Yasuyoshi Sato, Ikuo Wada, Kosuke Odaira, Akihiro Hosoi, Yukari Kobayashi, Koji Nagaoka, Takahiro Karasaki, Hirokazu Matsushita, Koichi Yagi, Hiroharu Yamashita, Masashi Fujita, Shuichi Watanabe, Takashi Kamatani, Fuyuki Miya, Junichi Mineno, Hidewaki Nakagawa, Tatsuhiko Tsunoda, Shunji Takahashi, Yasuyuki Seto, Kazuhiro Kakimi
OBJECTIVES: A better understanding of antitumor immunity will help predict the prognosis of gastric cancer patients and tailor the appropriate therapies in each patient. Therefore, we propose a novel immunological classification of gastric cancer. METHODS: We performed whole-exome sequencing (WES), RNA-Seq and flow cytometry in 29 gastric cancer patients who received surgery. The TCGA data set of 323 gastric cancer patients and RNA-Seq data of 45 patients who received pembrolizumab (Kim et al ...
2020: Clinical & Translational Immunology