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Measurable residual disease

Oznur Yilmaz, Tolga Karapinar
BACKGROUND: Information regarding the performance of the i-STAT, a point-of-care analyzer, to determine ionized calcium (iCa2+ ) concentration in bovine blood is limited. OBJECTIVE: The primary goal of this study was to evaluate the agreement of the i-STAT against a traditional bench-top blood gas analyzer (Radiometer ABL800 FLEX) in the measurement of iCa2+ in the blood of cattle with various disorders. METHODS: In this study, 121 cattle with various diseases were used...
February 20, 2019: Veterinary Clinical Pathology
Zhe Li, Tom E Forshaw, Reetta J Holmila, Stephen A Vance, Hanzhi Wu, Leslie B Poole, Cristina M Furdui, S Bruce King
Redox mediated protein modifications control numerous processes in both normal and disease metabolism. Protein sulfenic acids, formed from the oxidation of protein cysteine residues, play a critical role in thiol-based redox signaling. The reactivity of protein sulfenic acids requires their identification through chemical trapping and this paper describes the use of the triphenyl phosphonium ion to direct known sulfenic acid traps to the mitochondria, a verified source of cellular reactive oxygen species. Coupling of the triphenyl phosphonium (TPP) group with the 2, 4-(dioxocyclohexyl)propoxy (DCP) unit and the bicyclo[6...
February 20, 2019: Chemical Research in Toxicology
Shinn-Jong Jiang, Pei-I Tsai, Shih-Yi Peng, Chun-Chun Chang, Yi Chung, Hao-Hsiang Tsao, Hsin-Ting Huang, San-Yuan Chen, Hao-Jen Hsu
Chronic inflammation is a pivotal event in the pathogenesis of cardiovascular diseases, including atherosclerosis, restenosis, and coronary artery disease. The efficacy of current treatment or preventive strategies for such inflammation is still inadequate. Thus, new anti-inflammatory strategies are needed. In this study, based on molecular docking and structural analysis, a potential peptide KCF18 with amphiphilic properties (positively charged and hydrophobic residues) derived from the receptors of proinflammatory cytokines was designed to inhibit cytokine-induced inflammatory response...
February 19, 2019: Scientific Reports
Christiane Pott, Monika Brüggemann, Matthias Ritgen, Vincent H J van der Velden, Jacques J M van Dongen, Michael Kneba
Minimal residual disease (MRD) diagnostics is of high clinical relevance in patients with indolent B-cell non-Hodgkin lymphomas (B-NHL) and serves as a surrogate parameter to evaluate treatment effectiveness and long-term prognosis. MRD diagnostics performed by real-time quantitative PCR (RQ-PCR) is still the gold standard and currently the most sensitive and the most broadly applied method in follicular lymphoma (FL) and mantle cell lymphoma (MCL). Alternatively, droplet digital PCR (ddPCR) can be used for MRD monitoring in multiple myeloma, mantle cell lymphoma, and follicular lymphoma with comparable sensitivity, accuracy, and reproducibility...
2019: Methods in Molecular Biology
Carmen Rodríguez-Jiménez, Diego Gómez-Coronado, Manuel Frías Vargas, Francisca Cerrato, Carlos Lahoz, Jose Saban-Ruiz, Daniel González-Nieto, Miguel A Lasunción, José M Mostaza, Sonia Rodríguez-Nóvoa
BACKGROUND AND AIMS: Autosomal recessive hypercholesterolemia (ARH) is a rare disorder caused by mutations in LDLRAP1, which impairs internalization of hepatic LDL receptor (LDLR). ARH patients respond relatively well to statins or the combination of statins and Ezetimibe, but scarce and variable data on treatment with PCSK9 inhibitors is available. We aimed to identify and characterize the defect in a hypercholesterolemic patient with premature cardiovascular disease and determine the response to lipid-lowering treatment...
January 25, 2019: Atherosclerosis
Yoshiki Takeuchi, Hirotaka Kato, Masahiro Ishizaka, Akira Kubo
[Purpose] To investigate the effect of increased functional residual capacity on the finger-floor distance and to assess spinal curvature in the sagittal plane using the Spinal Mouse in healthy young participants. [Participants and Methods] Thirty-nine healthy volunteers (age=21.2 ± 0.8 years) participated in this study. The finger-floor distance was used to measure trunk flexion and was recorded at the resting expiration level and at 2 different functional residual capacity levels: 1,000 and 2,000 ml air inhaled at the resting expiration level...
January 2019: Journal of Physical Therapy Science
(no author information available yet)
BACKGROUND: Seizures and their consequences contribute to the burden of epilepsy because they can cause health loss (premature mortality and residual disability). Data on the burden of epilepsy are needed for health-care planning and resource allocation. The aim of this study was to quantify health loss due to epilepsy by age, sex, year, and location using data from the Global Burden of Diseases, Injuries, and Risk Factors Study. METHODS: We assessed the burden of epilepsy in 195 countries and territories from 1990 to 2016...
February 14, 2019: Lancet Neurology
Rhys A A Carter, Sébastien Allard, Jean-Philippe Croué, Cynthia A Joll
Swimming pools are disinfected to protect against the risk of microbial disease, however, the formation of disinfection by-products (DBPs) is an unwanted consequence. While many studies have reported the occurrence of commonly investigated DBPs (trihalomethanes and haloacetic acids) in pools, few studies have investigated emerging DBP classes, such as the haloketones or haloacetaldehydes, and the nitrogenous haloacetamides, halonitromethanes, haloacetonitriles and N-nitrosamines. This study investigated the occurrence of sixty four DBPs from the eight aforementioned DBP classes in pools employing different treatment methods...
February 2, 2019: Science of the Total Environment
Jéssica Cristiane Magalhães Ierich, Doralina Guimarães Brum, Ariana de Souza Moraes, Akemi Martins Higa, Pâmela Soto Garcia, Celina Massumi Miyazaki, Marystela Ferreira, Luís Antonio Peroni, Guedmiller Souza de Oliveira, Eduardo de Faria Franca, Luiz Carlos Gomide Freitas, Fabio Lima Leite
Antigen-antibody interaction is crucial in autoimmune disease pathogenesis, as multiple sclerosis and neuromyelitis optica. Given that, autoantibodies are essential biomolecules, of which the myelin oligodendrocyte glycoprotein (MOG) can figure as a target. Here we combined Molecular Dynamics (MD), Steered Molecular Dynamics (SMD), and Atomic Force Microscope (AFM) to detail MOG recognition by its specific antibody. The complex model consisted of the MOG external domain interacting with an experimental anti-MOG antibody from the Protein Data Bank (1PKQ)...
February 14, 2019: Scientific Reports
Stephen Milne, Kanika Jetmalani, David G Chapman, Joseph M Duncan, Claude S Farah, Cindy Thamrin, Gregory G King
Respiratory system reactance (Xrs) measured by the forced oscillation technique (FOT) is theoretically and experimentally related to lung volume. In chronic obstructive pulmonary disease (COPD), the absolute volume measured by body plethysmography includes a proportion which is inaccessible to pressure oscillations applied via the mouth - that is, a 'non-communicating' lung volume. We hypothesized that, in COPD, the presence of non-communicating lung would disrupt the expected Xrs-volume relationship when compared to plethysmographic functional residual capacity (FRCpleth )...
February 14, 2019: Journal of Applied Physiology
Barun Kumar Maity, Anand Kant Das, Simli Dey, Ullhas Kaarthi Moorthi, Amandeep Kaur, Arpan Dey, Dayana Surendran, Rucha Pandit, Mamata Kallianpur, Bappaditya Chandra, Muralidharan Chandrakesan, Senthil Arumugam, Sudipta Maiti
While the roles of intrinsically disordered protein domains in driving many interactions are increasingly well-appreciated, the mechanism of toxicity of disease-causing disordered proteins remains poorly understood. A prime example is Alzheimer's disease (AD) associated amyloid beta (Aβ). Aβ oligomers are highly toxic partially structured peptide assemblies with a distinct ordered region (residues ~10-40) and a shorter disordered region (residues ~1-9). Here, we investigate the role of this disordered domain and its relation to the ordered domain in the manifestation of toxicity through a set of Aβ fragments and stereo-isomers designed for this purpose...
February 14, 2019: ACS Chemical Neuroscience
Robert A Quinn, Sandeep Adem, Robert H Mills, William Comstock, Lindsay DeRight Goldasich, Gregory Humphrey, Alexander A Aksenov, Alexei V Melnik, Ricardo da Silva, Gail Ackermann, Nuno Bandeira, David J Gonzalez, Doug Conrad, Anthony J O'Donoghue, Rob Knight, Pieter C Dorrestein
BACKGROUND: Studies of the cystic fibrosis (CF) lung microbiome have consistently shown that lung function decline is associated with decreased microbial diversity due to the dominance of opportunistic pathogens. However, how this phenomenon is reflected in the metabolites and chemical environment of lung secretions remains poorly understood. METHODS: Here we investigated the microbial and molecular composition of CF sputum samples using 16S rRNA gene amplicon sequencing and untargeted tandem mass spectrometry to determine their interrelationships and associations with clinical measures of disease severity...
February 13, 2019: Microbiome
Lei Li, Shuiqing Ma, Xianjie Tan, Sen Zhong, Ming Wu
BACKGROUND: Little data exist about the impact of dissection methods on bladder function during nerve-sparing radical hysterectomy (NSRH). This randomized controlled trial compared the urodynamic and survival outcomes of different methods dissecting the inferior hypogastric plexus (IHP) during laparoscopic NSRH. METHODS: Eligible patients presenting with stage IB cervical cancer from 9 May 2013 to 27 October 2015 were randomized at a ratio of 1:1 and subjected to waterjet (study group) or traditional blunt (control group) dissection of the IHP for laparoscopic type C radical hysterectomy...
February 13, 2019: Annals of Surgical Oncology
Siyang Zeng, Andrea Tham, Bruce Bos, Joan Jin, Mehrdad Arjomandi
BACKGROUND: Abnormal lung volumes that represent air trapping are common in chronic obstructive pulmonary disease (COPD). However, their clinical significance in those without spirometrically defined COPD (normal forced expiratory volume in 1 s [FEV1 ] to forced vital capacity [FVC] ratio) is unclear. METHODS: Using the Veterans Administration Informatics and Computing Infrastructure (VINCI) database, we identified 7,479 patients at risk for COPD (smokers > 40 years of age without restrictive lung disease) who had preserved spirometry (FEV1 /FVC and FEV1  ≥ lower limit of normal) and also had concomitant lung volume measurements by plethysmography across 37 Veterans Affairs Medical Centers in the United States between 1985 and 2017, and examined their subsequent health records for clinical diagnoses of COPD, respiratory exacerbations, healthcare utilization, spirometry, and mortality...
December 2018: Annals of the American Thoracic Society
Nicola Gökbuget, Hervé Dombret, Sebastian Giebel, Monika Bruggemann, Michael Doubek, Robin Foà, Dieter Hoelzer, Christopher Kim, Giovanni Martinelli, Elena Parovichnikova, Alessandro Rambaldi, Josep-Maria Ribera, Marieke Schoonen, Julia M Stieglmaier, Gerhard Zugmaier, Renato Bassan
OBJECTIVES: Detectable minimal residual disease (MRD) after therapy for acute lymphoblastic leukemia (ALL) is the strongest predictor of hematologic relapse. This study evaluated outcomes of patients with B-cell precursor ALL with MRD of ≥10-4 Methods: Study population was from ALL study groups in Europe managed in national study protocols 2000-2014. MRD was measured by polymerase chain reaction or flow cytometry. Patients were age ≥15 years at initial ALL diagnosis. Patients were excluded if exposed to blinatumomab within 18 months of baseline or prior alloHSCT...
December 2019: Hematology (Amsterdam, Netherlands)
Angelita Habr-Gama, Guilherme Pagin São Julião, Laura Melina Fernandez, Bruna Borba Vailati, Andres Andrade, Sérgio Eduardo Alonso Araújo, Joaquim Gama-Rodrigues, Rodrigo Oliva Perez
BACKGROUND: Patients with rectal cancer who achieve complete clinical response after neoadjuvant chemoradiation have been managed by organ-preserving strategies and acceptable long-term outcomes. Controversy still exists regarding optimal timing for the assessment of tumor response after neoadjuvant chemoradiation. OBJECTIVE: The purpose of this study was to estimate the time interval for achieving complete clinical response using strict endoscopic and clinical criteria after a single neoadjuvant chemoradiation regimen...
February 6, 2019: Diseases of the Colon and Rectum
Chumnan Kietpeerakool, Apiwat Aue-Aungkul, Khadra Galaal, Chetta Ngamjarus, Pisake Lumbiganon
BACKGROUND: Radical hysterectomy is one of the standard treatments for stage Ia2 to IIa cervical cancer. Bladder dysfunction caused by disruption of the pelvic autonomic nerves is a common complication following standard radical hysterectomy and can affect quality of life significantly. Nerve-sparing radical hysterectomy is a modified radical hysterectomy, developed to permit resection of oncologically relevant tissues surrounding the cervical lesion, while preserving the pelvic autonomic nerves...
February 12, 2019: Cochrane Database of Systematic Reviews
Philip S Watson, Patricia Novy, Rafik Bekkat-Berkani, Florence Strubbe, Angelika Banzhoff
Meningococcal disease has an incidence peak spread over several years during adolescence and young adulthood in the United States. Meningococcal serogroup B (MenB) vaccines have been introduced relatively recently and may help protect individuals in these age groups. Currently there is insufficient long-term experience to determine the duration of disease protection after any MenB vaccine. Understanding antibody persistence after primary vaccination and responses to booster can help inform MenB vaccination strategies and optimize disease prevention...
February 11, 2019: Expert Review of Vaccines
Dan Fai Au, Dmitry Ostrovsky, Riqiang Fu, Liliya Vugmeyster
Amyloid fibril deposits observed in Alzheimer's disease comprise amyloid-β (Aβ) protein possessing a structured hydrophobic core and a disordered N-terminal domain (residues 1-16). The internal flexibility of the disordered domain is likely essential for Aβ aggregation. Here, we used 2 H static solid-state NMR methods to probe the dynamics of selected side chains of the N-terminal domain of Aβ(1-40) fibrils. Line shape and relaxation data suggested a two-state model, in which the domain's free state undergoes a diffusive motion that is quenched in the bound state, likely because of transient interactions with the structured C-terminal domain...
February 8, 2019: Journal of Biological Chemistry
Stine Linding Andersen, Stig Andersen, Allan Carlé, Peter Astrup Christensen, Aase Handberg, Jesper Karmisholt, Louise Knøsgaard, Søren Risom Kristensen, Inge Bülow Pedersen, Peter Vestergaard
BACKGROUND: Physiological changes in maternal thyroid function during pregnancy necessitate the use of pregnancy specific reference ranges. Dynamic changes in TSH within the first trimester of pregnancy have been reported, but more evidence is needed to substantiate the findings. The objective of this study was to estimate pregnancy week specific reference ranges for maternal TSH and free T4 (fT4) in the early pregnancy. METHODS: We consecutively recruited serum residues from blood samples collected as part of the prenatal screening in the North Denmark Region, 2011-2015...
February 8, 2019: Thyroid: Official Journal of the American Thyroid Association
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