Deepak Sharma, Dipika Maheshwari, Gilphy Philip, Ravish Rana, Shanu Bhatia, Manisha Singh, Reema Gabrani, Sanjeev K Sharma, Javed Ali, Rakesh Kumar Sharma, Shweta Dang
The aim of the present study was to optimize lorazepam loaded PLGA nanoparticles (Lzp-PLGA-NPs) by investigating the effect of process variables on the response using Box-Behnken design. Effect of four independent factors, that is, polymer, surfactant, drug, and aqueous/organic ratio, was studied on two dependent responses, that is, z-average and % drug entrapment. Lzp-PLGA-NPs were successfully developed by nanoprecipitation method using PLGA as polymer, poloxamer as surfactant and acetone as organic phase...
2014: BioMed Research International