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movement diseases

G Maragatham, Shobana Devi
The combination of big data and deep learning is a world-shattering technology that can make a great impact on any industry if used in a proper way. With the availability of large volume of health care datasets and progressions in deep learning techniques, systems are now well equipped in diagnosing many health problems. Utilizing the intensity of substantial historical information in electronic health record (EHR), we built up, a conventional predictive temporal model utilizing recurrent neural systems (RNN) like LSTM and connected to longitudinal time stepped EHR...
March 19, 2019: Journal of Medical Systems
Joachim P Sturmberg
The recent sacking of Peter Gøtzsche from the Cochrane Collaboration Board raised strong responses and highlights the neglected issue about priorities-maintaining the reputation of the organization or vigorously debating the merits of scientific approaches to find answers to complex problems? The Cochrane approach hales the randomized trial (RCT) as the gold standard research approach and affirms that meta-analysis provides the ultimate poof (or platinum standard) to settle contentious issues confronting the clinician...
March 19, 2019: Journal of Evaluation in Clinical Practice
Xiao-Yan Li, Yan-Bin Zhang, Miao Xu, Hong-Rong Cheng, Yi Dong, Wang Ni, Hong-Lei Li, Zhi-Ying Wu
Huntington's disease (HD) is an autosomal dominant degenerative disease that mainly encompasses movement, cognition, and behavioral symptoms. The apolipoprotein E (APOE) gene is thought to be associated with many neurodegenerative diseases. Here, we enrolled a cohort of 223 unrelated Han Chinese patients with HD and 1241 unrelated healthy controls in Southeastern China and analyzed the correlation between APOE genotypes and HD phenotypes. The results showed that the frequency of the E4 allele (7.1%) in HD patients was statistically less than that in controls (12...
March 18, 2019: Neuroscience Bulletin
Nutan Sharma
Background: Dystonia is characterized by sustained or intermittent muscle contractions resulting in abnormal, often repetitive, movements, postures, or both. Neuropathologic research has been essential in understanding the etiology and disease progression of other movement disorders, including Parkinson's disease and cerebellar ataxias. In the field of dystonia, however, research is stymied by the paucity of post-mortem tissue available and the phenotypic heterogeneity found in those with dystonia...
2019: Tremor and Other Hyperkinetic Movements
Laisi Cai, Ye Ma, Shuping Xiong, Yanxin Zhang
Objective: To quantify the concurrent accuracy and the test-retest reliability of a Kinect V2-based upper limb functional assessment system. Approach: Ten healthy males performed a series of upper limb movements, which were measured concurrently with Kinect V2 and the Vicon motion capture system (gold standard). Each participant attended two testing sessions, seven days apart. Four tasks were performed including hand to contralateral shoulder, hand to mouth, combing hair, and hand to back pocket...
2019: Applied Bionics and Biomechanics
Jason K Blackburn, Holly H Ganz, José Miguel Ponciano, Wendy C Turner, Sadie J Ryan, Pauline Kamath, Carrie Cizauskas, Kyrre Kausrud, Robert D Holt, Nils Chr Stenseth, Wayne M Getz
How a disease is transmitted affects our ability to determine R₀, the average number of new cases caused by an infectious host at the onset of an epidemic. R₀ becomes progressively more difficult to compute as transmission varies from directly transmitted diseases to diseases that are vector-borne to environmentally transmitted diseases. Pathogens responsible for diseases with environmental transmission are typically maintained in environmental reservoirs that exhibit a complex spatial distribution of local infectious zones (LIZs)...
March 17, 2019: International Journal of Environmental Research and Public Health
Moiyad Aljehani, Kathleen Madara, Lynn Snyder-Mackler, Cory Christiansen, Joseph A Zeni
BACKGROUND: Although unilateral symptoms and unilateral total knee arthroplasty (TKA) are common, many patients have bilateral radiographic osteoarthritis (OA). Because the contralateral (non-operated) limb is often used as a comparison for clinical and biomechanical outcomes, it is important to know if the presence of OA influences movement patterns in either limb. RESEARCH QUESTION: The purpose of this study was to compare bilateral sagittal plane biomechanics between subjects with and without contralateral knee OA after unilateral TKA...
March 8, 2019: Gait & Posture
Biswanath Dinda, Manikarna Dinda, Goutam Kulsi, Ankita Chakraborty, Subhajit Dinda
Alzheimer's disease (AD) and Parkinson's disease (PD) are the most common age-related neurodegenerative disorders, affecting several millions of aged people globally. Among these disorders, AD is more severe, affecting about 7% of individuals aged 65 and above. AD is primarily a dementia-related disorder from progressive cognitive deterioration and memory impairment, while PD is primarily a movement disorder illness having three major kinesia or movement disorder symptoms, bradykinesia (slowness of movements), hypokinesia (reduction of movement amplitude), and akinesia (absence of normal unconscious movements) along with muscle rigidity and tremor at rest...
March 8, 2019: European Journal of Medicinal Chemistry
Ioannis Mavroudis
Alzheimer's disease (AD) is one of the main causes of dementia in the western world. It is clinically characterized by memory impairment, deterioration of intellectual faculties and loss of professional skills. AD brains exhibit significant atrophy, predominantly in the temporal and parietal lobes, while light microscopy reveals deposition of senile plaques and neurofibrillary degeneration initially in the entorhinal cortex, the hippocampus, and in the acoustic and visual cortices, in the frontal lobe and the cerebellum in the advanced stages...
January 2019: Hellenic Journal of Nuclear Medicine
Jing Wang, Kang Xiao, Wei Zhou, Qi Shi, Xiao Ping Dong
BACKGROUND AND PURPOSE: Gerstmann-Sträussler-Scheinker disease (GSS) with a proline-to-leucine mutation at codon 102 (P102L) in the PRNP gene is the most frequently reported GSS subtype worldwide. This study aimed to determine the epidemiological, clinical, genetic, and laboratory characteristics of 12 Chinese patients with P102L-associated GSS (henceforth P102L GSS). METHODS: The enrolled P102L GSS cases were analyzed according to the diagnostic criteria for Creutzfeldt-Jakob disease (CJD) issued by the China National Health Commission...
March 11, 2019: Journal of Clinical Neurology
Eun Jin Yoon, Jee Young Lee, Hyunwoo Nam, Han Joon Kim, Beomseok Jeon, Jae Min Jeong, Yu Kyeong Kim
BACKGROUND AND PURPOSE: To identify a metabolic network reflecting neurodegeneration in patients with idiopathic rapid eye movement (REM) sleep behavior disorder (iRBD). METHODS: We recruited a prospective cohort comprising patients with de novo Parkinson's disease (PD) with probable REM sleep behavior disorder (PDRBD, n =21), polysomnography-confirmed iRBD patients ( n =28), and age-matched healthy controls (HC) ( n =24). PDRBD-related spatial covariance pattern (PDRBD-RP) were determined from 18F-fluorodeoxyglucose PET images of the PDRBD group and validated by reproduction in a separate PD cohort with polysomnography-confirmed REM sleep behavior disorder ( n =11)...
March 11, 2019: Journal of Clinical Neurology
Pedro Gonzalez-Alegre
During the last two decades, our knowledge on the genetic bases of Mendelian forms of dystonia has expanded significantly. This has translated into the generation of multiple cell and animal models to explore the neurobiological bases of this hyperkinetic movement disorder. A majority of these studies have focused on DYT1 dystonia, caused by dominant mutations in the gene encoding for the protein torsinA. Since its discovery, work in multiple laboratories helped identify the subcellular localization of torsinA, key structural features, functionally important physical interactions and biological pathways and physiological events influenced by torsinA...
March 12, 2019: Neurobiology of Disease
Elan D Louis, Jillian L Joyce, Stephanie Cosentino
INTRODUCTION: Although the hallmark feature of essential tremor (ET) is tremor, there is growing appreciation that cognitive impairment also occurs, including increased prevalence of mild cognitive impairment (MCI) and increased prevalence and incidence of dementia. With emerging knowledge of ET-cognitive impairment, come fundamental questions regarding its course, bases, predictors and clinical outcomes. Studies in the general population and in Parkinson's disease (PD), a related movement disorder, offer a starting point from which to begin filling these clinically important knowledge gaps...
March 1, 2019: Parkinsonism & related Disorders
Murtadha D Hssayeni, Michelle A Burack, Joohi Jimenez-Shahed, Behnaz Ghoraani
BACKGROUND AND OBJECTIVE: Motor fluctuations between akinetic (medication OFF) and mobile phases (medication ON) states are one of the most prevalent complications of patients with Parkinson's disease (PD). There is a need for a technology-based system to provide reliable information about the duration in different medication phases that can be used by the treating physician to successfully adjust therapy. METHODS: Two KinetiSense motion sensors were mounted on the most affected wrist and ankle of 19 PD subjects (age: 42-77, 14 males) and collected movement signals as the participants performed seven daily living activities in their medication OFF and ON phases...
March 12, 2019: Medical Engineering & Physics
Omar K Bangash, Arosha S Dissanayake, Shirley Knight, John Murray, Megan Thorburn, Nova Thani, Arul Bala, Rick Stell, Christopher R P Lind
OBJECTIVEPosterior subthalamic area (PSA) deep brain stimulation (DBS) targeting the zona incerta (ZI) is an emerging treatment for tremor syndromes, including Parkinson's disease (PD) and essential tremor (ET). Evidence from animal studies has indicated that the ZI may play a role in saccadic eye movements via pathways between the ZI and superior colliculus (incerto-collicular pathways). PSA DBS permitted testing this hypothesis in humans.METHODSSixteen patients (12 with PD and 4 with ET) underwent DBS using the MRI-directed implantable guide tube technique...
March 15, 2019: Journal of Neurosurgery
F Visser, L J Bour, Y X Lee, T R Ten Brinke, A F van Rootselaar
OBJECTIVE: To show that eye movement abnormalities differ between essential tremor (ET) and tremor dominant Parkinson's disease (PD-T), and that these abnormalities reflect cerebellar dysfunction in ET and basal ganglia pathology in PD-T. METHODS: In this exploratory study, in 23 patients with ET, 21 age-matched patients with PD-T, and 19 age-matched healthy controls (HCs), we investigated visually guided saccades, antisaccades, and smooth pursuit eye movements (SPEM)...
February 23, 2019: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
Andrea Z LaCroix, John Bellettiere, Eileen Rillamas-Sun, Chongzhi Di, Kelly R Evenson, Cora E Lewis, David M Buchner, Marcia L Stefanick, I-Min Lee, Dori E Rosenberg, Michael J LaMonte
Importance: To our knowledge, no studies have examined light physical activity (PA) measured by accelerometry and heart disease in older women. Objective: To investigate whether higher levels of light PA were associated with reduced risks of coronary heart disease (CHD) or cardiovascular disease (CVD) in older women. Design, Setting, and Participants: Prospective cohort study of older women from baseline (March 2012 to April 2014) through February 28, 2017, for up to 4...
March 1, 2019: JAMA network open
Jiaxin Liu, Li Chen, Xin Duan, Zhou Xiang
Objective: To evaluate the effect of early preoperative mobilization on the rehabilitation of the elderly patients with hip fractures after operation. Methods: The clinical data of 16 elderly patients with hip fractures between February 2017 and April 2018 who met the selection criteria was retrospectively analyzed. There were 8 males and 8 females, with an average age of 80.3 years (range, 69-90 years). There were 8 cases of intertrochanteric fracture and 8 cases of femoral neck fracture...
March 1, 2019: Chinese Journal of Reparative and Reconstructive Surgery
Guido Miccinesi, Augusto Caraceni, Ferdinando Garetto, Giovanni Zaninetta, Raffaella Bertè, Chiara M Broglia, Bruno Farci, P Lora Aprile, Massimo Luzzani, Annamaria M Marzi, Sebastiano Mercadante, Luigi Montanari, Matteo Moroni, Elena Piazza, Cristina Pittureri, Davide Tassinari, Leonardo Trentin, Adriana Turriziani, Vittorina Zagonel, Marco Maltoni
This paper is aimed at focusing on the writings and the experience of the Hospice movemente Founder, Dame Cicely Saunders. The in-depth analysis carried out had the objective of verifying if "the way" of Cicely to understand, live and propose palliative care was still current and "beautiful", so that we can nowadays refer to her fascinating "Original Palliative Care". With "beauty" we mean, on the one hand, a way able to allow a personal path of research of the meaning of the disease and of the care, both for those who care and for those who are cared for...
March 14, 2019: Journal of Palliative Care
Adrienne Henderson-Smith, Kathleen M Fisch, Jianping Hua, Ganqiang Liu, Eugenia Ricciardelli, Kristen Jepsen, Mathew Huentelman, Gabriel Stalberg, Steven D Edland, Clemens R Scherzer, Travis Dunckley, Paula Desplats
Parkinson's Disease (PD) is a common neurodegenerative disorder currently diagnosed based on the presentation of characteristic movement symptoms. Unfortunately, patients exhibiting these symptoms have already undergone significant dopaminergic neuronal loss. Earlier diagnosis, aided by molecular biomarkers specific to PD, would improve overall patient care. Epigenetic mechanisms, which are modified by both environment and disease pathophysiology, are emerging as important components of neurodegeneration. Alterations to the PD methylome have been reported in epigenome-wide association studies...
March 14, 2019: Epigenetics: Official Journal of the DNA Methylation Society
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