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cortisol biomarker

June Cho, Xiaogang Su, Diane Holditch-Davis
OBJECTIVES: To examine the concurrent use of self-report questionnaires and hormonal biomarkers, specifically levels of testosterone and cortisol, along with demographic variables and corrected age (CA) in the assessment of mental health and healthy behaviors among mothers of very-low-birthweight (VLBW, BW < 1,500 g) infants at five time points over 2 years post birth. METHOD: Data on 40 mothers from a neonatal intensive care unit of a tertiary medical center in the southeast United States were collected from the medical record, standard questionnaires for the mother (depressive symptoms, perceived stress, anxiety, mental health status, parenting stress, and healthy lifestyle behaviors), and biochemical measurement of maternal testosterone and cortisol using enzyme immunoassay at birth, 40 weeks' postmenstrual age, and 6, 12, and 24 months CA...
February 14, 2019: Biological Research for Nursing
Angela C Incollingo Rodriguez, A Janet Tomiyama, Christine M Guardino, Christine Dunkel Schetter
OBJECTIVE: Weight stigma adversely affects the health of the general population, but almost no studies have examined possible negative consequences of weight stigma in the context of pregnancy. The present study tested whether experiencing weight stigma in pregnancy is inversely related to mental and physical health in mothers during the first postpartum year. METHOD: This study examined associations between weight-related experiences of discrimination in everyday life, measured at 1 month after the birth of a child, and physical and mental health outcomes measured concurrently and at 6 months and 1 year postpartum in a sample of 214 women in the Community Child Health Network study...
March 2019: Health Psychology: Official Journal of the Division of Health Psychology, American Psychological Association
Mesut Savas, Vincent Wester, Yolanda B de Rijke, German Rubinstein, Stephanie Zopp, Kristien Dorst, Sjoerd van den Berg, Felix Beuschlein, Richard A Feelders, Martin Reincke, Elisabeth F C van Rossum
The current diagnostic workup of Cushing's syndrome (CS) requires various tests which only capture short-term cortisol exposure, whereas patients with endogenous CS generally have elevated long-term cortisol levels. Scalp hair assessment has emerged as a convenient test in capturing glucocorticoid concentrations over long periods of time. The aim of this multicenter, multinational, prospective, case-control study was to evaluate the diagnostic efficacy of scalp hair glucocorticoids in screening of endogenous CS...
February 13, 2019: Neuroendocrinology
Chun Gong, Xiaonan Duan, Puyu Su, Yuhui Wan, Yuanyuan Xu, Fangbiao Tao, Ying Sun
Pubertal timing has been suggested as biological factors implicated in the onset of depression in girls. This study aims to examine the prospective association between accelerated pubertal progression with depressive symptoms, and to further explore the possible role of individual reactivity to social stress in this association. A total of 56 girls with early puberty timing (assessed through breast Tanner stage) and 56 age-matched normal breast development girls were recruited at Wave 1 (grade 3) and followed for 4 years biennially...
February 5, 2019: Psychoneuroendocrinology
Maja Nyström-Hansen, Marianne S Andersen, Jennifer E Khoury, Kirstine Davidsen, Andrew Gumley, Karlen Lyons-Ruth, Angus MacBeth, Susanne Harder
Existing literature points to the possibility that cortisol could be one link between maternal adversity and poorer parenting quality, but most studies have examined salivary cortisol concentrations rather than hair cortisol concentrations. The current study examined hair cortisol concentration (HCC) during the third trimester of pregnancy as a mediator between maternal adversity indicators (childhood abuse, severe mental illness, symptomatic functioning) and maternal caregiving behavior at 4 months postpartum...
February 12, 2019: Developmental Psychobiology
Alina Oprea, Nicolas C G Bonnet, Olivier Pollé, Philippe A Lysy
Adrenal insufficiency is defined as impaired adrenocortical hormone synthesis. According to its source, the deficit is classified as primary (adrenal steroidogenesis impairment), secondary (pituitary adrenocorticotropic hormone deficit) or tertiary (hypothalamic corticotropin-releasing hormone deficit). The management of adrenal insufficiency resides primarily in physiological replacement of glucocorticoid secretion. Standard glucocorticoid therapy is shrouded in several controversies. Along the difficulties arising from the inability to accurately replicate the pulsatile circadian cortisol rhythm, come the uncertainties of dose adjustment and treatment monitoring (absence of reliable biomarkers)...
2019: Therapeutic Advances in Endocrinology and Metabolism
Laura Fernández-Alacid, Ignasi Sanahuja, Borja Ordóñez-Grande, Sergio Sánchez-Nuño, Ginés Viscor, Enric Gisbert, Marcelino Herrera, Antoni Ibarz
Knowledge concerning the health and welfare of fish is important to conserve species diversity. Fish mucosal surfaces, and particularly the skin, are of utmost importance to protect the integrity and homeostasis of the body and to prevent skin infections by pathogens. We performed three trials simulating different environmental and anthropogenic challenges: fish capture (air exposure), bacterial infection and fasting, with the aim of evaluating epidermal mucus as a non-invasive target of studies in fish. In this initial approach, we selected three well-known marine species: meagre (Argyrosomus regius), European sea bass (Dicentrarchus labrax) and gilthead sea bream (Sparus aurata) for our study...
December 10, 2018: Science of the Total Environment
Cindy H Liu, Stacey N Doan
Much of the existing research on biological mechanisms underlying the stress experience has focused largely on moment-to-moment stress, rather than on chronic stress, an arguably more powerful predictor of long-term outcomes. Recent methodological innovations have paved the way for new lines of research on chronic stress, with promising implications for developmental researchers and for those who study health and adversity. In particular, there are increasing studies that have focused on chronic stress assessments by relying on cortisol derived from hair and nails as a biomarker for chronic stress...
February 10, 2019: Developmental Psychobiology
Noor Aimie-Salleh, M B Malarvili, Anna C Whittaker
Adverse childhood experiences have been suggested to cause changes in physiological processes and can determine the magnitude of the stress response which might have a significant impact on health later in life. To detect the stress response, biomarkers that represent both the Autonomic Nervous System (ANS) and Hypothalamic-Pituitary-Adrenal (HPA) axis are proposed. Among the available biomarkers, Heart Rate Variability (HRV) has been proven as a powerful biomarker that represents ANS. Meanwhile, salivary cortisol has been suggested as a biomarker that reflects the HPA axis...
February 7, 2019: Medical & Biological Engineering & Computing
Taís Rieping, Guilherme Eustáquio Furtado, Rubens Vinícius Letieri, Matheus Uba Chupel, Juan C Colado, Eef Hogervorst, Edith Filaire, Ana Maria Miranda Botelho Teixeira, José Pedro Ferreira
PURPOSE: The aim of this study was to test the effects of chair-based exercise programs on salivary stress hormones, physical fitness, and functional autonomy of institutionalized older women. METHOD: In total, 47 participants (80 ± 8.04 years old) were recruited and allocated into three groups: chair-based aerobic exercises (CAE, n = 19), chair-based elastic-band strength exercises (CSE, n = 15), and a control group (CG, n = 13). A 14-week exercise intervention was done for the CAE and CSE groups, two times per week, in no consecutive days...
February 5, 2019: Research Quarterly for Exercise and Sport
Mahino Fatima, Saurabh Srivastav, Mir Hilal Ahmad, Amal Chandra Mondal
Prenatal stress (PNS) has gained attention with regard to its impact on hippocampal neurogenesis in neonates which serves as a risk factor for postnatal neurodevelopmental deficits. Evidences from animal models have suggested that depression responsive hypothalamic-pituitary-adrenal (HPA) axis and its hormonal response via cortisol, is responsible for critical neurodevelopmental deficits in the offspring which is transduced due to gestational stress. But knowledge in the area of assessing the effects of maternal chronic unpredictable mild stress (CUMS) on neurogenesis and expression of some key signaling molecules in the offsprings are limited...
February 4, 2019: Scientific Reports
Lisa J Berlin, Tiffany L Martoccio, Crystal I Bryce, Brenda Jones Harden
Attachment-based parenting interventions have shown positive effects on early cortisol regulation, a key biomarker. Evaluations to date have focused on diurnal cortisol production in high-risk infants. It is important to understand whether attachment-based intervention may also improve stress-induced cortisol production in typically developing infants. This randomized controlled trial tested an enhanced model of U.S. Early Head Start (EHS) services that combined home-based EHS with a brief, attachment-based parenting intervention, Attachment and Biobehavioral Catch-up (ABC)...
January 4, 2019: Psychoneuroendocrinology
Vytautas Žėkas, Reda Matuzevičienė, Dovilė Karčiauskaitė, Asta Mažeikienė, Neringa Burokienė, Mantas Radzevičius, Aušra Janilionienė, Aušra Linkevičiūtė, Zita Aušrelė Kučinskienė
BACKGROUND: Chronic and oxidative stress promotes injury to the endothelium. This happens early in the disease and novel biomarkers describing the rate of the damage may be important in early diagnostics and prevention. Microvesicles are shed from endothelial cells in response to oxidative stress, inflammation, coagulation, and angiogenesis. Their increased level in plasma could reflect the state of the endothelium. OBJECTIVES: The objective of this study was to test the association between oxidative and chronic stress markers, atherosclerosis risk factors and endothelial microvesicle (EMV) count in peripheral blood...
January 31, 2019: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
Shingo Haraki, Akiko Tsujisaka, Shigeru Nonoue, Teruaki Nochino, Mayo Kamimura, Hiroyoshi Adachi, Shoichi Ishigaki, Hirofumi Yatani, Masako Taniike, Takafumi Kato
AIMS: To investigate the objective and subjective characteristics of sleep and psychosomatic and physiologic variables in young subjects with different frequencies of rhythmic masticatory muscle activity (RMMA) during sleep. METHODS: A total of 54 young (mean age 23.8 ± 2.1 years), healthy subjects underwent polysomnographic (PSG) recordings for 2 nights. Sleep and psychosomatic states were assessed prior to PSG using validated questionnaires, and the following PSG variables were assessed before and after sleep: subjective sleep quality, physical symptoms, anxiety level, and salivary biomarkers...
January 2019: Journal of Oral & Facial Pain and Headache
Mingbang Wang, Jing Wan, Han Rong, Fusheng He, Hui Wang, Jiaxiu Zhou, Chunquan Cai, Yan Wang, Ruihuan Xu, Zhaoqing Yin, Wenhao Zhou
Changes in the gut microenvironment may influence the pathogenesis of autism spectrum disorders (ASD). Here, we investigated the composition of the gut microbiota and metabolites in children with ASD. Ninety-two children with ASD and 42 age-matched children exhibiting typical development (TD) were enrolled in the two-stage study. In the discovery stage, shotgun metagenomic sequencing and liquid chromatography-mass spectrometry (LC-MS) were performed simultaneously on fecal samples obtained from 43 children in the ASD group and 31 children in the TD group...
January 2019: MSystems
Brenda S Stevens, Kenneth D Royal, Kelli Ferris, Abigail Taylor, Amy M Snyder
OBJECTIVE: To determine students' stress while performing surgery and evaluate the ability of a mindfulness intervention to reduce this stress. STUDY DESIGN: Quasi-experimental design. SAMPLE POPULATION: Eighteen fourth-year DVM program students (n = 9 student/group). METHODS: Utilizing a quasi-experimental design, students were randomly assigned to a control or treatment group. The treatment group performed a 5-minute breathing (mindfulness) exercise immediately prior to performing surgery...
January 29, 2019: Veterinary Surgery: VS
Allison E Gaffey, Erin C Walsh, Charlotte O Ladd, Roxanne M Hoks, Heather C Abercrombie
BACKGROUND: Decades of research point to cortisol insensitivity as a biomarker of depression. Despite a vast literature on cortisol's effects on memory, the role of cortisol insensitivity in core psychological features of depression, such as emotional memory biases, is unknown. METHODS: Sixty-five premenopausal women with varying levels of depression completed this study involving an at-home low-dose dexamethasone suppression test and four experimental sessions (i...
December 4, 2018: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
Damián Escribano, Heng-Lun Ko, Qiai Chong, Lourdes Llonch, Xavier Manteca, Pol Llonch
In this study, the changes of salivary stress biomarkers were contrasted with skin lesions during weaning in piglets. The stress biomarkers evaluated were cortisol (as the reflection of hypothalamic-pituitary-adrenal (HPA) axis), chromogranin A (CgA) and alpha amylase (sAA) (both as the reflection of sympathoadrenal-medullary (SAM) axis). In addition, the accumulation of skin lesions were assessed as proxy measures of aggression. One hundred and two Danbred piglets (51 female and 51 male) from primiparous and multiparous sows were studied from birth to two days post-weaning...
January 17, 2019: Research in Veterinary Science
M Sekar, M Pandiaraj, S Bhansali, N Ponpandian, C Viswanathan
This study examines the use of a conductive carbon fiber to construct a flexible biosensing platform for monitoring biomarkers in sweat. Cortisol was chosen as a model analyte. Functionalization of the conductive carbon yarn (CCY) with ellipsoidal Fe2 O3 has been performed to immobilize the antibodies specific to cortisol. 1-Ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC) and N-Hydroxysuccinimide (NHS) chemistry has been used to immobilize the antibodies onto the Fe2 O3 modified CCY. Crystallinity, structure, morphology, flexibility, surface area, and elemental analysis were studied using X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), Raman spectroscopy, Field emission scanning electron microscopy with energy dispersive X-ray spectroscopy (FE-SEM/EDS) and Brunauer-Emmett-Teller (BET) analysis...
January 23, 2019: Scientific Reports
Ermina Bach, Niels Møller, Jens Otto Lunde Jørgensen, Mads Buhl, Holger Jon Møller
AIMS/HYPOTHESIS: The macrophage-specific glycoprotein sCD163 has emerged as a biomarker of low grade inflammation in the metabolic syndrome and related disorders. High sCD163 levels are seen in acute sepsis as result of direct lipopolysaccharide-mediated shedding of the protein from macrophage surfaces including Kupffer cells. The aims of this study were to investigate if low grade endotoxinemia in human subjects results in increasing levels of sCD163 in a cortisol-dependent manner. METHODS: We studied eight male hypopituitary patients and eight age and gender matched healthy controls during intravenous low dose LPS or placebo infusion administered continuously over 360 min...
January 1, 2019: Endocrine Connections
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