keyword
https://read.qxmd.com/read/38535092/performance-of-a-novel-eight-color-flow-cytometry-panel-for-measurable-residual-disease-assessment-of-chronic-lymphocytic-leukemia
#1
JOURNAL ARTICLE
Xiao Chen, Xia Chen, Sishu Zhao, Yu Shi, Ninghan Zhang, Zhen Guo, Chun Qiao, Huimin Jin, Liying Zhu, Huayuan Zhu, Jianyong Li, Yujie Wu
BACKGROUND: Measurable residual disease (MRD) is an important prognostic indicator of chronic lymphocytic leukemia (CLL). Different flow cytometric panels have been developed for the MRD assessment of CLL in Western countries; however, the application of these panels in China remains largely unexplored. METHODS: Owing to the requirements for high accuracy, reproducibility, and comparability of MRD assessment in China, we investigated the performance of a flow cytometric approach (CD45-ROR1 panel) to assess MRD in patients with CLL...
March 27, 2024: Cytometry. Part B, Clinical Cytometry
https://read.qxmd.com/read/38531830/homocysteine-modifies-the-association-of-coronary-stenosis-and-hiv-infection-in-an-inner-city-african-american-population
#2
JOURNAL ARTICLE
Thorsten M Leucker, Tarek Harb, Gary Gerstenblith, David D Celentano, Efthymios Ziogos, Glenn Treisman, Raul N Mandler, Jag Khalsa, Man Charurat, Shenghan Lai, Hong Lai
BACKGROUND AND AIMS: People with HIV (PWH) whose disease is controlled on anti-retroviral regimens remain at an increased risk for coronary artery disease (CAD). Traditional cardiovascular risk factors do not fully explain the residual risk in PWH suggesting contributions from nontraditional factors. Homocysteine (Hcy) may be one of these as prior work in adults without HIV demonstrate that Hcy may impair endothelial function by decreasing the availability of nitric oxide, promoting the development of atherosclerosis...
March 26, 2024: International Journal of STD & AIDS
https://read.qxmd.com/read/38531756/prostatic-artery-embolisation-versus-transurethral-resection-of-the-prostate-for-benign-prostatic-obstruction-5-year-outcomes-of-a-randomised-open-label-noninferiority-trial
#3
JOURNAL ARTICLE
Gautier Müllhaupt, Lukas Hechelhammer, Nicole Graf, Livio Mordasini, Hans-Peter Schmid, Daniel S Engeler, Dominik Abt
BACKGROUND AND OBJECTIVE: Prostatic artery embolisation (PAE) and transurethral resection of the prostate (TURP) are two of the surgical options for treatment of lower urinary tract symptoms/benign prostatic obstruction (LUTS/BPO). Our aim was to compare the efficacy and safety of PAE and TURP for LUTS/BPO treatment at long-term follow-up. METHODS: We conducted a randomised, open-label, single-centre trial at a Swiss tertiary care centre. The main outcome was the change in International Prostate Symptom Score (IPSS) after PAE versus TURP...
March 25, 2024: European Urology Focus
https://read.qxmd.com/read/38531288/de-escalating-axillary-management-after-neoadjuvant-chemotherapy-in-breast-cancer-the-ratio-of-positive-sentinel-lymph-nodes-matters
#4
JOURNAL ARTICLE
S Aragón-Sánchez, R Sánchez-Bayona, L López-Marín, E Ciruelos-Gil, L Parrilla-Rubio, Pablo Zaragoza-Ballester, A Galindo-Izquierdo, B García-Chapinal, L Álvaro-Valiente, M R Oliver-Pérez
BACKGROUND: De-escalation of axillary surgery in breast cancer (BC) patients diminishes sequelae without compromising cancer outcomes. Surgical management of the axilla is challenging after neoadjuvant treatment. We aimed to identify the factors associated with residual axillary disease amenable to lymphadenectomy in patients with positive sentinel lymph node biopsy (SLNB). METHODS: We conducted a retrospective observational study in Hospital 12 de Octubre (Spain)...
March 13, 2024: Surgical Oncology
https://read.qxmd.com/read/38529287/antibody-mediated-depletion-of-select-leukocyte-subsets-in-blood-and-tissue-of-nonhuman-primates
#5
JOURNAL ARTICLE
Matthew S Sutton, Allison N Bucsan, Chelsea C Lehman, Megha Kamath, Supriya Pokkali, Diogo M Magnani, Robert Seder, Patricia A Darrah, Mario Roederer
Understanding the immunological control of pathogens requires a detailed evaluation of the mechanistic contributions of individual cell types within the immune system. While knockout mouse models that lack certain cell types have been used to help define the role of those cells, the biological and physiological characteristics of mice do not necessarily recapitulate that of a human. To overcome some of these differences, studies often look towards nonhuman primates (NHPs) due to their close phylogenetic relationship to humans...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38528643/development-and-validation-of-the-perceived-symptom-manageability-scale-among-people-living-with-the-human-immunodeficiency-virus
#6
JOURNAL ARTICLE
Meilian Xie, Aiping Wang, Zhiyun Zhang, Kerong Wang, Yanping Yu, Xiaojing Ma, Zhaoxia Lin, Zhengli Yu, Jianxue Ke
BACKGROUND: "Perceived Symptom Manageability (PSM)" is essential in symptom management among people living with HIV. As a standardized assessment instrument was lacking, we developed a PSM scale for people living with human immunodeficiency virus (PSM-HIV). METHODS: Data analysis was performed using the sample from HIV-designated medical institutions (N = 540). Psychometric testing, namely reliability and validity, is assessed by unidimensionality, internal consistency, exploratory and confirmatory factor analysis, and structural equation modeling...
March 25, 2024: BMC Psychology
https://read.qxmd.com/read/38527835/-clinical-analysis-of-14-patients-aged-%C3%A2-50-years-with-high-risk-multiple-myeloma-treated-with-allogeneic-hematopoietic-stem-cell-transplantation
#7
JOURNAL ARTICLE
P Pan, J L Wang, W H Zhai, Q L Ma, D L Yang, S Z Feng, M Z Han, A M Pang, E L Jiang
Objective: To evaluate the efficacy of allogeneic hematopoietic stem cell transplantation (allo-HSCT) in young patients with high-risk multiple myeloma (HRMM) and analyzed the factors affecting patient prognosis. Methods: In this retrospective study, we analyzed the clinical data of 14 patients with HRMM with cytogenetic abnormalities or high-risk biological factors who underwent allo-HSCT at the Hematopoietic Stem Cell Transplantation Center of the Institute of Hematology & Blood Diseases Hospital between November 2016 and November 2022...
January 14, 2024: Zhonghua Xue Ye Xue za Zhi, Zhonghua Xueyexue Zazhi
https://read.qxmd.com/read/38527658/on-the-interplay-between-state-dependent-reconfigurations-of-global-signal-correlation-and-bold-fluctuations-an-fmri-study
#8
JOURNAL ARTICLE
Stefano Damiani, Paolo La-Torraca-Vittori, Livio Tarchi, Eleonora Tosi, Valdo Ricca, Andrea Scalabrini, Pierluigi Politi, Paolo Fusar-Poli
BACKGROUND: The dynamics of global, state-dependent reconfigurations in brain connectivity are yet unclear. We aimed at assessing reconfigurations of the global signal correlation coefficient (GSCORR), a measure of the connectivity between each voxel timeseries and the global signal, from resting-state to a stop-signal task. The secondary aim was to assess the relationship between GSCORR and blood-oxygen-level-dependent (BOLD) activations or deactivation across three different trial-conditions (GO, STOP-correct, and STOP-incorrect)...
March 23, 2024: NeuroImage
https://read.qxmd.com/read/38527614/the-impact-of-the-fluconazole-trailing-effect-on-the-persistence-of-candida-albicans-bloodstream-infection-when-treated-with-fluconazole
#9
JOURNAL ARTICLE
Shang-Yi Lin, Ho-Yin Huang, Lin-Li Chang, Ya-Ling Wang, Tun-Chieh Chen, Ko Chang, Hung-Pin Tu, Po-Liang Lu
OBJECTIVES: The trailing effect of Candida species is a phenomenon characterized by reduced but persistent growth at antifungal concentrations above the minimal inhibitory concentration (MIC). We assessed the impact of trailing growth on the persistence of Candida albicans candidemia in patients receiving fluconazole therapy. METHODS: We retrospectively investigated candidemia isolates at three hospitals in southern Taiwan between 2013 and 2020. Patients treated with fluconazole for fluconazole-susceptible C...
March 23, 2024: Clinical Microbiology and Infection
https://read.qxmd.com/read/38527461/effects-of-onabotulinum-toxin-a-injection-on-sexual-function-in-women-with-refractory-interstitial-cystitis-bladder-pain-syndrome-a-prospective-study
#10
JOURNAL ARTICLE
Murat Can Karaburun, Eralp Kubilay, Derya Öztuna, Mehmet İlker Gökçe, Evren Süer, Ömer Gülpınar
OBJECTIVES: To determine the effect of intravesical onabotulinum toxin-A (BoNT-A) treatment on sexual functions in female patients with refractory interstitial cystitis/bladder pain syndrome (IC/BPS). METHODS: Female patients with IC/BPS refractory to previous treatments were included in the study between January 2020 and April 2022. Patients were treated with the trigone-sparing injection (Group 1) or trigone-included injection (Group 2) techniques. 100 Units of BoNT-A was applied submucosally on 20 different points...
March 2024: Lower Urinary Tract Symptoms
https://read.qxmd.com/read/38526794/using-artificial-intelligence-to-interpret-clinical-flow-cytometry-datasets-for-automated-disease-diagnosis-and-or-monitoring
#11
JOURNAL ARTICLE
Yu-Fen Wang, Jeng-Lin Li, Chi-Chun Lee, Paul K Wallace, Bor-Sheng Ko
Flow cytometry (FC) is routinely used for hematological disease diagnosis and monitoring. Advancement in this technology allows us to measure an increasing number of markers simultaneously, generating complex high-dimensional datasets. However, current analytic software and methods rely on experienced analysts to perform labor-intensive manual inspection and interpretation on a series of 2-dimensional plots via a complex, sequential gating process. With an aggravating shortage of professionals and growing demands, it is very challenging to provide the FC analysis results in a fast, accurate, and reproducible way...
2024: Methods in Molecular Biology
https://read.qxmd.com/read/38525919/analytical-performance-evaluation-of-a-digital-real-time-pcr-for-quantifying-major-bcr-abl1-transcripts
#12
JOURNAL ARTICLE
Soo Jung Lee, Jong-Mi Lee, Ari Ahn, Sung-Eun Lee, Yuna Hong, Gun Dong Lee, Hyun-Woo Song, Min-Sik Song, Seung-Shick Shin, Myungshin Kim, Yonggoo Kim
BACKGROUND: Accurate quantification of the BCR::ABL1 transcripts is essential for measurable residual disease (MRD) monitoring in chronic myeloid leukemia (CML) after tyrosine kinase inhibitor (TKI) treatment. This study evaluated the newly developed digital real-time PCR method, Dr. PCR, as an alternative reverse transcription-PCR (qRT-PCR) for MRD detection. METHODS: The performance of Dr. PCR was assessed using reference and clinical materials. Precision, linearity, and correlation with qRT-PCR were evaluated...
March 25, 2024: Journal of Clinical Laboratory Analysis
https://read.qxmd.com/read/38523048/comparison-of-maximum-voided-volume-and-maximum-bladder-capacity-in-voiding-diary-uroflowmetry-and-cystometrography-in-children-with-non-neurogenic-lower-urinary-tract-dysfunction
#13
JOURNAL ARTICLE
Cagri Akin Sekerci, Yiloren Tanidir, Gunal Ozgur, Raziye Ergun, Mehmet Cetin, Tufan Tarcan, Selcuk Yucel
BACKGROUND: Maximum voided volumes (MVV) and maximum bladder capacities (MBC) are important parameters in the evaluation of lower urinary tract functions in children. However, consistency of MVV and MBC measurements between voiding diary (VD), uroflowmetry (UF) and cystometrography (CMG) in children with non-neurogenic lower urinary tract dysfunction (LUTD) has not been addressed specifically. OBJECTIVE: We aimed to compare the MVV in VD and UF and MBC in CMG in children with non-neurogenic LUT dysfunction and investigate for possible factors for discrepancies...
March 15, 2024: Journal of Pediatric Urology
https://read.qxmd.com/read/38521279/associations-of-fine-particulate-matter-with-incident-cardiovascular-disease-comparing-models-using-zip-code-level-and-individual-level-fine-particulate-matter-and-confounders
#14
JOURNAL ARTICLE
Jochem O Klompmaker, Jaime E Hart, Francesca Dominici, Peter James, Charlie Roscoe, Joel Schwartz, Jeff D Yanosky, Antonella Zanobetti, Francine Laden
BACKGROUND: PM2.5 has been positively associated with cardiovascular disease (CVD) incidence. Most evidence has come from cohorts and administrative databases. Cohorts typically have extensive information on potential confounders and residential-level exposures. Administrative databases are usually more representative but typically lack information on potential confounders and often only have exposures at coarser geographies (e.g., ZIP code). The weaknesses in both types of studies have been criticized for potentially jeopardizing the validity of their findings for regulatory purposes...
March 21, 2024: Science of the Total Environment
https://read.qxmd.com/read/38521087/global-fertility-in-204-countries-and-territories-1950-2021-with-forecasts-to-2100-a-comprehensive-demographic-analysis-for-the-global-burden-of-disease-study-2021
#15
JOURNAL ARTICLE
(no author information available yet)
BACKGROUND: Accurate assessments of current and future fertility-including overall trends and changing population age structures across countries and regions-are essential to help plan for the profound social, economic, environmental, and geopolitical challenges that these changes will bring. Estimates and projections of fertility are necessary to inform policies involving resource and health-care needs, labour supply, education, gender equality, and family planning and support. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021 produced up-to-date and comprehensive demographic assessments of key fertility indicators at global, regional, and national levels from 1950 to 2021 and forecast fertility metrics to 2100 based on a reference scenario and key policy-dependent alternative scenarios...
March 19, 2024: Lancet
https://read.qxmd.com/read/38520371/encapsulated-allyl-isothiocyanate-improves-soil-distribution-efficacy-against-soil-borne-pathogens-and-tomato-yield
#16
JOURNAL ARTICLE
Yi Zhang, Wensheng Fang, Dongdong Yan, Yutong Ji, Xinhua Chen, Anmin Guo, Zhaoxin Song, Yuan Li, Aocheng Cao, Qiuxia Wang
BACKGROUND: Crop quality, yield and farmer income are reduced by soil-borne diseases, nematodes and weeds. Allyl isothiocyanate (AITC) is a plant-derived soil fumigant that provides effective control of them. However, its efficacy against soil-borne pathogens varies mainly because of its chemical instability and uneven distribution in soil. Formulation modification is an effective measure to optimize pesticide application. We encapsulated AITC into modified diatomite granules (GR) and measured the formulation's loading content and stability, environmental fate and efficacy against soil-borne pathogens, and impact on tomatoes' growth and yield...
March 23, 2024: Pest Management Science
https://read.qxmd.com/read/38519799/measurable-residual-disease-quantification-in-adult-patients-with-kmt2a-rearranged-acute-lymphoblastic-leukemia
#17
JOURNAL ARTICLE
Thomas Burmeister, Aeint-Steffen Ströh, Britta Kehden, Heiko Trautmann, Claus Meyer, Rolf Marschalek, Patrizia Larghero, Stefan Schwartz, Björn Steffen, Bernd Spriewald, Thomas Heinicke, Nadja Jäkel, Jörg Westermann, Kathrin Nachtkamp, Andreas Viardot, Max S Topp, Martin Neumann, Claudia D Baldus, Nicola Gökbuget, Monika Brüggemann
No abstract text is available yet for this article.
March 22, 2024: Leukemia
https://read.qxmd.com/read/38517100/exposure-of-male-farmers-and-nonfarmers-to-neonicotinoid-pesticides-in-the-south-west-and-littoral-regions-of-cameroon-a-comparative-study
#18
JOURNAL ARTICLE
Faustin Pascal Tsagué Manfo, Collins Nimako, Edouard Akono Nantia, Christian Fusi Suh, Shu Policap Chenwi, Fidelis Cho-Ngwa, Paul Fewou Moundipa, Shouta M M Nakayama, Mayumi Ishizuka, Yoshinori Ikenaka
Pesticides, especially the newly developed neonicotinoids, are increasingly used in many countries around the world, including Cameroon, to control pests involved in crop destruction or disease transmission. Unfortunately, the pesticides also pose tremendous environmental problems because a predominant amount of their residues enter environmental matrices to affect other nontargeted species including humans. This therefore calls for continuous biomonitoring of these insecticides in human populations. The present study sought to assess the neonicotinoid insecticide exposures in two agrarian regions of Cameroon, the South-West region and Littoral region...
March 22, 2024: Environmental Toxicology and Chemistry
https://read.qxmd.com/read/38516523/gut-permeability-circulating-bacterial-fragments-and-measures-of-congestion-in-peritoneal-dialysis
#19
JOURNAL ARTICLE
Chuanlei Li, Jack Kit-Chung Ng, Gordon Chun-Kau Chan, Winston Wing-Shing Fung, Ka-Bik Lai, Peter Yam-Kau Poon, Cathy Choi-Wan Luk, Kai-Ming Chow, Cheuk-Chun Szeto
BACKGROUND: Limited data exist on the association between gut permeability, circulating bacterial fragment and volume overload in peritoneal dialysis (PD) patients. We measured circulating bacterial fragments, N-terminal pro B-type natriuretic peptide (NT-proBNP), calprotectin and zonulin levels, and evaluate their association with the clinical outcomes in PD patients. METHODS: This was a single-center prospective study on 108 consecutive incident PD patients. Plasma endotoxin and bacterial DNA, and serum NT-proBNP, calprotectin and zonulin levels were measured...
March 2024: Clinical Kidney Journal
https://read.qxmd.com/read/38512437/the-effect-of-oropharyngeal-resting-tremor-on-swallowing-function-in-a-clinical-cohort-of-people-with-parkinson-s-disease
#20
JOURNAL ARTICLE
Matthew Dumican, Kaitlynn Harper, Julia Stankiewicz
Parkinson's Disease (PD) is a progressive neurodegenerative disease, with hallmark symptomology typically consisting of tremor, bradykinesia, and rigidity. Though the classic "pill-rolling" rest tremor in the hand or upper limb are often the most salient, it can occur throughout the body including the lower limbs, jaw, face, or tongue. There have been investigations into other motor related phenomena potentially affecting swallow function in PwPD previously. However, there have been no investigations of how oropharyngeal resting tremor in structures such as the tongue or larynx explicitly affects swallowing physiology...
March 21, 2024: Dysphagia
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