keyword
https://read.qxmd.com/read/38439932/prehospital-anaesthesiologists-experience-with-cardiopulmonary-resuscitation-induced-consciousness-in-norway-a-national-cross-sectional-survey
#1
JOURNAL ARTICLE
Jostein Rødseth Brede, Eivinn Årdal Skjærseth, Marius Rehn
BACKGROUND: During cardiopulmonary resuscitation (CPR) cerebral blood flow may be sufficient to restore some cerebral function, and CPR-induced consciousness (CPRIC) may occur. CPRIC includes signs of life such as gasping, breathing efforts, eye opening, movements of extremities or communication with the rescuers. There is a lack in evidence for prevalence, experience, and possible treatment strategies for CPRIC. This survey aimed to assess prehospital anaesthesiologists experience with CPRIC in Norway...
June 2024: Resuscitation plus
https://read.qxmd.com/read/38378273/neuronal-and-molecular-mechanisms-underlying-chronic-pain-and-depression-comorbidity-in-the-paraventricular-thalamus
#2
JOURNAL ARTICLE
Mengqiao Cui, Ran Ji, Lingzhen Song, Xianlei Wang, Xiaoyuan Pan, Yi Han, Xiaojing Zhai, Lin Ai, Wenxin Zhang, An Xie, Zhou Wu, Weiyi Song, Jun-Xia Yang, Ankang Hu, He Liu, Jun-Li Cao, Hongxing Zhang
Patients with chronic pain often develop comorbid depressive symptoms, which makes the pain symptoms more complicated and refractory. However, the underlying mechanisms are poorly known. Here, in a repeated complete Freund's adjuvant (CFA) male mouse model, we reported a specific regulatory role of the paraventricular thalamic nucleus (PVT) glutamatergic neurons, particularly the anterior PVT (PVA) neurons, in mediating chronic pain and depression comorbidity (CDC). Our c-Fos protein staining observed increased PVA neuronal activity in CFA-CDC mice...
February 20, 2024: Journal of Neuroscience
https://read.qxmd.com/read/38307499/effects-of-midazolam-dexmedetomidine-with-buprenorphine-or-extended-release-buprenorphine-anesthesia-in-c57bl-6-mice
#3
JOURNAL ARTICLE
Lisa Hagan, Emily M David, Alanna R Horton, James O Marx
The effects of commonly used injectable combinations of anesthetics such as ketamine and xylazine, with or without acepromazine, vary widely across individuals, have a shallow-dose response curve, and do not provide long-term analgesia. These drawbacks indicate the importance of continuing efforts to develop safe and effective injectable anesthetic combinations for mice. In this study, a series of experiments was designed to validate the use of dexmedetomidine and midazolam to provide chemical restraint for nonpainful procedures and the addition of buprenorphine or extended-release buprenorphine to reliably provide a surgical plane of anesthesia in C57BL/6J mice...
February 2, 2024: Journal of the American Association for Laboratory Animal Science: JAALAS
https://read.qxmd.com/read/38108647/a-retrospective-comparison-of-electrocardiographic-parameters-in-ketamine-and-tiletamine-zolazepam-anesthetized-indian-rhesus-monkeys-macaca-mulatta
#4
JOURNAL ARTICLE
Laxit K Bhatt, Chitrang R Shah, Shital D Patel, Sudhir R Patel, Vipul A Patel, Rajesh J Patel, Nikita M Joshi, Niraj A Shah, Jitendra H Patel, Pankaj Dwivedi, Rajesh Sundar, Mukul R Jain
Electrocardiographic evaluation is performed in rhesus monkeys to establish the cardiovascular safety of candidate molecules before progressing to clinical trials. These animals are usually immobilized chemically by ketamine (KTM) and tiletamine-zolazepam (TZ) to obtain a steady-state heart rate and to ensure adequate human safety. The present study aimed to evaluate the effect of these anesthetic regimens on different electrocardiographic parameters. Statistically significant lower HR and higher P-wave duration, RR, QRS, and QT intervals were observed in the KTM-anesthetized group in comparison to TZ-anesthetized animals...
December 18, 2023: International Journal of Toxicology
https://read.qxmd.com/read/38066977/comparison-of-subcutaneous-versus-intramuscular-dexmedetomidine-midazolam-ketamine-morphine-dmkm-mixture-as-chemical-restraint-for-endoscopic-sex-determination-in-aldabra-giant-tortoises-aldabrachelys-gigantea
#5
JOURNAL ARTICLE
Marco Masi, Alessandro Vetere, Jacopo Casalini, Flavia Corsi, Francesco Di Ianni, Giordano Nardini
Sex identification through coelioscopy is a minimally invasive surgical technique used to determine the sex of chelonians by directly visualizing their internal reproductive organs. An adequate anaesthesiologic plan is essential to guarantee patient immobilization and proper analgesia during the entire surgical procedure. In this study, we evaluated the effects of a combination of dexmedetomidine (0.05 mg/kg), midazolam (1 mg/kg), ketamine (8 mg/kg), and morphine (1 mg/kg) (DMKM) randomly delivered intramuscularly (IM) or subcutaneously (SC) in twenty-one Aldabra giant tortoise ( Aldabrachelys gigantea ) into the right antebrachium for celioscopic sex identification...
November 23, 2023: Animals: An Open Access Journal From MDPI
https://read.qxmd.com/read/38065287/a-critical-step-in-antidepressants-onset-excitation-of-glutamatergic-pyramidal-neurons-in-rodents-medial-prefrontal-cortex
#6
JOURNAL ARTICLE
Jiao-Zhao Yan, Guang-Xiang Li, Si-Rui Sun, Lin-Yu Cui, Yong-Yu Yin, Yun-Feng Li
Although clinical antidepressants have varied mechanisms of action, it remains unclear whether they may have a common mechanism underlying their antidepressant effects. We investigated the behavioral effects of five different antidepressants (differing in target, chemical structure, and rate of onset) and their effects on the firing activities of glutamatergic pyramidal neurons in the medial prefrontal cortex (mPFC) using the forced swimming test (FST) and electrophysiological techniques (in vivo). We employed fiber photometry recordings to validate the effects of antidepressants on the firing activity of pyramidal neurons...
December 6, 2023: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://read.qxmd.com/read/37977752/hyperactive-delirium-with-severe-agitation
#7
REVIEW
Brian Springer
Hyperactive delirium with severe agitation is a clinical syndrome of altered mental status, psychomotor agitation, and a hyperadrenergic state. The underlying pathophysiology is variable and often results from sympathomimetic abuse, psychiatric disease, sedative-hypnotic withdrawal, and metabolic derangement. Patients can go from a combative state to periarrest with little warning. Safety of the patient and of the medical providers is paramount and the emergency department should be prepared to manage these patients with adequate staffing, restraints, and pharmacologic sedatives...
February 2024: Emergency Medicine Clinics of North America
https://read.qxmd.com/read/37977745/management-of-the-agitated-patient
#8
REVIEW
Carmen Wolfe, Nicole McCoin
The acutely agitated patient should be managed in a step-wise fashion, beginning with non-coercive de-escalation strategies and moving on to pharmacologic interventions and physical restraints as necessary. Face-to-face examination, monitoring, and documentation by the physician are essential. The emergency physician should be familiar with multiple pharmaceutical options, tailored to the individual patient. Use of ketamine, benzodiazepines and antipsychotics should be considered. Patient autonomy, safety, and medical well-being are paramount...
February 2024: Emergency Medicine Clinics of North America
https://read.qxmd.com/read/37949392/gamma-oscillations-in-the-mpfc-a-potential-predictive-biomarker-of-depression-and-antidepressant-effects
#9
JOURNAL ARTICLE
Yong-Yu Yin, Jiao-Zhao Yan, Shi-Xin Lai, Qian-Qian Wei, Si-Rui Sun, Li-Ming Zhang, Yun-Feng Li
Gamma oscillations have attracted much attention in the field of mood disorders, but their role in depression remains poorly understood. This study aimed to investigate whether gamma oscillations in the medial prefrontal cortex (mPFC) could serve as a predictive biomarker of depression. Chronic restraint stress (CRS) or lipopolysaccharide (LPS) were used to induce depression-like behaviors in mice; local field potentials (LFPs) in the mPFC were recorded by electrophysiological techniques; We found that both CRS and LPS induced significant depression-like behaviors in mice, including increasing immobility durations in the forced swimming test (FST) and tail suspension test (TST) and increasing the latency to feed in the novelty-suppressed feeding test (NSFT)...
November 8, 2023: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://read.qxmd.com/read/37937480/comparing-the-efficacy-of-two-immobilization-drug-combinations-for-the-chemical-restraint-of-bobcats-lynx-rufus
#10
JOURNAL ARTICLE
Christopher N Jacques, Robert W Klaver, Christopher S DePerno, Aimee P Rockhill
Chemical immobilization agents that provide rapid induction time, short duration of action, wide margin of safety, and postreversal recovery are important attributes to the handling process of immobilized animals. We evaluated differences in induction, recovery, and physiologic parameters in 23 (13 female, nine adults and four yearlings; 10 male, nine adults and one yearling) free-ranging bobcats (Lynx rufus) chemically immobilized with an intramuscular combination of ketamine (10 mg/kg) and xylazine (KX; 1...
November 3, 2023: Journal of Wildlife Diseases
https://read.qxmd.com/read/37840867/haloperidol-midazolam-vs-haloperidol-ketamine-in-controlling-the-agitation-of-delirious-patients-a-randomized-clinical-trial
#11
JOURNAL ARTICLE
Mehrad Aghili, HamidReza AkhavanHejazi, Zeinab Naderpour, Elnaz Vahidi, Morteza Saeedi
INTRODUCTION: Agitation management in delirious patients is crucial in a crowded emergency department (ED) for both patient and personnel safety. Benzodiazepines, antipsychotics, and newly derived ketamine are among the most commonly used drugs in controlling these cases. This study aimed to compare the effectiveness of haloperidol-midazolam with haloperidol-ketamine combination in this regard. METHODS: In this double-blind randomized clinical trial, delirious patients with agitation in ED were randomly assigned to a group: group A: haloperidol 2...
2023: Archives of Academic Emergency Medicine
https://read.qxmd.com/read/37810240/the-prl-glu-%C3%A2-avbnst-gaba-circuit-rapidly-modulates-depression-like-behaviors-in-male-mice
#12
JOURNAL ARTICLE
Jie-Ying Chen, Ke Wu, Miao-Miao Guo, Wei Song, Si-Ting Huang, Yong-Mei Zhang
Depression is a global disease with a high prevalence. Here, we examine the role of the circuit from prelimbic mPFC (PrL) to the anterior ventral bed nucleus of the stria terminalis (avBNST) in depression-like mice through behavioral tests, immunofluorescence, chemogenetics, optogenetics, pharmacology, and fiber photometry. Mice exposed to chronic restraint stress with individual housing displayed depression-like behaviors. Optogenetic or chemogenetic activation of the avBNST-projecting glutamatergic neurons in the PrL had an antidepressant effect...
October 20, 2023: IScience
https://read.qxmd.com/read/37578355/-s-ketamine-but-not-r-ketamine-shows-acute-effects-on-depression-like-behavior-and-sleep-wake-architecture-in-rats
#13
JOURNAL ARTICLE
Szabolcs Koncz, Noémi Papp, Dóra Pothorszki, György Bagdy
BACKGROUND: Racemic ketamine consists of two enantiomers, namely (R)ketamine and (S)ketamine, with distinguishable pharmacological properties. Both enantiomers have been reported to show rapid antidepressant effects in rodents. Currently, the (S)enantiomer has been approved for the treatment of major depression, while (R)ketamine failed to show antidepressant effect in recent clinical studies. Major depressive disorder is frequently characterized by disinhibition of rapid eye movement (REM) sleep and disruption of nonREM (NREM) sleep...
August 14, 2023: International Journal of Neuropsychopharmacology
https://read.qxmd.com/read/37159725/urban-biodiversity-cuterebriasis-in-free-ranging-robinson-s-mouse-opossum-marmosa-robinsoni-in-the-suburbs-of-barranquilla-colombia
#14
JOURNAL ARTICLE
Henrique Guimarães Riva, Lina Marcela Henao Montoya, Mónica Franco Gutiérrez, Mariapaz Dueñas Flórez, Christian Olaciregui, Eduardo Andrade, Yuliet Andrea Acevedo-Garcés, Iván Darío Soto-Calderón
The tropical dry forest is one of the world's most threatened ecosystems and is the habitat of the Robinson's Mouse Opossum ( Marmosa robinsoni ), a small marsupial within the Didelphidae family. This study aimed to describe cases of cuterebriases in free-ranging M. robinsoni by examining individuals caught in live animal traps. Sherman traps were deployed in four different sites over three different periods in five days. All animals passed through biometry, weighing, sampling parasites, and sampling feces...
August 2023: International Journal for Parasitology. Parasites and Wildlife
https://read.qxmd.com/read/37031618/retrospective-evaluation-of-ketamine-versus-droperidol-on-time-to-restraint-removal-in-agitated-emergency-department-patients
#15
JOURNAL ARTICLE
James R Krenz, Kristin Medeiros, Kathryn Lupez
PURPOSE: Acute agitation and violent behavior in the emergency department (ED) can lead to significant patient morbidity and contribute to the growing problem of workplace violence against health care providers. To our knowledge, there is no available literature directly comparing intramuscular ketamine to intramuscular droperidol in ED patients presenting with undifferentiated agitation. The purpose of this investigation was to compare the effectiveness and safety of these agents for acute agitation in the ED...
July 2023: American Journal of Emergency Medicine
https://read.qxmd.com/read/36969556/chronic-salmon-calcitonin-exerts-an-antidepressant-effect-via-modulating-the-p38-mapk-signaling-pathway
#16
JOURNAL ARTICLE
Wenhui Zhu, Weifen Li, Jian Jiang, Dilong Wang, Xinliang Mao, Jin Zhang, Xunzhi Zhang, Jinlong Chang, Peijia Yao, Xiuyan Yang, Clive Da Costa, Ying Zhang, Jiezhong Yu, Huiliang Li, Shupeng Li, Xinjin Chi, Ningning Li
Depression is a common recurrent psychiatric disorder with a high lifetime prevalence and suicide rate. At present, although several traditional clinical drugs such as fluoxetine and ketamine, are widely used, medications with a high efficiency and reduced side effects are of urgent need. Our group has recently reported that a single administration of salmon calcitonin (sCT) could ameliorate a depressive-like phenotype via the amylin signaling pathway in a mouse model established by chronic restraint stress (CRS)...
2023: Frontiers in Molecular Neuroscience
https://read.qxmd.com/read/36924669/3-4-dihydrobenzo-e-1-2-3-oxathiazine-2-2-dioxide-analogs-act-as-potential-ampa-receptor-potentiators-with-antidepressant-activity
#17
JOURNAL ARTICLE
Long Wei, Xueyu Qi, Xueli Yu, Yanghao Zheng, Xing Luo, Yingying Wei, Peiyan Ni, Liansheng Zhao, Qiang Wang, Xiaohong Ma, Wei Deng, Wanjun Guo, Xun Hu, Tao Li
Major depressive disorder is a common psychiatric disorder, with ∼30% of patients suffering from treatment-resistant depression. Based on preclinical studies on ketamine, α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor (AMPAR) activation may be a promising therapeutic approach. In this study, we synthesized a series of novel 3,4-dihydrobenzo[e][1,2,3]oxathiazine 2,2-dioxide analogs and analyzed their potential as AMPAR potentiators. Compounds 5aa and 7k exhibited high potentiation with little agonist activity in a high-throughput screen using a calcium influx assay in cultured hippocampal primary neurons...
March 10, 2023: European Journal of Medicinal Chemistry
https://read.qxmd.com/read/36914961/anesthetic-effects-of-isoflurane-and-fentanyl-infusion-in-capuchin-monkeys-sapajus-sp-undergoing-salpingectomy-or-deferentectomy-previously-chemically-restrained-with-ketamine-midazolam-or-ketamine-dexmedetomidine
#18
JOURNAL ARTICLE
Viviane Horta Gomes, Mayara Muniz Freitas, Thuane do Nascimento Morais, Thiago Queiroz de Menezes, Anieli Vidal Stocco, Marcela de Oliveira Loureiro da Silva, Daniel de Almeida Balthazar
BACKGROUND: This study evaluated the anesthetic and cardiorespiratory effects of two anesthetic protocols for salpingectomy or deferentectomy in capuchin monkeys (Sapajus sp). MATERIALS AND METHODS: Five capuchin monkeys (5 per group) received ketamine (20 mg/kg) combined with midazolam (0.5 mg/kg; group KM) or dexmedetomidine (5 μg/kg; group KD) intramuscularly. Anesthesia is induced with propofol intravenously and maintained with isoflurane...
March 13, 2023: Journal of Medical Primatology
https://read.qxmd.com/read/36542981/subanesthetic-dose-of-s-ketamine-improved-cognitive-dysfunction-via-the-inhibition-of-hippocampal-astrocytosis-in-a-mouse-model-of-post-stroke-chronic-stress
#19
JOURNAL ARTICLE
Li-Min Zhang, Zhi-You Wu, Ji-Zhen Liu, Yan Li, Jin-Meng Lv, Lu-Ying Wang, Yu-Dong Shan, Rong-Xin Song, Hui-Tao Miao, Wei Zhang, Dong-Xue Zhang
Post-stroke chronic stress (PSCS) is generally associated with the poorer recovery and more pronounced cognitive dysfunction. Recent evidence has implied that S-ketamine can reduce suicidal ideation in treatment-resistant depression. In this current study, we aimed to investigate whether the administration of S-ketamine ameliorated cognitive deficits under PSCS conditions, which was established by a model combining middle cerebral artery occlusion (MCAO) and chronic restraint stress. Our data suggested that mice exposed to PSCS exhibited depression-like behavior and cognitive impairment, which coincided with astrocytosis as indicated by increased GFAP-positive cells and impairment of long-time potentiation (LTP) in the hippocampal CA1...
December 16, 2022: Journal of Psychiatric Research
https://read.qxmd.com/read/36521829/sedative-effect-of-ketamin-midazolam-administered-at-acupoint-gv20-compared-to-intramuscular-route-in-blue-fronted-amazon-amazona-aestiva-a-pilot-study
#20
JOURNAL ARTICLE
Aricia Noelli Brega Monteiro, Bruno Simões Sérgio Petri, Haroldo Furuya, Liliane Milanelo, Márcia Valéria Rizzo Scognamillo, Ayne Murata Hayashi
BACKGROUND: The growth of exotic pet medicine is leading to fast developments in clinical investigations on birds. Acupuncture, specifically pharmacopuncture, offers safe chemical restraint options. OBJECTIVES: To investigate pharmacopuncture at acupoint GV20 in blue-fronted Amazon parrots (Amazona aestiva) using ketamine and midazolam. METHODS: Sixteen healthy birds were distributed into four groups (C: intramuscular control; 1/2 C: 1/2 dose intramuscular control; 1/2 GV20: 1/2 dose at acupoint GV20; 1/5 GV20: 1/5 dose at acupoint GV20)...
October 31, 2022: Journal of Acupuncture and Meridian Studies
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