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Hormonal treatment of endometriosis

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https://read.qxmd.com/read/30775688/investigation-of-anti-mullerian-hormone-amh-level-and-ovarian-response-in-infertile-women-with-endometriosis-in-ivf-cycles
#1
Leili Safdarian, Seyedeh Noushin Ghalandarpoor Attar, Ashraf Aleyasin, Marzieh Aghahosseini, Fateme Sadaf Sarfjoo, Sedigheh Hosseinimousa
Background: Endometriosis, can cause ovarian conflict and reduced ovarian reserve that could lead to lower response to assisted reproductive techniques. Objective: Current study was conducted to determine the association between level of anti-mullerian hormone (AMH) and the infertility treatment outcomes in infertile females with endometriosis versus the non-endometriosis infertile subject. Materials and Methods: In this case-control study, 64 infertile females who referred to Shariati Hospital from April 2015 to November 2017 were enrolled...
November 2018: International Journal of Reproductive Biomedicine (Yazd, Iran)
https://read.qxmd.com/read/30773264/a-calcium-dependent-phospholipase-a2-cpla2-expression-is-regulated-by-mig-6-during-endometrial-tumorigenesis
#2
Hanna E Teasley, Munseok Paul Jeong, Tae Hoon Kim
The ovarian steroid hormones, estrogen (E2) and progesterone (P4), are essential regulators of uterine biology. The imbalance of these ovarian steroid hormones leads to uterine diseases such as endometrial cancer, endometriosis, and infertility. Mitogen-inducible gene 6 (MIG-6) is an adaptor protein. MIG-6 mediates P4 signaling and acts as a tumor suppressor during endometrial tumorigenesis in both humans and mice. In previous studies, we developed the conditional knockout of Mig-6 in all uterine compartments (Pgrcre/+ Mig-6f/f ; Mig-6KO ) and endometrial epithelial cell-specific Mig-6 knockout (Sprr2fcre/+ Mig-6f/f ; Mig-6Ep-KO ) mice...
February 14, 2019: Biochemical and Biophysical Research Communications
https://read.qxmd.com/read/30772872/-clinical-assessment-of-fourteen-cases-of-thoracic-endometriosis
#3
Naoya Ishibashi, Toshiharu Tabata, Akira Koyanagi, Ryo Nonomura, Takanobu Sasaki, Hideki Mitomo, Takafumi Sugawara, Takashi Kondo, Kazuhiro Murakami, Motoyasu Sagawa
We retrospectively assessed the clinical and pathological features of 14 patients with thoracic endometriosis who were treated at our hospital from 2007 to 2017. Thirteen patients presented pneumothorax and 1 patient presented bloody sputum. All were treated surgically. Pneumothorax occurs on the right side in all 13 cases and bloody sputum was from left side lesion. Ten patients presented symptoms closely related with their menstrual cycle (days -2 to 5). At surgery, dark red or dark brown spots, small hiatus and scar-like findings on the surface of the visceral pleura or diaphragm were identified in all cases...
February 2019: Kyobu Geka. the Japanese Journal of Thoracic Surgery
https://read.qxmd.com/read/30763525/a-comprehensive-review-of-hormonal-and-biological-therapies-for-endometriosis-latest-developments
#4
Fabio Barra, Giovanni Grandi, Matteo Tantari, Carolina Scala, Fabio Facchinetti, Simone Ferrero
Endometriosis is a chronic benign estrogen dependent disease characterized by the presence of endometriotic glands and stroma outside the uterine cavity. Although combined hormonal contraceptives and progestins, currently available first-line treatments for endometriosis, are efficacious and well tolerated for treating disease-related pain, some women experience partial or no improvement of pain or its recurrence is frequent after discontinuation of the therapies. For these reasons, new drugs are under investigation for the treatment of endometriosis...
February 14, 2019: Expert Opinion on Biological Therapy
https://read.qxmd.com/read/30737768/reply-to-adhesion-proteins-suitable-therapeutic-targets-or-biomarkers-of-therapy-response-for-endometriosis
#5
Endah Rahmawati, Wei-Chung Vivian Yang, Chii-Ruey Tzeng
We are pleased to read the recent letter to editor by Barra and Ferrero who have been interested in our recent publication in AOGS. In that report, we demonstrated the decreased expression of Tensin 1 (TNS1) in tissue and serum of women with endometriosis after receiving gonadotropin-releasing-hormone agonist (GnRHa) treatment. In our study, we only recruited patients with ovarian endometriosis as mentioned in the material and methods section. We agree that the expression and the changes of TNS1 might be different across endometriosis subtypes such as peritoneal endometriosis and deep infiltrating endometriosis...
February 8, 2019: Acta Obstetricia et Gynecologica Scandinavica
https://read.qxmd.com/read/30708067/surgical-management-of-superficial-peritoneal-adolescent-endometriosis
#6
Marc R Laufer, Jon I Einarsson
BACKGROUND: Adolescent endometriosis typically presents as Stage I with superficial peritoneal disease [SPD] and less commonly as Stage III or IV with deeply infiltrative disease [DIE]. Endometriosis lesions can be destroyed (cautery or laser), cutting out the discrete lesion with excision and destroyed, or radically excised with removal of the lesion and surrounding tissue. It has been shown to be beneficial to excise DIE to improve pain. Radical excision has been promoted by a subset of surgeons and involves removal of large areas of peritoneum with the promise/proposal of a cure and suggestion of no need for medical suppression of endometriosis...
January 29, 2019: Journal of Pediatric and Adolescent Gynecology
https://read.qxmd.com/read/30707023/identification-of-a-benzimidazolecarboxylic-acid-derivative-bay-1316957-as-a-potent-and-selective-human-prostaglandin-e2-receptor-subtype-4-hep4-r-antagonist-for-the-treatment-of-endometriosis
#7
Stefan Bäurle, Jens Nagel, Olaf Peters, Nico Bräuer, Antonius M Ter Laak, Cornelia Preusse, Antje Rottmann, Dieter Heldmann, Ulrich Bothe, Thorsten Blume, Ludwig Erhard Zorn, Daryl Walter, Thomas M Zollner, Andreas Steinmeyer, Gernot Langer
The presence and growth of endometrial tissue outside the uterine cavity in endometriosis patients is primarily driven by hormone-dependent and inflammatory processes - the latter being frequently associated with severe, acute and chronic pelvic pain. The EP4 subtype of prostaglandin E2 (PGE2) receptors (EP4-R) is a particularly promising anti-inflammatory and anti-nociceptive target as both this receptor subtype and the pathways forming PGE2 are highly expressed in endometriotic lesions. High-throughput screening resulted in the identification of benzimidazole derivatives as novel hEP4-R antagonists...
February 1, 2019: Journal of Medicinal Chemistry
https://read.qxmd.com/read/30699134/the-cost-effectiveness-of-oral-contraceptives-compared-to-no-hormonal-treatment-for-endometriosis-related-pain-an-economic-evaluation
#8
Tobias Sydendal Grand, Hasan Basarir, Louise J Jackson
OBJECTIVE: To develop a preliminary cost-effectiveness model that compares oral contraceptives and 'no hormonal treatment' for the treatment of endometriosis-related pain. METHODS: A de novo preliminary state transition (Markov) model was developed. The model was informed by systematic literature review and expert opinion. The uncertainty around the results was assessed both by deterministic and probabilistic sensitivity analyses. The economic evaluation was conducted from National Health Service (NHS) England perspective...
2019: PloS One
https://read.qxmd.com/read/30697075/high-grade-endometrial-stromal-sarcoma-a-retrospective-study-of-factors-influencing-prognosis
#9
Yan-Yan Zhang, Yan Li, Meng Qin, Yan Cai, Ying Jin, Ling-Ya Pan
Objectives: The aim of this study was to evaluate the factors associated with progress-free survival (PFS) and overall survival (OS) in patients with high-grade endometrial stromal sarcoma (HG-ESS). Patients and methods: A total of 40 patients were enrolled in this study at the Peking Union Medical College Hospital, Beijing, China, from 2006 to 2016. The study retrospectively analyzed clinical and pathological data, and associations of these variables with PFS and OS were evaluated...
2019: Cancer Management and Research
https://read.qxmd.com/read/30675821/use-of-a-mouse-model-of-experimentally-induced-endometriosis-to-evaluate-and-compare-the-effects-of-bisphenol-a-and-bisphenol-af-exposure
#10
Rebecca L Jones, Stephanie A Lang, Jessica A Kendziorski, Alexis D Greene, Katherine A Burns
BACKGROUND: Endometriosis is a gynecological disease affecting 1 in 10 women of reproductive age. Endometriosis incidence has risen; however, whether this rise is due to disease awareness or environmental contamination is not known. OBJECTIVE: The objective of this study was to determine if bisphenol A (BPA) or bisphenol AF (BPAF) potentiate the development of endometriosis and if hormonal status alters how toxicant exposure affects disease. METHODS: A mouse model of endometriosis, where minced uterine tissue is injected into the peritoneal cavity of a host mouse, was used to examine the effects of BPA and BPAF on endometriosis lesion development in ovariectomized and hormonally intact mice...
December 2018: Environmental Health Perspectives
https://read.qxmd.com/read/30668182/effects-of-bazedoxifene-conjugated-estrogens-on-reproductive-endocrinology-and-reproductive-tract-ultrasonographic-appearance-in-premenopausal-women-a-preliminary-study
#11
Valerie A Flores, Cheryl Leone, Hugh S Taylor, Nina S Stachenfeld
Bazedoxifene (BZA) paired with conjugated estrogens (CE) is the first tissue selective estrogen receptor complex (TSEC) approved by the United States Food and Drug Administration for the treatment of menopausal symptoms. Clinical trials in menopausal women and in premenopausal murine models of endometriosis have demonstrated safety and efficacy, however, the impact of BZA/CE on premenopausal women is not known. Here we report a case series study in premenopausal women assessing effects of BZA/CE on reproductive hormones, and uterine/ovarian ultrasonographic appearance...
January 22, 2019: Gynecological Endocrinology
https://read.qxmd.com/read/30664383/hormonal-contraception-in-women-with-endometriosis-a-systematic-review
#12
Giovanni Grandi, Fabio Barra, Simone Ferrero, Filomena Giulia Sileo, Emma Bertucci, Antonella Napolitano, Fabio Facchinetti
OBJECTIVE: A systematic review was carried out of studies of women with endometriosis, to examine the evidence for efficacy of the use of hormonal contraception to improve disease-related pain and decrease postoperative risk of disease recurrence. METHODS: A search of the Medline/PubMed and Embase databases was performed to identify all published English language studies on hormonal contraceptive therapies (combined hormonal contraceptives [CHCs], combined oral contraceptives [COCs], progestin-only pills [POPs] and progestin-only contraceptives [POCs]) in women with a validated endometriosis diagnosis, in comparison with placebo, comparator therapies or other hormonal therapies...
January 21, 2019: European Journal of Contraception & Reproductive Health Care
https://read.qxmd.com/read/30659784/treatment-of-ovarian-endometrial-cysts-in-the-context-of-recurrence-and-fertility
#13
REVIEW
Izabela Nowak-Psiorz, Sylwester M Ciećwież, Agnieszka Brodowska, Andrzej Starczewski
An approach to ovarian endometrial cysts has changed considerably during recent years, especially in regard to treatment of recurrent endometriosis, fertility sparing and infertility management. Surgical treatment is the primary therapeutic option. The most efficient types of treatment are radical procedures involving adhesiolysis, removal of the cyst along with its capsule and any remaining endometriotic foci. However, small asymptomatic cysts should not be treated surgically, especially in patients older than 35 years...
January 15, 2019: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://read.qxmd.com/read/30644244/comparing-the-effects-of-glycyrrhiza-glabra-root-extract-a-cyclooxygenase-2-inhibitor-celecoxib-and-a-gonadotropin-releasing-hormone-analog-diphereline-in-a-rat-model-of-endometriosis
#14
Bahia Namavar Jahromi, Farnaz Farrokhnia, Nader Tanideh, Perikala Vijayananda Kumar, Mohammad Ebrahim Parsanezhad, Sanaz Alaee
Background: The purpose of this study was to compare the effects of Glycyrrhiza glabra (Licorice), a cyclooxygenase- 2 inhibitor (Celecoxib) and a gonadotropin-releasing hormone analog (Diphereline®), with a control group on endometrial implants in rats. Materials and Methods: In this experimental study, endometriosis was induced in rats by auto transplantation and after confirmation, the rats were divided into 4 groups that were treated for 6 weeks with normal saline (0...
April 2019: International Journal of Fertility & Sterility
https://read.qxmd.com/read/30628469/endometriosis-seeking-optimal-management-in-women-approaching-menopause
#15
L Alio, S Angioni, S Arena, L Bartiromo, V Bergamini, N Berlanda, V Bonanni, C Bonin, L Buggio, M Candiani, G Centini, M N D'Alterio, F De Stefano, A Di Cello, C Exacoustos, L Fedele, M P Frattaruolo, E Geraci, E Lavarini, L Lazzeri, S Luisi, A Maiorana, S Makieva, F Maneschi, F Martire, C Massarotti, A Mattei, L Muzii, J Ottolina, L Pagliardini, A Perandini, F Perelli, I Pino, M G Porpora, V Remorgida, G Scagnelli, R Seracchioli, E Solima, E Somigliana, G Sorrenti, A Ticino, R Venturella, P Viganò, M Vignali, F Zullo, E Zupi
The incidence of endometriosis in middle-aged women is not minimal compared to that in the reproductive age group. The treatment of affected women after childbearing age to the natural transition toward menopause has received considerably poor attention. Disease management is problematic for these women due to increased contraindications regarding hormonal treatment and the possibility for malignant transformation, considering the increased cancer risk in patients with a long-standing history of the disease...
January 10, 2019: Climacteric: the Journal of the International Menopause Society
https://read.qxmd.com/read/30588070/the-comorbidities-of-dysmenorrhea-a-clinical-survey-comparing-symptom-profile-in-women-with-and-without-endometriosis
#16
Susan F Evans, Tiffany A Brooks, Adrian J Esterman, M Louise Hull, Paul E Rolan
Purpose: Dysmenorrhea is a common disorder that substantially disrupts the lives of young women. The frequency of 14 associated symptoms both within and outside the pelvis was determined. Patients and methods: Symptom questionnaires were completed by 168 women with dysmenorrhea, allocated to three groups based on their diagnostic status for endometriosis confirmed (Endo+), endometriosis excluded (Endo-), or endometriosis diagnosis unknown (No Lap). Those with endometriosis confirmed were further divided into current users (Endo+ Hx+) and non-users of hormonal treatments (Endo+ Hx-)...
2018: Journal of Pain Research
https://read.qxmd.com/read/30578826/dual-inhibition-of-erk1-2-and-akt-pathways-is-required-to-suppress-the-growth-and-survival-of-endometriotic-cells-and-lesions
#17
Joe A Arosh, Sakhila K Banu
Endometriosis is an estrogen-dependent and progesterone-resistant gynecological inflammatory disease of reproductive-age women. Current hormonal therapies targeting estrogen can be prescribed only for a short time. It indicates a need for non-hormonal therapy. ERK1/2 and AKT pathways control several intracellular signaling molecules that control growth and survival of cells. Objectives of the present study are to (i) determine the dual inhibitory effects of ERK1/2 and AKT pathways on proliferation, survival, and apoptosis of human endometrioitc epithelial cells and stromal cells in vitro; (ii) on growth and survival of endometrioitc lesions in vivo in xenograft mouse model of endometriosis of human origin; and (iii) establish the associated ERK1/2 and AKT downstream intracellular signaling modules in the pathogenesis of endometriosis...
December 19, 2018: Molecular and Cellular Endocrinology
https://read.qxmd.com/read/30572916/a-multi-center-randomized-controlled-clinical-trial-of-the-application-of-a-shortened-protocol-of-long-acting-triptorelin-down-regulated-prior-to-ivf-icsi-among-patients-with-endometriosis-a-protocol
#18
RANDOMIZED CONTROLLED TRIAL
Huijuan Kong, Linli Hu, Ling Nie, Xiaona Yu, Wei Dai, Jing Li, Caihong Chen, Zhiqin Bu, Hao Shi, Qiongfang Wu, Yichun Guan, Yingpu Sun
BACKGROUND: Endometriosis is the major cause of progressive pelvic pain and subfertility. Up to 50% of reproductive-age women suffer from pelvic pain. Endometriosis is a classic indication for IVF. Compared with women whose inability to procreate is caused by simple tubal infertility, women with endometriosis often have lower pregnancy rates following in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI). The administration of gonadotrophin-releasing hormone (GnRH) agonists prior to IVF/ICSI can improve the successful pregnancy rate...
December 20, 2018: Reproductive Health
https://read.qxmd.com/read/30572523/oncological-markers-ca-125-ca-19-9-and-endometriosis
#19
Ludek Fiala, Petr Bob, Jiri Raboch
The endometrium tissue is functionally androgen related which plays an important role in women's fertility regulation. In addition recent findings show that endometrium related pathology is closely linked to disrupted androgen biosynthesis and associated regulatory functions. These findings also suggest that androgens might play an important role in endometrium related cancer pathology with significant implications for treatment.Based on these findings, we have assessed 50 female outpatients with endometriosis and the clinical investigations were focused on biochemical serum analysis of DHEAS, oncological markers CA-125 and CA 19-9, estradiol, thyreothropic hormone, and prolactin...
December 2018: Medicine (Baltimore)
https://read.qxmd.com/read/30569127/melatonin-restricts-the-viability-and-angiogenesis-of-vascular-endothelial-cells-by-suppressing-hif-1%C3%AE-ros-vegf
#20
Jiao Cheng, Hui-Li Yang, Chun-Jie Gu, Yu-Kai Liu, Jun Shao, Rui Zhu, Yin-Yan He, Xiao-Yong Zhu, Ming-Qing Li
Angiogenesis is an essential process involved in various physiological, including placentation, and pathological, including cancer and endometriosis, processes. Melatonin (MLT), a well‑known natural hormone secreted primarily in the pineal gland, is involved in regulating neoangiogenesis and inhibiting the development of a variety of cancer types, including lung and breast cancer. However, the specific mechanism of its anti‑angiogenesis activity has not been systematically elucidated. In the present study, the effect of MLT on viability and angiogenesis of human umbilical vein endothelial cells (HUVECs), and the production of vascular endothelial growth factor (VEGF) and reactive oxygen species (ROS), under normoxia or hypoxia was analyzed using Cell Counting kit 8, tube formation, flow cytometry, ELISA and western blot assays...
December 10, 2018: International Journal of Molecular Medicine
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