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Panu Rantakokko, Eva Kumar, Joris Braber, Taya Huang, Hannu Kiviranta, Enrique Cequier, Cathrine Thomsen
Brominated and phosphorous flame retardants (BFRs, PFRs) are added to household and consumer products to reduce their flammability. Some FRs are persistent in the environment and may have adverse health effects. As exposure indoors contributes significantly to total exposure, we wanted to estimate the exposure of children (3 years of age) through dust ingestion, inhalation, and dermal absorption. We measured 17 BFRs and 10 PFRs in indoor dust, predicted their respective concentrations in the indoor air and assessed children's exposure...
February 8, 2019: Chemosphere
Jesper Grønlund Holm, Tove Agner, Maja-Lisa Clausen, Simon Francis Thomsen
We aimed to explore the association of key clinical characteristics with disease severity in atopic dermatitis (AD) and its relation to components of the atopic march in a large hospital cohort. Outpatients with AD referred to the Department of Dermatology, Bispebjerg Hospital, Copenhagen, Denmark, between January 2012 and December 2017, were compared based on disease severity (SCORAD); mild (< 25), moderate (25-50) and severe (> 50). A total of 470 AD patients were included: 122 small children (< 4 years of age), 103 children/adolescents (age 4-15 years) and 245 adults (> 15 years of age)...
February 15, 2019: Archives of Dermatological Research
Camilla L Nord, Seung-Goo Kim, Mette Buhl Callesen, Timo L Kvamme, Mads Jensen, Mads Uffe Pedersen, Kristine Rømer Thomsen, Valerie Voon
Impulsivity has been suggested as a neurocognitive endophenotype conferring risk across a number of neuropsychiatric conditions, including substance and behavioural addictions, eating disorders, and attention deficit/hyperactivity disorder. We used a paradigm with interspecies translation validity (the four-choice serial reaction time task, 4CSRTT) to assess 'waiting' impulsivity in a youth sample (N = 99, aged 16-26 years). We collected magnetization prepared two rapid acquisition gradient echo (MP2RAGE) scans, which enabled us to measure R1, the longitudinal relaxation rate, a parameter closely related to tissue myelin content, as well as quantify grey matter volume...
February 15, 2019: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
Peter Lykke Eriksen, Michael Sørensen, Henning Grønbæk, Stephen Hamilton-Dutoit, Hendrik Vilstrup, Karen Louise Thomsen
BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) is a major health concern affecting 25% of the world's population. It is generally held that a fatty liver does not influence liver function, but quantitative measurements of metabolic liver functions have not been systematically performed. We aimed to study selected hepatocellular metabolic functions in patients with different stages of NAFLD. METHODS: Twenty-five non-diabetic, biopsy-proven NAFLD patients [12 with simple steatosis; 13 with non-alcoholic steatohepatitis (NASH)] and ten healthy controls were included in a cross-sectional study...
February 12, 2019: Clinics and Research in Hepatology and Gastroenterology
Karin Melin, Gudmundur Skarphedinson, Per Hove Thomsen, Bernhard Weidle, Nor Christian Torp, Robert Valderhaug, Davíð R M A Højgaard, Katja A Hybel, Judith Becker Nissen, Sanne Jensen, Kitty Dahl, Ingela Skärsäter, Bente Storm Haugland, Tord Ivarsson
OBJECTIVE: This study evaluates the long-term outcomes of a stepped care treatment for pediatric obsessive-compulsive disorder (OCD) and investigates whether response to first-step cognitive-behavioral therapy (CBT) is an important indicator of three-year outcomes. METHOD: This study is a part of the Nordic Long-term OCD Treatment study (NordLOTS), in which 269 children and adolescents were treated with CBT. Non-responders to CBT were randomized to an extended treatment with continued CBT or pharmacotherapy with sertraline...
February 13, 2019: Journal of the American Academy of Child and Adolescent Psychiatry
Rikke Aarhus, Tine Tjørnhøj-Thomsen, Britta Tarp, Peter Vedsted, Rikke S Andersen
OBJECTIVE: Healthcare systems increasingly make use of case managers to handle organisational complexity. In Danish cancer patient pathways, case managers handle the complexities of cancer diagnostics and treatment while adhering to pathway guidelines. This article explores how case managers handle their various responsibilities and focuses on the micro-politics of case management. METHODS: An ethnographic study was carried out in three Danish cancer patient pathways...
February 14, 2019: European Journal of Cancer Care
Mohamed H Shamji, Irene Thomsen, Janice Layhadi, Jasper Kappen, Gabriële Holtappels, Umit Sahiner, Amy Switzer, Stephen R Durham, Oliver Pabst, Claus Bachert
BACKGROUND: Chronic rhinosinusitis with nasal polyps (CRSwNP) is often characterized by local production of polyclonal IgE-idiotypes. Whilst tissue IgE concentrations can be in the range of several thousand kU/L, the regulatory mechanisms by which IgE-mediated inflammation is controlled in the nasal polyps is not well understood. OBJECTIVE: We sought to determine whether locally induced IgG antibodies in the nasal polyps can inhibit IgE-mediated pro-allergic response...
February 11, 2019: Journal of Allergy and Clinical Immunology
Maja K Thomsen, Andreas Nyvang, James P S Walsh, Philip C Bunting, Jeffrey R Long, Frank Neese, Michael Atanasov, Alessandro Genoni, Jacob Overgaard
A breakthrough in the study of single-molecule magnets occurred with the discovery of zero-field slow magnetic relaxation and hysteresis for the linear iron(I) complex [Fe(C(SiMe3 )3 )2 ]- (1), which has one of the largest spin-reversal barriers among mononuclear transition-metal single-molecule magnets. Theoretical studies have suggested that the magnetic anisotropy in 1 is made possible by pronounced stabilization of the iron d z2 orbital due to 3d z2 -4s mixing, an effect which is predicted to be less pronounced in the neutral iron(II) complex Fe(C(SiMe3 )3 )2 (2)...
February 14, 2019: Inorganic Chemistry
Kurt O Thomsen
The needs of sub-regional and local entities for water resource management are immediate, and required information is not forthcoming in a timely and relatively inexpensive manner. The following method allows one to use all available well record data to produce baseline hydrogeologic unit maps using geographic information system (GIS) querying and mapping techniques. Subjective borehole and geophysical strata descriptions are converted to objective equivalent numerical values by establishing the average hydraulic conductivity of the combined soils making up the stratum of interest...
February 14, 2019: Ground Water
Jesper Grønlund Holm, Maja-Lisa Clausen, Tove Agner, Simon Francis Thomsen
BACKGROUND: Treatment of atopic dermatitis (AD) may be challenging, therefore some patients seek complementary and alternative medications (CAM). We determined prevalence and predictors for CAM use in a hospital cohort of AD patients. MATERIAL AND METHODS: Between January 1, 2012, and December 31, 2017, AD patients referred to the dermatological outpatient clinic at Bispebjerg Hospital were included in the study. Information on CAM use, demographics and disease characteristics were obtained by questionnaire, and associations were determined by χ2 and t test separately for children (< 16 years) and adults (≥16 years)...
February 13, 2019: Dermatology: International Journal for Clinical and Investigative Dermatology
Andreas Lodberg, Bram C J van der Eerden, Bianca Boers-Sijmons, Jesper Skovhus Thomsen, Annemarie Brüel, Johannes P T M van Leeuwen, Marco Eijken
Inhibitors of the activin receptor signaling pathway (IASPs) have become candidate therapeutics for sarcopenia and bone remodeling disorders because of their ability to increase muscle and bone mass. However, IASPs utilizing activin type IIA and IIB receptors are also potent stimulators of erythropoiesis, a feature that may restrict their usage to anemic patients because of increased risk of venous thromboembolism. Based on the endogenous TGF-β superfamily antagonist follistatin (FST), a molecule in the IASP class, FSTΔHBS -mFc, was generated and tested in both ovariectomized and naive BALB/c and C57BL/6 mice...
February 13, 2019: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
Sofie Bratberg Jensen, Helle Stentoft Dalum, Lisa Korsbek, Carsten Hjorthøj, John Hagel Mikkelsen, Karin Thomsen, Kristen Kistrup, Mette Olander, Jane Lindschou, Kim T Mueser, Merete Nordentoft, Lene Falgaard Eplov
BACKGROUND: Illness Management and Recovery (IMR) is a curriculum-based rehabilitation program for people with severe mental illness with the short-term aim of improving illness self-management and the long-term aim of helping people achieve clinical and personal recovery. METHOD: Participants with schizophrenia or bipolar disorders were recruited from three community mental health centers in the Capital Region of Denmark and randomized to receive group-based IMR and treatment as usual or only the usual intervention...
February 11, 2019: BMC Psychiatry
Xueqian Zhang, Marianne Thomsen
This review provides a systematic overview of the spatial and temporal variations in the content of biomolecular constituents of Saccharina latissima on the basis of 34 currently-available scientific studies containing primary measurements. We demonstrate the potential revenue of seaweed production and biorefinery systems by compiling a product portfolio of high-value extract products. An investigation into the endogenous rhythms and extrinsic factors that impact the biomolecular composition of S. latissima is presented, and key performance factors for optimizing seaweed production are identified...
February 10, 2019: Marine Drugs
Sofie Theresa Thomsen, Waldo de Boer, Sara M Pires, Brecht Devleesschauwer, Sisse Fagt, Rikke Andersen, Morten Poulsen, Hilko van der Voet
Accounting for substitution of foods is inevitable when evaluating health impact of dietary changes. But substitution behavior and the associated health impact may vary between individuals. We therefore propose the use of probabilistic methods to model substitution and assess health impact distributions in risk-benefit assessment (RBA) of foods. We investigated the health impact of substituting red and processed meat with fish in the Danish adult population and the variability in health impact. We applied probabilistic approaches in modeling the substitution to reflect variability between individual substitution behaviors...
February 8, 2019: Food and Chemical Toxicology
Lydiane Agier, Xavier Basagaña, Lea Maitre, Berit Granum, Philippa K Bird, Maribel Casas, Bente Oftedal, John Wright, Sandra Andrusaityte, Montserrat de Castro, Enrique Cequier, Leda Chatzi, David Donaire-Gonzalez, Regina Grazuleviciene, Line S Haug, Amrit K Sakhi, Vasiliki Leventakou, Rosemary McEachan, Mark Nieuwenhuijsen, Inga Petraviciene, Oliver Robinson, Theano Roumeliotaki, Jordi Sunyer, Ibon Tamayo-Uria, Cathrine Thomsen, Jose Urquiza, Antonia Valentin, Rémy Slama, Martine Vrijheid, Valérie Siroux
BACKGROUND: Several single-exposure studies have documented possible effects of environmental factors on lung function, but none has relied on an exposome approach. We aimed to evaluate the association between a broad range of prenatal and postnatal lifestyle and environmental exposures and lung function in children. METHODS: In this analysis, we used data from 1033 mother-child pairs from the European Human Early-Life Exposome (HELIX) cohort (consisting of six existing longitudinal birth cohorts in France, Greece, Lithuania, Norway, Spain, and the UK of children born between 2003 and 2009) for whom a valid spirometry test was recorded for the child...
February 5, 2019: Lancet. Planetary Health
Lene R Madsen, Lisbeth M Baggesen, Bjørn Richelsen, Reimar W Thomsen
AIMS/HYPOTHESIS: The aim of this study was to examine the effect of Roux-en-Y gastric bypass (RYGB) surgery on diabetes remission, subsequent diabetes relapse and micro- and macrovascular complications in individuals with type 2 diabetes and obesity (BMI >35 kg/m2 ) in a real-world setting. METHODS: This was a population-based cohort study of 1111 individuals with type 2 diabetes treated by RYGB at hospitals in Northern Denmark (2006-2015), and 1074 matched non-operated individuals with type 2 diabetes...
February 6, 2019: Diabetologia
Beverley Lim Høeg, Tine Tjørnhøj-Thomsen, Julie Alling Skaarup, Henriette Langstrup, Vibeke Zoffmann, Lena Saltbaek, Randi Valbjørn Karlsen, Susanne Oksbjerg Dalton, Christoffer Johansen, Pernille Envold Bidstrup
BACKGROUND: Patient and public involvement (PPI) is increasingly becoming a requirement in the effort to improve the relevance and quality of healthcare research. We examined how involving patients with lower education levels affected PPI in the development of the MyHealth randomized clinical trial of breast cancer follow-up from the perspectives of the patients and professionals. MATERIAL AND METHODS: Eight women who had completed breast cancer treatment, four with fewer than 10 years of education, were recruited as members of a patient panel advising researchers in the development of the trial...
February 6, 2019: Acta Oncologica
Farima Dalaei, Mads Nybo, Michael Brix, Jørn Bo Thomsen, Jens Ahm Sørensen
It is increasingly recognised that individuals with non-0 blood groups may be at elevated risk of venous thromboembolism (VTE) compared with blood group 0 individuals. Multiple studies suggest that individuals with a non-0 blood group have an approximately twofold increased risk of VTE. The largest risk is seen in individuals with combined factor VLeiden mutation and non-0 blood group. In this review, we outline an overview of the existing literature regarding AB0 blood groups and the risk of VTE.
January 21, 2019: Ugeskrift for Laeger
John Sahl Andersen, Flemming Bro, Jens Søndergaard, Janus Laust Thomsen
No abstract text is available yet for this article.
January 21, 2019: Ugeskrift for Laeger
Signe Møller-Bisgaard, Kim Hørslev-Petersen, Bo Ejbjerg, Merete Lund Hetland, Lykke Midtbøll Ørnbjerg, Daniel Glinatsi, Jakob Møller, Mikael Boesen, Robin Christensen, Kristian Stengaard-Pedersen, Ole Rintek Madsen, Bente Jensen, Jan Alexander Villadsen, Ellen-Margrethe Hauge, Philip Bennett, Oliver Hendricks, Karsten Asmussen, Marcin Kowalski, Hanne Lindegaard, Sabrina Mai Nielsen, Henning Bliddal, Niels Steen Krogh, Torkell Ellingsen, Agnete H Nielsen, Lone Balding, Anne Grethe Jurik, Henrik S Thomsen, Mikkel Østergaard
Importance: Whether using magnetic resonance imaging (MRI) to guide treatment in patients with rheumatoid arthritis (RA) improves disease activity and slows joint damage progression is unknown. Objective: To determine whether an MRI-guided treat-to-target strategy vs a conventional clinical treat-to-target strategy improves outcomes in patients with RA in clinical remission. Design, Setting, and Participants: Two-year, randomized, multicenter trial conducted at 9 hospitals in Denmark...
February 5, 2019: JAMA: the Journal of the American Medical Association
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