Ayako Takamori, Aya Nambu, Keiko Sato, Sachiko Yamaguchi, Kenshiro Matsuda, Takafumi Numata, Takeru Sugawara, Takamichi Yoshizaki, Ken Arae, Hideaki Morita, Kenji Matsumoto, Katsuko Sudo, Ko Okumura, Jiro Kitaura, Hiroshi Matsuda, Susumu Nakae
IL-31, which is a member of the IL-6 family of cytokines, is produced mainly by activated CD4+ T cells, in particular activated Th2 cells, suggesting a contribution to development of type-2 immune responses. IL-31 was reported to be increased in specimens from patients with atopic dermatitis, and IL-31-transgenic mice develop atopic dermatitis-like skin inflammation, which is involved in the pathogenesis of atopic dermatitis. However, the role of IL-31 in development of contact dermatitis/contact hypersensitivity (CHS), which is mediated by hapten-specific T cells, including Th2 cells, is not fully understood...
April 27, 2018: Scientific Reports