keyword
https://read.qxmd.com/read/38415821/the-role-of-the-cx3cl1-cx3cr1-axis-as-potential-inflammatory-biomarkers-in-subjects-with-periodontitis-and-rheumatoid-arthritis-a-systematic-review
#1
REVIEW
Mario A Alarcón-Sánchez, Julieta S Becerra-Ruiz, Celia Guerrero-Velázquez, Seyed A Mosaddad, Artak Heboyan
OBJECTIVE: This systematic review aimed to investigate the role of the C-X3-C motif ligand 1/chemokine receptor 1 C-X3-C motif (CX3CL1/CX3CR1) axis in the pathogenesis of periodontitis. Furthermore, as a secondary objective, we determine whether the CX3CL1/CX3CR1 axis could be considered complementary to clinical parameters to distinguish between periodontitis and rheumatoid arthritis (RA) and/or systemically healthy subjects. METHODS: The protocol used for this review was registered in OSF (10...
February 2024: Immunity, Inflammation and Disease
https://read.qxmd.com/read/38303837/immunoglobulin-a-response-to-sars-cov-2-n-protein-potentially-persists-in-oral-fluids-of-patients-with-periodontitis-six-months-after-mrna-vaccine-administration
#2
JOURNAL ARTICLE
Endang W Bachtiar, Yuniarti Soeroso, Natalina Haerani, Nada Ismah, Esti Chahyani Adiati, Boy M Bachtiar
Few studies have investigated the mucosal immune response after BNT162b2-booster vaccination in individuals with periodontitis. In this study, we evaluated the persistence of IgA anti-SARS-CoV-2-N-protein in saliva and gingival crevicular fluid (GCF) of patients with periodontitis for at least six months post BNT162b2 vaccine booster. We included patients with moderate (n = 7) and severe (n = 7) periodontitis and participants without periodontitis (n = 7) as controls. The Bradford method measured the protein concentrations in the samples, and an enzyme-linked immunosorbent assay of the SARS-CoV-2 N protein was performed to analyze the targeted IgA level...
January 2024: Journal of Dental Sciences
https://read.qxmd.com/read/38226238/salivary-and-gingival-crevicular-fluid-biomarkers-of-periodontal-health-and-or-obesity-among-children-and-adolescents-a-systematic-review-and-meta-analysis
#3
JOURNAL ARTICLE
Qianyi Deng, Hai Ming Wong, Simin Peng
OBJECTIVES: To investigate the association of salivary and gingival crevicular fluid (GCF) biomarkers with periodontal status and obesity in children and adolescents. DATA/SOURCES: A literature search up to July 2023 was conducted through PubMed, Web of Science, Embase, ProQuest Medical Database, ProQuest SciTech Premium Collection, and the Cochrane Library. Observational studies comparing salivary and GCF biomarkers in children and adolescents with compromised periodontal status and/or obesity were included for data extraction...
January 15, 2024: Heliyon
https://read.qxmd.com/read/38033941/assessment-of-salivary-and-gingival-crevicular-fluids-il6-il-8-il-12-and-il-17-levels-in-healthy-subjects-and-patients-with-periodontal-disease
#4
JOURNAL ARTICLE
Zeyad N Majeed, Sura D Jassim, Zainab H Kamil
BACKGROUND: Biomarkers present in the oral fluid (saliva and GCF) have been studied thoroughly in order to be used as adjuncts to the diagnosis of periodontal disease. In periodontal diseases, inflammatory mediators, including IL6, IL-8, IL-12, and IL-17, may promote the degeneration of periodontal tissues. AIM: The aim of the present study was to quantify IL6, IL-8, IL-12, and IL-17 levels in the saliva and GCF for patients with generalized periodontitis and compare it with healthy subjects...
2023: Journal of Oral and Maxillofacial Pathology: JOMFP
https://read.qxmd.com/read/37939794/salivary-and-crevicular-fluid-proinflammatory-cytokines-and-advanced-glycation-end-products-in-patients-with-different-glycemic-levels-undergoing-fixed-orthodontic-treatment
#5
JOURNAL ARTICLE
Muhammad Abdullah Kamran
OBJECTIVE: To examine whether patients with different blood glycemic levels undergoing fixed orthodontic therapy demonstrate changes in the biochemical profiles of crevicular fluid and salivary advanced glycation end products (AGEs) and proinflammatory cytokine levels in comparison with nondiabetic healthy subjects. MATERIALS AND METHODS: Prediabetic subjects, subjects with type 2 diabetes mellitus (T2DM), and subjects without a diabetes mellitus diagnosis undergoing fixed orthodontic therapy with MBT prescription brackets (0...
November 9, 2023: Angle Orthodontist
https://read.qxmd.com/read/37937148/meta-analysis-of-assessment-of-total-oxidative-stress-and-total-antioxidant-capacity-in-patients-with-periodontitis
#6
REVIEW
Khadijah Mohideen, Krithika Chandrasekaran, Harsha Veeraraghavan, Shahul Hameed Faizee, Safal Dhungel, Snehashish Ghosh
BACKGROUND: Periodontitis is intricately linked to oxidative stress-antioxidant (redox) imbalance. The antioxidant system scavenges the oxygen free radicals in biological fluids in patients with periodontitis. However, little is still known about the free radicals mediated oxidative stress and reductive ability of the antioxidant system. Thus, the present meta-analysis aims to quantitatively review the literature that assessed the oxidative stress marker total oxidative stress (TOS) and total antioxidant capacity (TAC) in various biological fluids of patients with periodontitis...
2023: Disease Markers
https://read.qxmd.com/read/37934738/periodontal-disease-and-visfatin-level-a-systematic-review-and-meta-analysis
#7
JOURNAL ARTICLE
Mojtaba Bayani, MohammadTaha Heidari, Amir Almasi-Hashiani
Visfatin is considered an inflammatory biomarker in periodontal disease (PD). In this meta-analysis, we aimed to evaluate the relationship between Visfatin biomarker level with PD. In this study, Medline, Scopus, Web of Science, and Google Scholar were searched. We included studies that examined visfatin levels in samples from healthy people and periodontal disease until March 2023. The quality of the selected articles was evaluated using the Newcastle-Ottawa assessment scale. Depending on heterogeneity of studies, random-effects or fixed-effect models were used to pool results and report the standardized mean difference (SMD)...
2023: PloS One
https://read.qxmd.com/read/37884949/periodontitis-is-associated-with-the-increased-levels-of-visfatin-a-meta-analysis
#8
JOURNAL ARTICLE
Junfei Zhu, Suhan Zhang, Jing Shi, Ning Ning, Ying Wei, Ye Zhang
OBJECTIVE: Periodontitis is a common inflammatory disease associated with systemic factors. Visfatin is a pleiotropic adipokine that exerts metabolic and immune functions. Studies have shown visfatin played roles in the development of periodontitis. The present study aims to compare the levels of visfatin in body fluids including serum, saliva, and gingival crevicular fluid (GCF) between periodontitis patients and healthy individuals, and to elucidate the alteration of visfatin levels after periodontal treatments...
October 26, 2023: BMC Oral Health
https://read.qxmd.com/read/37693966/immediate-response-of-diode-laser-on-the-microbial-load-in-subjects-with-chronic-periodontitis
#9
JOURNAL ARTICLE
Toshi, Sneha Mayuri, Mayuri Prasad, Nikhil Raj, Monica R Kedia, L Himabindu
BACKGROUND: Chronic periodontitis is the most common dental disease reported globally as well as in India. Periodontal pathogens are usually seen in samples of gingival tissues, crevicular blood, GCF (gingival crevicular fluid), and dental plaque. Apart from the conventional mechanical treatment, laser disinfection is a recent advancement that change shows greater efficacy in reducing the disease progression and changing the bacterial flora. AIM: The present study aimed to assess the Immediate response of diode laser on the microbial load in subjects with chronic Periodontitis as assessed in saliva, crevicular blood, and GCF (gingival crevicular fluid) samples...
July 2023: Journal of Pharmacy & Bioallied Sciences
https://read.qxmd.com/read/37681356/decreased-gcf-del-1-and-increased-gcf-neutrophils-with-increasing-probing-pocket-depth
#10
JOURNAL ARTICLE
Seong-Ho Jin, Eun-Mi Lee, Jun-Beom Park, Youngkyung Ko
PURPOSE: Developmental endothelial locus-1 (DEL-1) plays a role in regulating neutrophil migration within the periodontium. The objective of this study was to evaluate the levels of DEL-1 in saliva and gingival crevicular fluid (GCF), as well as the number of neutrophils in patients with periodontitis. METHODS: Forty systemically healthy, non-smoking periodontitis patients participated in this study. Clinical periodontal parameters, including the plaque index, probing pocket depth (PPD), clinical attachment level, bleeding on probing, modified sulcular bleeding index, and marginal bone level, were measured...
July 21, 2023: Journal of Periodontal & Implant Science
https://read.qxmd.com/read/37669407/biomarkers-in-body-fluids-as-indicators-of-skeletal-maturity-a-systematic-review-and-meta-analysis
#11
JOURNAL ARTICLE
Priyanka Kapoor, Rajiv Balachandran, Aman Chowdhry, Giuseppe Perinetti, Om Prakash Kharbanda
OBJECTIVES: This review aimed to critically appraise the evidence for biomarkers in blood serum, gingival crevicular fluid (GCF), saliva, and urine in comparison with standard radiographic indices for skeletal maturation assessment. MATERIALS AND METHODS: A thorough literature search in multiple databases was conducted for biomarkers in body fluids for skeletal maturation assessed with cervical vertebrae in lateral cephalograms or on hand-wrist radiographs. Different combinations including free text, MeSH terms, and Boolean operators were used...
September 1, 2023: Rambam Maimonides Medical Journal
https://read.qxmd.com/read/37634578/symptomatic-irreversible-pulpitis-induces-increased-levels-of-human-nlrp3-in-gingival-crevicular-fluid-compared-to-saliva-a-case-control-observational-study
#12
JOURNAL ARTICLE
Dax Abraham, Arundeep Singh, Anjana Goyal
AIM: The goal of this case-control observational study was to compare the levels of the human nucleotide-binding domain, leucine-rich repeat, and pyrin domain-containing-3 (NLRP3) protein in the saliva and gingival crevicular fluid of patients with symptomatic irreversible pulpitis (SIP) and healthy controls. METHODS: The 16 patients in the control group were matched with the 16 patients in the SIP group to create a total of 32 patients. In addition to saliva, gingival crevicular fluid (n = 48) samples were collected from the involved tooth (n = 16), contralateral tooth (n = 16), and adjacent tooth (n = 16) in the SIP group...
August 25, 2023: Journal of Endodontics
https://read.qxmd.com/read/37608638/accuracy-of-periodontitis-diagnosis-obtained-using-multiple-molecular-biomarkers-in-oral-fluids-a-systematic-review-and-meta-analysis
#13
REVIEW
T Blanco-Pintos, A Regueira-Iglesias, I Seijo-Porto, C Balsa-Castro, P Castelo-Baz, L Nibali, I Tomás
AIM: To determine the accuracy of biomarker combinations in gingival crevicular fluid (GCF) and saliva through meta-analysis to diagnose periodontitis in systemically healthy subjects. METHODS: Studies on combining two or more biomarkers providing a binary classification table, sensitivity/specificity values or group sizes in subjects diagnosed with periodontitis were included. The search was performed in August 2022 through PUBMED, EMBASE, Cochrane, LILACS, SCOPUS and Web of Science...
November 2023: Journal of Clinical Periodontology
https://read.qxmd.com/read/37602819/a-protease-responsive-polymer-peptide-conjugate-and-reversible-assembly-of-silver-clusters-for-the-detection-of-porphyromonas-gingivalis-enzymatic-activity
#14
JOURNAL ARTICLE
Maurice Retout, Lubna Amer, Wonjun Yim, Matthew N Creyer, Benjamin Lam, Diego F Trujillo, Jan Potempa, Anthony J O'Donoghue, Casey Chen, Jesse V Jokerst
We report the reversible aggregation of silver nanoparticle (AgNP) assemblies using the combination of a cationic arginine-based peptide and sulfur-capped polyethylene glycol (PEG). The formation and dissociation of the aggregates were studied by optical methods and electron microscopy. The dissociation of silver clusters depends on the peptide sequence and PEG size. A molecular weight of 1 kDa for PEG was optimal for the dissociation. The most important feature of this dissociation method is that it can operate in complex biofluids such as plasma, saliva, bile, urine, cell media, or even seawater without a significant decrease in performance...
August 21, 2023: ACS Nano
https://read.qxmd.com/read/37566245/effects-of-smoking-on-the-salivary-and-gcf-levels-of-il-17-and-il-35-in-periodontitis
#15
JOURNAL ARTICLE
Ezgi Sila Taskaldiran, Gulay Tuter, Aysegul Atak Yucel, Melek Yaman
Periodontitis progression is associated with a host response in which anti-inflammatory and pro-inflammatory cytokine networks play a key role. Smoking is involved in the production of various mediators. The study aims to evaluate the levels of IL-17 and IL-35 in saliva and gingival crevicular fluid (GCF), to investigate the effects of smoking on these cytokines in smoker and non-smoker periodontitis patients. 19 smokers with periodontitis, 20 non-smokers with periodontitis, and 18 periodontally healthy subjects were included in the study...
August 11, 2023: Odontology
https://read.qxmd.com/read/37539392/insight-into-the-laboratory-diagnosis-of-periimplantitis-using-reactive-oxygen-metabolite-levels-a-biochemical-study
#16
JOURNAL ARTICLE
Navina Ravindran, Uma Sudhakar, Nimisha Mithradas, Snophia Suresh, Sherine L Asirvatham, Steffy J, Jhansi L Kotaru, Bakkiya A, Sundaran K R, Bhavishya B
Aim The study aims to substantiate the quantitative role of the predominant periodontopathogen ( Porphyromonas gingivalis ) associated with peri-implantitis and evaluate the reactive oxygen metabolite levels in peri-implantitis patients. Methodology A total of 40 participants were taken from the department of periodontology, Thai Moogambigai Dental College and Hospital, Chennai, and divided into groups I (control) and II (test). Group I included 20 participants with healthy peri-implant tissue, and group II included 20 participants with infected peri-implant tissues...
July 2023: Curēus
https://read.qxmd.com/read/37535199/biomarkers-for-diagnosis-of-stage-iii-grade-c-with-molar-incisor-pattern-periodontitis-in-children-and-young-adults-a-systematic-review-and-meta-analysis
#17
REVIEW
Meaad M Alamri, Georgios N Antonoglou, Gordon Proctor, Carlos Balsa-Castro, Inmaculada Tomás, Luigi Nibali
AIM: To explore the existing salivary, gingival crevicular fluid (GCF), blood, and serum biomarkers associated with grade C molar-incisor pattern (C/MIP) periodontitis in systemically healthy children and young adults. MATERIALS AND METHODS: Cross-sectional, case-control, and cohort studies on stage III grade C periodontitis or former equivalent diagnosis with analysis of molecular biomarkers in saliva, GCF, blood, or serum were retrieved from six databases and screened based on the eligibility criteria...
August 3, 2023: Clinical Oral Investigations
https://read.qxmd.com/read/37522314/ammp-8-point-of-care-diagnostic-methods-and-treatment-modalities-in-periodontitis-and-peri-implantitis
#18
REVIEW
Hanna Lähteenmäki, Tommi Pätilä, C Pirjo Pärnänen, Ismo Räisänen, Taina Tervahartiala, Shipra Gupta, Timo Sorsa
INTRODUCTION: When collected in a standardized fashion, oral fluid analysis can refine the diagnosis of periodontal and peri-implant disease. In practice, dental professionals can perform active matrix metalloproteinase (aMMP-8) analysis chairside. AREAS COVERED: Periodontal tissues are mainly made up of type I collagen, and collagen breakdown is one of the main events in periodontal and peri-implantitis destructive lesions. In addition to traditional measurements, their diagnosis can be refined with tests utilizing oral fluids...
July 31, 2023: Expert Opinion on Therapeutic Targets
https://read.qxmd.com/read/37455397/interleukin-38-a-crucial-player-in-periodontitis
#19
JOURNAL ARTICLE
Hilal Korkmaz, Mükerrem Hatipoğlu, Nezahat Arzu Kayar
BACKGROUND: The objective of this study was to compare the levels of gingival crevicular fluid (GCF), salivary, and serum matrix metalloproteinase-9, interleukin (IL)-17, IL-36γ, and IL-38 in individuals with healthy periodontium, gingivitis, and periodontitis and to evaluate their correlations with clinical periodontal parameters. MATERIALS AND METHODS: Ninety systemically healthy and nonsmoking volunteers divided into a healthy (H) group (n = 30), a gingivitis (G) group (n = 30), and a periodontitis (P) group (n = 30) were included in this study...
July 16, 2023: Oral Diseases
https://read.qxmd.com/read/37433175/parkinson-s-disease-is-positively-associated-with-periodontal-inflammation
#20
JOURNAL ARTICLE
Melis Yilmaz, Ekin Yay, Nur Balci, Hilal Toygar, Basak Bolluk Kılıc, Ali Zirh, Carla Alvarez Rivas, Alpdogan Kantarci
BACKGROUND: Parkinson's disease (PA) affects 1% of the global population above 60 years. PA pathogenesis involves severe neuroinflammation that impacts systemic and local inflammatory changes. We tested the hypothesis that PA is associated with periodontal tissue inflammation promoting a greater systemic inflammatory burden. METHODS: We recruited 60 patients with Stage III, Grade B periodontitis (P) with and without PA (n = 20 for each). We also included systemically and periodontally healthy individuals as controls (n = 20)...
July 11, 2023: Journal of Periodontology
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