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https://read.qxmd.com/read/30856428/highly-efficient-luminol-immobilization-approach-and-exponential-strand-displacement-reaction-based-electrochemiluminescent-strategy-for-monitoring-microrna-expression-in-cell
#1
Yali Yuan, Xue Li, An-Yi Chen, Hai-Jun Wang, Ya-Qin Chai, Ruo Yuan
This work used 3,4,9,10-perylenetetracarboxylic acid-luminol composite (PTCA-luminol) as signal tag with improved ECL signal and applied cruciform DNA structure mediated exponential strand displacement reaction (SDR) to construct an ultrasensitive electrochemiluminescence (ECL) biosensor for microRNA-21 (miRNA-21) detection. The novel luminol-based signal tags was synthesized utilizing the π-π stacking interaction between PTCA and luminol, realizing highly effective and stable immobilization of luminol and resulting in good stability and strong ECL response...
February 23, 2019: Biosensors & Bioelectronics
https://read.qxmd.com/read/30855347/matrine-suppresses-lipopolysaccharide-induced-fibrosis-in-human-peritoneal-mesothelial-cells-by-inhibiting-the-epithelial-mesenchymal-transition
#2
Yi-Zheng Li, Xi Peng, Yun-Hua Ma, Fu-Ji Li, Yun-Hua Liao
BACKGROUND: Peritoneal fibrosis is the primary reason that patients with end-stage renal disease (ESRD) have to cease peritoneal dialysis. Peritonitis caused by Gram-negative bacteria such as Escherichia coli (E. coli) were on the rise. We had previously shown that matrine inhibited the formation of biofilm by E. coli. However, the role of matrine on the epithelial-mesenchymal transition (EMT) in peritoneal mesothelial cells under chronic inflammatory conditions is still unknown. METHODS: We cultured human peritoneal mesothelial cells (HPMCs) with lipopolysaccharide (LPS) to induce an environment that mimicked peritonitis and investigated whether matrine could inhibit LPS-induced EMT in these cells...
March 20, 2019: Chinese Medical Journal
https://read.qxmd.com/read/30852764/medicinal-plants-and-their-isolated-phytochemicals-for-the-management-of-chemotherapy-induced-neuropathy-therapeutic-targets-and-clinical-perspective
#3
Vahideh Oveissi, Mahboobe Ram, Roodabeh Bahramsoltani, Farnaz Ebrahimi, Roja Rahimi, Rozita Naseri, Tarun Belwal, Hari Prasad Devkota, Zahra Abbasabadi, Mohammad Hosein Farzaei
BACKGROUND: Chemotherapy, as one of the main approaches of cancer treatment, is accompanied with several adverse effects, including chemotherapy-induced peripheral neuropathy (CIPN). Since current methods to control the condition are not completely effective, new treatment options should be introduced. Medicinal plants can be suitable candidates to be assessed regarding their effects in CIPN. Current paper reviews the available preclinical and clinical studies on the efficacy of herbal medicines in CIPN...
March 9, 2019: Daru: Journal of Faculty of Pharmacy, Tehran University of Medical Sciences
https://read.qxmd.com/read/30845734/evolution-and-biological-evaluation-of-matrinic-derivatives-with-amantadine-fragments-as-new-anti-influenza-virus-agents
#4
Tianyu Niu, Xiaoqiang Zhao, Jing Jiang, Haiyan Yan, Yinghong Li, Sheng Tang, Yuhuan Li, Danqing Song
A series of novel tricyclic matrinic derivatives with 11-adamantyl substitution were designed, synthesized, and evaluated for their activities against Influenza A H3N2 virus, based on the privileged structure strategy. Structure-activity relationship (SAR) analysis indicated that the introduction of an 11-adamantyl might be helpful for the potency. Among them, compounds 9f and 9j exhibited the promising anti-H3N2 activities with IC50 values of 7.2 μM and 10.2 μM, respectively, better than that of lead 1 ...
March 6, 2019: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/30822611/matrine-alleviates-staphylococcus-aureus-lipoteichoic-acid-induced-endometritis-via-suppression-of-tlr2-mediated-nf-%C3%AE%C2%BAb-activation
#5
Kangfeng Jiang, Shuai Guo, Jing Yang, Junfeng Liu, Aftab Shaukat, Gan Zhao, Haichong Wu, Ganzhen Deng
Endometritis is one of the main diseases that causes great economic losses in the dairy industry. Recent studies have shown that matrine extracted from the traditional Chinese herb Sophora flavescens is an alkaloid with a broad range of bioactivities. Here, we aimed to investigate the protective effects of matrine on Staphylococcus aureus lipoteichoic acid (LTA)-induced endometritis in mice and elucidate the possible molecular mechanisms in vitro. Histopathological changes showed that matrine remarkably attenuated the uterus injury in a mouse model of LTA-induced endometritis...
February 26, 2019: International Immunopharmacology
https://read.qxmd.com/read/30809416/simultaneous-determination-of-six-active-components-in-danggui-kushen-pills-via-quantitative-analysis-of-multicomponents-by-single-marker
#6
Huiwei Bao, Jihong Chi, Huailei Yang, Fangxin Liu, Kuo Fang, Yang Xu
In this paper, a valid evaluation method for the quality control of Danggui Kushen pills (DKP) has been established based on quantitative analysis of multicomponents by single marker (QAMS). Gallic acid, matrine, oxymatrine, catechin, ferulic acid, and rutin were selected as the indexes for quality evaluation of DKP. The analysis was achieved on an Agilent ZORBAX SB-C18 column (250  mm × 4.6  mm, 5  μ m) via gradient elution. Gallic acid was used as internal standard to determine the relative correction factors (RCF) between gallic acid and other five constituents in DKP...
2019: Journal of Analytical Methods in Chemistry
https://read.qxmd.com/read/30800071/matrine-mediates-inflammatory-response-via-gut-microbiota-in-tnbs-induced-murine-colitis
#7
Peiyuan Li, Jiajun Lei, Guangsheng Hu, Xuanmin Chen, Zhifeng Liu, Jing Yang
This study mainly investigated the effect of matrine on TNBS-induced intestinal inflammation in mice. TNBS treatment caused colonic injury and gut inflammation. Matrine (1, 5, and 10 mg/kg) treatment alleviated colonic injury and gut inflammation via reducing bleeding and diarrhea and downregulating cytokines expression (IL-1β and TNF-α). Meanwhile, serum immunoglobulin G (IgG) was markedly reduced in TNBS treated mice, while 5 and 10 mg/kg matrine alleviated IgG reduction. Fecal microbiota was tested using 16S sequencing and the results showed that TNBS caused gut microbiota dysbiosis, while matrine treatment markedly improved gut microbiota communities (i...
2019: Frontiers in Physiology
https://read.qxmd.com/read/30791732/network-meta-analysis-of-chinese-herbal-injections-plus-the-folfox-regimen-for-the-treatment-of-colorectal-cancer-in-china
#8
Dan Zhang, Jiarui Wu, Xiaojiao Duan, Kaihuan Wang, Mengwei Ni, Shuyu Liu, Xiaomeng Zhang, Bing Zhang, Yi Zhao
OBJECTIVE: The aim of the present network meta-analysis (NMA) was to explore the comparative effectiveness and safety of different Chinese herbal injections (CHIs) combined with the FOLFOX regimen versus FOLFOX alone for colorectal cancer (CRC). METHODS: A comprehensive search for randomized controlled trials (RCTs) was performed with regard to different CHIs for treating CRC in several electronic databases up to July 2016. The quality assessment of the included RCTs was conducted according to the Cochrane risk of bias tool...
January 2019: Integrative Cancer Therapies
https://read.qxmd.com/read/30790622/the-nuclear-matrix-protein-matr3-regulates-processing-of-the-synaptic-microrna-138-5p
#9
Kerstin Weiss, Thomas Treiber, Gunter Meister, Gerhard Schratt
microRNA-dependent post-transcriptional control represents an important gene-regulatory layer in post-mitotic neuronal development and synaptic plasticity. We recently identified the brain-enriched miR-138 as a negative regulator of dendritic spine morphogenesis in rat hippocampal neurons. A potential involvement of miR-138 in cognition is further supported by a recent GWAS study on memory performance in a cohort of aged (>60 years) individuals. The expression of miR-138, which is encoded in two independent genomic loci (miR-138-1 and -2), is subject to both cell-type and developmental stage-specific regulation, the underlying molecular mechanisms however are poorly understood...
February 18, 2019: Neurobiology of Learning and Memory
https://read.qxmd.com/read/30788949/-effect-of-matrine-on-tumor-growth-and-inflammatory-factors-and-immune-function-in-wistar-rat-with-breast-cancer
#10
Rui-Kui Zhang, Chao Wang
OBJECTIVE: To study the effect of matrine on tumor growth, inflammatory factors and immune function in Wistar rat with breast cancer. METHODS: Sixty female Wistar rats were randomly divided into control group ( n =10) and the modeling group of breast cancer cell tumor-bearing rat ( n =50), then the rats in modeling group were randomly divided into five groups ( n =10):vehicle group, matrine low dose group (50 mg/kg), medium dose group (100 mg/kg), high dose group (200 mg/kg), and lentinan group (200 mg/kg)...
April 8, 2018: Chinese Journal of Applied Physiology
https://read.qxmd.com/read/30770623/matrine-attenuates-high-fat-diet-induced-in-vivo-and-ox-ldl-induced-in-vitro-vascular-injury-by-regulating-the-pkc%C3%AE-enos-and-pi3k-akt-enos-pathways
#11
Song Zhang, Shun Guo, Xiao-Bo Gao, An Liu, Wei Jiang, Xi Chen, Peng Yang, Lin-Na Liu, Lei Shi, Yan Zhang
Lipid metabolism disorders lead to vascular endothelial injury. Matrine is an alkaloid that has been used to improve obesity and diabetes and for the treatment of hepatitis B. However, its effect on lipid metabolism disorders and vascular injury is unclear. Here, we investigated the effect of matrine on high-fat diet fed mice and oxidized low-density lipoprotein (ox-LDL)-induced human umbilical vein endothelial cells (HUVECs). Computational virtual docking analyses, phosphoinositide 3-kinase (PI3K) and protein kinase C-α (PKCα) inhibitors were used to localize matrine in vascular injuries...
February 15, 2019: Journal of Cellular and Molecular Medicine
https://read.qxmd.com/read/30738807/matrine-ameliorates-anxiety-and-depression-like-behaviour-by-targeting-hyperammonemia-induced-neuroinflammation-and-oxidative-stress-in-ccl4-model-of-liver-injury
#12
Adnan Khan, Bushra Shal, Muhammad Naveed, Fawad Ali Shah, Ayesha Atiq, Naseem Ullah Khan, Yeong Shik Kim, Salman Khan
Acute or chronic liver injury is associated with hyperammonemia which induced neuroinflammation and oxidative stress in the brain. Neuroinflammation, oxidative stress, reduced neurogenesis, and apoptosis are critical factors for the development of anxiety and depression. The present study was aimed to evaluate the anxiolytic and antidepressant properties of matrine against acute liver injury in the rodent model. Acute liver injury in mice was induced by administration of the acute hepatotoxic dose of carbon tetrachloride (CCl4) (1 ml/kg, i...
February 7, 2019: Neurotoxicology
https://read.qxmd.com/read/30733313/matrine-reduces-cigarette-smoke-induced-airway-neutrophilic-inflammation-by-enhancing-neutrophil-apoptosis
#13
Xuhua Yu, Huei Jiunn Seow, Hao Wang, Desiree Anthony, Steven Bozinovski, Lin Lin, Ji-Ming Ye, Ross Vlahos
Chronic Obstructive Pulmonary Disease (COPD) is a major incurable global health burden and will become the third largest cause of death in the world by 2030. It is well established that an exaggerated inflammatory and oxidative stress response to cigarette smoke (CS) leads to, emphysema, small airway fibrosis, mucus hypersecretion and progressive airflow limitation. Current treatments have limited efficacy in inhibiting chronic inflammation and consequently do not reverse the pathology that initiate and drive the long-term progression of disease...
February 7, 2019: Clinical Science (1979-)
https://read.qxmd.com/read/30693516/iron-overload-threatens-the-growth-of-osteoblast-cells-via-inhibiting-the-pi3k-akt-foxo3a-dusp14-signaling-pathway
#14
Demeng Xia, Jianghong Wu, Malcolm Xing, Yang Wang, Hongyue Zhang, Yan Xia, Panyu Zhou, Shuogui Xu
Iron overload is a common stress in the development of cells. Growing evidence has indicated that iron overload is associated with osteoporosis. Therefore, enhancing the understanding of iron overload would benefit the development of novel approaches to the treatment of osteoporosis. The purpose of the present study was to analyze the effect of iron overload on osteoblast cells, via the MC3T3-E1 cell line, and to explore its possible underlying molecular mechanisms. Ferric ammonium citrate (FAC) was utilized to simulate iron overload conditions in vitro...
January 29, 2019: Journal of Cellular Physiology
https://read.qxmd.com/read/30672935/a-simple-matrine-derivative-for-the-facile-syntheses-of-mesoporous-zeolites-itq-37-and-itq-43
#15
Chuanqi Zhang, Xu Li, Xinzhu Li, Jibo Hu, Liangkui Zhu, Yan Li, Jiuxing Jiang, Zhendong Wang, Weimin Yang
ITQ-37 and ITQ-43 possessing mesoporous structures have aroused great interest because of their promising applications involving large molecules. However, it is challenging to synthesize these zeolites. Herein, MAS-ITQ-37 and MAS-ITQ-43 with enhanced Si/Ge ratios of 1.7 and 3.0 have been synthesized by using a simple matrine-derived organic structure-directing agent.
January 23, 2019: Chemical Communications: Chem Comm
https://read.qxmd.com/read/30635051/an-integrated-characterization-of-contractile-electrophysiological-and-structural-cardiotoxicity-of-sophora-tonkinensis-gapnep-in-human-pluripotent-stem-cell-derived-cardiomyocytes
#16
Ruiying Wang, Min Wang, Shan Wang, Ke Yang, Ping Zhou, Xueheng Xie, Qi Cheng, Jingxue Ye, Guibo Sun, Xiaobo Sun
BACKGROUND: Cardiotoxicity remains an important concern in drug discovery and clinical medication. Meanwhile, Sophora tonkinensis Gapnep. (S. tonkinensis) held great value in the clinical application of traditional Chinese medicine, but cardiotoxic effects were reported, with matrine, oxymatrine, cytisine, and sophocarpine being the primary toxic components. METHODS: In this study, impedance and extracellular field potential (EFP) of human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) were recorded using the cardio non-labeled cell function analysis and culture system (Cardio-NLCS)...
January 11, 2019: Stem Cell Research & Therapy
https://read.qxmd.com/read/30591797/ursolic-acid-benzaldehyde-chalcone-leads-to-inhibition-of-cell-proliferation-and-arrests-cycle-in-g1-g0-phase-in-colon-cancer
#17
Xinying Zhuang, Aihua Dong, Ruicai Wang, Hongyun Cao
The present study investigates the effect of matrine on colon cancer cell viability and apoptosis and tumor growth in mice xenograft model. The results from MTT assay revealed a concentration and time dependent reduction in viability of HCT8 and HT29 colon cancer cells by matrine. The viability of HCT8 and HT29 cells was reduced to 24.67 and 29.32% on treatment with 4 µM/ml concentration of matrine after 48 h (P < 0.05). The results from flow cytometry revealed increase in population of HCT8 and HT29 cells to 77...
December 2018: Saudi Journal of Biological Sciences
https://read.qxmd.com/read/30554494/matrine-suppresses-pancreatic-fibrosis-by-regulating-tgf-%C3%AE-smad-signaling-in-rats
#18
Pi Liu, Luhong Zhu, Guohui Zou, Huajing Ke
PURPOSE: This study aimed to elucidate the molecular mechanisms of the anti-pancreatic fibrosis effects of matrine in rats. MATERIALS AND METHODS: Trinitrobenzene sulfonic acid was administrated to rats to establish a pancreatic fibrosis model. Rats were divided into four groups: Control, Sham, Model, and Matrine (n=8). Hematoxylin-eosin staining, Masson staining, and Azan staining were performed to evaluate pancreatic fibrosis. Expression of transforming growth factor-β1 (TGF-β1), α-smooth muscle actin (α-SMA), and collagen I in pancreatic tissues was evaluated by immunohistochemical staining...
January 2019: Yonsei Medical Journal
https://read.qxmd.com/read/30466620/matrine-induces-apoptosis-in-multiple-colorectal-cancer-cell-lines-in-vitro-and-inhibits-tumour-growth-with-minimum-side-effects-in-vivo-via-bcl-2-and-caspase-3
#19
Yue-Yu Gu, Meng-Hua Chen, Brian H May, Xiao-Zhong Liao, Jia-Hui Liu, Lan-Ting Tao, Daniel Man-Yuen Sze, Anthony Lin Zhang, Sui-Lin Mo
BACKGROUND: The World Health Organization (WHO) reported that colorectal cancer (CRC) was the third most common cancer in men and the second in women, worldwide. Our previous meta-analysis found Sophora flavescens increased tumour response rate in randomised controlled trials of CRC. We hypothesised that its principal constituent matrine had exerted anti-tumour effects. PURPOSE: To elucidate its mechanisms of action we investigated the dose-related anti-tumour effects of matrine on four human CRC cell-lines: LS174T, Caco-2, SW1116 and RKO...
December 1, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://read.qxmd.com/read/30458883/matrine-attenuates-endoplasmic-reticulum-stress-and-mitochondrion-dysfunction-in-nonalcoholic-fatty-liver-disease-by-regulating-serca-pathway
#20
Xiaobo Gao, Shun Guo, Song Zhang, An Liu, Lei Shi, Yan Zhang
BACKGROUND: Endoplasmic reticulum (ER) stress, which can promote lipid metabolism disorders and steatohepatitis, contributes significantly to the pathogenesis of nonalcoholic fatty liver disease (NAFLD). Calcium (Ca2+ ) homeostasis is considered to play a key role in ER stress. Matrine (Mat) has been applied for the treatment of hepatitis B, but its effect on NAFLD is still unknown, and there is no unified view of Mat on the regulation of ER stress in the previous literature. METHODS: The pharmacological effects were studied in high-fat-diet or methionine-choline-deficient diet induced C57BL/6J mice models and in palmitic acid (PA) induced L02 human liver cell model...
November 20, 2018: Journal of Translational Medicine
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