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Hiroya Iida, Masaki Kaibori, Kosuke Matsui, Morihiko Ishizaki, Masanori Kon
AIM: To provide a simple surrogate marker predictive of liver cirrhosis (LC). METHODS: Specimens from 302 patients who underwent resection for hepatocellular carcinoma between January 2006 and December 2012 were retrospectively analyzed. Based on pathologic findings, patients were divided into groups based on whether or not they had LC. Parameters associated with hepatic functional reserve were compared in these two groups using Mann-Whitney U -test for univariate analysis...
January 27, 2018: World Journal of Hepatology
Gaurang Nandkishor Vaidya
Exercise electrocardiogram (ECG) tests boasts of being more widely available, less resource intensive, lower cost and absence of radiation. In the presence of a normal baseline ECG, an exercise ECG test is able to generate a reliable and reproducible result almost comparable to Technitium-99m sestamibi perfusion imaging. Exercise ECG changes when combined with other clinical parameters obtained during the test has the potential to allow effective redistribution of scarce resources by excluding low risk patients with significant accuracy...
July 2017: Indian Heart Journal
Piotr Kabziński, Jacek Rac, Tadeusz Dorobisz, Wiktor Pawłowski, Agnieszka Ziomek, Mariusz Chabowski, Dawid Janczak, Michał Leśniak, Dariusz Janczak
UNLABELLED: At present, sentinel lymph node biopsy is a standard procedure to assess the advancement of breast cancer and cutaneous melanoma. The aim of the study was to assess the role of the sentinel lymph node biopsy in the treatment of patients with breast cancer in our own material. MATERIAL AND METHODS: Analyzed was medical documentation of 258 patients with initially operable breast cancer, qualified for operation with sentinel lymph node biopsy in 2004-2014 in the Department of Surgery of the 4th Military Teaching Hospital...
May 1, 2016: Polski Przeglad Chirurgiczny
Imran Uddin, Absar Ahmad, Ejaz Ahmad Siddiqui, Sk Hasanur Rahaman, Sanjay Gambhir
Bismuth sulphide (Bi2S3) is an excellent semiconductor and its nanoparticles have numerous significant applications including photovoltaic materials, photodiode arrays, bio-imaging, etc. Nevertheless, these nanoparticles when fabricated by chemical and physical routes tend to easily aggregate in colloidal solutions, are eco-unfriendly, cumbrous and very broad in size distribution. The aim of the present manuscript was to ecologically fabricate water dispersible, safe and stable Bi2S3 nanoparticles such that these may find use in animal imaging, diagnostics, cell labeling and other biomedical applications...
2016: Current Topics in Medicinal Chemistry
Shiong Wen Low, Kejia Teo, Sein Lwin, Leonard L L Yeo, Prakash R Paliwal, Aftab Ahmad, Arvind K Sinha, Hock Luen Teoh, Lily Y H Wong, Vincent F Chong, Raymond C S Seet, Bernard P L Chan, Tseng Tsai Yeo, Ning Chou, Vijay K Sharma
OBJECT: Both the older and the recent extracranial-intracranial (EC-IC) bypass trials for symptomatic carotid occlusion failed to demonstrate a reduction in stroke recurrence. However, the role of superficial temporal artery (STA)-middle cerebral artery (MCA) bypass in patients with symptomatic intracranial stenoocclusive disease has been rarely evaluated. The authors evaluated serial changes in various cerebral hemodynamic parameters in patients with severe stenoocclusive disease of the intracranial internal carotid artery (ICA) or middle cerebral artery (MCA) and impaired cerebral vasodilatory reserve (CVR), treated by STA-MCA bypass surgery or medical treatment...
September 2015: Journal of Neurosurgery
Romeeta Trehan, Rajeev K Seam, Manoj K Gupta, Ashwani Sood, Kislay Dimri, Rohit Mahajan
Locally advanced breast cancer (LABC) is a common cancer in the developing countries. Neoadjuvant chemotherapy (NACT) is a very important step in the treatment of such tumors and hence that the disease can be down staged and made amenable for surgery. All the tumors do not respond to the therapy equally. Hence, it becomes very important to predict the response of chemotherapy in such cases. This study evaluated the role of scintimammography in assessing the response to NACT in 23 patients with LABC. Histologically proven 23 patients of LABC were recruited in this study...
September 2014: World Journal of Nuclear Medicine
Deepshikha Tewari, Mohd Parvez Khan, Nitin Sagar, Shyamsundar P China, Atul K Singh, Subhash C Kheruka, Sukanta Barai, Mahesh C Tewari, Geet K Nagar, Achchhe L Vishwakarma, Omeje E Ogechukwu, Jayesh R Bellare, Sanjay Gambhir, Naibedya Chattopadhyay
We investigated deleterious changes that take place in mesenchymal stem cells (MSC) and its fracture healing competence in ovariectomy (Ovx)-induced osteopenia. MSC from bone marrow (BM) of ovary intact (control) and Ovx rats was isolated. (99m)Tc-HMPAO (Technitium hexamethylpropylene amine oxime) labeled MSC was systemically transplanted to rats and fracture tropism assessed by SPECT/CT. PKH26 labeled MSC (PKH26-MSC) was bound in scaffold and applied to fracture site (drill-hole in femur metaphysis). Osteoinduction was quantified by calcein binding and microcomputed tomography...
April 2015: Stem Cell Reviews
Arvind Krishnamurthy, Ramachandran Krishna Kumar, Praveen Ravishankaran, Vijayalaksmi Ramshankar, Ahamed Sultan Balkis Begum, Gomadam Kuppuswamy Rangarajan
BACKGROUND: Many radio-pharmaceuticals have been used over the years to localize the recurrences in patients with medullary carcinoma thyroid (MCT), including iodine-131-metaiodobenzylguanidine, thallium-201, technitium-99m dimercaptosuccinyl acid [Tc-99m DMSA (V)], Tc-99m methoxyisobutylisonitril, Tc-99 ethylenediamine diacetic acid/hydrazinonicotinyl-Tyr (3)-octreotide, and In-111 diethylenetriaminepenta-acetic acid-octreotide with varying sensitivities and specificities. AIMS: The aim of this study is to explore the role of Tc-99m DMSA (V) scan in MCT patients with postoperative persistent hypercalcitoninemia in the positron emission tomography-computerized tomography (PET-CT) era...
July 2014: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
Deepak Sharma, Dipika Maheshwari, Gilphy Philip, Ravish Rana, Shanu Bhatia, Manisha Singh, Reema Gabrani, Sanjeev K Sharma, Javed Ali, Rakesh Kumar Sharma, Shweta Dang
The aim of the present study was to optimize lorazepam loaded PLGA nanoparticles (Lzp-PLGA-NPs) by investigating the effect of process variables on the response using Box-Behnken design. Effect of four independent factors, that is, polymer, surfactant, drug, and aqueous/organic ratio, was studied on two dependent responses, that is, z-average and % drug entrapment. Lzp-PLGA-NPs were successfully developed by nanoprecipitation method using PLGA as polymer, poloxamer as surfactant and acetone as organic phase...
2014: BioMed Research International
Swati Jadhav, Rajeev Kasaliwal, Nitin S Shetty, Suyash Kulkarni, Krantikumar Rathod, Bhavesh Popat, Harshal Kakade, Amol Bukan, Shruti Khare, Sweta Budyal, Varsha S Jagtap, Anurag R Lila, Tushar Bandgar, Nalini S Shah
CONTEXT: Tumor-induced osteomalacia is curable if the tumors can be totally excised. However, when the tumors are present in locations that make surgery disproportionately risky, the need for less invasive strategies like radiofrequency ablation (RFA) is realized. PATIENTS AND METHODS: We describe three patients with suspected tumor-induced osteomalacia who were treated in our department between 2006 and 2013 with tumors in surgically difficult locations and were subjected to single or multiple sessions of RFA...
September 2014: Journal of Clinical Endocrinology and Metabolism
Uday Yanamandra, Narendra Kotwal, Anil Menon, Velu Nair
Autoimmune endocrinopathies and, less commonly, thyroid autoimmune disease have been reported in patients with sarcoidosis. Similarities exist in the pathogenesis of these two conditions. Concomitant sarcoidosis in the thyroid gland in patients with Graves' disease may contribute to the resistance to antithyroid drugs and radioiodine therapy. We present the clinical, laboratory, imaging, and pathologic findings of a patient with Graves' disease who was unresponsive to medical management. This 37-year-old man presented with thyrotoxicosis...
March 2013: Indian Journal of Endocrinology and Metabolism
Shivanand Bhushan, Rajesh Kumar
PURPOSE OF THE STUDY: The purpose of the present study is to find out the correlation between the glomerular filtration rate (GFR by Gates gamma camera method) and serum creatinine clearance (SCrCl by Cockcroft and Gault's method) within ± 3 weeks' time difference. MATERIALS AND METHODS: Study design retrospectively in 59 patients with serum creatinine value calculated for SCrCl with Cockcroft and Gault's formula as an index parameter for kidney function underwent the 99m-Technitium labeled Di-ethyl Triamine Penta Acetic Acid (99mTc-DTPA) renogram with ECIL planar gamma camera...
April 2012: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
Manasmita Das, Satyajit R Datir, Raman Preet Singh, Sanyog Jain
The present study reports the design, synthesis, and biological evaluation of a novel, intravenously injectable, theranostic prodrug based on multiwalled carbon nanotubes (MWCNTs) concomitantly decorated with a fluorochrome (Alexa-fluor, AF488/647), radionucleide (Technitium-99m), tumor-targeting module (folic acid, FA), and anticancer agent (methotrexate, MTX). Specifically, MTX was conjugated to MWCNTs via a serum-stable yet intracellularly hydrolyzable ester linkage to ensure minimum drug loss in circulation...
July 1, 2013: Molecular Pharmaceutics
Indira Maisnam, Deep Dutta, Rajesh Jain, Sujoy Ghosh, Satinath Mukhopadhyay, Subhankar Chowdhury
Thyroid stimulating hormone (TSH) secreting adenomas are the rarest type of pituitary adenomas (1:1000000 in the population; 0.2- 2.8% of adenomas). Plurihormonal thyrotropic adenomas are even rarer usually having cosecretion of growth hormone (GH) and prolactin. We report perhaps for the first time, TSH, GH, adrenocorticotrophic hormone (ACTH) and gonadotropins secreting pituitary macroadenoma diagnosed in a 40 year lady presenting with features of thyrotoxicosis for 5 months, amenorrhea for 3 months and newly diagnosed diabetes and hypertension for 2 months along with headache, nausea, and vomiting, who had acromegaloid habitus, grade-II goitre, increased uptake on Technitium-99 pertechnate thyroid scan (4...
December 2012: Indian Journal of Endocrinology and Metabolism
Daisuke Hayashi, Satoru Ohshima, Satoshi Isobe, Xian Wu Cheng, Kazumasa Unno, Hidehito Funahashi, Norihiro Shinoda, Takahiro Okumura, Akihiro Hirashiki, Katsuhiko Kato, Toyoaki Murohara
OBJECTIVES: This study investigated whether the technitium-99m sestamibi (MIBI) washout rate (WR) would predict mitochondrial damage and myocardial dysfunction in patients with dilated cardiomyopathy (DCM). BACKGROUND: Myocardial mitochondrial damage reduces adenosine triphosphate production, resulting in myocardial dysfunction. Increased myocardial (99m)Tc-MIBI washout is reportedly caused by mitochondrial dysfunction. METHODS: Twenty DCM patients (New York Heart Association functional class I-III) underwent myocardial (99m)Tc-MIBI scintigraphy and cardiac catheterization...
May 14, 2013: Journal of the American College of Cardiology
A Priyadarshini, Anita Saxena, Chetan Patel, Vinod K Paul, Rakesh Lodha, Balram Airan
The outcome of children born with cyanotic congenital heart disease has markedly improved over the years. Follow up is recommended for most post-operated cases as complications may occur over long term. One of the complications is the development of ventricular dysfunction, often seen after a successful Fontan surgery (or one of its modifications) for single ventricle. The aim of this study was to determine the prevalence of myocardial perfusion abnormalities in the ventricular myocardium of asymptomatic patients, older than 8 years of age, who had earlier undergone either a univentricular palliation (modified Fontan procedure) or a biventricular repair for tetralogy of Fallot, more than a year ago...
April 2013: Pediatric Cardiology
Saleh Othman, Abdurrahman Al-Hawas, Rafat Al-Maqtari
OBJECTIVE: To determine the potentials of technitium-99m mercaptoacetyltriglycine (99mTc MAG3) to replace technitium-99m dimercaptosuccinic acid (99mTc DMSA) in assessment of renal cortex and split renal function (SRF). MATERIAL AND METHODS: This a retrospective study in which we reviewed the scintigraphic results of 52 patients with age range of 7 days-10 years (mean, 5.3 years). A total of 104 studies (1 99mTc MAG3 and 1 99mTc DMSA per patient) were performed between 1 January, 2009 and 31 December, 2010 because of various renal disorders...
April 2012: Clinical Nuclear Medicine
Oliver Dudeck, Skadi Wilhelmsen, Gerhard Ulrich, David Löwenthal, Maciej Pech, Holger Amthauer, Jens Ricke
PURPOSE: To evaluate the efficacy of a workflow consisting of repeat assessment in patients planned for yttrium-90 ((90)Y) radioembolization in case of nontarget visceral technetium-99m ((99m)Tc)-macroaggregated albumin (MAA) accumulation despite initial prophylactic coil embolization of nonhepatic arteries. MATERIALS AND METHODS: In 341 patients with primary and secondary liver cancer, pretreatment hepatic angiograms, as well as single-photon emission computed tomography coregistered with magnetic resonance imaging scans, were obtained...
October 2012: Cardiovascular and Interventional Radiology
Ghasem Raziei, Alireza Tavakoli, Shahram Seifollahi Asl, Mahasti Amoiei, Hamid Javadi, Majid Assadi
INTRODUCTION: The aim of the present study was to evaluate the clinical outcome of a normal stress technetium-99m (99mTc)-Sestamibi single photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) with different probabilities of coronary artery disease (CAD). MATERIAL AND METHODS: A total of 1,047 subjects with a normal 99mTc-MIBI SPECT were followed up for one year and hard and soft cardiac events were assessed. Hard cardiac events were defined as cardiac death or non-fatal myocardial infarction (MI)...
July 2011: Perfusion
B A Khaw, J Narula
Antimyosin antibody is highly specific for in vivo delineation of acute myocyte necrosis as only irreversibly damaged myocytes with sarcolemmal disruption will enable access of the administered antibody to the once-privileged intracellular antigen-myosin. Thus, antimyosin radiolabeled with either indium-111 or technitium-99m has been used for the noninvasive diagnosis of myocyte necrosis associated with acute myocardial infarction, myocarditis, heart transplant rejection, as well as in other cardiac disorders such as rheumatic carditis or adriamycin cardiotoxicity...
September 1992: Trends in Cardiovascular Medicine
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