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Allogenic platelet rich plasma

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https://read.qxmd.com/read/30736898/allogeneic-platelet-rich-plasma-serves-as-a-scaffold-for-articular-cartilage-derived-chondroprogenitors
#1
Elizabeth Vinod, Deepak Vinod Francis, Soosai Manickam Amirtham, Solomon Sathishkumar, P R J V C Boopalan
Limited self-restorative ability of the cartilage has necessitated the use of cell and tissue engineering based therapies. Recent advances in the isolation, expansion and characterization of articular cartilage derived chondroprogenitors(CPs) has gained popularity in its role for cartilage repair. Platelet rich plasma (PRP) is a reliable biological scaffold for in-vitro and in-vivo studies with reported therapeutic applications in cartilage and bone pathologies. The aim of this study was to evaluate whether human allogeneic PRP could serve as a biological scaffold for chondroprogenitors (CPs) in cartilage repair...
February 2019: Tissue & Cell
https://read.qxmd.com/read/30734299/allogeneic-major-histocompatibility-are-necessary-and-sufficient-for-partial-tolerance-induced-by-transfusion-of-pathogen-reduced-platelets-in-mice
#2
Johnson Q Tran, Marcus O Muench, John W Heitman, Rachael P Jackman
BACKGROUND AND OBJECTIVES: Alloimmunization is common following transfusion with platelet-rich plasma (PRP) and can cause complications such as platelet refractoriness or transplant rejection. It has previously been shown that pathogen reduction of PRP with riboflavin and UV light (UV+R) can protect against alloimmunization in mice and induce partial tolerance to subsequent transfusions. MATERIALS AND METHODS: Using B6 H2d congenic mice, this study evaluated the relative contributions of major histocompatibility complex (MHC) antigens and minor antigens to both the alloresponse to PRP transfusion and the partial tolerance induced by UV+R treatment...
February 7, 2019: Vox Sanguinis
https://read.qxmd.com/read/30717500/responsible-safe-and-effective-use-of-biologics-in-the-management-of-low-back-pain-american-society-of-interventional-pain-physicians-asipp-guidelines
#3
Annu Navani, Laxmaiah Manchikanti, Sheri L Albers, Richard E Latchaw, Jaya Sanapati, Alan D Kaye, Sairam Atluri, Sheldon Jordan, Ashim Gupta, David Cedeno, Alejandro Vallejo, Bert Fellows, Nebojsa Nick Knezevic, Miguel Pappolla, Sudhir Diwan, Andrea M Trescot, Amol Soin, Adam M Kaye, Steve M Aydin, Aaron K Calodney, Kenneth D Candido, Sanjay Bakshi, Ramsin M Benyamin, Ricardo Vallejo, Art Watanabe, Douglas Beall, Todd P Stitik, Patrick M Foye, Erik M Helander, Joshua A Hirsch
BACKGROUND: Regenerative medicine is a medical subspecialty that seeks to recruit and enhance the body's own inherent healing armamentarium in the treatment of patient pathology. This therapy's intention is to assist in the repair, and to potentially replace or restore damaged tissue through the use of autologous or allogenic biologics. This field is rising like a Phoenix from the ashes of underperforming conventional therapy midst the hopes and high expectations of patients and medical personnel alike...
January 2019: Pain Physician
https://read.qxmd.com/read/30708148/effects-of-platelet-rich-plasmapheresis-during-cardiovascular-surgery-a-meta-analysis-of-randomized-controlled-clinical-trials
#4
Qing Zhai, Yun Wang, Zhiguo Yuan, Rongwei Zhang, Ayong Tian
OBJECTIVE: This study aimed to explore the effects of platelet-rich plasmapheresis (PRP) on the amount of postoperative blood loss and the requirements for allogeneic fresh frozen plasma (FFP) and red blood cell (RBC) transfusions during cardiovascular surgery. METHODS: A literature search of 7 online databases was conducted. Randomized control trials (RCT) comparing intraoperative PRP or appropriate control groups were considered suitable for this current study...
January 29, 2019: Journal of Clinical Anesthesia
https://read.qxmd.com/read/30517440/characteristics-of-human-natal-stem-cells-cultured-in-allogeneic-medium
#5
Jakub Suchánek, Klara Zoe Browne, Sherine Adel Nasry, Tereza Suchánková Kleplová, Nela Pilbauerová, Jan Schmidt, Tomáš Soukup
Recently, human natal dental pulp stem cells (hNDP-SCs) have been characterized in vitro and it has been shown that they satisfy criteria defining human mesenchymal stromal cells (MSCs), as proposed by the International Society for Cellular Therapy. However, these results were reached in the presence of xenogeneic expansion medium, which has the potential to alter the cells' functional capacity. To determine the validity of the previously reported hNDP-SCs characteristics for human cell therapy, we have cultured hNDP-SCs in allogeneic expansion medium...
September 2018: Brazilian Dental Journal
https://read.qxmd.com/read/30497435/the-effect-of-autologous-platelet-rich-plasma-on-tenocytes-of-the-human-rotator-cuff
#6
Stephan Pauly, Franka Klatte-Schulz, Katharina Stahnke, Markus Scheibel, Britt Wildemann
BACKGROUND: Platelet rich plasma (PRP) is widely used in rotator cuff repairs but its effect on the healing process is unclear. Several cell culture studies on the effect of allogenic PRP have reported promising results but are not transferable to clinical practice. The aim of the present study is to assess the possible effect of autologous PRP on rotator cuff tendon cells. The amount of growth factors involved with tendon-bone healing (PDGF-AB, IGF-1, TGF-β1, BMP-7 and -12) is quantified...
November 30, 2018: BMC Musculoskeletal Disorders
https://read.qxmd.com/read/30481239/the-in-vivo-impact-of-leukocyte-injections-on-normal-rat-achilles-tendons-potential-detriment-to-tendon-morphology-cellularity-and-vascularity
#7
David E Komatsu, Lucas King, Mikhail Gurevich, Benjamin Kahn, James M Paci
In this study, we determine the in vivo effects of injecting sub-populations of leukocytes into normal rat Achilles tendons via a controlled laboratory study. Allogenic monocytes, granulocytes, or plasma were injected into 24 healthy rat Achilles tendons. Treated and contralateral un-treated control tendons then assessed for cellularity, histologic morphology, and vascularity after 7 and 14 days. Significant increases of 221% and 249% in cellularity (P = 0.014) were seen on day 14 within Achilles tendons injected with granulocytes as compared to plasma and monocytes, respectively...
October 2018: American Journal of Orthopedics
https://read.qxmd.com/read/30466717/orthobiologics-for-focal-articular-cartilage-defects
#8
REVIEW
Taylor M Southworth, Neal B Naveen, Benedict U Nwachukwu, Brian J Cole, Rachel M Frank
Focal chondral defects of the knee are extremely common and often result in pain, dysfunction, joint deterioration, and, ultimately, the development of osteoarthritis. Due to the limitations of conventional treatments for focal chondral defects of the knee, orthobiologics have recently become an area of interest. Orthobiologics used for cartilage defects include (but are not limited to) bone marrow aspirate concentrate, adipose-derived mesenchymal stem cells, platelet-rich plasma, and micronized allogeneic cartilage...
January 2019: Clinics in Sports Medicine
https://read.qxmd.com/read/30311796/allogenic-pure-platelet-rich-plasma-therapy-for-rotator-cuff-disease-a-bench-and-bed-study
#9
Chris Hyunchul Jo, Seung Yeon Lee, Kang Sup Yoon, Sohee Oh, Sue Shin
BACKGROUND: Although platelet-rich plasma (PRP) is a popular option for rotator cuff disease, the underlying mechanism of PRP and its clinical indications are unclear. Further, some kinds of PRP might be detrimental to patients. Allogenic PRP prepared through a standardized process and fully characterized could eliminate variations in PRP as well as uncertainties regarding its use in each patient, which could provide clues about its mechanism of action and indications for its use. PURPOSE: To assess the effects of pure PRP on tenocytes with or without inflammation in an in vitro study and to evaluate the safety and efficacy of a fully characterized pure PRP injection in patients with rotator cuff disease in a clinical study...
November 2018: American Journal of Sports Medicine
https://read.qxmd.com/read/30023361/pooled-platelet-rich-plasma-lysate-therapy-increases-synoviocyte-proliferation-and-hyaluronic-acid-production-while-protecting-chondrocytes-from-synoviocyte-derived-inflammatory-mediators
#10
Jessica M Gilbertie, Julie M Long, Alicia G Schubert, Alix K Berglund, Thomas P Schaer, Lauren V Schnabel
Platelet-rich plasma (PRP) preparations are being used with moderate success to treat osteoarthritis (OA) in humans and in veterinary species. Such preparations are hindered, however, by being autologous in nature and subject to tremendous patient and processing variability. For this reason, there has been increasing interest in the use of platelet lysate preparations instead of traditional PRP. Platelet lysate preparations are acellular, thereby reducing concerns over immunogenicity, and contain high concentrations of growth factors and cytokines...
2018: Frontiers in Veterinary Science
https://read.qxmd.com/read/29998744/nondestructive-assessment-of-articular-cartilage-electromechanical-properties-after-osteochondral-autologous-and-allogeneic-transplantation-in-a-goat-model
#11
Tomas Mickevicius, Alius Pockevicius, Audrius Kucinskas, Rimtautas Gudas, Justinas Maciulaitis, Arvydas Usas
Objective To determine the applicability of a minimally invasive diagnostic device to evaluate the quality of articular cartilage following autologous (OAT) and allogeneic (OCA) osteochondral graft transplantation in goat model. Design OAT grafts were harvested from lateral femoral condyles (LFCs) and transplanted into osteochondral defects created in medial femoral condyles (MFCs) of contralateral knees. OCA grafts were transplanted into MFC condyles after in vitro storage. Autologous platelet-rich plasma (PRP) was administered intraarticularly after the surgery and at 1 and 2 months postoperatively...
July 1, 2018: Cartilage
https://read.qxmd.com/read/29905054/-research-of-acellular-xenogeneic-nerve-combined-with-adipose-derived-stem-cells-and-platelet-rich-plasma-in-repair-of-rabbit-facial-nerve-injury
#12
Yanna Sun, Rongming Zhang, Xu Mao, Mengshu Zhang
Objective: To investigate the early effects of acellular xenogeneic nerve combined with adipose-derived stem cells (ADSCs) and platelet rich plasma (PRP) in repairing facial nerve injury in rabbits. Methods: The bilateral sciatic nerves of 15 3-month-old male Sprague-Dawley rats were harvested and decellularized as xenografts. The allogeneic ADSCs were extracted from the neck and back fat pad of healthy adult New Zealand rabbits with a method of digestion by collagenase type Ⅰ and the autologous PRP was prepared by two step centrifugation...
June 1, 2018: Chinese Journal of Reparative and Reconstructive Surgery
https://read.qxmd.com/read/29744432/bone-grafts-and-biomaterials-substitutes-for-bone-defect-repair-a-review
#13
REVIEW
Wenhao Wang, Kelvin W K Yeung
Bone grafts have been predominated used to treat bone defects, delayed union or non-union, and spinal fusion in orthopaedic clinically for a period of time, despite the emergency of synthetic bone graft substitutes. Nevertheless, the integration of allogeneic grafts and synthetic substitutes with host bone was found jeopardized in long-term follow-up studies. Hence, the enhancement of osteointegration of these grafts and substitutes with host bone is considerably important. To address this problem, addition of various growth factors, such as bone morphogenetic proteins (BMPs), parathyroid hormone (PTH) and platelet rich plasma (PRP), into structural allografts and synthetic substitutes have been considered...
December 2017: Bioactive Materials
https://read.qxmd.com/read/29608156/effects-of-allogeneic-platelet-rich-plasma-prp-on-the-healing-process-of-sectioned-achilles-tendons-of-rats-a-methodological-description
#14
Laura Greimers, Pierre V Drion, Alain Colige, Vincent Libertiaux, Vincent Denoël, Christelle Lecut, André Gothot, Jean-François Kaux
This article describes the experimental procedures used to observe if PRP can positively affect tendon healing. There are 4 main steps to follow: induce a lesion in the Achilles tendon; prepare PRP and inject it (or the saline solution); remove the tendon; and perform biomechanical, molecular, and histological evaluations. At each step, all the procedures and methods are described in detail, so they can be reproduced easily. Achilles tendons have been surgically sectioned (removal of a 5-mm long section). Afterwards, PRP or saline solution was injected to study whether PRP has a positive effect on the healing of the tendon...
March 19, 2018: Journal of Visualized Experiments: JoVE
https://read.qxmd.com/read/29582705/comparative-assessment-of-prophylactic-transfusions-of-platelet-concentrates-obtained-by-the-prp-or-buffy-coat-methods-in-patients-undergoing-allogeneic-hematopoietic-stem-cell-transplantation
#15
COMPARATIVE STUDY
Hermógenes Fernández-Muñoz, Eva M Plaza, José Miguel Rivera-Caravaca, María José Candela, Marta Romera, Felipe De Arriba, María L Lozano, Vicente Vicente, Inmaculada Heras, Cristina Castilla-Llorente, José Rivera
OBJECTIVES: Whole blood-derived platelet concentrates can be obtained by the platelet-rich plasma (PRP-PCs) or the buffy-coat (BC-PCs) method. Few studies have shown that BC-PCs display lower in vitro platelet activation, but scarce information exists regarding transfusion efficacy. We have performed a retrospective study assessing platelet transfusion in patients undergoing allogeneic hematopoietic cell transplantation (AHCT) in our clinic, before and after the implementation of BC-PCs...
October 2018: Hematology (Amsterdam, Netherlands)
https://read.qxmd.com/read/29399444/arthroscopic-management-of-isolated-tibial-plateau-defect-with-microfracture-and-micronized-allogeneic-cartilage-platelet-rich-plasma-adjunct
#16
Kevin C Wang, Rachel M Frank, Eric J Cotter, David R Christian, Brian J Cole
Articular cartilage lesions of the tibial plateau are an uncommonly encountered clinical entity, and they have been comparatively less well studied than femoral condyle or patellofemoral defects. The management of these lesions is complicated by the challenging geometry, difficult surgical approach, and proximity to important anatomic structures, and thus, treating these lesions by previously established methods, such as osteochondral allograft transplantation or osteochondral autograft transfer, can be a technically challenging endeavor...
October 2017: Arthroscopy Techniques
https://read.qxmd.com/read/29387635/the-effect-of-intra-articular-allogenic-platelet-rich-plasma-in-dunkin-hartley-guinea-pig-model-of-knee-osteoarthritis
#17
Himanshu Kanwat, Dhillon Mandeep Singh, Chouhan Devendra Kumar, Bhatia Alka, Saikia Biman, Hooda Aman
Objectives: To investigate the pathway for disease modifying effect of the PRP in osteoarthritis of knee. Design: Two experimental models (group I and II) of Twelve Dunkin-Hartley guinea pigs each were enrolled as a part of a prospective controlled experimental study. One knee was enrolled for intervention and the other knee of the same animal used as control, the intervention being three intra-articular allogenic PRP injections given at a weekly interval. Equal volume of isotonic saline injection were given simultaneously in the control knees...
July 2017: Muscles, Ligaments and Tendons Journal
https://read.qxmd.com/read/29352758/-arthroscopic-rotator-cuff-surgery-new-and-established-methods
#18
REVIEW
S Pauly, M Scheibel
This present article summarizes established and current developments and aspects of rotator cuff surgery. Achieved milestones as well as current approaches are presented and assessed with respect to their clinical and radiographic impact. Despite biomechanical and technical improvements in modern rotator cuff repair techniques, re-defect and re-tearing rates could not be fully eliminated. Meanwhile, the importance of biological processes around successful tendon-bone reintegration has been increasingly recognized...
February 2018: Der Orthopäde
https://read.qxmd.com/read/29320421/comparative-analysis-of-different-platelet-lysates-and-platelet-rich-preparations-to-stimulate-tendon-cell-biology-an-in-vitro-study
#19
Franka Klatte-Schulz, Tanja Schmidt, Melanie Uckert, Sven Scheffler, Ulrich Kalus, Markus Rojewski, Hubert Schrezenmeier, Axel Pruss, Britt Wildemann
The poor healing potential of tendons is still a clinical problem, and the use of Platelet Rich Plasma (PRP) was hypothesized to stimulate healing. As the efficacy of PRPs remains unproven, platelet lysate (PL) could be an alternative with its main advantages of storage and characterization before use. Five different blood products were prepared from 16 male donors: human serum, two PRPs (Arthrex, (PRP-ACP); RegenLab (PRP-BCT)), platelet concentrate (apheresis, PC), and PL (freezing-thawing destruction of PC)...
January 10, 2018: International Journal of Molecular Sciences
https://read.qxmd.com/read/29146943/cryopreservation-of-human-mesenchymal-stem-cells-in-an-allogeneic-bioscaffold-based-on-platelet-rich-plasma-and-synovial-fluid
#20
Haritz Gurruchaga, Laura Saenz Del Burgo, Ane Garate, Diego Delgado, Pello Sanchez, Gorka Orive, Jesús Ciriza, Mikel Sanchez, Jose Luis Pedraz
Transplantation of mesenchymal stem cells (MSCs) has emerged as an alternative strategy to treat knee osteoarthritis. In this context, MSCs derived from synovial fluid could provide higher chondrogenic and cartilage regeneration, presenting synovial fluid as an appropriate MSCs source. An allogeneic and biomimetic bioscaffold composed of Platelet Rich Plasma and synovial fluid that preserve and mimics the natural environment of MSCs isolated from knee has also been developed. We have optimized the cryopreservation of knee-isolated MSCs embedded within the aforementioned biomimetic scaffold, in order to create a reserve of young autologous embedded knee MSCs for future clinical applications...
November 16, 2017: Scientific Reports
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