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Liming Liang

Lei Shi, Zhaohui Guo, Fang Liang, Xiyuan Xiao, Chi Peng, Peng Zeng, Wenli Feng, Hongzhen Ran
Cadmium (Cd) in paddy soil is one of the most harmful potentially toxic elements threatening human health. In order to study the effect of lime combined with intermittent and flooding conditions on the soil pH, Cd availability and its accumulation in tissues at the tillering, filling and maturity stages of rice, as well as enzyme activity and the microbial community in contaminated soil, a field experiment was conducted. The results showed that liming under flooding conditions is a more suitable strategy for in situ remediation of Cd-contaminated paddy soil than intermittent conditions...
February 11, 2019: International Journal of Environmental Research and Public Health
Liyan Pan, Guangjian Liu, Xiaojian Mao, Huixian Li, Jiexin Zhang, Huiying Liang, Xiuzhen Li
BACKGROUND: Central precocious puberty (CPP) in girls seriously affects their physical and mental development in childhood. The method of diagnosis-gonadotropin-releasing hormone (GnRH)-stimulation test or GnRH analogue (GnRHa)-stimulation test-is expensive and makes patients uncomfortable due to the need for repeated blood sampling. OBJECTIVE: We aimed to combine multiple CPP-related features and construct machine learning models to predict response to the GnRHa-stimulation test...
February 12, 2019: JMIR Medical Informatics
Y F Chen, Y Y Pan, Y C Liu, H P Cheng, C H Tsou, H C Liang
Efficient high-power continuous-wave Nd:YVO4 visible lasers at versatile wavelengths of 532 (green), 559 (lime), and 588 nm (yellow) are demonstrated to be achieved by using the identical cavity mirrors and gain medium. A dichroic coating is deposited on one end surface of the gain medium to gather the backward green-yellow emission. The green, lime, and yellow outputs are individually optimized by using different phase-matched lithium triborate (LBO) crystals for second harmonic generation (SHG) of the fundamental field, sum frequency generation (SFG) of the fundamental and the stimulated Raman fields, and SHG of the stimulated Raman field, respectively...
February 4, 2019: Optics Express
Wonil Chung, Jun Chen, Constance Turman, Sara Lindstrom, Zhaozhong Zhu, Po-Ru Loh, Peter Kraft, Liming Liang
We introduce cross-trait penalized regression (CTPR), a powerful and practical approach for multi-trait polygenic risk prediction in large cohorts. Specifically, we propose a novel cross-trait penalty function with the Lasso and the minimax concave penalty (MCP) to incorporate the shared genetic effects across multiple traits for large-sample GWAS data. Our approach extracts information from the secondary traits that is beneficial for predicting the primary trait based on individual-level genotypes and/or summary statistics...
February 4, 2019: Nature Communications
Liang Liu, Zhaoyang Han, Liming Fang, Zuchao Ma
IoT devices are now enriching people's life. However, the security of IoT devices seldom attracts manufacturers' attention. There are already some solutions to the problem of connecting a smart device to a user's wireless network based on the 802.11 transmission such as Smart Config from TI. However, it is insecure in many situations, and it does not have a satisfactory transmission speed, which does not mean that it has a low bit rate. It usually takes a long time for the device to recognize the data it receives and decode them...
February 1, 2019: Sensors
Bo Liang, Yuan Gao, Jiabao Xu, Yizhi Song, Liming Xuan, Ting Shi, Ning Wang, Zhaoxu Hou, Yi-Lei Zhao, Wei E Huang, Zi-Jiang Chen
OBJECTIVE: To develop and validate Raman metabolic footprint analysis to determine chromosome euploidy and aneuploidy in embryos fertilized in vitro. DESIGN: Retrospective study. SETTING: Academic hospital. PATIENT(S): Unselected assisted reproductive technology population. INTERVENTION(S): To establish the analysis protocol, spent embryo culture medium samples with known genetic outcomes from 87 human embryos were collected and measured with the use of Raman spectroscopy...
January 22, 2019: Fertility and Sterility
Xiaomeng Wang, Hekai Jiang, Di Fang, Jianru Liang, Lixiang Zhou
Acid mine drainage (AMD) has been recognized as a major challenge to the global mining industry due to its environmental consequences. Lime neutralization has been a traditional treatment for AMD, but the abundance of iron and sulfate in AMD usually renders it ineffective by forming iron hydroxide and gypsum precipitate coating on the surface of lime. In light of ubiquitous biological mineralization phenomena present at AMD sites, a rapid chemical mineralization was developed to reduce iron and sulfate and recovery of iron from AMD prior to lime neutralization...
January 9, 2019: Water Research
Junnan Chen, Linying Lai, Kui Ma, Xiao Xu, Zhenya Huang, Guiwen Zhou, Yunchao Zhou, Liming Liang, Minliang Chen
BACKGROUND: Chyle fat transplantation has shown positive effects on preexisting human hypertrophic scars (HSs) in a nude mouse HS graft model. METHODS: Hypertrophic scar fragments were obtained from 5 surgically treated burn patients and implanted into the backs of nude mice in 3 groups: group A, control; group B, triamcinolone; and group C, chyle fat. The specimens were implanted after the corresponding intralesional injection in each group, and the mice were observed for 4 weeks...
January 9, 2019: Annals of Plastic Surgery
Christopher J Stewart, Jonathan M Mansbach, Nadim J Ajami, Joseph F Petrosino, Zhaozhong Zhu, Liming Liang, Carlos A Camargo, Kohei Hasegawa
Background: Emerging evidence suggests relations of nasopharyngeal metabolome and microbiota with bronchiolitis severity. However, the influence of host systemic metabolism on disease pathobiology remains unclear. We aimed to examine metabolome profiles and their association with higher severity, defined by use of positive pressure ventilation (PPV), in infants hospitalized for bronchiolitis. Methods: In 140 infants with bronchiolitis, metabolomic profiling was performed on serum: n=70 in the training dataset and n=70 independent samples in the test dataset...
January 9, 2019: Journal of Infectious Diseases
Yuwen Jiao, Haojun Yang, Jun Qian, Yu Gong, Hanyang Liu, Siyuan Wu, Liang Cao, Liming Tang
Gastric cancer (GC) is one of the most common and fatal types of cancers worldwide and the specific mechanism has not been completely elucidated. microRNA (miR)‑3664‑5P has rarely been studied and the aim of the present study was to assess an association between miR‑3664‑5P and GC. Differences in miR‑3664‑5P expression in 100 GC (0.1846±0.08276) and paired normal tissues (0.4382±0.1595) were detected using reverse transcription‑quantitative polymerase chain reaction assays (P<0.001). 5‑Ethynyl‑2‑deoxyuridine, Cell Counting Kit‑8, transwell and flow cytometry assays were performed in vitro and the results were further verified using a mouse xenotransplantation and a lung metastasis model in vivo...
January 8, 2019: International Journal of Oncology
Yifan Dai, Liang-Yuan Chiu, Yongkun Sui, Quanbin Dai, Srinivasa Penumutchu, Niyati Jain, Liming Dai, Christian A Zorman, Blanton S Tolbert, R Mohan Sankaran, Chung Chiun Liu
The analysis of protein-nucleic acid interactions is essential for biophysics related research. However, simple, rapid, and accurate methods for quantitative analysis of biomolecular interactions are lacking. We herein establish an electrochemical biosensor approach for protein-nucleic acid binding analysis. Nanoparticle based sensors are fabricated by highly-controlled inkjet printing followed by plasma conversion. A novel bioconjugation method is demonstrated as a simple and rapid approach for protein-based biosensor fabrication...
April 1, 2019: Talanta
Yiting Wang, Liang Yan, Jingyang Liu, Shitong Chen, Guangming Liu, Yali Nie, Pei Wang, Weihong Yang, Liming Chen, Xiaobo Zhong, Shengna Han, Lirong Zhang
Expression of cytochrome P450s (CYPs) is regulated by epigenetic factors, such as DNA methylation, histone modifications, and non-coding RNAs through different mechanisms. Among these factors, long non-coding RNAs (lncRNAs) have been shown to play important roles in the regulation of gene expression; however, little is known about the effects of lncRNAs on the regulation of CYP expression. The aim of this study was to explore the role of lncRNAs in the regulation of CYP expression by using human liver tissues and hepatoma Huh7 cells...
January 2, 2019: Journal of Pharmacology and Experimental Therapeutics
Yunyi Li, Jialiang Liang, Zihao Yang, Hang Wang, Yangsheng Liu
In this work, a series of long-term treatment trials were conducted to evaluate the remediation performance of amorphous iron pyrite (FeS2( am) ) toward hexavalent chromium (Cr(VI)) in chromite ore processing residue (COPR). The effectiveness of FeS2( am) was assessed using alkaline digestion, the synthetic precipitation leaching procedure (SPLP) and the physiologically based extraction test (PBET). Reaction mechanisms were explored by monitoring the changes in the solid pH, redox potential (Eh), the chemical states of relevant elements as well as the crystal forms present in COPR...
December 5, 2018: Science of the Total Environment
Mark D Chaffin, Liu Cao, Amy A Deik, Clary B Clish, Frank B Hu, Miguel A Martínez-González, Cristina Razquin, Monica Bullo, Dolores Corella, Enrique Gómez-Gracia, Miquel Fiol, Ramon Estruch, José Lapetra, Montserrat Fitó, Fernando Arós, Lluís Serra-Majem, Emilio Ros, Liming Liang
High-throughput metabolomics using liquid chromatography and mass spectrometry (LC/MS) provide a useful method to identify biomarkers of disease and explore biological systems. However, the majority of metabolic features detected from untargeted metabolomics experiments have unknown ion signatures, making it critical that data should be thoroughly quality controlled to avoid analyzing false signals. Here we present a post-alignment method relying on intermittent pooled study samples to separate genuine metabolic features from potential measurement artifacts...
December 18, 2018: Journal of Proteome Research
Junliang Fei, Bin Liang, Chunzhi Jiang, Haifeng Ni, Liming Wang
Osteoarthritis (OA) is a joint disease characterized by inflammation and cartilage degradation. Accumulating evidence has demonstrated that luteolin, a natural flavonoid, has anti-inflammatory and anticatabolic effects. The present study aimed to assess the protective effect of luteolin on interleukin (IL)-1β-stimulated rat chondrocytes and a monosodium iodoacetate (MIA)-induced model of OA. Rat chondrocytes were pretreated with luteolin (0, 25, 50, and 100 μM for 12 h) prior to stimulation with IL-1β (10 ng/ml for 24 h)...
January 2019: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Fumihiko Takeuchi, Masato Akiyama, Nana Matoba, Tomohiro Katsuya, Masahiro Nakatochi, Yasuharu Tabara, Akira Narita, Woei-Yuh Saw, Sanghoon Moon, Cassandra N Spracklen, Jin-Fang Chai, Young-Jin Kim, Liang Zhang, Chaolong Wang, Huaixing Li, Honglan Li, Jer-Yuarn Wu, Rajkumar Dorajoo, Jovia L Nierenberg, Ya Xing Wang, Jing He, Derrick A Bennett, Atsushi Takahashi, Yukihide Momozawa, Makoto Hirata, Koichi Matsuda, Hiromi Rakugi, Eitaro Nakashima, Masato Isono, Matsuyuki Shirota, Atsushi Hozawa, Sahoko Ichihara, Tatsuaki Matsubara, Ken Yamamoto, Katsuhiko Kohara, Michiya Igase, Sohee Han, Penny Gordon-Larsen, Wei Huang, Nanette R Lee, Linda S Adair, Mi Yeong Hwang, Juyoung Lee, Miao Li Chee, Charumathi Sabanayagam, Wanting Zhao, Jianjun Liu, Dermot F Reilly, Liang Sun, Shaofeng Huo, Todd L Edwards, Jirong Long, Li-Ching Chang, Chien-Hsiun Chen, Jian-Min Yuan, Woon-Puay Koh, Yechiel Friedlander, Tanika N Kelly, Wen Bin Wei, Liang Xu, Hui Cai, Yong-Bing Xiang, Kuang Lin, Robert Clarke, Robin G Walters, Iona Y Millwood, Liming Li, John C Chambers, Jaspal S Kooner, Paul Elliott, Pim van der Harst, Zhengming Chen, Makoto Sasaki, Xiao-Ou Shu, Jost B Jonas, Jiang He, Chew-Kiat Heng, Yuan-Tsong Chen, Wei Zheng, Xu Lin, Yik-Ying Teo, E-Shyong Tai, Ching-Yu Cheng, Tien Yin Wong, Xueling Sim, Karen L Mohlke, Masayuki Yamamoto, Bong-Jo Kim, Tetsuro Miki, Toru Nabika, Mitsuhiro Yokota, Yoichiro Kamatani, Michiaki Kubo, Norihiro Kato
Blood pressure (BP) is a major risk factor for cardiovascular disease and more than 200 genetic loci associated with BP are known. Here, we perform a multi-stage genome-wide association study for BP (max N = 289,038) principally in East Asians and meta-analysis in East Asians and Europeans. We report 19 new genetic loci and ancestry-specific BP variants, conforming to a common ancestry-specific variant association model. At 10 unique loci, distinct non-rare ancestry-specific variants colocalize within the same linkage disequilibrium block despite the significantly discordant effects for the proxy shared variants between the ethnic groups...
November 28, 2018: Nature Communications
Rosie M Martinez, Russ Hauser, Liming Liang, Abdallah Mansur, Michal Adir, Laura Dioni, Catherine Racowsky, Valentina Bollati, Andrea A Baccarelli, Ronit Machtinger
BACKGROUND: Phenols and phthalates are potential endocrine disrupting chemicals (EDCs) that are associated with adverse health outcomes. These EDCs dysregulate a number of biomolecules and pathways, including microRNAs. MicroRNAs can be carried in transport systems called extracellular vesicles (EVs) that are present in most biofluids. EVs in the follicular fluid, which fills the ovarian follicle and influences oocyte developmental competency, carry microRNAs (EV-miRNAs) that have been associated with In Vitro Fertilization (IVF) outcomes...
November 24, 2018: Environment International
Rosie M Martinez, Liming Liang, Catherine Racowsky, Laura Dioni, Abdallah Mansur, Michal Adir, Valentina Bollati, Andrea A Baccarelli, Russ Hauser, Ronit Machtinger
Encapsulated microRNAs (i.e., miRNAs within the extracellular vesicles, i.e., EV-miRNAs) have been detected in follicular fluid in both animal and human studies and different profiles have been associated with IVF cycle characteristics. However, limited studies to date have investigated other IVF outcomes, including fertilization status and embryo quality on day three". In this cohort, we performed a cross-sectional analysis on 126 women who contributed follicular fluid from a single follicle during a single IVF cycle...
November 19, 2018: Scientific Reports
Dong D Wang, Yan Zheng, Estefanía Toledo, Cristina Razquin, Miguel Ruiz-Canela, Marta Guasch-Ferré, Edward Yu, Dolores Corella, Enrique Gómez-Gracia, Miquel Fiol, Ramón Estruch, Emilio Ros, José Lapetra, Montserrat Fito, Fernando Aros, Lluis Serra-Majem, Clary B Clish, Jordi Salas-Salvadó, Liming Liang, Miguel A Martínez-González, Frank B Hu
Background: Perturbed lipid metabolic pathways may play important roles in the development of cardiovascular disease (CVD). However, existing epidemiological studies have focused more on discovering individual lipid metabolites for CVD risk prediction rather than assessing metabolic pathways. Methods: This study included a subcohort of 787 participants and all 230 incident CVD cases from the PREDIMED trial. Applying a network-based analytical method, we identified lipid subnetworks and clusters from a global network of 200 lipid metabolites and linked these subnetworks/clusters to CVD risk...
November 13, 2018: International Journal of Epidemiology
Jisen Zhang, Xingtan Zhang, Haibao Tang, Qing Zhang, Xiuting Hua, Xiaokai Ma, Fan Zhu, Tyler Jones, Xinguang Zhu, John Bowers, Ching Man Wai, Chunfang Zheng, Yan Shi, Shuai Chen, Xiuming Xu, Jingjing Yue, David R Nelson, Lixian Huang, Zhen Li, Huimin Xu, Dong Zhou, Yongjun Wang, Weichang Hu, Jishan Lin, Youjin Deng, Neha Pandey, Melina Mancini, Dessireé Zerpa, Julie K Nguyen, Liming Wang, Liang Yu, Yinghui Xin, Liangfa Ge, Jie Arro, Jennifer O Han, Setu Chakrabarty, Marija Pushko, Wenping Zhang, Yanhong Ma, Panpan Ma, Mingju Lv, Faming Chen, Guangyong Zheng, Jingsheng Xu, Zhenhui Yang, Fang Deng, Xuequn Chen, Zhenyang Liao, Xunxiao Zhang, Zhicong Lin, Hai Lin, Hansong Yan, Zheng Kuang, Weimin Zhong, Pingping Liang, Guofeng Wang, Yuan Yuan, Jiaxian Shi, Jinxiang Hou, Jingxian Lin, Jingjing Jin, Peijian Cao, Qiaochu Shen, Qing Jiang, Ping Zhou, Yaying Ma, Xiaodan Zhang, Rongrong Xu, Juan Liu, Yongmei Zhou, Haifeng Jia, Qing Ma, Rui Qi, Zhiliang Zhang, Jingping Fang, Hongkun Fang, Jinjin Song, Mengjuan Wang, Guangrui Dong, Gang Wang, Zheng Chen, Teng Ma, Hong Liu, Singha R Dhungana, Sarah E Huss, Xiping Yang, Anupma Sharma, Jhon H Trujillo, Maria C Martinez, Matthew Hudson, John J Riascos, Mary Schuler, Li-Qing Chen, David M Braun, Lei Li, Qingyi Yu, Jianping Wang, Kai Wang, Michael C Schatz, David Heckerman, Marie-Anne Van Sluys, Glaucia Mendes Souza, Paul H Moore, David Sankoff, Robert VanBuren, Andrew H Paterson, Chifumi Nagai, Ray Ming
In the version of this article originally published, the accession codes listed in the data availability section were incorrect and the section was incomplete. The text for this section should have read "The genome assembly and gene annotation have been deposited in the NCBI database under accession number QVOL00000000, BioProject number PRJNA483885 and BioSample number SAMN09753102. The data can also be downloaded from the following link: ...
December 2018: Nature Genetics
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