Mengqiao Cui, Ran Ji, Lingzhen Song, Xianlei Wang, Xiaoyuan Pan, Yi Han, Xiaojing Zhai, Lin Ai, Wenxin Zhang, An Xie, Zhou Wu, Weiyi Song, Jun-Xia Yang, Ankang Hu, He Liu, Jun-Li Cao, Hongxing Zhang
Patients with chronic pain often develop comorbid depressive symptoms, which makes the pain symptoms more complicated and refractory. However, the underlying mechanisms are poorly known. Here, in a repeated complete Freund's adjuvant (CFA) male mouse model, we reported a specific regulatory role of the paraventricular thalamic nucleus (PVT) glutamatergic neurons, particularly the anterior PVT (PVA) neurons, in mediating chronic pain and depression comorbidity (CDC). Our c-Fos protein staining observed increased PVA neuronal activity in CFA-CDC mice...
February 20, 2024: Journal of Neuroscience