keyword
https://read.qxmd.com/read/38536222/bridging-and-bonding-social-capital-by-analyzing-the-demographics-user-activities-and-social-network-dynamics-of-sexual-assault-centers-on-twitter-mixed-methods-study
#1
JOURNAL ARTICLE
Jia Xue, Qiaoru Zhang, Yun Zhang, Hong Shi, Chengda Zheng, Jingchuan Fan, Linxiao Zhang, Chen Chen, Luye Li, Micheal L Shier
BACKGROUND: Social media platforms have gained popularity as communication tools for organizations to engage with clients and the public, disseminate information, and raise awareness about social issues. From a social capital perspective, relationship building is seen as an investment, involving a complex interplay of tangible and intangible resources. Social media-based social capital signifies the diverse social networks that organizations can foster through their engagement on social media platforms...
March 27, 2024: Journal of Medical Internet Research
https://read.qxmd.com/read/38536053/fibrosis-on-chip-a-guide-to-recapitulate-the-essential-features-of-fibrotic-disease
#2
REVIEW
Emma M Streutker, Utku Devamoglu, Madelon C Vonk, Wouter P R Verdurmen, Séverine Le Gac
Fibrosis, which is primarily marked by excessive extracellular matrix (ECM) deposition, is a pathophysiological process associated with many disorders, which ultimately leads to organ dysfunction and poor patient outcomes. Despite the high prevalence of fibrosis, currently there exist few therapeutic options, and importantly, there is a paucity of in vitro models to accurately study fibrosis. This review discusses the multifaceted nature of fibrosis from the viewpoint of developing organ-on-chip (OoC) disease models, focusing on five key features: the ECM component, inflammation, mechanical cues, hypoxia and vascularization...
March 27, 2024: Advanced Healthcare Materials
https://read.qxmd.com/read/38535126/current-methods-of-newborn-screening-follow-up-for-sickle-cell-disease-are-highly-variable-and-without-quality-assurance-results-from-the-enhance-study
#3
JOURNAL ARTICLE
Najibah Galadanci, Shannon Phillips, Alyssa Schlenz, Nataliya Ivankova, Julie Kanter
Newborn screening (NBS) for sickle cell disease (SCD) has significantly improved childhood survival but there are still gaps resulting in delayed care for affected infants. As a state-run program, there are no national quality assurance programs to ensure each state achieves consistent, reliable outcomes. We performed this qualitative study of NBS follow-up practices to better evaluate and understand the multi-level, state-specific processes of how each state's public health department delivers the NBS results to families, how/if they ensure affected infants are seen quickly by sickle cell specialists, and to determine the close-out processes used in each state...
March 8, 2024: International Journal of Neonatal Screening
https://read.qxmd.com/read/38532493/menarche-pubertal-timing-and-the-brain-female-specific-patterns-of-brain-maturation-beyond-age-related-development
#4
JOURNAL ARTICLE
Nina Gottschewsky, Dominik Kraft, Tobias Kaufmann
BACKGROUND: Puberty depicts a period of profound and multifactorial changes ranging from social to biological factors. While brain development in youths has been studied mostly from an age perspective, recent evidence suggests that pubertal measures may be more sensitive to study adolescent neurodevelopment, however, studies on pubertal timing in relation to brain development are still scarce. METHODS: We investigated if pre- vs. post-menarche status can be classified using machine learning on cortical and subcortical structural magnetic resonance imaging (MRI) data from strictly age-matched adolescent females from the Adolescent Brain Cognitive Development (ABCD) cohort...
March 26, 2024: Biology of Sex Differences
https://read.qxmd.com/read/38532181/anti-and-pro-fibrillatory-effects-of-pulmonary-vein-isolation-gaps-in-human-atrial-fibrillation-digital-twins
#5
JOURNAL ARTICLE
Ze Jin, Taehyun Hwang, Daehoon Kim, Byounghyun Lim, Oh-Seok Kwon, Sangbin Kim, Moon-Hyun Kim, Je-Wook Park, Hee Tae Yu, Tae-Hoon Kim, Jae-Sun Uhm, Boyoung Joung, Moon-Hyoung Lee, Hui-Nam Pak
Although pulmonary vein isolation (PVI) gaps and extrapulmonary vein triggers contribute to recurrence after atrial fibrillation (AF) ablation, their precise mechanisms remain unproven. Our study assessed the impact of PVI gaps on rhythm outcomes using a human AF digital twin. We included 50 patients (76.0% with persistent AF) who underwent catheter ablation with a realistic AF digital twin by integrating computed tomography and electroanatomical mapping. We evaluated the final rhythm status, including AF and atrial tachycardia (AT), across 600 AF episodes, considering factors including PVI level, PVI gap number, and pacing locations...
March 26, 2024: NPJ Digital Medicine
https://read.qxmd.com/read/38532112/evaluation-of-farmers-friendly-ipm-modules-for-the-management-of-fall-armyworm-spodoptera-frugiperda-je-smith-in-maize-in-the-hot-semiarid-region-of-india
#6
JOURNAL ARTICLE
Mandla Rajashekhar, Banda Rajashekar, Thalla Prabhakar Reddy, Keerthi Manikyanahalli Chandrashekara, Kalisetti Vanisree, Kommagoni Ramakrishna, Vanam Sunitha, Ongolu Shaila, Eetela Sathyanarayana, Shahanaz, Somireddy Srinivasa Reddy, Adhi Shankar, Afifa Jahan, Padala Vinod Kumar, Maligi Jagan Mohan Reddy
Invasive alien species (IAS) pose a severe threat to global agriculture, with their impact projected to escalate due to climate change and expanding international trade. The fall armyworm (FAW), Spodoptera frugiperda (J. E. Smith), a native of the Americas, has rapidly spread across various continents, causing significant damage to several food crops, especially maize. Integrated pest management (IPM) programs are vital for sustainable FAW control, combining multiple strategies for sustainable results. Over three consecutive years, 2019-20, 2020-21 and 2021-22, the field demonstrations were conducted in semiarid regions of India, testing a four-component IPM approach viz...
March 26, 2024: Scientific Reports
https://read.qxmd.com/read/38529943/nir-ii-absorbing-tmb-derivative-for-1064-nm-excited-photothermal-immunoassay
#7
JOURNAL ARTICLE
Henglin Liu, Xiao Zhang, Xianming Li, Peng Wu
Materials exhibiting strong absorption in the NIR-II region are appealing for photothermal conversion-based imaging, diagnosis, and therapy, due to better thermal effect and decreased absorption of water in such a region. 3,3',5,5'-Tetramethylbenzidine (TMB), the typical substrate in ELISA, has been explored in photothermal immunoassay, since its oxidation product (oxTMB) is photothermally active in the NIR region. However, its absorption at 1064 nm (the most often used laser wavelength in photothermal studies) is not appreciable, thus limiting the assay sensitivity...
March 26, 2024: Analytical Chemistry
https://read.qxmd.com/read/38529816/bright-near-infrared-emission-from-the-au-39-sr-29-nanocluster
#8
JOURNAL ARTICLE
Zhongyu Liu, Lianshun Luo, Jie Kong, Ellen Kahng, Meng Zhou, Rongchao Jin
The synthesis of atomically precise gold nanoclusters with high photoluminescence quantum yield (PLQY) in the near-infrared (NIR) region and understanding their photoluminescence mechanism are crucial for both fundamental science and practical applications. Herein, we report a highly luminescent, molecularly pure Au39 (PET)29 (PET = 2-phenylethanethiolate) nanocluster with PLQY of 19% in the NIR range (915 nm). Steady state and time-resolved PL analyses, as well as temperature-dependent PL measurements reveal the emission nature of Au39 (PET)29 , which consists of prompt fluorescence (weak), thermally activated delayed fluorescence (TADF), and phosphorescence (predominant)...
March 26, 2024: Nanoscale
https://read.qxmd.com/read/38528929/adme-profiling-molecular-docking-dft-and-mep-analysis-reveal-cissamaline-cissamanine-and-cissamdine-from-cissampelos-capensis-l-f-as-potential-anti-alzheimer-s-agents
#9
JOURNAL ARTICLE
Maram B Alhawarri, Mohammad G Al-Thiabat, Amit Dubey, Aisha Tufail, Dania Fouad, Bilal Harieth Alrimawi, Mohamad Dayoob
The current pharmacotherapies for Alzheimer's disease (AD) demonstrate limited efficacy and are associated with various side effects, highlighting the need for novel therapeutic agents. Natural products, particularly from medicinal plants, have emerged as a significant source of potential neuroprotective compounds. In this context, Cissampelos capensis L.f., renowned for its medicinal properties, has recently yielded three new proaporphine alkaloids; cissamaline, cissamanine, and cissamdine. Despite their promising bioactive profiles, the biological targets of these alkaloids in the context of AD have remained unexplored...
March 20, 2024: RSC Advances
https://read.qxmd.com/read/38528907/a-deep-learning-approach-to-analyzing-continuous-time-cognitive-processes
#10
JOURNAL ARTICLE
Cory Shain, William Schuler
The dynamics of the mind are complex. Mental processes unfold continuously in time and may be sensitive to a myriad of interacting variables, especially in naturalistic settings. But statistical models used to analyze data from cognitive experiments often assume simplistic dynamics. Recent advances in deep learning have yielded startling improvements to simulations of dynamical cognitive processes, including speech comprehension, visual perception, and goal-directed behavior. But due to poor interpretability, deep learning is generally not used for scientific analysis...
2024: Open Mind: Discoveries in Cognitive Science
https://read.qxmd.com/read/38528808/treatment-of-depression-in-huntington-s-disease-a-systematic-review
#11
JOURNAL ARTICLE
Shayan Abdollah Zadegan, Frank Ramirez, Kirthan S Reddy, Onur Sahin, Natalia Pessoa Rocha, Antonio L Teixeira, Erin Furr Stimming
Depression is a common psychiatric disorder among individuals with Huntington's disease (HD). Depression in HD and major depressive disorder appear to have different pathophysiological mechanisms. Despite the unique pathophysiology, the treatment of depression in HD is based on data from the treatment of major depressive disorder in the general population. The objective of this systematic review was to conduct a comprehensive evaluation of the available evidence. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines were followed...
March 26, 2024: Journal of Neuropsychiatry and Clinical Neurosciences
https://read.qxmd.com/read/38527962/achieving-efficient-dark-blue-room-temperature-phosphorescence-with-ultra-wide-range-tunable-lifetime
#12
JOURNAL ARTICLE
Lei Zhou, Jinming Song, Zhenyi He, Yiwei Liu, Ping Jiang, Tao Li, Xiang Ma
Tunable-lifetime room-temperature phosphorescence (RTP) materials have been widely studied due to their broad applications. However, only few reports have achieved wide-range lifetime modulation. In this work, ultra-wide range tunable-lifetime efficient dark blue RTP materials were realized by doping methyl benzoate derivatives into polyvinyl alcohol (PVA) matrix. The phosphorescence lifetimes of the doped film can be increased from 32.8 ms to 1925.8 ms. Such wide range of phosphorescence lifetime modulation is extremely rare in current reports...
March 25, 2024: Angewandte Chemie
https://read.qxmd.com/read/38526679/exploring-genetic-diversity-within-aus-rice-germplasm-insights-into-the-variations-in-agro-morphological-traits
#13
JOURNAL ARTICLE
Puranjoy Sar, Sonal Gupta, Motilal Behera, Koushik Chakraborty, Umakanta Ngangkham, Bibhash Chandra Verma, Amrita Banerjee, Prashantkumar S Hanjagi, Debarati Bhaduri, Sandip Shil, Jitendra Kumar, Nimai Prasad Mandal, Paresh Chandra Kole, Michael D Purugganan, Somnath Roy
The aus (Oryza sativa L.) varietal group comprises of aus, boro, ashina and rayada seasonal and/or field ecotypes, and exhibits unique stress tolerance traits, making it valuable for rice breeding. Despite its importance, the agro-morphological diversity and genetic control of yield traits in aus rice remain poorly understood. To address this knowledge gap, we investigated the genetic structure of 181 aus accessions using 399,115 SNP markers and evaluated them for 11 morpho-agronomic traits. Through genome-wide association studies (GWAS), we aimed to identify key loci controlling yield and plant architectural traits...
March 25, 2024: Rice
https://read.qxmd.com/read/38526508/reactive-carbon-capture-enables-co-2-electrolysis-with-liquid-feedstocks
#14
JOURNAL ARTICLE
Douglas J D Pimlott, Yongwook Kim, Curtis P Berlinguette
ConspectusThe electrochemical reduction of carbon dioxide (CO2RR) is a promising strategy for mitigating global CO2 emissions while simultaneously yielding valuable chemicals and fuels, such as CO, HCOO- , and C2 H4 . This approach becomes especially appealing when integrated with surplus renewable electricity, as the ensuing production of fuels could facilitate the closure of the carbon cycle. Despite these advantages, the realization of industrial-scale electrolyzers fed with CO2 will be challenged by the substantial energy inputs required to isolate, pressurize, and purify CO2 prior to electrolysis...
March 25, 2024: Accounts of Chemical Research
https://read.qxmd.com/read/38524441/ultrasonic-or-microwave-modified-continuous-flow-chemistry-for-the-synthesis-of-tetrahydrocannabinol-observing-effects-of-various-solvents-and-acids
#15
JOURNAL ARTICLE
Giovanni A Ramirez, Tesfay T Tesfatsion, Maite L Docampo-Palacios, Ivan Cruces, Adam J Hellmann, Alex Okhovat, Monica K Pittiglio, Kyle P Ray, Westley Cruces
Synthesizing tetrahydrocannabinol is a lengthy process with minimal yields and little applicability on an industrial scale. To close the gap between bench chemistry and industry process chemistry, this paper introduces a small-scale flow chemistry method that utilizes a microwave or ultrasonic medium to produce major tetrahydrocannabinol isomers. This process produces excellent yields and minimal side products, which leads to more efficient large-scale production of the desired cannabinoids.
March 19, 2024: ACS Omega
https://read.qxmd.com/read/38524011/the-role-of-bone-mineral-density-in-a-successful-lumbar-interbody-fusion-a-narrative-review
#16
REVIEW
Kyriakos N Bekas, Christos Zafeiris
BACKGROUND: The incidence of osteoporosis is a prime concern, especially in parts of the world where the population is aging, such as Europe or the US. Many new therapy strategies have been described to enhance bone healing. Lumbar interbody fusion (LIF) is a surgical procedure that aims to stabilize the lumbar spine by fusing two or more vertebrae using an interbody cage. LIF is a standard treatment for various spinal conditions, such as degenerative disc disease, spinal stenosis, and spondylolisthesis...
February 2024: Curēus
https://read.qxmd.com/read/38521144/chromosome-level-genome-assembly-and-transcriptome-analysis-of-e11-cells-infected-by-tilapia-lake-virus
#17
JOURNAL ARTICLE
Xingxing Wang, Xudong Liu, Lu Tan, Ladan Jahangiri, Wenlong Cai, Dal Young Kim, Runsheng Li
The E11 cell line, derived from striped snakehead fish (Channa striata), possesses a distinctive feature: it is persistently infected with a C-type retrovirus. Notably, it exhibits high permissiveness to piscine nodavirus and the emerging tilapia lake virus (TiLV). Despite its popularity in TiLV research, the absence of genome assembly for the E11 cell line and Channa striata has constrained research on host-virus interactions. This study aimed to fill this gap by sequencing, assembling, and annotating the E11 cell line genome...
March 21, 2024: Fish & Shellfish Immunology
https://read.qxmd.com/read/38520734/-it-s-not-just-linguistically-there-s-much-more-going-on-the-experiences-and-practices-of-bilingual-paediatric-speech-and-language-therapists-in-the-uk
#18
JOURNAL ARTICLE
Mélanie Gréaux, Jenny L Gibson, Napoleon Katsos
BACKGROUND: Despite the high prevalence of bilingualism in the United Kingdom, few speech and language therapists (SLTs) are bilingual themselves. Most SLT research on bilingualism has generated knowledge to inform service delivery for bilingual clients, but few studies have investigated how being a bilingual SLT influences one's professional experiences and practices. Better understanding the unique positionality of bilingual SLTs can yield critical insights to meaningfully address issues of diversity, inclusion and equity in the profession...
March 23, 2024: International Journal of Language & Communication Disorders
https://read.qxmd.com/read/38519035/optimizing-mycelial-protein-yield-in-pleurotus-djamor-via-artp-mutagenesis-and-hybridization-strategies
#19
JOURNAL ARTICLE
Jing Pan, Yunhui Bao, Hefen Wei, Qingguo Liu, Wenhui Xu, Jian Zhang
With the world's population rapidly increasing, the demand for high-quality protein is on the rise. Edible fungi breeding technology stands as a crucial avenue to obtain strains with high yield, high-quality protein, and robust stress resistance. To address the protein supply gap, Atmospheric and Room Temperature Plasma (ARTP) mutagenesis, and spore hybridization techniques were employed to enhance Pleurotus djamor mycelium protein production. Beginning with the original strain Pleurotus djamor JD-1, ARTP was utilized to mutate spore suspension...
March 20, 2024: Journal of Biotechnology
https://read.qxmd.com/read/38517793/addressing-the-discrepancies-between-animal-models-and-human-alzheimer-s-disease-pathology-implications-for-translational-research
#20
REVIEW
Baruh Polis, Abraham O Samson
Animal models, particularly transgenic mice, are extensively used in Alzheimer's disease (AD) research to emulate key disease hallmarks, such as amyloid plaques and neurofibrillary tangles formation. Although these models have contributed to our understanding of AD pathogenesis and can be helpful in testing potential therapeutic interventions, their reliability is dubious. While preclinical studies have shown promise, clinical trials often yield disappointing results, highlighting a notable gap and disparity between animal models and human AD pathology...
March 19, 2024: Journal of Alzheimer's Disease: JAD
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