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JOURNAL ARTICLE
Estefanía Vásquez-Echeverri, Marco Antonio Yamazaki-Nakashimada, Edna Venegas Montoya, Selma Cecilia Scheffler Mendoza, Lina Maria Castano-Jaramillo, Edgar Alejandro Medina-Torres, Maria Edith González-Serrano, Melissa Espinosa-Navarro, Juan Carlos Bustamante Ogando, María Guadalupe González-Villarreal, Margarita Ortega Cisneros, Pedro Francisco Valencia Mayoral, Alejandra Consuelo Sanchez, Gustavo Varela-Fascinetto, Rosa María Nideshda Ramírez-Uribe, Yuridia Salazar Gálvez, Laura Cecilia Bonifaz Alonzo, Ezequiel Moisés Fuentes-Pananá, Noemí Gómez Hernández, César Mauricio Rojas Maruri, Jean-Laurent Casanova, Sara Elva Espinosa-Padilla, Aidé Tamara Staines Boone, Gabriel López-Velázquez, Bertrand Boisson, Saul Oswaldo Lugo Reyes
BACKGROUND: Hereditary actin-related protein 2/3 complex subunit 1B deficiency is characterized clinically by ear, skin, and lung infections, bleeding, eczema, food allergy, asthma, skin vasculitis, colitis, arthritis, short stature, and lymphadenopathy. OBJECTIVE: We aimed to describe the clinical, laboratory, and genetic features of six patients from four Mexican families. METHODS: We performed exome sequencing in patients of four families with suspected actinopathy, collected their data from medical records, and reviewed the literature for reports of other patients with actin-related protein 2/3 complex subunit 1B deficiency...
January 25, 2023: Journal of Allergy and Clinical Immunology in Practice
#22
JOURNAL ARTICLE
Yoshiyuki Yamada
Gastrointestinal (GI) allergies are broadly associated with food allergies and divided into groups based on the degree of allergen-specific immunoglobulin E (IgE) involvement: IgE-mediated, non-IgE-mediated, and mixed. Non-IgE-mediated GI food allergies are mostly observed in neonates and infants and include food protein-induced enterocolitis syndrome (FPIES), food protein-induced allergic proctocolitis (FPIAP), and food protein-induced enteropathy (FPE). In addition to the classical phenotype, unique phenotypes such as vomiting and bloody stool, suspected sepsis, and overlapping eosinophilic GI disorders (EGIDs) have increased in Japan over the past two decades...
January 9, 2023: Clinical and experimental pediatrics
#23
JOURNAL ARTICLE
Ruyi Wang, Shijie Cao, Mohamed Elfatih H Bashir, Lauren A Hesser, Yanlin Su, Sung Min Choi Hong, Andrew Thompson, Elliot Culleen, Matthew Sabados, Nicholas P Dylla, Evelyn Campbell, Riyue Bao, Eric B Nonnecke, Charles L Bevins, D Scott Wilson, Jeffrey A Hubbell, Cathryn R Nagler
The microbiome modulates host immunity and aids the maintenance of tolerance in the gut, where microbial and food-derived antigens are abundant. Yet modern dietary factors and the excessive use of antibiotics have contributed to the rising incidence of food allergies, inflammatory bowel disease and other non-communicable chronic diseases associated with the depletion of beneficial taxa, including butyrate-producing Clostridia. Here we show that intragastrically delivered neutral and negatively charged polymeric micelles releasing butyrate in different regions of the intestinal tract restore barrier-protective responses in mouse models of colitis and of peanut allergy...
January 2023: Nature Biomedical Engineering
#24
JOURNAL ARTICLE
Qian Guo, Jian Gao, Hui Guo, Jun Xie, Jingmin Cheng
INTRODUCTION: Impressive advances in immunotherapy, especially immune checkpoint inhibitors (ICIs), have made great progress in treating multiple cancers. However, ICIs can also cause serious, even incurable, immune-related adverse events (irAEs), most often in patients with colitis, dermatitis, hepatitis, and thyroiditis. Rare autoimmune hematologic toxicities have been reported in the literature but are poorly described. Pure red cell aplasia (PRCA) induced by ICIs is a life-threatening autoimmune disease; however, only a few cases have been reported in the literature...
November 29, 2022: International Immunopharmacology
#25
JOURNAL ARTICLE
Pejman Rohani, Narjes Raja Beheshti, Hosein Alimadadi, Mohammad Hassan Sohouli
INTRODUCTION: Fecal calprotectin (FC) is a noninvasive biomarker for assessing the inflammatory status of the gastrointestinal tract. The aim of this study was to determine the association between FC levels and Eosinophilic colitis (EC) before and after treatment in pediatrics. METHOD: In this cross-sectional study, 330 patients with rectorrhagia and FC levels > 200 μg/g were included in the study. Patients were then subjected to colonoscopy, and if 30 or more eosinophils were observed in the pathology of at least two parts of the colon, EC was diagnosed...
September 30, 2022: Allergy, Asthma, and Clinical Immunology
#26
JOURNAL ARTICLE
Lin Mi, Chen Zhang, Xiao-Feng Yu, Jian Zou, Yang Yu, Zhi-Jun Bao
BACKGROUND AND OBJECTIVES: Inflammatory bowel disease (IBD) is a multifactorial condition involving the complex interplay of genomics, microbiota, immunology, environment, and personal behaviors, particularly diet. METHODS AND STUDY DESIGN: A case-control study in a tertiary referral hospital. Fifty patients with IBD and 50 controls without gastrointestinal diseases were enrolled consecutively from October 1, 2016, to December 31, 2017. Sociodemographic and Food Frequency Questionnaires (FFQs) were completed, and dietary risk factors for IBD were identified...
2022: Asia Pacific Journal of Clinical Nutrition
#27
JOURNAL ARTICLE
Sofia Kröger, Marleena Repo, Pauliina Hiltunen, Martine Vornanen, Heini Huhtala, Laura Kivelä, Kalle Kurppa
Objectives and study: Gastrointestinal endoscopy is often performed when investigating abdominal complaints in children. While atrophic changes of the duodenal mucosa are usually caused by celiac disease, the prevalence and clinical significance of non-atrophic duodenal changes are less clear. We studied these issues in a large pediatric endoscopic cohort. Methods: Comprehensive data on clinical features, diagnostic findings and long-term outcomes of children who had undergone upper gastrointestinal endoscopy with systematic duodenal sampling were collected...
2022: Frontiers in Pediatrics
#28
JOURNAL ARTICLE
Dominika Lendvai-Emmert, Vanessza Emmert, Alexandra Makai, Katalin Fusz, Viktória Prémusz, Kata Eklics, Patrícia Sarlós, Péter Tóth, Krisztina Amrein, Gergely Tóth
INTRODUCTION: The most prevalent food allergy in younger children is cow's milk protein allergy (CMPA), a hypersensitivity reaction to cow's milk protein and its most common clinical manifestation is allergic colitis. The goal of our recent study was to assess somatic symptoms of CMPA and to prospectively observe the effects of a dairy elimination diet using objective parameters and questionnaires. METHODS: The County Hospital in Szekszárd, Hungary, investigated children aged 1 to 18 who had clinical signs that might indicate CMPA...
2022: Frontiers in Pediatrics
#29
JOURNAL ARTICLE
Donald C Moore, Joseph B Elmes, Justin R Arnall, Scott A Strassels, Jai N Patel
INTRODUCTION: Immune checkpoint inhibitors (ICIs) are used for a variety of cancers and are associated with a risk of developing immune-related adverse events, most commonly colitis, dermatitis, hepatitis, and thyroiditis. Rare autoimmune hematologic toxicities have been reported but are less well-described in the literature. Acquired thrombotic thrombocytopenic purpura (TTP) is a life-threatening autoimmune condition that has been reported with ICIs but has been limited to case reports...
September 2022: International Immunopharmacology
#30
REVIEW
Huan Zhang, Zhilin Zhang, Yiqun Liao, Wenjie Zhang, Dong Tang
The human gut microbiome is important for human health. The development of stable microbial communities in the gastrointestinal tract is closely related to the early growth and development of host immunity. After the birth of a baby, immune cells and the gut microbiome mature in parallel to adapt to the complex gut environment. The gut microbiome is closely linked to the immune system and influences each other. This interaction is associated with various diseases in infants and young children, such as asthma, food allergies, necrotizing colitis, obesity, and inflammatory bowel disease...
2022: Frontiers in Cellular and Infection Microbiology
#31
JOURNAL ARTICLE
Joris van der Veeken, Clarissa Campbell, Yuri Pritykin, Michail Schizas, Jacob Verter, Wei Hu, Zhong-Min Wang, Fanny Matheis, Daniel Mucida, Louis-Marie Charbonnier, Talal A Chatila, Alexander Y Rudensky
Regulatory T (Treg) cells expressing the transcription factor Foxp3 are an essential suppressive T cell lineage of dual origin: Foxp3 induction in thymocytes and mature CD4+ T cells gives rise to thymic (tTreg) and peripheral (pTreg) Treg cells, respectively. While tTreg cells suppress autoimmunity, pTreg cells enforce tolerance to food and commensal microbiota. However, the role of Foxp3 in pTreg cells and the mechanisms supporting their differentiation remain poorly understood. Here, we used genetic tracing to identify microbiota-induced pTreg cells and found that many of their distinguishing features were Foxp3 independent...
July 12, 2022: Immunity
#32
REVIEW
Kunal Gupta, Mamatha Tappiti, Armaan M Nazir, Bhavya Koganti, Marrium S Memon, Muhammad Bin Aslam Zahid, Vignarth Shantha Kumar, Jihan A Mostafa
Fecal Microbiota Transplantation (FMT) is the process of transferring the fecal microbiome from a healthy donor to an individual with repeated multiple episodes of Clostridium difficile infection. It is also known as stool transplant. Fecal microbiota transplant is effective and safe in various studies, the approval from the Food and Drug Administration (FDA) remains pending. The main objective of this systemic review is to evaluate the efficacy and safety of stool transplant in studies with only treatment groups (FMT) and studies with treatment (FMT) and antibiotic (AB) groups and previous studies...
May 2022: Curēus
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JOURNAL ARTICLE
Liping Wang, Tiantian Ji, Ye Yuan, Haoyu Fu, Yang Wang, Shaobo Tian, Jia Hu, Lin Wang, Zheng Wang
The dramatically increasing incidence and prevalence of inflammatory bowel disease (IBD) are reportedly related to a Western diet, which is characterized by high sugar consumption. Dietary simple sugars aggravate IBD in animal models. However, the mechanisms underlying this effect remain unclear. Given that high-fructose corn syrup (HFCS) is a major added sugar in food and beverages, we focus on HFCS and investigated the effects of HFCS on a dextran sulfate sodium (DSS)-induced murine colitis model and in RAW264...
August 2022: International Immunopharmacology
#34
JOURNAL ARTICLE
Wen-Hui Qi, Yan-Yan Zhang, Kun Xing, Dong-Xia Hao, Fei Zhang, Rui-Ning Wang, Ming-Yue Bao, Meng-Yuan Tian, Ya-Na Yang, Xing Li, Yuan Zhang
Multiple sclerosis, inflammatory bowel disease and organ transplant rejection are related to Th17 cell development and inflammatory respond. RORγt, a specific transcription factor regulating Th17 cell differentiation, is a pivotal target for the treatment of diseases. However, the clinical application of RORγt inverse agonists reported so far has been hindered due to limited efficacy and toxic side effects. Plant-derived natural products with drug-like properties and safety are wide and valuable resources for candidate drug discovery...
July 2022: International Immunopharmacology
#35
REVIEW
Hanna Leister, Felix F Krause, Rouzbeh Mahdavi, Ulrich Steinhoff, Alexander Visekruna
The participation of proteasomes in vital cellular and metabolic processes that are involved in tumor growth has made this protease complex an attractive target for cancer treatment. In contrast to ubiquitously available constitutive proteasome, the increased enzymatic activity of immunoproteasome is associated with tumor-infiltrating immune cells, such as antigen-presenting cells and T lymphocytes. In various tumors, an effective anti-tumor immunity is provided through generation of tumor-associated antigens by proteasomes, contributing crucially to cancer eradication by T lymphocytes...
January 22, 2022: Archivum Immunologiae et Therapiae Experimentalis
#36
JOURNAL ARTICLE
Marc E Rothenberg, Shawna K B Hottinger, Nirmala Gonsalves, Glenn T Furuta, Margaret H Collins, Nicholas J Talley, Kathryn Peterson, Calies Menard-Katcher, Macie Smith, Ikuo Hirano, Robert M Genta, Mirna Chehade, Sandeep K Gupta, Jonathan M Spergel, Seema S Aceves, Evan S Dellon
The US Food and Drug Administration hosted a workshop on July 21, 2021, to discuss the disease characteristics, natural history, and end points to assess treatment benefit in patients with eosinophilic gastrointestinal disorders (EGIDs) beyond eosinophilic esophagitis (EoE). Notably, EGIDs beyond EoE, such as eosinophilic gastritis, eosinophilic enteritis, and eosinophilic colitis, herein referred to as non-EoE EGIDs, are understudied relative to EoE. This workshop provided a forum for open discussion among stakeholders-medical professionals (including their societies and research groups), Food and Drug Administration representatives, an industry representative, and a patient representative-to facilitate drug development...
March 2022: Journal of Allergy and Clinical Immunology
#37
JOURNAL ARTICLE
Xin Chen, Joanne Lai, Ying Song, Nan Yang, Sacha Gnjatic, Virginia Gillespie, William Hahn, Ezra Chefitz, Nanci Pittman, Jacqueline Jossen, Keith Benkov, Marla Dubinsky, Xiu-Min Li, David Dunkin
Background: TNF-α has a major role in the pathogenesis of Crohn's disease (CD). In contrast, GM-CSF may be beneficial for its anti-inflammatory role in a subset of patients with CD with antibodies against GM-CSF as seen in prior trials of GM-CSF which resulted in clinical improvement in CD. We developed butanol purified Food Allergy Herbal Formula-2 (B-FAHF-2) by refining FAHF-2. FAHF-2 suppressed TNF-α production by human peripheral blood mononuclear cells (PBMCs) and colonic mucosa, and abrogated colitis in a murine model...
2021: Frontiers in Medicine
#38
REVIEW
Charlie Bridgewood, Darren Newton, Nicola Bragazzi, Miriam Wittmann, Dennis McGonagle
The IL-23/IL-17 cytokine axis is related to spondyloarthropathy (SpA) pattern diseases that target the skin, eye, gut and joints. These share overlapping target tissues with Th2 type or allergic diseases, including the skin, eye and gut but SpA diseases exhibit distinct microanatomical topography, molecular characteristics, and clinical features including uveitis, psoriasis, apical pulmonary involvement, lower gastrointestinal involvement with colitis, and related arthritides including psoriatic arthritis and ankylosing spondylitis...
November 16, 2021: Seminars in Immunology
#39
JOURNAL ARTICLE
Istvan Fedor, Eva Zold, Zsolt Barta
BACKGROUND: Microscopic colitides are chronic immune-inflammatory bowel diseases. The typical presentation is chronic, watery diarrhoea. Inflammation mostly cannot be visualized via macroscopic inspection. The diagnosis thus requires histologic sampling. The clinical picture can vary. New investigations can prove valuable in setting up recommendations. PATIENTS: A total of 103 patients with microscopic colitis (MC) [28 lymphocytic colitis (LC) 27.2%, 75 collagenous colitis (CC) 72...
December 2021: Annals of Medicine
#40
Jeonghui Yun, Sanggyu Park, Hojun Park, Won Lim, Taeyeong Lee, Chulsoo Song
Eosinophilic colitis is a rare disease that is characterized by eosinophilic infiltration in the colon wall in symptomatic patients. Thus far, the epidemiology and pathophysiology of eosinophilic colitis have not been well defined, but the hypersensitivity response is likely to play a role in its pathogenesis. The clinical presentation of eosinophilic colitis is usually nonspecific and depends on the layer of the intestinal wall affected by the eosinophilic infiltrate. Eosinophilic colitis is diagnosed generally by exclusion, i...
June 25, 2021: Korean Journal of Gastroenterology, Taehan Sohwagi Hakhoe Chi
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