keyword
https://read.qxmd.com/read/38535298/effects-of-different-feed-additives-on-intestinal-metabolite-composition-of-weaned-piglets
#1
JOURNAL ARTICLE
Mingxuan Zhao, Jian Zhang, Fuzhou Liu, Lv Luo, Mingbang Wei, Yourong Ye, Chamba Yangzom, Peng Shang
To study the effects of different feed additives on the weaning stress of Tibetan piglets, we selected 28 healthy, 30-day-old Tibetan weaned piglets and divided them into four groups, namely, the control group (basal feed without any antibiotic additions) (Nor), the group with the addition of the antibiotic lincomycin (Ant), the group with the addition of fifteen-flavor black pills of Tibetan medicine (Tib), and the group with the addition of fecal bacterial supernatant (Fec). We measured growth performance, blood physiological indexes, and metabolomics...
February 26, 2024: Metabolites
https://read.qxmd.com/read/38534039/a-narrative-review-of-periodic-breathing-during-sleep-at-high-altitude-from-acclimatizing-lowlanders-to-adapted-highlanders
#2
JOURNAL ARTICLE
Alexander Patrician, James D Anholm, Philip N Ainslie
Periodic breathing during sleep at high altitude is almost universal among sojourners. Here, in the context of acclimatization and adaptation, we provide a contemporary review on periodic breathing at high altitude, and explore whether this is an adaptive or maladaptive process. The mechanism(s), prevalence and role of periodic breathing in acclimatized lowlanders at high altitude are contrasted with the available data from adapted indigenous populations (e.g. Andean and Tibetan highlanders). It is concluded that (1) periodic breathing persists with acclimatization in lowlanders and the severity is proportional to sleeping altitude; (2) periodic breathing does not seem to coalesce with poor sleep quality such that, with acclimatization, there appears to be a lengthening of cycle length and minimal impact on the average sleeping oxygen saturation; and (3) high altitude adapted highlanders appear to demonstrate a blunting of periodic breathing, compared to lowlanders, comprising a feature that withstands the negative influences of chronic mountain sickness...
March 27, 2024: Journal of Physiology
https://read.qxmd.com/read/38533641/mechanisms-underpinning-sympathoexcitation-in-hypoxia
#3
JOURNAL ARTICLE
Lydia L Simpson, Mike Stembridge, Christoph Siebenmann, Jonathan P Moore, Justin S Lawley
Sympathoexcitation is a hallmark of hypoxic exposure, occurring acutely, as well as persisting in acclimatised lowland populations and with generational exposure in highland native populations of the Andean and Tibetan plateaus. The mechanisms mediating altitude sympathoexcitation are multifactorial, involving alterations in both peripheral autonomic reflexes and central neural pathways, and are dependent on the duration of exposure. Initially, hypoxia-induced sympathoexcitation appears to be an adaptive response, primarily mediated by regulatory reflex mechanisms concerned with preserving systemic and cerebral tissue O2 delivery and maintaining arterial blood pressure...
March 27, 2024: Journal of Physiology
https://read.qxmd.com/read/38530279/unusual-immunosuppressive-pyridine-containing-bisnor-c-23-tetranor-c-21-and-pentanor-c-20-sesterterpenoids-from-tibetan-leucosceptrum-canum
#4
JOURNAL ARTICLE
Man Li, Ling Feng, Han Zhang, Yan-Chun Liu, Ting-Ting Zhou, Yu Zheng, Kai Guo, Yan Liu, Sheng-Hong Li
An unusual pyridine-containing sesterterpenoid, leucosceptrodine (1), and five new nor -leucosceptrane sesterterpenoids, including bisnor - (C23 , 2), tetranor - (C21 , 3) and pentanor - (C20 , 4-6) skeletons, were isolated from the leaves of Tibetan Leucosceptrum canum . Their structures including their absolute configurations were determined by extensive spectroscopic analyses and quantum chemical calculations. A single crystal of one epimer (5) was crystallized from a pair of inseparable epimers, and its structure including its absolute configuration was determined by X-ray crystallographic analysis...
March 26, 2024: Organic & Biomolecular Chemistry
https://read.qxmd.com/read/38529066/phylogeographic-analysis-reveals-extensive-genetic-variation-of-native-grass-elymus-nutans-poaceae-on-the-qinghai-tibetan-plateau
#5
JOURNAL ARTICLE
Jin Li, Xinda Li, Changbing Zhang, Qingping Zhou, Shiyong Chen
INTRODUCTION: Elymus nutans holds ecological and pastoral significance due to its adaptability and nutritional value, the Qinghai-Tibet Plateau (QTP) is a key hub for its genetic diversity. To conserve and harness its genetic resources in highland ecosystems, a thorough assessment is vital. However, a comprehensive phylogeographic exploration of E. nutans is lacking. The objective of this study was to unravel the genetic diversity, adaptation, and phylogenetics of E. nutans populations...
2024: Frontiers in Plant Science
https://read.qxmd.com/read/38527718/microbial-difference-and-its-influencing-factors-in-ice-covered-lakes-on-the-three-poles
#6
JOURNAL ARTICLE
Min Cai, Beichen Wang, Jibin Han, Jian Yang, Xiying Zhang, Xiangyu Guan, Hongchen Jiang
Most lakes in the world are permanently or seasonally covered with ice. However, little is known about the distribution of microbes and their influencing factors in ice-covered lakes worldwide. Here we analyzed the microbial community composition in the waters of 14 ice-covered lakes in the Hoh Xil region of northern Qinghai-Tibetan Plateau (QTP), and conducted a meta-analysis by integrating published microbial community data of ice-covered lakes in the tripolar regions (the Arctic, Antarctica and QTP). The results showed that there were significant differences in microbial diversity, community composition and distribution patterns in the ice-covered tripolar lakes...
March 23, 2024: Environmental Research
https://read.qxmd.com/read/38524764/-methylomonadaceae-was-the-active-and-dominant-methanotroph-in-tibet-lake-sediments
#7
JOURNAL ARTICLE
Yongcui Deng, Chulin Liang, Xiaomeng Zhu, Xinshu Zhu, Lei Chen, Hongan Pan, Fan Xun, Ye Tao, Peng Xing
Methane (CH4 ), an important greenhouse gas, significantly impacts the local and global climate. Our study focused on the composition and activity of methanotrophs residing in the lakes on the Tibetan Plateau, a hotspot for climate change research. Based on the field survey, the family Methylomonadaceae had a much higher relative abundance in freshwater lakes than in brackish and saline lakes, accounting for ~92% of total aerobic methanotrophs. Using the microcosm sediment incubation with 13 CH4 followed by high throughput sequencing and metagenomic analysis, we further demonstrated that the family Methylomonadaceae was actively oxidizing CH4 ...
January 2024: ISME Commun
https://read.qxmd.com/read/38524406/provenance-analysis-in-the-nima-basin-during-paleogene-and-its-implications-for-the-decline-of-the-tibetan-central-valley
#8
JOURNAL ARTICLE
Yuhang Luo, Wentian Mi, Yuan Gao, Luqing Qin
It is unclear what caused the Bangong Nujiang suture zone in the central Tibetan plateau to rise from less than 2 km in early Cenozoic to more than 4 km at present. The zircon U-Pb ages and trace elements of samples from the Niubao Formation in the Paleogene of the Nima basin were analyzed and tested. Combined with the isostasy theory, the surface uplift height of the Nima Basin during the Cenozoic period was calculated. The zircon U-Pb age results of the Niubao formation are consistent with the ages of the Lhasa terrane on the south side of the basin, the Qiangtang terrane on the north side, and the uplift in central...
March 19, 2024: ACS Omega
https://read.qxmd.com/read/38522625/effects-of-tibetan-medicine-longdan-zhike-tablet-on-chronic-obstructive-pulmonary-disease-through-mapk-pathway
#9
JOURNAL ARTICLE
Yulin Feng, Pengfei Qin, Rong Wang, Yahui Mi, You Li, Jiahao Feng, Wenbin Shen, Haijuan Dong, Jietai Duo, Liming Ma, Xiaowu Yao, Xiaolong Hu, Fei Xiong, Xinhong Shi, Hao Wang
ETHNOPHARMACOLOGICAL RELEVANCE: Longdan zhike tablet (LDZK) is a Tibetan medicine formula commonly used in the highland region of Tibet, China, to ameliorate respiratory diseases, such as acute bronchitis and asthma. In Chinese traditional medicine, some herbal formulas with anti-inflammatory properties targeting the respiratory system are clinically adopted as supplementary therapies for chronic obstructive pulmonary disease (COPD). However, the specific anti-COPD effects of LDZK remain to be evaluated...
March 22, 2024: Journal of Ethnopharmacology
https://read.qxmd.com/read/38521984/bacterial-diversity-in-a-continuum-from-supraglacial-habitats-to-a-proglacial-lake-on-the-tibetan-plateau
#10
JOURNAL ARTICLE
Tingting Xing, Keshao Liu, Mukan Ji, Yuying Chen, Yongqin Liu
Mountain glaciers are frequently assessed for their hydrological connectivity from glaciers to proglacial lakes. Ecological process on glacier surfaces and downstream ecosystems have often been investigated separately, but few studies have focused on the connectivity between the different glacial habitats. Therefore, it remains a limited understanding of bacterial community assembly across different habitats along the glacier hydrological continuum. In this study, we sampled along a glacial catchment from supraglacial snow, cryoconite holes, supraglacial runoff, ice-marginal moraine and proglacial lake on the Tibetan Plateau...
March 23, 2024: FEMS Microbiology Letters
https://read.qxmd.com/read/38521805/assessing-the-spatial-occupation-and-ecological-impact-of-human-activities-in-chengguan-district-lhasa-city-tibetan-plateau
#11
JOURNAL ARTICLE
Lin Xu, Yong Xu, Jian Duan, Yingying Wang, Hua Yang
In this study, the ecological impact of human activities and the space occupied by construction and arable land on the Tibetan Plateau were examined, focusing on changes in the net primary productivity (NPP) as a key indicator of ecological health. With the utilization of land use data and multiyear average NPP data from 2002 to 2020, we analyzed the effects of the conversion of zonal vegetation into construction and arable land on carbon sequestration and oxygen release in Chengguan District, Lhasa city. Our findings indicated a marked spatial difference in the NPP among different land types...
March 23, 2024: Scientific Reports
https://read.qxmd.com/read/38521775/the-role-of-mountains-in-shaping-the-global-meridional-overturning-circulation
#12
JOURNAL ARTICLE
Haijun Yang, Rui Jiang, Qin Wen, Yimin Liu, Guoxiong Wu, Jiangping Huang
The meridional overturning circulation (MOC) in the ocean is a key player in the global climate system, while continental topography provides an essential backdrop to the system. In this study, we design a series of coupled model sensitivity experiments to investigate the influence of various mountain ranges on the global thermohaline circulation. The results highlight the influence of the Tibetan Plateau (TP) on the global thermohaline circulation. It emerges as a requisite for establishing the Atlantic MOC (AMOC) and a determining factor for the cessation of the Pacific MOC (PMOC)...
March 23, 2024: Nature Communications
https://read.qxmd.com/read/38521264/strong-associations-between-dissolved-organic-matter-and-microbial-communities-in-the-sediments-of-qinghai-tibetan-plateau-lakes-depend-on-salinity
#13
JOURNAL ARTICLE
Peilian Zhang, Hanxiao Zhang, Yi Li, Jingtian Zhang, Chunzi Ma, Nanyan Weng, Xing Gao, Fengchang Wu, Shouliang Huo
In aquatic ecosystems, dissolved organic matter (DOM) plays a vital role in microbial communities and the biogeochemical cycling of elements. However, little is known about the associations between DOM and microbial communities in lake sediments. This study investigated the composition of water-extractable organic matter and microbial communities in surface sediments of lakes with different salinities on the Qinghai-Tibet Plateau. Ultrahigh-resolution mass spectrometry and high-throughput microbial sequencing techniques were employed to assess the associations between molecular diversity and microbial diversity and the effects of salinity in 19 lakes spanning a salinity range from 0...
March 21, 2024: Science of the Total Environment
https://read.qxmd.com/read/38520902/targeted-and-untargeted-metabolomics-reveals-meat-quality-in-grazing-yak-during-different-phenology-periods-on-the-qinghai-tibetan-plateau
#14
JOURNAL ARTICLE
Tongqing Guo, Qian Zhang, Xungang Wang, Xianli Xu, Yalin Wang, Lin Wei, Na Li, Hongjin Liu, Linyong Hu, Na Zhao, Shixiao Xu
Yak meat is more popular among consumers because of its high nutritional value, but little attention has been paid to its meat quality, which is affected by different phenology periods grass. We hypothesized that seasonal variations in grass composition influenced the ruminal bacteria community, and eventually affected the meat quality of yaks. This study aims to investigate the relationship of meat quality in grazing yak as well as the key rumen bacteria using targeted and untargeted metabolomics and 16S rRNA during different phenology periods...
February 27, 2024: Food Chemistry
https://read.qxmd.com/read/38520840/subtypes-of-blastocystis-in-tibetan-antelope-pantholops-hodgsonii
#15
JOURNAL ARTICLE
Wei-Lan Yan, Xiao-Man Li, Si-Yuan Qin, Nian-Yu Xue, Yang Zou, Jing-Hao Li, Xiao-Xuan Zhang, Hong-Bo Ni
Blastocystis is a protist that is distributed in the gut tract of humans and animals. However, the reports about Blastocystis infection in Tibetan antelope are scarce. We collected 173 Tibetan antelope feces samples from Xinjiang, Qinghai and Xizang, and amplified the SSU rRNA gene of 600 bp region of Blastocystis in our research. Fifty-one samples in total were positive for Blastocystis, with all subtypes being ST31. The lowest prevalence of Blastocystis was observed in Xizang (2/20, 9.1%), followed by Qinghai (18/92, 16...
March 20, 2024: Research in Veterinary Science
https://read.qxmd.com/read/38519940/total-iridoid-glycoside-extract-of-lamiophlomis-rotata-benth-kudo-accelerates-diabetic-wound-healing-by-the-nrf2-cox2-axis
#16
JOURNAL ARTICLE
Xiaoyu Geng, Ying Wang, Huan Li, Liang Song, Chen Luo, Xiaojie Gu, Haixin Zhong, Huilin Chen, Xinzhu Chen, Jianwei Wang, Zheng Pan
BACKGROUND: Lamiophlomis rotata (Benth.) Kudo (L. rotata), the oral Traditional Tibetan herbal medicine, is adopted for treating knife and gun wounds for a long time. As previously demonstrated, total iridoid glycoside extract of L. rotata (IGLR) induced polarization of M2 macrophage to speed up wound healing. In diabetic wounds, high levels inflammatory and chemotactic factors are usually related to high reactive oxygen species (ROS) levels. As a ROS target gene, nuclear factor erythroid 2-related factor 2 (NRF2), influences the differentiation of monocytes to M1/M2 macrophages...
March 22, 2024: Chinese Medicine
https://read.qxmd.com/read/38518405/comparative-analysis-of-the-clinical-features-of-nonvalvular-atrial-fibrillation-among-tibetan-han-and-hui-patients-in-qinghai-province-china
#17
JOURNAL ARTICLE
Jiandong Cao, Xiaofeng Ma, Yong Deng, Hong Wang, Shengqi Zhang, Longxiang Zhao, Feifei Cao
Global nonvalvular AF rises, impacting health severely. In Qinghai, China's diverse setting, studying AF among varied ethnic groups is crucial OBJECTIVES: The purpose of this study was to compares cardiac features in AF among Tibetan, Han, and Hui patients to develop tailored prevention and treatment strategies for this region, the goal was to enhance the understanding of AF and provide an empirical basis for developing prevention and treatment strategies specific to this region METHODS: This study included a total of 3445 Tibetan, Han, and Hui patients diagnosed with nonvalvular atrial fibrillation and treated at the Qinghai Cardiovascular and Cerebrovascular Specialist Hospital, China, between January 2019 and January 2021...
March 21, 2024: Heart & Lung: the Journal of Critical Care
https://read.qxmd.com/read/38513855/atmospheric-precipitation-chemistry-and-environmental-significance-in-major-anthropogenic-regions-globally
#18
JOURNAL ARTICLE
Lanping Si, Zongxing Li
In order to investigate the spatiotemporal distribution and influencing factors of global precipitation chemistry, we conducted a comprehensive analysis using multiple data sources, revealing the impact of human activities on the natural environment. The results indicate a decreasing trend in global precipitation acidity over the past 20 years. The distribution of global precipitation is influenced by both natural and anthropogenic factors. Alkaline cation concentrations are higher in desert and arid regions, while high concentrations of SO4 2- and NO3 - are primarily found in industrial areas, and agricultural areas exhibit higher NH4 + concentrations...
March 19, 2024: Science of the Total Environment
https://read.qxmd.com/read/38513851/the-seasonal-variability-of-future-evapotranspiration-over-china-during-the-21st-century
#19
JOURNAL ARTICLE
Shan Lin, Xiangyang Sun, Kewei Huang, Chunlin Song, Juying Sun, Shouqin Sun, Genxu Wang, Zhaoyong Hu
The evapotranspiration (ET) plays a crucial role in shaping regional climate patterns and serves as a vital indicator of ecosystem function. However, there remains a limited understanding of the seasonal variability of future ET over China and its correlation with environmental drivers. This study evaluated the skills of 27 models from the Six Phase of Coupled Model Intercomparison Project in modeling ET and the Bayesian Model Averaging (BMA) method was employed to merge monthly simulated ET based on the top five best-performing models...
March 19, 2024: Science of the Total Environment
https://read.qxmd.com/read/38503156/rhodiola-crenulata-alleviates-hypobaric-hypoxia-induced-brain-injury-by-maintaining-bbb-integrity-and-balancing-energy-metabolism-dysfunction
#20
JOURNAL ARTICLE
Ya Hou, Fuhan Fan, Na Xie, Yi Zhang, Xiaobo Wang, Xianli Meng
BACKGROUND/PURPOSE: Rhodiola crenulata (Hook. f. et Thoms.) H. Ohba (R. crenulate), a famous and characteristic Tibetan medicine, has been demonstrated to exert an outstanding brain protection role in the treatment of high-altitude hypoxia disease. However, the metabolic effects of R. crenulate on high-altitude hypoxic brain injury (HHBI) are still incompletely understood. Herein, the anti-hypoxic effect and associated mechanisms of R. crenulate were explored through both in vivo and in vitro experiments...
March 11, 2024: Phytomedicine
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