keyword
https://read.qxmd.com/read/38291738/phase-incremented-steady-state-free-precession-as-an-alternate-route-to-high-resolution-nmr
#1
JOURNAL ARTICLE
Tian He, Yuval Zur, Elton T Montrazi, Lucio Frydman
Pulsed Fourier transform nuclear magnetic resonance (FT-NMR) has reigned supreme in high-resolution, high-field spectroscopy─particularly when targeting complex liquid-state samples involving multiple sharp peaks spread over large spectral bandwidths. It is known, however, that if spectral resolution is not a must, the FT-based approach is not necessarily the optimal route for maximizing NMR sensitivity: if T 2 ≈ T 1 , as often found in solutions, Carr's steady-state free-precession (SSFP) approach can in principle provide a superior signal-to-noise ratio per √(acquisition_time) (SNRt )...
January 30, 2024: Journal of the American Chemical Society
https://read.qxmd.com/read/38114950/application-of-the-suture-needle-retrograde-threading-method-in-scleral-fixation-of-intraocular-lenses
#2
JOURNAL ARTICLE
Zhou Zhou, Gang Yao, Guangyi Huang, Haibin Zhong, Qi Chen, Ke Yang, Shan Zhong, Min Li, Fan Xu
BACKGROUND: Here we described a new threading technique for the universal fixation of any posterior chamber intraocular lens (IOL). METHODS: Twenty-seven eyes of 27 patients whose surgery done by Surgeon A with the needle-guided method or the suture needle retrograde threading (SNRT) method for intrascleral IOL fixation were enrolled in the first group. Thirty-four eyes of 34 patients whose surgery done by Surgeon A, Surgeon B or Surgeon C with the SNRT method for intrascleral IOL fixation were grouped into three sub-groups by surgeon...
December 19, 2023: BMC Ophthalmology
https://read.qxmd.com/read/37778105/determining-the-risk-of-spinal-pathology-progression-in-neurofibromatosis-type-1-patients-a-national-tertiary-neurofibromatosis-type-1-centre-study
#3
JOURNAL ARTICLE
Daniel Robinson, Sayan Biswas, Christopher Torrie, Joshua MacArthur, Ella Snowdon, Moska Sial, Ved Sarkar, K Joshi George
BACKGROUND: Neurofibromatosis type 1 (NF1) gives rise to a variety of spinal pathologies that include dural ectasia (DE), vertebral malalignments (VMA), spinal deformities (SD), syrinx, meningoceles, spinal nerve root tumours (SNRT), and spinal plexiform tumours (SPT). The relationship between these and the progression of these pathologies has not been explored before in detail and this paper aims to address this. METHODS: Data was retrospectively collected from adult NF1 multi-disciplinary team meetings from 2016 to 2022 involving a total of 593 patients with 20 distinct predictor variables...
September 20, 2023: Clinical Neurology and Neurosurgery
https://read.qxmd.com/read/36747643/cholecystokinin-a-signaling-regulates-automaticity-of-pacemaker-cardiomyocytes-and-shortens-sinus-node-recovery-time
#4
Hongmei Ruan, Ravi Mandla, Namita Ravi, Giselle Galang, Amanda W Soe, Jeffrey E Olgin, Di Lang, Vasanth Vedantham
AIMS: The behavior of pacemaker cardiomyocytes (PCs) in the sinoatrial node (SAN) is modulated by neurohormonal and paracrine factors, many of which signal through G-protein coupled receptors (GPCRs). The aims of the present study are to catalog GPCRs that are differentially expressed in the mammalian SAN and to define the acute physiological consequences of activating the cholecystokinin-A signaling system in the SAN and in isolated PCs. METHODS AND RESULTS: Using bulk and single cell RNA sequencing datasets, we identify a set of GPCRs that are differentially expressed between SAN and right atrial tissue, including several whose roles in PCs and in the SAN have not been thoroughly characterized...
January 24, 2023: bioRxiv
https://read.qxmd.com/read/36438214/interdisciplinary-social-needs-response-team-a-community-case-study-in-social-needs-targeted-care-during-the-covid-19-pandemic-and-beyond
#5
JOURNAL ARTICLE
Isabelle Mullen, Melanie Agnes Mariano, Jaya Aysola
This case study illustrates the role and value of a social needs response team during times of crisis and beyond. The COVID-19 pandemic resulted in two simultaneous crises-the infectious disease crisis and the socioeconomic crisis. Unemployment and lost wages, housing and food insecurity, and increased childcare needs are just a few examples of the socioeconomic needs that skyrocketed during the COVID-19 pandemic. At the start of the pandemic, the University of Pennsylvania Health System (UPHS) formed an interdisciplinary team of physicians, social workers, nurse practitioners and students of these professions to reimagine social needs screening in a way that could reach people during the pandemic and provide sustainable support for individual's evolving social needs...
2022: Frontiers in Public Health
https://read.qxmd.com/read/35954430/salvage-nodal-radiotherapy-as-metastasis-directed-therapy-for-oligorecurrent-prostate-cancer-detected-by-positron-emission-tomography-shows-favorable-outcome-in-long-term-follow-up
#6
JOURNAL ARTICLE
Jörg Tamihardja, Leonie Zehner, Philipp Hartrampf, Dominik Lisowski, Susanne Kneitz, Sinan Cirsi, Gary Razinskas, Michael Flentje, Bülent Polat
BACKGROUND: The study aimed to access the long-term outcome of salvage nodal radiotherapy (SNRT) in oligorecurrent prostate cancer. METHODS: A total of 95 consecutive patients received SNRT for pelvic and/or extrapelvic nodal recurrence after prostate-specific membrane antigen (PSMA) or choline PET from 2010 to 2021. SNRT was applied as external beam radiotherapy with simultaneous integrated boost up to a median total dose of 62.9 Gy (EQD21.5Gy ) to the recurrent lymph node metastases...
August 2, 2022: Cancers
https://read.qxmd.com/read/35488721/electrocardiographic-characteristics-of-trained-and-untrained-standardbred-racehorses
#7
JOURNAL ARTICLE
Sarah D Nissen, Rikke Weis, Elisabeth K Krag-Andersen, Eva M Hesselkilde, Jonas L Isaksen, Helena Carstensen, Jørgen K Kanters, Dominik Linz, Prashanthan Sanders, Charlotte Hopster-Iversen, Thomas Jespersen, Steen Pehrson, Rikke Buhl
BACKGROUND: Long-term exercise induces cardiac remodeling that potentially influences the electrical properties of the heart. HYPOTHESIS/OBJECTIVES: We assessed whether training alters cardiac conduction in Standardbred racehorses. ANIMALS: Two hundred one trained and 52 untrained Standardbred horses. METHODS: Cross-sectional study. Resting ECG recordings were analyzed to assess heart rate (HR) along with standard ECG parameters and for identification of atrial and ventricular arrhythmias...
April 30, 2022: Journal of Veterinary Internal Medicine
https://read.qxmd.com/read/34739524/impact-of-the-sinus-node-recovery-time-after-termination-of-atrial-fibrillation-during-catheter-ablation-on-clinical-outcomes-in-patients-with-persistent-atrial-fibrillation
#8
JOURNAL ARTICLE
Keita Watanabe, Yasutoshi Nagata, Giichi Nitta, Shinichiro Okata, Masashi Nagase, Ryoichi Miyazaki, Sho Nagamine, Masakazu Kaneko, Tetsumin Lee, Toshihiro Nozato, Takashi Ashikaga, Masahiko Goya, Tetsuo Sasano
BACKGROUND: Although long sinus arrest is occasionally observed during atrial fibrillation (AF) catheter ablation when the fibrillation was terminated, its meaning and prognosis have not yet been clearly elucidated. We hypothesized that sinus node recovery time (SNRT) after termination of AF (time from termination of AF to the earliest sinus node activation) could reflect the extent of atrial remodeling, influencing the formation of non-pulmonary vein (non-PV) triggers and post-ablation outcomes...
2021: PloS One
https://read.qxmd.com/read/34497287/a-five-year-retrospective-study-on-the-epidemiology-of-hand-foot-and-mouth-disease-in-sabah-malaysia
#9
JOURNAL ARTICLE
Siat Yee Fong, Daisuke Mori, Christina Rundi, Jun Fai Yap, Muhammad Jikal, A L Liza Binti Abd Latip, Victor Johnny, Kamruddin Ahmed
Hand, foot, and mouth disease (HFMD) is endemic in Malaysia, with the number of cases increasing. Sabah has experienced several HFMD outbreaks, but information on the epidemiology and molecular characteristics of responsible viruses is scarce. In this study, data of 17,574 reports of HFMD cases in Sabah from 2015 to 2019 were extracted from a public health disease surveillance system and analyzed. Twenty-one swab samples from 13 children were collected from Beaufort, Sabah, during an outbreak in August 2018 for detection and serotyping of causative viruses by semi-nested reverse transcription-polymerase chain reaction (snRT-PCR) of the VP4-VP2 region and consensus degenerate hybrid oligonucleotide primer PCR of the VP1 region, respectively...
September 8, 2021: Scientific Reports
https://read.qxmd.com/read/34114047/acute-effects-of-inhaled-iloprost-on-intracardiac-conduction-in-patients-with-pulmonary-arterial-hypertension
#10
JOURNAL ARTICLE
Mustafa Yildiz, Serkan Kahraman, Ozgur Surgit, Hicaz Zencirkiran Agus, Begum Uygur, Ali R Demir, Mehmet E Kalkan, Kadriye Memic Sancar, Ender Oner, İsmail Gurbak, Ali K Kalkan
BACKGROUND: Pulmonary arterial hypertension (PAH) is a severe, life-threatening disorder despite the availability of specific drug therapy. A lack of endogenous prostacyclin secondary to downregulation of prostacyclin synthase in PAH may contribute to vascular pathologies. Therefore, prostacyclin and its analogs including inhaled iloprost may decrease pulmonary arterial pressure and ventricular pressure. METHODS: Here, we studied that acute effects of iloprost used in pulmonary vasoreactivity testing on the intracardiac conduction system in patients with PAH...
June 10, 2021: Herz
https://read.qxmd.com/read/33098128/propofol-suppresses-the-his-ventricular-conduction-in-paediatric-patients
#11
JOURNAL ARTICLE
Mayuka Matsushima, Seishi Kimura, Atsuhiro Kitaura, Shinichi Hamasaki, Tatsushige Iwamoto, Takashi Mino, Kenichi Masui, Shinichi Nakao
WHAT IS KNOWN AND OBJECTIVE: Propofol is the most commonly used intravenous anaesthetic worldwide and is considered to be safe for all ages. However, there have been some reports that propofol induces severe atrioventricular (AV) blocks in humans and some studies demonstrated that propofol suppressed the cardiac conduction system in animals. A precise mechanism by which the block is induced has not been elucidated yet in humans. The objective of this study was to investigate the effects of propofol on the cardiac conduction system and the cardiac autonomic nervous balance in children...
October 24, 2020: Journal of Clinical Pharmacy and Therapeutics
https://read.qxmd.com/read/32836621/household-financial-vulnerability-in-indonesia-measurement-and-determinants
#12
JOURNAL ARTICLE
Sri Noerhidajati, Agung Bayu Purwoko, Hesti Werdaningtyas, Amalia Insan Kamil, Teguh Dartanto
This study assesses the level of financial vulnerability of Indonesian households using data from the Household's Balance Sheet Survey (Survei Neraca Rumah Tangga/SNRT) 2016 and 2017. The SNRT are micro-unit of household data that contains information on preferences and behavior. Through both objective and subjective measurements of the Household Financial Vulnerability Index (FVI), we find that the financial vulnerability of Indonesian households is not only strongly influenced by income factors, but also by finance-related behavioral characteristics and several socio-economic factors...
April 2, 2020: Economic Modelling
https://read.qxmd.com/read/32365085/characterization-of-a-porcine-model-of-atrial-arrhythmogenicity-in-the-context-of-ischaemic-heart-failure
#13
JOURNAL ARTICLE
Sebastian Clauss, Dominik Schüttler, Christina Bleyer, Julia Vlcek, Mehdi Shakarami, Philipp Tomsits, Sarah Schneider, Florian Maderspacher, Kavi Chataut, Anna Trebo, Christine Wang, Jan Kleeberger, Ruibing Xia, Elisabeth Baloch, Bianca Hildebrand, Steffen Massberg, Reza Wakili, Stefan Kääb
Atrial fibrillation (AF) is a major healthcare challenge contributing to high morbidity and mortality. Treatment options are still limited, mainly due to insufficient understanding of the underlying pathophysiology. Further research and the development of reliable animal models resembling the human disease phenotype is therefore necessary to develop novel, innovative and ideally causal therapies. Since ischaemic heart failure (IHF) is a major cause for AF in patients we investigated AF in the context of IHF in a close-to-human porcine ischaemia-reperfusion model...
2020: PloS One
https://read.qxmd.com/read/31570931/biochemical-verification-of-tobacco-use-and-abstinence-2019-update
#14
JOURNAL ARTICLE
Neal L Benowitz, John T Bernert, Jonathan Foulds, Stephen S Hecht, Peyton Jacob, Martin J Jarvis, Anne Joseph, Cheryl Oncken, Megan E Piper
BACKGROUND: The changing prevalence and patterns of tobacco use, the advent of novel nicotine delivery devices, and the development of new biomarkers prompted an update of the 2002 Society for Research on Nicotine and Tobacco (SRNT) report on whether and how to apply biomarker verification for tobacco use and abstinence. METHODS: The SRNT Treatment Research Network convened a group of investigators with expertise in tobacco biomarkers to update the recommendations of the 2002 SNRT Biochemical Verification Report...
October 1, 2019: Nicotine & Tobacco Research
https://read.qxmd.com/read/30612002/two-methods-for-modeling-of-sick-sinus-syndrome-in-rats-ischemia-reperfusion-and-sodium-hydroxide-induced-injury
#15
JOURNAL ARTICLE
Wantong Zhang, Baochen Zhu, Jianxun Ren, Fang Lu, Yi Qi, Weiliang Weng, Rui Gao
The Sick Sinus Syndrome (SSS) is a serious life-threatening heart disease. It is important to establish a credible and stable sinus node damage model. In this study, we use two methods to construct an SSS damage model in rats. One is to inject sodium hydroxide to the SSS area through internal jugular vein. Another is to cause ischemia-reperfusion injury on the SSS area. 43 healthy SD rats were randomly divided into 4 groups, namely ischemia-reperfusion injury group (IRIG), inject sodium hydroxide group (ISHG), and propranolol group (PG) and the control group (CG)...
March 2019: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/29743409/impact-of-sinus-node-recovery-time-after-long-standing-atrial-fibrillation-termination-on-the-long-term-outcome-of-catheter-ablation
#16
COMPARATIVE STUDY
Naoko Yamaguchi, Yasuo Okumura, Ichiro Watanabe, Koichi Nagashima, Keiko Takahashi, Kazuki Iso, Ryuta Watanabe, Masaru Arai, Hiroaki Mano, Rikitake Kogawa, Sayaka Kurokawa, Kimie Ohkubo, Toshiko Nakai, Atsushi Hirayama, Kazumasa Sonoda, Toshimasa Tosaka
Atrial electrical and structural remodeling is related to the perpetuation of atrial fibrillation (AF) subsequent to sinus node dysfunction. We investigated the relationship between AF recurrence after catheter ablation and sinus node dysfunction in long-standing persistent AF patients using the sinus node recovery time (SNRT) after defibrillation.Fifty-one consecutive patients who underwent a first ablation for long-standing persistent AF were enrolled. Intracardiac cardioversion was applied before ablation in the absence of any antiarrhythmic drugs, and the power required to defibrillate, number, and SNRT after defibrillation were measured...
May 30, 2018: International Heart Journal
https://read.qxmd.com/read/29623481/effect-of-antazoline-on-electrophysiological-properties-of-atrial-muscle-and-conduction-system-of-the-heart
#17
JOURNAL ARTICLE
Bartłomiej Jacek Bińkowski, Marcin Makowski, Paweł Kubiński, Andrzej Lubiński
PURPOSE: Antazoline is a first-generation antihistaminic agent with additional anticholinergic properties and antiarrhythmic potential. Recent data shows its high effectiveness in sinus rhythm restoration among patients with paroxysmal atrial fibrillation. The effect of antazoline on electrophysiological parameters of the heart in vivo has not yet been examined. The aim of this study was to evaluate changes in electrophysiological parameters of the heart muscle and conduction system as a response to increasing doses of antazoline...
April 2018: Cardiovascular Drugs and Therapy
https://read.qxmd.com/read/28369243/age-dependent-down-regulation-of-hyperpolarization-activated-cyclic-nucleotide-gated-channel-4-causes-deterioration-of-canine-sinoatrial-node-function
#18
JOURNAL ARTICLE
Jianlin Du, Songbai Deng, Di Pu, Yajie Liu, Jun Xiao, Qiang She
The activity of pacemaker cells in the sinoatrial node (SAN) is an indicator of normal sinus rhythm. Clinical studies have revealed that the dysfunction of the SAN progressively increases with aging. In this study, we determined the changes in hyperpolarization-activated cyclic nucleotide-gated channel 4 (HCN4) expression and the relationship between aging and canine SAN dysfunction. The results of cardiac electrophysiological determination revealed that the intrinsic heart rate decreased from 168 ± 11 beats min-1 in young canines to 120 ± 9 beats min-1 in adults and to 88 ± 9 beats min-1 in aged canines...
May 1, 2017: Acta Biochimica et Biophysica Sinica
https://read.qxmd.com/read/28028980/normal-values-for-heart-electrophysiology-parameters-of-healthy-swine-determined-on-electrophysiology-study
#19
JOURNAL ARTICLE
Agnieszka Noszczyk-Nowak, Alicja Cepiel, Adrian Janiszewski, Robert Pasławski, Jacek Gajek, Urszula Pasławska, Józef Nicpoń
BACKGROUND: Swine are a well-recognized animal model for human cardiovascular diseases. Despite the widespread use of porcine model in experimental electrophysiology, still no reference values for intracardiac electrical activity and conduction parameters determined during an invasive electrophysiology study (EPS) have been developed in this species thus far. OBJECTIVES: The aim of the study was to develop a set of normal values for intracardiac electrical activity and conduction parameters determined during an invasive EPS of swine...
November 2016: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://read.qxmd.com/read/27598221/the-impacts-of-age-and-frailty-on-heart-rate-and-sinoatrial-node-function
#20
JOURNAL ARTICLE
Motahareh Moghtadaei, Hailey J Jansen, Martin Mackasey, Sara A Rafferty, Oleg Bogachev, John L Sapp, Susan E Howlett, Robert A Rose
KEY POINTS: Sinoatrial node (SAN) function declines with age; however, not all individuals age at the same rate and health status can vary from fit to frail. Frailty was quantified in young and aged mice using a non-invasive frailty index so that the impacts of age and frailty on heart rate and SAN function could be assessed. SAN function was impaired in aged mice due to alterations in electrical conduction, changes in SAN action potential morphology and fibrosis in the SAN. Changes in SAN function, electrical conduction, action potential morphology and fibrosis were correlated with, and graded by, frailty...
December 1, 2016: Journal of Physiology
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