Hsu Po Chiang, Miguel O D Aguiar, Bruno G Tavares, Vitor E E Rosa, Sergio Barros Gomes, Mucio T Oliveira, Alexandre Soeiro, Jose C Nicolau, Henrique B Ribeiro, João C Sbano, Carlos E Rochitte, Roberto Kalil Filho, Jose A F Ramires, Thomas R Porter, Wilson Mathias, Jeane M Tsutsui
BACKGROUND: The diagnostic ultrasound-guided high mechanical index (MI) impulses during an intravenous microbubble infusion (sonothrombolysis) improves myocardial perfusion in acute ST segment elevation myocardial infarction (STEMI), but its effect on left ventricular diastolic dysfunction (DD), left atrial (LA) mechanics and remodeling are unknown. We assessed the effect of sonothrombolysis on DD grade and LA mechanics. METHODS: 100 patients (59±10 years; 34% women) were randomized to receive either high MI impulses plus percutaneous coronary intervention (PCI) (therapy group), or receive PCI only (control group) (n=50 in each group)...
December 16, 2022: Journal of the American Society of Echocardiography