway-type 2 immune response with a profuse inflammatory process widely affecting the world population. Due to the compromise of quality of life and the lack of specific pharmacotherapy, the search for new molecules becomes relevant. This study aimed to evaluate the effectiveness of the Morita-Bailys-Hillman adduct (CISACN) treatment in the CARAS experimental model. Female BALB/c mice were ovalbumin (OVA) -sensitized and -challenged and treated with CISACN...
February 23, 2024: International Immunopharmacology
https://read.qxmd.com/read/38398096/infrequent-presentations-of-chronic-npm1-mutated-myeloid-neoplasms-clinicopathological-features-of-eight-cases-from-a-single-institution-and-review-of-the-literature
#35
REVIEW
Sandra Castaño-Díez, Francesca Guijarro, Mònica López-Guerra, Amanda Isabel Pérez-Valencia, Marta Gómez-Núñez, Dolors Colomer, Marina Díaz-Beyá, Jordi Esteve, María Rozman
Non-acute myeloid neoplasms (MNs) with NPM1 mutations ( NPM1 mut-MNs) pose a diagnostic and therapeutic dilemma, primarily manifesting as chronic myelomonocytic leukemia (CMML) and myelodysplastic syndromes (MDS). The classification and treatment approach for these conditions as acute myeloid leukemia (AML) are debated. We describe eight cases of atypical NPM1 mut-MNs from our institution and review the literature. We include a rare case of concurrent prostate carcinoma and MN consistent with chronic eosinophilic leukemia, progressing to myeloid sarcoma of the skin...
February 7, 2024: Cancers
https://read.qxmd.com/read/38397316/comparison-of-eosinophil-counts-in-inflammatory-conditions-multisystem-inflammatory-syndrome-in-children-kawasaki-disease-and-infectious-mononucleosis
#36
JOURNAL ARTICLE
Erdal Sarı, Özlem Erdede
This study examined the distinctions between multisystem inflammatory syndrome associated with coronavirus disease 2019, Kawasaki disease, and infectious mononucleosis. These three inflammatory disorders have commonalities according to clinical and laboratory results, particularly in relation to eosinophil levels. In this retrospective, single-center study, we documented the examination records (acute phase reactants and complete blood count) and clinical and cardiological findings of 130 patients diagnosed with multisystem inflammatory syndrome, Kawasaki disease, and infectious mononucleosis...
February 5, 2024: Children
https://read.qxmd.com/read/38396936/autoimmunity-and-autoinflammation-relapsing-polychondritis-and-vexas-syndrome-challenge
#37
REVIEW
Anca Cardoneanu, Ioana Irina Rezus, Alexandra Maria Burlui, Patricia Richter, Ioana Bratoiu, Ioana Ruxandra Mihai, Luana Andreea Macovei, Elena Rezus
Relapsing polychondritis is a chronic autoimmune inflammatory condition characterized by recurrent episodes of inflammation at the level of cartilaginous structures and tissues rich in proteoglycans. The pathogenesis of the disease is complex and still incompletely elucidated. The data support the important role of a particular genetic predisposition, with HLA-DR4 being considered an allele that confers a major risk of disease occurrence. Environmental factors, mechanical, chemical or infectious, act as triggers in the development of clinical manifestations, causing the degradation of proteins and the release of cryptic cartilage antigens...
February 13, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38380836/dress-syndrome-with-multiorgan-involvement-and-hhv-6-reactivation-in-the-absence-of-a-drug-trigger
#38
JOURNAL ARTICLE
Yi Tong Vincent Aw, Meidelynn Ooi, Adel Ekladious
Drug reaction with eosinophilia and systemic symptoms (DRESS) is a severe drug reaction where patients present with fever, morbilliform rash and multiorgan manifestations, which may include acute renal failure, acute respiratory distress syndrome and eosinophilic myocarditis. We present a case of a 60-year-old woman with acute heart failure, DRESS syndrome features and human herpesvirus 6 reactivation in the absence of a drug trigger. She was diagnosed with eosinophilic myocarditis and successfully treated with corticosteroid therapy...
February 21, 2024: Internal Medicine Journal
https://read.qxmd.com/read/38378547/a-multidisciplinary-study-on-clinostomum-infections-in-nile-tilapia-micro-morphology-oxidative-stress-immunology-and-histopathology
#39
JOURNAL ARTICLE
Olfat A Mahdy, Sahar Z Abdel-Maogood, Mohamed Abdelsalam, Mai A Salem
Yellow grub disease, caused by Clinostomum metacercaria, is an endemic zoonotic infection in freshwater fish, responsible for Halzoun syndrome transmitted through the consumption of raw infected fish. This study aimed to conduct a multidisciplinary investigation integrating detailed morphology, oxidative stress, immunology, and histopathology alteration to advance our understanding of Clinostomum infection. In this annual study, 400 Nile tilapia (Oreochromis niloticus) were collected from the Nile River at Al Bahr Al Aazam, Giza Governorate to assess Clinostomum infection prevalence...
February 20, 2024: BMC Veterinary Research
https://read.qxmd.com/read/38377376/eosinophilic-fasciitis-illustrated-by-18f-fdg-pet-ct
#40
JOURNAL ARTICLE
Agathe Fevrier, Pierre-Alban Dufour
Eosinophilic fasciitis is a rare sclerodermiform disease characterized by upper and lower limb edema. We present the case of a 71-year-old woman currently hospitalized for painful lower limb edema. Laboratory tests reveal moderate eosinophilia (0.8 g/L) and an inflammatory syndrome. Abdominopelvic ultrasound reveals no abnormalities. In light of the unexplained inflammatory syndrome, a 18F-FDG PET/CT scan currently shows intense hypermetabolism of the fasciae in the lower and upper limbs. Following an MRI, a biopsy is performed, and the anatomopathology currently confirms eosinophilic fasciitis...
February 12, 2024: Clinical Nuclear Medicine
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