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Alonso Narváez Barros, Roser Guiteras, Anna Sola, Anna Manonelles, Juan Morote, Josep M Cruzado
BACKGROUND/AIMS: Reversible unilateral ureteral obstruction (R-UUO) is a model of renal injury used to study the structural and functional recovery of the kidneys after relief of the obstruction. This model has a prominent potential for the study of inflammatory and immune processes, cellular and tissue regeneration. Here we sought to describe a model of renal injury and repair R-UUO in mice. METHODS: Eight week-old C57BL/6J male mice were divided into 5 groups (n = 5 each): UUO day 1, 2, 3, 4 and 5...
February 15, 2019: Nephron
Jose Antonio Merchán-Baeza, David Pérez-Cruzado, Manuel González-Sánchez, Antonio Cuesta-Vargas
BACKGROUND: Given the increase in the prevalence of muscular strength problems in people with intellectual and developmental disability and the potentially serious consequences for their day-to-day life, there is a need for comprehensive evaluations of strength. AIMS: To design a new index of the muscular strength of people with intellectual and developmental disability using principal components analysis. METHODS AND PROCEDURES: The sample consisted of 978 individuals with intellectual and developmental disability, 637 men and 341 women, with a mean age of 34...
February 2, 2019: Disability and Rehabilitation
Miguel Hueso, Josep M Cruzado, Joan Torras, Estanis Navarro
BACKGROUND: CD34⁺ Endothelial Progenitor Cells (EPCs) play an important role in the recovery of injured endothelium and contribute to atherosclerosis (ATH) pathogenesis. Previously we described a potential atherogenic role for miR-125 that we aimed to confirm in this work. METHODS: Microarray hybridization, TaqMan Low Density Array (TLDA) cards, qPCR, and immunohistochemistry (IHC) were used to analyze expression of the miRNAs, proteins and transcripts here studied...
January 21, 2019: Genes
Sofiia Kolchanova, Sergei Kliver, Aleksei Komissarov, Pavel Dobrinin, Gaik Tamazian, Kirill Grigorev, Walter W Wolfsberger, Audrey J Majeske, Jafet Velez-Valentin, Ricardo Valentin de la Rosa, Joanne R Paul-Murphy, David Sanchez-Migallon Guzman, Michael H Court, Juan L Rodriguez-Flores, Juan Carlos Martínez-Cruzado, Taras K Oleksyk
Islands have been used as model systems for studies of speciation and extinction since Darwin published his observations about finches found on the Galapagos. Amazon parrots inhabiting the Greater Antillean Islands represent a fascinating model of species diversification. Unfortunately, many of these birds are threatened as a result of human activity and some, like the Puerto Rican parrot, are now critically endangered. In this study we used a combination of de novo and reference-assisted assembly methods, integrating it with information obtained from related genomes to perform genome reconstruction of three amazon species...
January 16, 2019: Genes
Isaac Llaó, Francesc Formiga, Albert Ariza Solé, Josep M Cruzado, Juan Sanchís, Inés Rama, Manuel Martínez-Sellés, Alberto Garay, Carme Guerrero, Pablo Díez-Villanueva, Oriol Alegre, Emad Abu-Assi, Àngel Cequier
Although a significant association between renal function and outcomes in patients with acute coronary syndromes (ACS) has been consistently described, little information exists about the magnitude of this association in patients at older ages. No study assessed the prognostic role of renal function according to frailty in patients with ACS. The LONGEVO-SCA registry included unselected ACS patients aged ≥80 years. Frailty was asessesed by the FRAIL scale, and baseline creatinine clearance was calculated by the Cockroff-Gault formula...
December 4, 2018: American Journal of Cardiology
Josep M Cruzado
No abstract text is available yet for this article.
December 27, 2018: New England Journal of Medicine
Evaristo Medina-Cucurella, Jorge Acevedo-Canabal, Jeidiel De León-Arbucias, Rafael Martínez-Torres, Gustavo Cruzado-Ramos, Josefina Romaguera
OBJECTIVE: To describe the level of knowledge about Zika virus exposure, symptoms, complications, and transmission prevention in Hispanic women living in Puerto Rico. METHODS: A sample of 168 women aged 21 to 64 at the general community, consented to complete a self-administered questionnaire of 112 questions from October 2016 to July 2017. RESULTS: A univariate analysis showed that the participating women recognized that the Zika virus was transmitted through mosquito bites (95...
December 2018: Puerto Rico Health Sciences Journal
Virginia María Durán Muñoz-Cruzado, Jason David Peñuela Arredondo, Ignacio Alfredo Meneses Freitte, Adolfo Gonzálaez Haddad, Mario Alain Herrera Tobon
No abstract text is available yet for this article.
December 14, 2018: Cirugía Española
Alexandre Favà, Xavier Fulladosa, Nuria Montero, Juliana Draibe, Joan Torras, Montse Gomà, Josep M Cruzado
Renal injury is a common complication in multiple myeloma (MM). In fact, as many as 10% of patients with MM develop dialysis-dependent acute kidney injury related to increased free light chain (FLC) production by a plasma cell clone. Myeloma cast nephropathy (MCN) is the most prevalent pathologic diagnosis associated with renal injury, followed by light chain deposition disease and light chain amyloidosis. Several FLC removal techniques have been explored to improve kidney disease in MM but their impact on renal clinical outcomes remains unclear...
December 2018: Clinical Kidney Journal
Manel Vera, Sergi Torramade-Moix, Susana Martin-Rodriguez, Aleix Cases, Josep M Cruzado, Jose Rivera, Gines Escolar, Marta Palomo, Maribel Diaz-Ricart
BACKGROUND/AIMS: Accelerated atherosclerosis in chronic kidney disease (CKD) is preceded by endothelial dysfunction (ED), which exhibits a proinflammatory and prothrombotic phenotype and enhanced oxidative stress. In this study, the effect of several compounds with anti-inflammatory and/or antioxidant properties on uremia-induced endothelial dysfunction has been evaluated in an in vitro model. METHODS: Endothelial cells (ECs) were exposed to sera from uremic patients in the absence and presence of the flavonoids apigenin, genistein and quercetin, the antioxidant enzyme mimetics (AEM) ebselen (glutathione peroxidase mimetic), EUK-134 and EUK-118 (both superoxide dismutase mimetics), and the pharmacological drug N-acetylcysteine (NAC)...
November 27, 2018: Cellular Physiology and Biochemistry
Roser Guiteras, Anna Sola, Maria Flaquer, Anna Manonelles, Georgina Hotter, Josep M Cruzado
Alternatively activated macrophages (M2) have regenerative properties and shown promise as cell therapy in chronic kidney disease. However, M2 plasticity is one of the major hurdles to overcome. Our previous studies showed that genetically modified macrophages stabilized by neutrophil gelatinase-associated lipocalin (NGAL) were able to preserve their M2 phenotype. Nowadays, little is known about M2 macrophage effects in diabetic kidney disease (DKD). The aim of the study was to investigate the therapeutic effect of both bone marrow-derived M2 (BM-фM2) and ф-NGAL macrophages in the db/db mice...
November 8, 2018: Journal of Cellular and Molecular Medicine
Alba Santos García, Nicolás Macías Carmona, Almudena Vega Martínez, Soraya Abad Estébanez, Tania Linares Grávalos, Inés Aragoncillo Sauco, Ursula Verdalles Guzmán, Nayara Panizo González, Leonidas Cruzado Vega, Juan Manuel López Gómez
INTRODUCTION: The aim of this study is to compare molecule removal and albumin leakage in postdilution online hemodiafiltration with different high-flux dialyzers. METHODS: We studied seven high-flux dialyzers (Polyflux 210H®, Evodial 2.2®, FxCordiax1000®, Elisio21H®, TS-2.1SL®, XevontaHi20®, VitaPES 210-HF®) in 6 patients. The reduction ratio (RR) of small- and middle-sized molecules was calculated. Dialysate samples were collected to estimate the albumin leakage...
October 27, 2018: Hemodialysis International
Anna Manonelles, Roser Guiteras, Edoardo Melilli, Elena Lazzeri, Montse Goma, Elena Crespo, Oriol Bestard, Anna Sola, Paola Romagnani, Josep M Cruzado
Long-term kidney transplant outcomes have reached mild improvements recently. Parietal epithelial cells (PECs) are progenitor cells located along the Bowman's capsule that can be isolated in urine, and display the capability to replace podocytes, but in certain situations cause glomerulosclerosis. In this study, a cohort of stable kidney transplant recipients with 6 months protocol biopsy was divided in two groups depending on the presence (uPEC+; n = 41) or absence (uPEC-; n = 25) of PECs in urine and followed for 2 years...
2018: Frontiers in Physiology
Laura Martinez Valenzuela, Juliana Draibe, Maria Quero Ramos, Xavier Fulladosa Oliveras, Edoardo Melilli, Josep Maria Cruzado Garrit, Juan Torras Ambrós
BACKGROUND: Calprotectin is produced by neutrophils and macrophages, and released during the acute phase of the ANCA vasculitis. The aim of our study was to determine if serum and urine calprotectin are disease activity and prognosis biomarkers in ANCA vasculitis patients during remission. METHODS: Forty-two ANCA vasculitis patients were included. Twenty-seven patients were in remission phase under immunosuppressive therapy, and 15 patients were in the acute phase...
2018: PloS One
Carmen R Silva-Correa, José L Cruzado-Razco, María V González-Blas, Juan M García-Armas, Segundo G Ruiz-Reyes, Víctor E Villarreal-La Torre, César D Gamarra-Sánchez
OBJECTIVE. : To identify and determine the phytoconstituent structure of Tessaria integrifolia Ruiz & Pav. leaves with leishmanicidal activity. MATERIALS AND METHODS.: Fluid extract of leaves was prepared, concentrated to soft extract, and used to evaluate leishmanicidal activity in Mesocricetus auratus with experimental leishmaniasis, at the dose of 250 mg/kg of soft extract by intramuscular route for 15 days. Extract was fractionated in 45 cm column chromatography with a 2...
April 2018: Revista Peruana de Medicina Experimental y Salud Pública
Marta Jarque, Edoardo Melilli, Elena Crespo, Anna Manonelles, Nuria Montero, Joan Torras, Josep M Cruzado, Sergi Luque, Salvador Gil-Vernet, Josep M Grinyó, Oriol Bestard
BACKGROUND: Whether cytomegalovirus (CMV)-specific cell-mediated immunity (CMI) at prophylaxis cessation predicts D+/R+ kidney transplants at risk of late-onset CMV infection after receiving distinct induction therapies is still not well characterized. METHODS: We prospectively assessed CMV-specific CMI predicting late-onset CMV infection at prophylaxis withdrawal and at earlier time-points, in 96 consecutive D+/R+ patients receiving either anti-interleukin 2-receptor antibody (anti-IL2RA; n = 50) or rabbit antithymoglobulin (n = 46)...
November 2018: Transplantation
Juliana Draibe, Xavier Rodó, Xavier Fulladosa, Laura Martínez-Valenzuela, Montserrat Diaz-Encarnación, Lara Santos, Helena Marco, Luis Quintana, Eva Rodriguez, Xoana Barros, Rosa Garcia, Anna Balius, Josep M Cruzado, Joan Torras
Background: The closure of long-standing gaps in our knowledge of aetiological factors behind anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a major challenge. Descriptive and analytical epidemiological studies can improve our understanding of environmental influences. Reported seasonal variations in AAV, mainly related to Wegener's disease, have shown an increasing number of cases in the winter months, which could be related to an extrinsic factor underlying infection...
August 2018: Clinical Kidney Journal
Michaela Jung, Bernhard Brüne, Andreas von Knethen, Roser Guiteras, Josep Maria Cruzado, Georgina Hotter, Anna Sola
Macrophage-epithelial cross-talk regulates cell cycle progression and represents an important factor in rescuing epithelial cells from cell cycle arrest in order to maintain a healthy epithelial phenotype. However, the underlying mechanisms are still not well defined. We provide evidence that macrophage-secreted lipocalin-2 (Lcn-2) plays a key role during this process. In a co-culture setup using cell cycle arrested NRK52e renal epithelial cells and primary bone marrow-derived macrophages, Lcn-2 restores proliferation through inhibition of peroxisome proliferator-activated receptor (PPAR)-γ...
November 2018: Laboratory Investigation; a Journal of Technical Methods and Pathology
Sergi Luque, Marc Lúcia, Edoardo Melilli, Carmen Lefaucheur, Marta Crespo, Alex Loupy, David Bernal, Montse Gomà, Marta Jarque, Elena Crespo, Núria Montero, Anna Manonelles, Josep M Cruzado, Salvador Gil-Vernet, Josep M Grinyó, Oriol Bestard
Antibody-mediated rejection (ABMR) is defined by specific histopathological lesions and evidence of circulating donor-specific antibodies (DSA). While DSA are not always detectable, monitoring donor-reactive memory B-cells (mBC) could recognize at-risk patients of developing ABMR. Peripheral donor-reactive mBC using a novel HLA B-cell ELISpot assay, serum DSA and numbers of different B-cell subsets were assessed in 175 consecutive kidney transplants undergoing either for-cause or 6 and 24-month surveillance biopsies for their association with main histological lesions of ABMR and impact on allograft outcome...
August 7, 2018: American Journal of Transplantation
José Tinoco-González, Mercedes Rubio-Manzanares-Dorado, Ana Senent-Boza, Virginia Durán-Muñoz-Cruzado, Luis Tallón-Aguilar, Felipe Pareja-Ciuró, Javier Padillo-Ruíz
OBJECTIVES: To analyze the clinical presentation, management, and outcome of acute appendicitis (AA) in pregnant and nonpregnant women of childbearing age. MATERIAL AND METHODS: Descriptive study of 2 cohorts of women (pregnant -P- and nonpregnant -NP-). The women, who were matched according to risk factors, were included when they underwent an emergency appendectomy based on clinical suspicion of AA. We recorded age, medical history, clinical presentation, management, and outcome...
2018: Emergencias: Revista de la Sociedad Española de Medicina de Emergencias
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