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David M Rosenfeld, Kathleen E Knapp, Joshua A Spiro, Andrew W Gorlin, Harish Ramakrishna, Terrence L Trentman
Background and Aims: There are limited data on the effect of ampule size on drug dosing. The objective of this study is to determine the effect of ampule size on perioperative opioid dosing and post-anesthesia care unit (PACU) outcomes. Material and Methods: This was a retrospective review of patients undergoing robotically assisted laparoscopic radical prostatectomy before and after a 5-ml fentanyl ampule was discontinued. The primary outcome was intraoperative opioid administration divided into fentanyl at induction of anesthesia, total fentanyl, and total opioid...
October 2018: Journal of Anaesthesiology, Clinical Pharmacology
Lindsay C Burrage, John J Reynolds, Nissan Vida Baratang, Jennifer B Phillips, Jeremy Wegner, Ashley McFarquhar, Martin R Higgs, Audrey E Christiansen, Denise G Lanza, John R Seavitt, Mahim Jain, Xiaohui Li, David A Parry, Vandana Raman, David Chitayat, Ivan K Chinn, Alison A Bertuch, Lefkothea Karaviti, Alan E Schlesinger, Dawn Earl, Michael Bamshad, Ravi Savarirayan, Harsha Doddapaneni, Donna Muzny, Shalini N Jhangiani, Christine M Eng, Richard A Gibbs, Weimin Bi, Lisa Emrick, Jill A Rosenfeld, John Postlethwait, Monte Westerfield, Mary E Dickinson, Arthur L Beaudet, Emmanuelle Ranza, Celine Huber, Valérie Cormier-Daire, Wei Shen, Rong Mao, Jason D Heaney, Jordan S Orange, Débora Bertola, Guilherme L Yamamoto, Wagner A R Baratela, Merlin G Butler, Asim Ali, Mehdi Adeli, Daniel H Cohn, Deborah Krakow, Andrew P Jackson, Melissa Lees, Amaka C Offiah, Colleen M Carlston, John C Carey, Grant S Stewart, Carlos A Bacino, Philippe M Campeau, Brendan Lee
SPONASTRIME dysplasia is an autosomal-recessive spondyloepimetaphyseal dysplasia characterized by spine (spondylar) abnormalities, midface hypoplasia with a depressed nasal bridge, metaphyseal striations, and disproportionate short stature. Scoliosis, coxa vara, childhood cataracts, short dental roots, and hypogammaglobulinemia have also been reported in this disorder. Although an autosomal-recessive inheritance pattern has been hypothesized, pathogenic variants in a specific gene have not been discovered in individuals with SPONASTRIME dysplasia...
February 11, 2019: American Journal of Human Genetics
Ian H Bell
This work investigates the link between residual entropy and viscosity based on wide-ranging, highly accurate experimental and simulation data. This link was originally postulated by Rosenfeld in 1977 [Rosenfeld Y (1977) Phys Rev A 15:2545-2549], and it is shown that this scaling results in an approximately monovariate relationship between residual entropy and reduced viscosity for a wide range of molecular fluids [argon, methane, [Formula: see text], [Formula: see text], refrigerant R-134a (1,1,1,2-tetrafluoroethane), refrigerant R-125 (pentafluoroethane), methanol, and water] and a range of model potentials (hard sphere, inverse power, Lennard-Jones, and Weeks-Chandler-Andersen)...
February 15, 2019: Proceedings of the National Academy of Sciences of the United States of America
Eric H Rosenfeld, Patricio Lau, Sohail R Shah, Bindi Naik-Mathuria, David E Wesson, Derek S Wakeman, Adam M Vogel
PURPOSE: The purpose of this study was to describe the epidemiology and evaluate the clinical significance of traumatic sternal fractures. METHODS: Patients age ≤18 years with sternal fractures in the National Trauma Database research datasets from 2007-2014 were identified. Patient demographics, injuries, procedures, and outcomes were analyzed using descriptive statistics and logistic regression. RESULTS: Three thousand one hundred sixty patients with sternal fracture were identified...
January 31, 2019: Journal of Pediatric Surgery
Elie Motulsky, Fang Zheng, Yingying Shi, José M B Garcia, Giovanni Gregori, Philip J Rosenfeld
BACKGROUND AND OBJECTIVE: Swept-source optical coherence tomography (SS-OCT) imaging was performed on eyes with epiretinal membranes (ERMs), and the extent of the ERMs were compared between the 12 mm × 12 mm scans and the more routine 6 mm × 6 mm field of view (FOV). PATIENTS AND METHODS: Eyes containing ERMs were imaged using a 12 mm × 12 mm SS-OCT scan. En face images derived from vitreoretinal interface (VRI) slabs were reviewed to assess the full extent of the ERM...
February 1, 2019: Ophthalmic Surgery, Lasers & Imaging Retina
Tracy E Crane, Terry A Badger, Alla Sikorskii, Chris Segrin, Chiu-Hsieh Hsu, Anne G Rosenfeld
OBJECTIVES: To identify subgroups of Latina breast cancer survivors with unique trajectories of depression and anxiety and examine predictors associated with these subgroups. SAMPLE & SETTING: Secondary analysis of Latina breast cancer survivors (N = 293) from three psychosocial intervention studies. METHODS & VARIABLES: Depression and anxiety were assessed at intake and at weeks 8 and 16. Group-based growth mixture modeling was used to identify subgroups who followed distinct trajectories of depression and anxiety...
March 1, 2019: Oncology Nursing Forum
Eric Rosenfeld, Patricio Lau, Wei Zhang, Robert T Russell, Sohail R Shah, Bindi Naik-Mathuria, Adam M Vogel
PURPOSE: The purpose of this study was to identify an optimal definition of massive transfusion (MT) in civilian pediatric trauma. METHODS: Severely injured children (age ≤18 years, injury severity score ≥25) in the Trauma Quality Improvement Program research datasets 2014-2015 that received blood products were identified. Children with traumatic brain injury and non-survivable injuries were excluded. Early mortality was defined as death within 24 h and delayed mortality as death after 24 h from hospital admission...
January 31, 2019: Journal of Pediatric Surgery
Marian Galovic, Anne Julia Stauber, Natascha Leisi, Werner Krammer, Florian Brugger, Jochen Vehoff, Philipp Balcerak, Anna Müller, Marlise Müller, Jochen Rosenfeld, Alexandros Polymeris, Sebastian Thilemann, Gian Marco De Marchis, Thorsten Niemann, Maren Leifke, Philippe Lyrer, Petra Saladin, Timo Kahles, Krassen Nedeltchev, Hakan Sarikaya, Simon Jung, Urs Fischer, Concetta Manno, Carlo W Cereda, Josemir W Sander, Barbara Tettenborn, Bruno J Weder, Sandro J Stoeckli, Marcel Arnold, Georg Kägi
Importance: Predicting the duration of poststroke dysphagia is important to guide therapeutic decisions. Guidelines recommend nasogastric tube (NGT) feeding if swallowing impairment persists for 7 days or longer and percutaneous endoscopic gastrostomy (PEG) placement if dysphagia does not recover within 30 days, but, to our knowledge, a systematic prediction method does not exist. Objective: To develop and validate a prognostic model predicting swallowing recovery and the need for enteral tube feeding...
February 11, 2019: JAMA Neurology
Madison B Sharp, Aaron Soufer, Medhat Abdelmessih, Lynda E Rosenfeld, Lauren A Baldassarre, Edward J Miller
No abstract text is available yet for this article.
February 8, 2019: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
Sukran Poyrazoglu, Vivian Hwa, Firdevs Bas, Andrew Dauber, Ron Rosenfeld, Feyza Darendeliler
Acid-labile subunit (ALS) forms ternary complexes with insulin like growth factor-1 (IGF-1) and IGF-binding protein-3 (IGFBP-3) and is essential for normal circulating IGF-1 levels. The IGFALS gene encodes the ALS, and mutations in IGFALS cause ALS deficiency. We describe a patient with ALS deficiency with a novel homozygous frameshift mutation in IGFALS presenting with short stature and delayed puberty but ultimately achieving an adult height (AH) comparable to his target height (TH). A 15 3/12 year old boy presented with short stature (149...
February 5, 2019: Journal of Clinical Research in Pediatric Endocrinology
Megan E Grove, Shana White, Dianna G Fisk, Shannon Rego, Orit Dagan-Rosenfeld, Jennefer N Kohler, Chloe M Reuter, Devon Bonner, Matthew T Wheeler, Jonathan A Bernstein, Kelly E Ormond, Andrea K Hanson-Kahn
With the wide adoption of next-generation sequencing (NGS)-based genetic tests, genetic counselors require increased familiarity with NGS technology, variant interpretation concepts, and variant assessment tools. The use of exome and genome sequencing in clinical care has expanded the reach and diversity of genetic testing. Regardless of the setting where genetic counselors are performing variant interpretation or reporting, most of them have learned these skills from colleagues, while on the job. Though traditional, lecture-based learning around these topics is important, there has been growing need for the inclusion of case-based, experiential training of genomics and variant interpretation for genetic counseling students, with the goal of creating a strong foundation in variant interpretation for new genetic counselors, regardless of what area of practice they enter...
February 1, 2019: Journal of Genetic Counseling
Aishwarya Vijay, John C Stendahl, Lynda E Rosenfeld
Mycoplasma pneumoniae is an atypical bacterium that is frequently implicated in respiratory infections, but uncommonly identified as a cause of pericarditis. We report 2 cases of pericarditis attributed to M. pneumoniae that were characterized by prolonged respiratory prodromes, pericardial, and pleural effusions, elevated inflammatory markers, and relapsing clinical courses. In conclusion, our experience suggests that M. pneumoniae should be considered as a potential cause in cases of pericarditis associated with upper respiratory symptoms, pneumonia, pleural effusions, arthralgia, and/or a recurrent/refractory clinical course...
January 24, 2019: American Journal of Cardiology
Zhongdi Chu, Qinqin Zhang, Hao Zhou, Yingying Shi, Fang Zheng, Giovanni Gregori, Philip J Rosenfeld, Ruikang K Wang
Background: To investigate the correlation and agreement of two previously published choriocapillaris (CC) quantification methods using a normal database with swept-source optical coherence tomography angiography (SS-OCTA). Methods: Normal adult subjects from all age groups imaged by SS-OCTA were used in this study. Each subject was imaged with 3 mm × 3 mm and 6 mm × 6 mm scan patterns centered on fovea, upon which en face CC images were generated by segmenting volumetric OCTA data...
December 2018: Quantitative Imaging in Medicine and Surgery
Yifat Bar-Zakay Rosenfeld, Miriam Krumbein, Avner Yeffet, Nathan Schiffmann, Inbal Mishalian, Eli Pikarsky, Froma Oberman, Zvi Fridlender, Joel K Yisraeli
The VICKZ (Igf2bp) family of RNA binding proteins regulate RNA function at many levels, including intracellular RNA localization, RNA stability, and translational control. One or more of the three VICKZ paralogs are upregulated in many different types of cancers. Here, we show how VICKZ1 enhances, and dominant negative VICKZ1 inhibits, cell migration, growth in soft agar, and wound healing in a mouse lung adenocarcinoma cell line containing a constitutively active, mutant Kras. Similarly, modulation of VICKZ1 activity promotes or inhibits metastases upon implantation of these cells into syngeneic mice...
January 30, 2019: Oncogene
Eric H Rosenfeld, Patricio Lau, Megan E Cunningham, Wei Zhang, Robert T Russell, Bindi Naik-Mathuria, Adam M Vogel
The purpose of this study was to identify an optimal definition of massive transfusion in civilian pediatric trauma with severe traumatic brain injury (TBI) METHODS: Severely injured children (age ≤18 y) with severe TBI in the Trauma Quality Improvement Program research data sets 2015-2016 that received blood products were identified. Data were analyzed using descriptive statistics, Wilcoxon rank-sum, chi-square, and logistic regression. Continuous variables are presented as median (interquartile range)...
December 4, 2018: Journal of Surgical Research
Eric H Rosenfeld, Kirea Mazzolini, Annalyn S DeMello, Yangyang R Yu, Aleena Karediya, Jed G Nuchtern, Sohail R Shah
BACKGROUND: In patients requiring gastrostomies, ventriculoperitoneal (VP) shunts are a frequently encountered comorbidity. The objective of this study is to evaluate the postoperative management of children with VP shunts that undergo laparoscopic gastrostomy placement and determine their incidence of complications. MATERIALS AND METHODS: Children 18 y old or younger who underwent laparoscopic gastrostomy placement at a freestanding academic children's hospital between January 2014 and October 2016 were reviewed...
December 13, 2018: Journal of Surgical Research
Cheryl S Rosenfeld
No abstract text is available yet for this article.
January 28, 2019: Proceedings of the National Academy of Sciences of the United States of America
Yan Tat Wong, Timothy Feleppa, Anand Mohan, Damien Browne, Julian Szlawski, Jeffrey V Rosenfeld, Arthur Lowery
OBJECTIVE: Implantable neural stimulating and recording devices have the potential to restore capabilities such as vision or motor control to disabled patients, improving quality of life. Implants with a large number of stimulating electrodes typically utilize implanted batteries and/or subcutaneous wiring to deal with their high-power consumption and high data throughput needed to address all electrodes with low latency. The use of batteries places severe limitations on the implant's size, usable duty cycle, device longevity while subcutaneous wiring increases the risk of infection and mechanical damage due to device movement...
January 28, 2019: Journal of Neural Engineering
Walter Zegarra, Ron Rosenfeld, David M Maahs
No abstract text is available yet for this article.
February 2019: Journal of Pediatrics
Madison T Ortega, Nathan J Bivens, Takamichi Jogahara, Asato Kuroiwa, Scott A Givan, Cheryl S Rosenfeld
BACKGROUND: Brain sexual differentiation is sculpted by precise coordination of steroid hormones during development. Programming of several brain regions in males depends upon aromatase conversion of testosterone to estrogen. However, it is not clear the direct contribution that Y chromosome associated genes, especially sex-determining region Y (Sry), might exert on brain sexual differentiation in therian mammals. Two species of spiny rats: Amami spiny rat (Tokudaia osimensis) and Tokunoshima spiny rat (T...
January 25, 2019: BMC Genomics
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