Read by QxMD icon Read


Wantong Zhang, Baochen Zhu, Jianxun Ren, Fang Lu, Yi Qi, Weiliang Weng, Rui Gao
The Sick Sinus Syndrome (SSS) is a serious life-threatening heart disease. It is important to establish a credible and stable sinus node damage model. In this study, we use two methods to construct an SSS damage model in rats. One is to inject sodium hydroxide to the SSS area through internal jugular vein. Another is to cause ischemia-reperfusion injury on the SSS area. 43 healthy SD rats were randomly divided into 4 groups, namely ischemia-reperfusion injury group (IRIG), inject sodium hydroxide group (ISHG), and propranolol group (PG) and the control group (CG)...
January 3, 2019: Biomedicine & Pharmacotherapy
Naoko Yamaguchi, Yasuo Okumura, Ichiro Watanabe, Koichi Nagashima, Keiko Takahashi, Kazuki Iso, Ryuta Watanabe, Masaru Arai, Hiroaki Mano, Rikitake Kogawa, Sayaka Kurokawa, Kimie Ohkubo, Toshiko Nakai, Atsushi Hirayama, Kazumasa Sonoda, Toshimasa Tosaka
Atrial electrical and structural remodeling is related to the perpetuation of atrial fibrillation (AF) subsequent to sinus node dysfunction. We investigated the relationship between AF recurrence after catheter ablation and sinus node dysfunction in long-standing persistent AF patients using the sinus node recovery time (SNRT) after defibrillation.Fifty-one consecutive patients who underwent a first ablation for long-standing persistent AF were enrolled. Intracardiac cardioversion was applied before ablation in the absence of any antiarrhythmic drugs, and the power required to defibrillate, number, and SNRT after defibrillation were measured...
May 30, 2018: International Heart Journal
Bartłomiej Jacek Bińkowski, Marcin Makowski, Paweł Kubiński, Andrzej Lubiński
PURPOSE: Antazoline is a first-generation antihistaminic agent with additional anticholinergic properties and antiarrhythmic potential. Recent data shows its high effectiveness in sinus rhythm restoration among patients with paroxysmal atrial fibrillation. The effect of antazoline on electrophysiological parameters of the heart in vivo has not yet been examined. The aim of this study was to evaluate changes in electrophysiological parameters of the heart muscle and conduction system as a response to increasing doses of antazoline...
April 2018: Cardiovascular Drugs and Therapy
Jianlin Du, Songbai Deng, Di Pu, Yajie Liu, Jun Xiao, Qiang She
The activity of pacemaker cells in the sinoatrial node (SAN) is an indicator of normal sinus rhythm. Clinical studies have revealed that the dysfunction of the SAN progressively increases with aging. In this study, we determined the changes in hyperpolarization-activated cyclic nucleotide-gated channel 4 (HCN4) expression and the relationship between aging and canine SAN dysfunction. The results of cardiac electrophysiological determination revealed that the intrinsic heart rate decreased from 168 ± 11 beats min-1 in young canines to 120 ± 9 beats min-1 in adults and to 88 ± 9 beats min-1 in aged canines...
May 1, 2017: Acta Biochimica et Biophysica Sinica
Agnieszka Noszczyk-Nowak, Alicja Cepiel, Adrian Janiszewski, Robert Pasławski, Jacek Gajek, Urszula Pasławska, Józef Nicpoń
BACKGROUND: Swine are a well-recognized animal model for human cardiovascular diseases. Despite the widespread use of porcine model in experimental electrophysiology, still no reference values for intracardiac electrical activity and conduction parameters determined during an invasive electrophysiology study (EPS) have been developed in this species thus far. OBJECTIVES: The aim of the study was to develop a set of normal values for intracardiac electrical activity and conduction parameters determined during an invasive EPS of swine...
November 2016: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
Motahareh Moghtadaei, Hailey J Jansen, Martin Mackasey, Sara A Rafferty, Oleg Bogachev, John L Sapp, Susan E Howlett, Robert A Rose
KEY POINTS: Sinoatrial node (SAN) function declines with age; however, not all individuals age at the same rate and health status can vary from fit to frail. Frailty was quantified in young and aged mice using a non-invasive frailty index so that the impacts of age and frailty on heart rate and SAN function could be assessed. SAN function was impaired in aged mice due to alterations in electrical conduction, changes in SAN action potential morphology and fibrosis in the SAN. Changes in SAN function, electrical conduction, action potential morphology and fibrosis were correlated with, and graded by, frailty...
December 1, 2016: Journal of Physiology
Heidi L Lujan, Joshua P Rivers, Stephen E DiCarlo
Mice may now be the preferred animal model for biomedical research due to its anatomical, physiological, and genetic similarity to humans. However, little is known about accentuated antagonism of chronotropic and dromotropic properties in conscious mice. Accordingly, we describe the complex and interacting influence of the autonomic nervous system on cardiac electrophysiology in conscious mice. Specifically, we report the effects of single and combined cardiac autonomic blockade on measurements of pulse interval (heart rate), atrio-ventricular interval, sinus node recovery time (SNRT), SNRT corrected for spontaneous sinus cycle, and Wenckebach cycle length in conscious mice free of the confounding influences of anesthetics and surgical trauma...
December 2016: Autonomic Neuroscience: Basic & Clinical
Constantin von Deuster, Christian T Stoeck, Martin Genet, David Atkinson, Sebastian Kozerke
PURPOSE: To compare signal-to-noise ratio (SNR) efficiency and diffusion tensor metrics of cardiac diffusion tensor mapping using acceleration-compensated spin-echo (SE) and stimulated echo acquisition mode (STEAM) imaging. METHODS: Diffusion weighted SE and STEAM sequences were implemented on a clinical 1.5 Tesla MR system. The SNR efficiency of SE and STEAM was measured (b = 50-450 s/mm(2) ) in isotropic agar, anisotropic diffusion phantoms and the in vivo human heart...
September 2016: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
S Spiegel, A Chiu, A S James, J D Jentsch, K H Karlsgodt
Numerous studies have implicated DTNBP1, the gene encoding dystrobrevin-binding protein or dysbindin, as a candidate risk gene for schizophrenia, though this relationship remains somewhat controversial. Variation in dysbindin, and its location on chromosome 6p, has been associated with cognitive processes, including those relying on a complex system of glutamatergic and dopaminergic interactions. Dysbindin is one of the seven protein subunits that comprise the biogenesis of lysosome-related organelles complex 1 (BLOC-1)...
November 2015: Genes, Brain, and Behavior
Ming Zhang, Ximin Wang, Xinxing Xie, Zhongsu Wang, Xiaoyan Liu, Juan Guan, Weizong Wang, Zhan Li, Jiangrong Wang, Mei Gao, Yinglong Hou
BACKGROUND: Long-term effects of ganglionated plexi (GP) ablation on sinoatrial node (SAN) and atrioventricular node (AVN) remain unclear. This study is to investigate the long-term effects of ablation of cardiac anterior right GP (ARGP) and inferior right GP (IRGP) on function and structure of SAN and AVN in canine. METHODS: Thirty-two dogs were randomly divided into an operated group (n = 24) and sham-operated group (n = 8). ARGP and IRGP were ablated in operated group which was randomly divided into three subgroups according to the period of evaluation after operation (1 month, 6 months, 12 months)...
October 2015: Pacing and Clinical Electrophysiology: PACE
Naizhi Geng, Ning Jiang, Cailiang Peng, Huaiping Wang, Shuoxin Zhang, Tianyu Chen, Lixia Liu, Yaping Wu, Dandan Liu
Sodium hydroxide pinpoint pressing permeation (SHPPP) was investigated in order to build a rat model of sick sinus syndrome (SSS), which is easy to operate and control the degree of damage, with fewer complications and applicable for large and small animals.Thirty healthy Wistar rats (15 males and 15 females, weighing 250-350 g) were randomly divided into 3 groups, namely a formaldehyde thoracotomy wet compressing group (FTWC), formaldehyde pinpoint pressing permeation group (FPPP) group, and SHPPP group. The number of surviving rats, heart rate (HR), sinoatrial node recovery time (SNRT), corrected SNRT (CSNRT), and sinoatrial conduction time (SACT) were recorded 3 days, one week, and two weeks after modeling...
2015: International Heart Journal
Beh Poay Ling, Farid Azizi Jalilian, Nabil Saad Harmal, Putri Yubbu, Zamberi Sekawi
Hand, foot and mouth disease (HFMD) is a common viral infection among infants and children. The major causative agents of HFMD are enterovirus 71 (EV71) and coxsackievirus A16 (CVA16). Recently, coxsackievirus A6 (CVA6) infections were reported in neighboring countries. Infected infants and children may present with fever, mouth/throat ulcers, rashes and vesicles on hands and feet. Moreover, EV71 infections might cause fatal neurological complications. Since 1997, EV71 caused fatalities in Sarawak and Peninsula Malaysia...
December 2014: Tropical Biomedicine
George E Billman, Kristen L Cagnoli, Thomas Csepe, Ning Li, Patrick Wright, Peter J Mohler, Vadim V Fedorov
The mechanisms responsible for exercise-induced reductions in baseline heart rate (HR), known as training bradycardia, remain controversial. Therefore, changes in cardiac autonomic regulation and intrinsic sinoatrial nodal (SAN) rate were evaluated using dogs randomly assigned to either a 10- to 12-wk exercise training (Ex, n = 15) or an equivalent sedentary period (Sed, n = 10). Intrinsic HR was revealed by combined autonomic nervous system (ANS) blockade (propranolol + atropine, iv) before and after completion of the study...
June 1, 2015: Journal of Applied Physiology
Aalap D Narichania, J William Schleifer, Win-Kuang Shen
Patients with episodic sinus tachycardia and associated orthostatic intolerance present a diagnostic and management dilemma to the clinician. We define this group of disorders to include sinus node reentrant tachycardia (SNRT), inappropriate sinus tachycardia (IAST), and postural orthostatic tachycardia syndrome (POTS). After a brief review of the current understanding of the pathophysiology and epidemiology of this group of disorders, we focus on the diagnosis and management of IAST and POTS. Our approach attempts to recognize the considerable overlap in pathophysiology and clinical presentation between these two heterogeneous conditions...
2014: Cardiology Journal
Paul M Scola, Li-Qiang Sun, Alan Xiangdong Wang, Jie Chen, Ny Sin, Brian L Venables, Sing-Yuen Sit, Yan Chen, Anthony Cocuzza, Donna M Bilder, Stanley V D'Andrea, Barbara Zheng, Piyasena Hewawasam, Yong Tu, Jacques Friborg, Paul Falk, Dennis Hernandez, Steven Levine, Chaoqun Chen, Fei Yu, Amy K Sheaffer, Guangzhi Zhai, Diana Barry, Jay O Knipe, Yong-Hae Han, Richard Schartman, Maria Donoso, Kathy Mosure, Michael W Sinz, Tatyana Zvyaga, Andrew C Good, Ramkumar Rajamani, Kevin Kish, Jeffrey Tredup, Herbert E Klei, Qi Gao, Luciano Mueller, Richard J Colonno, Dennis M Grasela, Stephen P Adams, James Loy, Paul C Levesque, Huabin Sun, Hong Shi, Lucy Sun, William Warner, Danshi Li, Jialong Zhu, Nicholas A Meanwell, Fiona McPhee
The discovery of asunaprevir (BMS-650032, 24) is described. This tripeptidic acylsulfonamide inhibitor of the NS3/4A enzyme is currently in phase III clinical trials for the treatment of hepatitis C virus infection. The discovery of 24 was enabled by employing an isolated rabbit heart model to screen for the cardiovascular (CV) liabilities (changes to HR and SNRT) that were responsible for the discontinuation of an earlier lead from this chemical series, BMS-605339 (1), from clinical trials. The structure-activity relationships (SARs) developed with respect to CV effects established that small structural changes to the P2* subsite of the molecule had a significant impact on the CV profile of a given compound...
March 13, 2014: Journal of Medicinal Chemistry
Heidi L Lujan, Stephen E DiCarlo
Cardiac electrophysiological dysfunction is a major cause of death in humans. Accordingly, electrophysiological testing is routinely performed in intact, conscious, humans to evaluate arrhythmias and disorders of cardiac conduction. However, to date, in vivo electrophysiological studies in mice are limited to anesthetized open-chest or closed-chest preparations. However, cardiac electrophysiology in anesthetized mice or mice with surgical trauma may not adequately represent what occurs in conscious mice. Accordingly, an intact, conscious murine model of cardiac electrophysiology has the potential to be of major importance for advancing the concepts and methods that drive cardiovascular therapies...
April 15, 2014: American Journal of Physiology. Heart and Circulatory Physiology
Fengxia Yu, Lingting Kong, Shujuan Wang
The aim of this study was to explore the mechanism of racemic higenamine in the treatment of sick sinus syndrome (SSS). A total of 40 New Zealand rabbits were randomly divided into normal sinus node and damaged sinus node (SND) groups, and each group was randomly divided into treatment and control groups (n=10). The SND model was established by formaldehyde wet dressing of the sinus node area. The treatment groups were administered an intravenous infusion of 0.04 mg/kg racemic higenamine via the marginal ear vein within 5 min...
February 2013: Experimental and Therapeutic Medicine
Junbeom Park, Jaemin Shim, Jae-Sun Uhm, Boyoung Joung, Moon-Hyoung Lee, Hui-Nam Pak
BACKGROUND: Electro-anatomical remodeling of the atria has been reported to be associated with sinus node dysfunction in patients with atrial fibrillation (AF). We hypothesized that post-shock sinus node recovery time (PS-SNRT: the time from cardioversion to the earliest sinus node activation) is related to the degree of left atrial (LA) remodeling and the clinical outcome of radiofrequency catheter ablation (RFCA) in patients with longstanding persistent AF (L-PeAF). METHODS AND RESULTS: We included 117 patients with L-PeAF (82...
October 3, 2013: International Journal of Cardiology
Tao Luo, Cui-Xian Chang, Xin Zhou, Shi-Kui Gu, Tie-Ming Jiang, Yu-Ming Li
The detailed mechanisms of age-related atrial structural and electrophysiological changes remain elusive. Small animal models have recently been used for the investigation of atrial tachyarrhythmia. In this study, we investigated the hypothesis that atrial structural and electrical characterization with aging provides a substrate for atrial fibrillation using a mouse model of aging. Male Kunming mice aged 2 (young), 12 (middle-aged) and 24 months (aged) were used in this study. A surface electrocardiogram and sinus node recovery time (SNRT) were recorded at baseline...
January 2013: International Journal of Molecular Medicine
Beata Graff, Grzegorz Graff, Edward Koźluk, Monika Tokarczyk, Agnieszka Piątkowska, Szymon Budrejko, Dariusz Kozłowski, Alicja Dąbrowska-Kugacka, Ewa Lewicka, Grażyna Swiątecka, Grzegorz Raczak
INTRODUCTION: Syncope is a common presentation of sinus node dysfunction (SND). Some patients who receive a permanent pacemaker due to SND do not benefit from it and further diagnostic workup leads to the diagnosis of vasovagal syncope (VVS). The aim of the study was to identify electrophysiological criteria that can be used for identification of patients with SND and concurrent VVS. MATERIAL AND METHODS: Transoesophageal atrial pacing (TAP) was performed in 100 patients divided into four groups depending on symptoms and TAP results...
December 31, 2011: Archives of Medical Science: AMS
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"