Denis P Blondin, Francois Haman, Tracy M Swibas, Sophie Hogan-Lamarre, Lauralyne Dumont, Jolan Guertin, Gabriel Richard, Quentin Weissenburger, Kerry L Hildreth, Irene E Schauer, Shelby Panter, Liza Wayland, André C Carpentier, Yubin Miao, Jiayun Shi, Elizabeth Jaruez-Colunga, Wendy M Kohrt, Edward L Melanson
In rodents, loss of estradiol (E2 ) reduces brown adipose tissue (BAT) metabolic activity. Whether E2 impacts BAT activity in women is not known. BAT oxidative metabolism was measured in premenopausal (N=27, 35±9 years, body mass index (BMI) = 26.0±5.3 kg/m2 ) and postmenopausal (N=25, 51±8 years, BMI = 28.0±5.0 kg/m2 ) women at room temperature (RT) and during acute cold exposure using [11 C]-acetate with positron emission tomography coupled with computed tomography (PET/CT). BAT glucose uptake was also measured during acute cold exposure using 2-deoxy-2-[18 F]fluoro-D-glucose ([18 F]FDG)...
March 13, 2024: American Journal of Physiology. Endocrinology and Metabolism