keyword
https://read.qxmd.com/read/38547218/rosiglitazone-alleviates-lps-induced-endometritis-via-suppression-of-tlr4-mediated-nf-%C3%AE%C2%BAb-activation
#1
JOURNAL ARTICLE
Hongchu Bao, Jianxiang Cong, Qinglan Qu, Shunzhi He, Dongmei Zhao, Huishan Zhao, Shuyuan Yin, Ding Ma
OBJECTIVE: The aim of this study was to investigate the anti-inflammatory effect of Rosiglitazone (RGZ) on lipopolysaccharide (LPS) -induced Endometritis and explore its possible mechanism. METHODS: The preventive and therapeutic effects of RGZ on Endometritis were studied in vivo and in vitro. A total of 40 female C57BL/6 mice were randomly divided into the following 4 groups: RGZ+LPS, RGZ control, LPS and DMSO control. The mice uterine tissue sections were performed with HE and immunohistochemical staining...
2024: PloS One
https://read.qxmd.com/read/38545803/the-small-extracellular-vesicle-mediated-intercellular-transformation-of-cxcr1-low-to-cxcr1-high-tumour-cells-promotes-the-progression-of-head-and-neck-squamous-cell-carcinoma
#2
JOURNAL ARTICLE
Qiaoshi Xu, Aoming Cheng, Bo Li, Xutengyue Tian, Zhengxue Han, Zhien Feng
The heterogeneity of tumour cells enables cancers to dynamically adapt to microenvironmental stresses during progression. However, the mechanism underlying the transformation and intercellular communication between heterogeneous tumour cells has remained elusive. Here, we report a "contagion model" that mediates intercellular transformation between heterogeneous tumour cells which facilitates tumour progression. Initially identifying heterogeneous expression of CXCR1, a receptor for interleukin-8, in head and neck squamous cell carcinoma (HNSCC) tumour cells, we found that CXCR1High tumour cells had higher abilities for migration and invasion...
April 2024: Journal of Extracellular Vesicles
https://read.qxmd.com/read/38543188/chlojaponilactone-b-attenuates-thp-1-macrophage-pyroptosis-by-inhibiting-the-tlr-myd88-nf-%C3%AE%C2%BAb-pathway
#3
JOURNAL ARTICLE
Qiyin Wen, Bingjinfeng Zhan, Lu Jin, Zijing Peng, Ju Liu, Longping Zhu, Depo Yang, Xinjun Xu, Lixia Zhang, Ge Li, Zhimin Zhao
Pyroptosis, an innate immune response, plays a crucial role in the pathological process of inflammatory diseases. Although pyroptosis blockade is considered a potential therapeutic strategy, no ideal candidate drug has been identified. The natural product Chojaponilactone B (CJB) has demonstrated anti-inflammatory effects, but its role in macrophage pyroptosis has not been studied. This study aimed to investigate the effect and mechanism of CJB in inhibiting macrophage pyroptosis. Using an LPS/ATP-induced THP-1 macrophage pyroptosis model, we found that CJB significantly inhibited pyroptosis and reduced the levels of NLRP3, caspase 1, N-GSDMD, and inflammatory cytokines IL-1β and IL-18...
March 21, 2024: Pharmaceuticals
https://read.qxmd.com/read/38542876/saponins-from-allium-macrostemon-bulbs-attenuate-endothelial-inflammation-and-acute-lung-injury-via-the-nf-%C3%AE%C2%BAb-vcam-1-pathway
#4
JOURNAL ARTICLE
Li Liu, Liang Qiu, Jing Xue, Chao Zhong, Manman Qin, Yifeng Zhang, Chuanming Xu, Yanfei Xie, Jun Yu
Endothelial inflammation is a multifaceted physiological process that plays a pivotal role in the pathogenesis and progression of diverse diseases, encompassing but not limited to acute lung infections like COVID-19, coronary artery disease, stroke, sepsis, metabolic syndrome, certain malignancies, and even psychiatric disorders such as depression. This inflammatory response is characterized by augmented expression of adhesion molecules and secretion of pro-inflammatory cytokines. In this study, we discovered that saponins from Allium macrostemon bulbs (SAMB) effectively inhibited inflammation in human umbilical vein endothelial cells induced by the exogenous inflammatory mediator lipopolysaccharide or the endogenous inflammatory mediator tumor necrosis factor-α, as evidenced by a significant reduction in the expression of pro-inflammatory factors and vascular cell adhesion molecule-1 (VCAM-1) with decreased monocyte adhesion...
March 11, 2024: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/38542434/neuroprotective-effects-of-aucubin-against-cerebral-ischemia-and-ischemia-injury-through-the-inhibition-of-the-tlr4-nf-%C3%AE%C2%BAb-inflammatory-signaling-pathway-in-gerbils
#5
JOURNAL ARTICLE
Joon Ha Park, Tae-Kyeong Lee, Dae Won Kim, Ji Hyeon Ahn, Myoung Cheol Shin, Jun Hwi Cho, Moo-Ho Won, Il Jun Kang
Aucubin, an iridoid glycoside, possesses beneficial bioactivities in many diseases, but little is known about its neuroprotective effects and mechanisms in brain ischemia and reperfusion (IR) injury. This study evaluated whether aucubin exhibited neuroprotective effects against IR injury in the hippocampal CA1 region through anti-inflammatory activity in gerbils. Aucubin (10 mg/kg) was administered intraperitoneally once a day for one week prior to IR. Neuroprotective effects of aucubin were assessed by neuronal nuclei (NeuN) immunofluorescence and Floro-Jade C (FJC) histofluorescence...
March 19, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38539828/chemical-characterization-of-honeysuckle-polyphenols-and-their-alleviating-function-on-ultraviolet-b-damaged-hacat-cells-by-modulating-the-nrf2-nf-%C3%AE%C2%BAb-signaling-pathways
#6
JOURNAL ARTICLE
Shuo-Lei Zheng, Yu-Mei Wang, Chang-Feng Chi, Bin Wang
Scientific evidence attests that the epidermis receives excessive ultraviolet B (UVB) radiation, triggering the generation of substantial quantities of reactive oxygen species (ROS), which disrupted the delicate equilibrium of oxidation-reduction, leading to oxidative stress and inflammation. The historical use of honeysuckle polyphenols (HPs) has garnered our attention due to their efficacy in inhibiting oxidative damage. In this study, HPs were prepared from honeysuckle flowers employing an ultrasonic-assisted extraction method and quantitatively analyzed by a LC-MS/MS, and the mechanisms underlying HPs' antioxidative and anti-inflammatory effects on a UVB-irradiated HaCaT cell model were systematically investigated...
February 28, 2024: Antioxidants (Basel, Switzerland)
https://read.qxmd.com/read/38535478/effect-of-ishige-okamurae-extract-on-osteoclastogenesis-in-vitro-and-in-vivo
#7
JOURNAL ARTICLE
Su-Hyeon Cho, Hyun-Soo Kim, Juhee Ahn, Bomi Ryu, Jun-Geon Jea, Kyubin Lee, Kyunghwan Kim, Ginnae Ahn, WonWoo Lee, Kyung-Min Choi, Kil-Nam Kim
We demonstrated the effect of Ishige okamurae extract (IOE) on the receptor activator of nuclear factor-κB ligand (RANKL)-promoted osteoclastogenesis in RAW 264.7 cells and confirmed that IOE inhibited RANKL-induced tartrate-resistant acid phosphatase (TRAP) activity and osteoclast differentiation. IOE inhibited protein expression of TRAP, metallopeptidase-9 (MMP-9), the calcitonin receptor (CTR), and cathepsin K (CTK). IOE treatment suppressed the expression of activated T cell cytoplasmic 1 and activator protein-1, thus controlling the expression of osteoclast-related factors...
March 20, 2024: Marine Drugs
https://read.qxmd.com/read/38531802/formononetin-restrains-tumorigenesis-of-breast-tumor-by-restraining-sting-nf-%C3%AE%C2%BAb-and-interfering-with-the-activation-of-pd-l1
#8
JOURNAL ARTICLE
Hongmei Liu, Zhipeng Wang, Zhigang Liu
BACKGROUND: Breast cancer (BC), a common tumor in women, has high morbidity and mortality. Formononetin, an active ingredient in red clover and Astragalus membranaceus , has a wide range of pharmacological applications, including as an anticancer agent. Since immunotherapy is a hot topic in the treatment strategy of BC, it was dedicated to appraising the specific mechanism of formononetin in BC immunotherapy in this research. METHODS: Different formononetin concentrations (0, 20, 40, 60, 80, 100 μM) were used to treat BC cells transfected with pcDNA3...
March 2024: Discovery Medicine
https://read.qxmd.com/read/38531792/upregulated-atf1-promotes-lipopolysaccharide-induced-inflammatory-response-and-inhibits-osteogenic-differentiation-of-human-periodontal-ligament-cells-by-regulating-nf-%C3%AE%C2%BAb-pathway
#9
JOURNAL ARTICLE
Wei Guo, Shuyun Yan, Ge Zhao
BACKGROUND: Periodontitis is a chronic inflammatory disease resulting from bacterial plaque infection. While the involvement of activating transcription factor 1 (ATF1) has been extensively explored in various human diseases, its specific role in periodontitis remains unclear. This study aims to elucidate the expression and biological function of ATF1 in the context of periodontitis. METHODS: Primary human periodontal ligament cells (hPDLCs) were procured from clinical samples and subsequently characterized...
March 2024: Discovery Medicine
https://read.qxmd.com/read/38529553/huperzine-a-ameliorates-neurological-deficits-after-spontaneous-subarachnoid-hemorrhage-through-endothelial-cell-pyroptosis-inhibition
#10
JOURNAL ARTICLE
Qiang Hu, Rong Zhang, Xiaoqiao Dong, Dingbo Yang, Wenhua Yu, Quan Du
Spontaneous subarachnoid hemorrhage (SAH) is a kind of hemorrhagic stroke which causes neurological deficits in survivors. Huperzine A has a neuroprotective effect, but its role in SAH is unclear. Therefore, we explore the effect of Huperzine A on neurological deficits induced by SAH and the related mechanism. In this study, Evans blue assay, TUNEL staining, immunofluorescence, western blot analysis, and ELISA are conducted. We find that Huperzine A can improve neurological deficits and inhibit the apoptosis of nerve cells in SAH rats...
March 26, 2024: Acta Biochimica et Biophysica Sinica
https://read.qxmd.com/read/38527574/xiaoer-niuhuang-qingxin-powder-alleviates-influenza-a-virus-infection-by-inhibiting-the-activation-of-the-tlr4-myd88-nf%C3%AE%C2%BAb-signaling-pathway
#11
JOURNAL ARTICLE
Lanying Ma, Tong Wang, Meiyi Liu, Lingyun Ji, Yanan Wang, Shuting Li, YaNan Zhang, Yuan Wang, WenXiao Zhao, ZhiChun Wu, HuaYun Yu, HaiJun Zhao
ETHNOPHARMACOLOGICAL RELEVANCE: Xiaoer Niuhuang Qingxin Powder (XNQP) is a classic traditional Chinese medicine formula with significant clinical efficacy for treating febrile convulsions and influenza. AIM OF THE STUDY: This study aims to explore the potential mechanisms of XNQP in combating combating the influenza A virus, providing a theoretical basis for its clinical application. MATERIALS AND METHODS: The present investigation employed network pharmacology and bioinformatics analysis to determine the TLR4/MYD88/NF-κB signaling pathway as a viable target for XNQP intervention in IAV infection...
March 23, 2024: Journal of Ethnopharmacology
https://read.qxmd.com/read/38527438/demethylzeylasteral-t-96-alleviates-allergic-asthma-via-inhibiting-mapk-erk-and-nf-%C3%AE%C2%BAb-pathway
#12
JOURNAL ARTICLE
Jianan Huang, Hui Cai, Xiaofen Ye, Ge Zhang, Ling Ye, Chunxin Yang, Jian Wang, Meiling Jin
INTRODUCTION: Demethylzeylasteral (T-96), a new extract of Tripterygium wilfordii Hook F, exerted immunomodulatory properties in autoimmune diseases, but its effect on airway inflammatory diseases remains unclear. Our study aims to explore the protective effect and underlying mechanism of T-96 in allergic asthma. METHODS: The OVA-induced asthmatic mice were administered by gavage with T-96 (0.1 mg/10 g, 0.3 mg/10 g, or 0.6 mg/10 g) 1 h before each challenge. The airway hyperresponsiveness was assessed, pathological changes were evaluated by HE and PAS staining, and expressions of Th2 cytokines were determined by PCR and ELISA...
March 25, 2024: International Archives of Allergy and Immunology
https://read.qxmd.com/read/38522392/discovery-of-potential-components-characteristic-by-conjugated-enone-from-the-branches-and-leaves-of-croton-lauioides-with-anti-neuroinflammatory-activity-via-regulating-the-nf-%C3%AE%C2%BAb-pathway
#13
JOURNAL ARTICLE
Yue Jin, Zongxin Guo, Huilin Zhu, Zixuan Zhang, Xiaowen Jiang, Yiren Yang, Pengyu Liu, Yu Yang, Miao Wang, Huiyuan Gao
In this study, the chemical composition and pharmacological activity of Croton lauioides were investigated for the first time. The bioactive and HPLC-UV guided isolation led to the discovery of twenty-three conjugated enone-type components (1-23), including nine previously unknown sesquiterpenoid derivatives (1-4, 9-10, 12-14). Notably, compounds 1 and 12 are epoxides containing an endoperoxide bridge (1) or a unique dioxaspiro core (12), respectively. Compounds 2-7 are non-benzenoid aromatics featuring a tropone function, while 9-11 possess a rare rearranged scaffold with tropone shift into benzene...
March 20, 2024: Bioorganic Chemistry
https://read.qxmd.com/read/38520693/matrilin-3-supports-neuroprotection-in-ischemic-stroke-by-suppressing-astrocyte-mediated-neuroinflammation
#14
JOURNAL ARTICLE
Xianyong Zhou, Yongming Zhu, Defei Gao, Min Li, Liang Lin, Zhanxiang Wang, Huaping Du, Yuan Xu, Jin Liu, Yang He, Yi Guo, Shuai Wang, Shigang Qiao, Yingshi Bao, Yuan Liu, Huiling Zhang
In the brain, the role of matrilin-3, an extracellular matrix component in cartilage, is unknown. Here, we identify that matrilin-3 decreased in reactive astrocytes but was unchanged in neurons after ischemic stroke in animals. Importantly, it declined in serum of patients with acute ischemic stroke. Genetic or pharmacological inhibition or supplementation of matrilin-3 aggravates or reduces brain injury, astrocytic cell death, and glial scar, respectively, but has no direct effect on neuronal cell death. RNA sequencing demonstrates that Matn3-/- mice display an increased inflammatory response profile in the ischemic brain, including the nuclear factor κB (NF-κB) signaling pathway...
March 21, 2024: Cell Reports
https://read.qxmd.com/read/38520399/inhibition-of-nf-%C3%AE%C2%BAb-mediated-proinflammatory-transcription-by-ru-ii-complexes-of-anti-angiogenic-ligands-in-triple-negative-breast-cancer
#15
JOURNAL ARTICLE
Ayan Chakraborty, Shilpendu Ghosh, Manas Pratim Chakraborty, Sujato Mukherjee, Shantanu Saha Roy, Rahul Das, Moulinath Acharya, Arindam Mukherjee
Nuclear factor kappa beta (NF-κB) plays a pivotal role in breast cancer, particularly triple-negative breast cancer, by promoting inflammation, proliferation, epithelial-mesenchymal transition, metastasis, and drug resistance. Upregulation of NF-κB boosts vascular endothelial growth factor (VEGF) expression, assisting angiogenesis. The Ru(II) complexes of methyl- and dimethylpyrazolyl-benzimidazole N , N donors inhibit phosphorylation of ser536 in p65 and translocation of the NF-κB heterodimer (p50/p65) to the nucleus, disabling transcription to upregulate inflammatory signaling...
March 23, 2024: Journal of Medicinal Chemistry
https://read.qxmd.com/read/38518665/intermittent-mild-cold-acclimation-ameliorates-intestinal-inflammation-and-immune-dysfunction-in-acute-cold-stressed-broilers-by-regulating-the-tlr4-myd88-nf-%C3%AE%C2%BAb-pathway
#16
JOURNAL ARTICLE
Yanju Bi, Haidong Wei, Yiwen Chai, Hongyu Wang, Qiang Xue, Jianhong Li
To investigate the potential protective effect of prior cold stimulation on broiler intestine induced by acute cold stress (ACS). A total of 384 one-day-old broilers were divided into control (CON), ACS, cold stimulation Ⅰ (CS3+ACS), and cold stimulation Ⅱ (CS9+ACS) groups. Broilers in CON and ACS groups were reared normally, and birds in CS3+ACS and CS9+ACS groups were reared at 3℃ and 9℃ below CON group for 5 h, respectively, on alternate days from d 15 to 35. Broilers in ACS, CS3+ACS, and CS9+ACS groups were subjected to 10℃ for 24 h on d 43...
March 8, 2024: Poultry Science
https://read.qxmd.com/read/38516898/diosgenin-protects-against-cationic-bovine-serum-albumin-induced-membranous-glomerulonephritis-by-attenuating-oxidative-stress-and-renal-inflammation-via-the-nf-%C3%AE%C2%BAb-pathway
#17
JOURNAL ARTICLE
Shiyan Jia, Ruihua Si, Guangzhen Liu, Qiming Zhong
CONTEXT: Membranous glomerulonephritis (MGN) is a leading cause of nephrotic syndrome in adults. Diosgenin (DG) has been reported to exert antioxidative and anti-inflammatory effects. OBJECTIVE: To investigate the renoprotective activity of DG in a cationic bovine serum albumin-induced rat model of MGN. MATERIALS AND METHODS: Fourty male Sprague-Dawley rats were randomized into four groups. The MGN model was established and treated with a DG dose (10 mg/kg) and a positive control (TPCA1, 10 mg/kg), while normal control and MGN groups received distilled water by gavage for four consecutive weeks...
December 2024: Pharmaceutical Biology
https://read.qxmd.com/read/38516705/gallic-acid-attenuates-lps-induced-inflammation-in-caco-2-cells-by-suppressing-the-activation-of-the-nf-%C3%AE%C2%BAb-mapk-signaling-pathway
#18
JOURNAL ARTICLE
Chu Chu, Huan Ru, Yuyan Chen, Jinhua Xu, Caihong Wang, Yuanxiang Jin
Inflammatory bowel disease (IBD) is a chronic inflammatory disease characterized by intestinal barrier dysfunction, inflammatory synergistic effects and excessive tissue injury. Gallic acid (GA) is renowned for its remarkable biological activity, encompassing anti-inflammatory and antioxidant properties. However, the underlying mechanisms by which GA protects against intestinal inflammation have not been fully elucidated. The aim of this study is to investigate the effect of GA on the inflammation of a lipopolysaccharide (LPS)-stimulated human colon carcinoma cell line (Caco-2) and on the intestinal barrier dysfunction, and explore the underlying molecular mechanism involved...
March 22, 2024: Acta Biochimica et Biophysica Sinica
https://read.qxmd.com/read/38515015/chromatin-accessibility-and-h3k9me3-landscapes-reveal-long-term-epigenetic-effects-of-fetal-neonatal-iron-deficiency-in-rat-hippocampus
#19
JOURNAL ARTICLE
Shirelle X Liu, Aarthi Ramakrishnan, Li Shen, Jonathan C Gewirtz, Michael K Georgieff, Phu V Tran
BACKGROUND: Iron deficiency (ID) during the fetal-neonatal period results in long-term neurodevelopmental impairments associated with pervasive hippocampal gene dysregulation. Prenatal choline supplementation partially normalizes these effects, suggesting an interaction between iron and choline in hippocampal transcriptome regulation. To understand the regulatory mechanisms, we investigated epigenetic marks of genes with altered chromatin accessibility (ATAC-seq) or poised to be repressed (H3K9me3 ChIP-seq) in iron-repleted adult rats having experienced fetal-neonatal ID exposure with or without prenatal choline supplementation...
March 21, 2024: BMC Genomics
https://read.qxmd.com/read/38514058/role-of-nf-%C3%AE%C2%BAb-p65-tnf-%C3%AE-in-cell-apoptosis-in-the-fetal-membranes-of-pregnant-women-with-preterm-premature-rupture-of-membranes
#20
JOURNAL ARTICLE
Shi-Huan Tang, Xian Tang, Ling Liu, Lu Peng, Hong-Mei Zhang, Hui Zhang, Ting Long, Pei-Ling Wu, Xian-Ping Zhang
OBJECTIVE: This study aimed to investigate the roles of nuclear factor-kappa B p65 (NF-[Formula: see text]B p65) and tumor necrosis factor- α (TNF- α ) in cell apoptosis occurring in the fetal membranes of pregnant women who experience preterm premature rupture of membranes (PPROM). METHODS: This was a case-control study involving 57 pregnant women who delivered in the obstetric department of Affiliated Loudi Hospital, Hengyang Medical School, University of South China, from June 2021 to June 2022...
January 2024: Annals of Clinical and Laboratory Science
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