Jiaming Gu, Jiajing Chen, Quanwen Yin, Mengdie Dong, Yunjia Zhang, Minghong Chen, Xiang Chen, Jiao Min, Xian He, Yongkang Tan, Longbin Zheng, Hong Jiang, Bingjian Wang, Xuesong Li, Hongshan Chen
BACKGROUND: Senescence is a series of degenerative changes in the structure and physiological function of an organism. Whether JPX-a newly identified age-related noncoding RNA by us-is associated with atherosclerosis is still unknown. Our study was to investigate the role of JPX and provide insights into potential therapies targeting atherosclerosis. METHODS: We analyzed clinical data from multiple tissues including meniscus tissue, leukemia cells, and peripheral blood monocytes to identify age-related noncoding RNAs in senescent vascular smooth muscle cells (VSMCs)...
November 9, 2023: Arteriosclerosis, Thrombosis, and Vascular Biology