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amphipterygium adstringens

Miriam Trenado-Uribe, Mayra Silva-Miranda, José F Rivero-Cruz, Karol Rodríguez-Peña, Clara I Espitia-Pinzón, Romina Rodríguez-Sanoja, Sergio Sánchez
The search for new compounds effective against Mycobacterium tuberculosis is still a priority in medicine. The evaluation of microorganisms isolated from non-conventional locations offers an alternative to look for new compounds with antimicrobial activity. Endophytes have been successfully explored as source of bioactive compounds. In the present work we studied the nature and antimycobacterial activity of a compound produced by Streptomyces scabrisporus, an endophyte isolated from the medicinal plant Amphipterygium adstringens...
October 11, 2018: Molecular Biology Reports
Peter Knauth, Gustavo J Acevedo-Hernández, M Eduardo Cano, Melesio Gutiérrez-Lomelí, Zaira López
Seven out of eight methanolic extracts from five plants native to Mexico were inactive against ten bacterial strains of clinical interest. The fruit extract of Chenopodium ambrosioides inhibited the bacteria Enterococcus faecalis (MIC = 4375  μ g/ml), Escherichia coli (MIC = 1094  μ g/ml), and Salmonella typhimurium (MIC = 137  μ g/ml). The fruit extract of C. ambrosioides was with CC50 = 45  μ g/ml most cytotoxic against the cell-line Caco-2, followed by the leaf extract from Pithecellobium dulce (CC50 = 126  μ g/ml); interestingly, leaves of C...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
Melissa Vazquez-Hernandez, Corina Diana Ceapa, Stefany Daniela Rodríguez-Luna, Romina Rodríguez-Sanoja, Sergio Sánchez
No abstract text is available yet for this article.
June 15, 2017: Genome Announcements
Melissa Vazquez-Hernandez, Corina Diana Ceapa, Stefany Daniela Rodríguez-Luna, Romina Rodríguez-Sanoja, Sergio Sánchez
We report the draft genome sequence of Streptomyces scabrisporus NF3, an endophyte isolated from Amphipterygium adstringens in Chiapas, Mexico. This strain produces a new modified linaridin peptide. The genome harbors at least 50 gene clusters for synthases of polyketide and nonribosomal peptides, suggesting a prospective production of various secondary metabolites.
April 27, 2017: Genome Announcements
Rocio Gómez-Cansino, Silvia Laura Guzmán-Gutiérrez, María Guadalupe Campos-Lara, Clara Ines Espitia-Pinzón, Ricardo Reyes-Chilpa
In Mexican Traditional Medicine 187 plant species are used in the treatment of respiratory conditions that may be associated with tuberculosis. In this contribution, we review the ethnobotany, chemistry and pharmacology of 63 species whose extracts have been assayed for antimycobacterial activity in vitro. Among these, the most potent is Aristolochia brevipes (MIC= 12.5 µg/mL), followed by Aristolochia taliscana, Citrus sinensis, Chrysactinia mexicana, Persea americana, and Olea europaea (MIC<64 µg/mL)...
January 2017: Anais da Academia Brasileira de Ciências
Mario Rodriguez-Canales, Ruben Jimenez-Rivas, Maria Margarita Canales-Martinez, Ana Judith Garcia-Lopez, Nelly Rivera-Yañez, Oscar Nieto-Yañez, Yadira Ledesma-Soto, Luvia Enid Sanchez-Torres, Miriam Rodriguez-Sosa, Luis Ignacio Terrazas, Marco Aurelio Rodriguez-Monroy
Amphipterygium adstringens is an endemic species in Mexico commonly known as "cuachalalate." Healers to treat gastritis, gastric ulcers, and gastrointestinal cancer have traditionally used the bark. We investigated the effects of alcoholic extract of A. adstringens (AaEE) in DSS-induced colitis in mice. The protective effect of AaEE was determined at 200 mg/kg by oral gavage for 10 days. We determine the effect of AaEE on clinical features (disease activity index), antioxidants, anti-inflammatory, and immunomodulatory activities in relation to the activity of SOD, CAT, and GPx, levels of proinflammatory cytokines, and changes both macroscopic and microscopic of the colonic mucosa...
2016: Mediators of Inflammation
A Rodriguez-Garcia, I T A Peixoto, M J Verde-Star, S De la Torre-Zavala, H Aviles-Arnaut, A L T G Ruiz
Amphipterygium adstringens is a plant widely used in Mexican traditional medicine for its known anti-inflammatory and antiulcer properties. In this work, we evaluated the in vitro antimicrobial and antiproliferative activities of the methanolic extract of A. adstringens against oral pathogens such as Streptococcus mutans, Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans, Candida albicans, and Candida dubliniensis, using microdilution (MIC) and agar diffusion methods (MBC), and the antiproliferative activity evaluating total growth inhibition (TGI) by staining the protein content with sulforhodamine B (SRB), using nine human cancer cell lines...
2015: Evidence-based Complementary and Alternative Medicine: ECAM
J N Rashida Gnanaprakasam, Elizabet Estrada-Muñiz, Libia Vega
Amphipterygium adstringens is a plant traditionally used to treat gingivitis, gastric ulcer and even gastric cancer but the mechanism involved in the regulation of the immune response is not elucidated yet. The 6-pentadecylsalicylic acid (6SA) is the main anacardic acid found in A. adstringens. In order to evaluate the immune-modulatory abilities of 6SA, we used mouse splenocytes and determined the phosphorylation of the transcription factor NF-κB and MAP kinases ERK1/2, JNK and p38 in helper and cytotoxic T cells, natural killer (NK) cells and F4/80(+) macrophages...
December 2015: International Immunopharmacology
David Alam-Escamilla, Elizabet Estrada-Muñiz, Erik Solís-Villegas, Guillermo Elizondo, Libia Vega
In Mexico, as in many other countries, traditional medicine is used for the treatment of several diseases. In particular, Amphipterygium adstringens infusion is used for gastritis, gastric ulcers, and gastric cancer. Extracts from this tree have microbicidal effects against Helicobacter pylori, an important risk factor for gastric cancer development. Anacardic acids are constituents of A. adstringens, and 6-pentadecyl salicylic acid (6-PSA) is the most abundant. However, there is a lack of information regarding the effects of 6-PSA on cancer cells...
January 1, 2015: Mutation Research. Genetic Toxicology and Environmental Mutagenesis
Hongbiao Huang, Xianliang Hua, Ningning Liu, Xiaofen Li, Shouting Liu, Xin Chen, Chong Zhao, Xiaoying Lan, Changshan Yang, Q Ping Dou, Jinbao Liu
Anacardic acid (6-pentadecylsalicylic acid, AA), a natural compound isolated from the traditional medicine Amphipterygium adstringens, has been reported to possess antitumor activities. However, its molecular targets have not been thoroughly studied. Here, we report that AA is a potent inducer of endoplasmic reticulum (ER) stress, leading to apoptosis in hepatoma HepG2 and myeloma U266 cells. Induction of ER stress by AA was supported by a dose- and time-dependent increase in expression of the ER signaling downstream molecules, such as GRP78/BiP, phosphorylated eIF2α, ATF4 and CHOP in both HepG2 and U266 cell lines...
August 4, 2014: Toxicology Letters
Israel Castillo-Juárez, Rodolfo García-Contreras, Norma Velázquez-Guadarrama, Marcos Soto-Hernández, Mariano Martínez-Vázquez
BACKGROUND AND AIMS: Quorum sensing (QS) is a process of bacterial cell-cell communication that controls a large number of systems affecting pathogenicity. Interrupting this communication system can provide nonvirulent pathogenic bacteria. The aim of this study was to evaluate the anti-quorum sensing (anti-QS) potential of an anacardic acids mixture isolated from Amphipterygium adstringens, a medicinal plant known as "cuachalalate", to prevent the onset of bacterial infections as an alternate to antibiotics...
October 2013: Archives of Medical Research
Yazmín Rosas-Piñón, Alicia Mejía, Gloria Díaz-Ruiz, María Isabel Aguilar, Sobeida Sánchez-Nieto, J Fausto Rivero-Cruz
ETHNOPHARMACOLOGICAL RELEVANCE: The ethnobotanical survey conducted in this study showed 47 plant species used in the Altiplane region of Mexico for the treatment of dental diseases such as toothache, dental caries, periodontal disease and gingivitis. MATERIALS AND METHODS: Information was collected by performing interviews. The following data were recorded: name of the patients or herbalists with their age, sex; date and place of gathering information; pathology of persons interviewed; name of the drug (vernacular name); parts used (leaves, bark, fruits, seeds, aerial parts), mode of preparation and administration, and possible combinations...
June 14, 2012: Journal of Ethnopharmacology
Yuanyuan Wu, Lijun He, Li Zhang, Jing Chen, Zhengfang Yi, Jian Zhang, Mingyao Liu, Xiufeng Pang
Anacardic acid (6-pentadecylsalicylic acid), a natural inhibitor of histone acetyltransferase from Amphipterygium adstringens, has been shown to have anti-inflammatory, anticancer, antioxidative, and antimicrobial functions. However, whether this salicylic acid could block angiogenesis has not been elucidated to date. Here, we postulate that anacardic acid affects multiple steps of tumor angiogenesis to contribute to tumor inhibition. In this study, we found that vascular endothelial growth factor (VEGF)-induced cell proliferation, migration, and adhesion and capillary-like structure formation of primary cultured human umbilical vascular endothelial cells (HUVECs) could all be significantly suppressed by anacardic acid in vitro, without detectable cellular toxicity...
November 2011: Journal of Pharmacology and Experimental Therapeutics
Blanca E Rivero-Cruz, Nuria Esturau, Sobeida Sánchez-Nieto, Irma Romero, Israel Castillo-Juárez, J Fausto Rivero-Cruz
A new anacardic acid, 6-[16'Z-nonadecenyl]-salicylic acid (1), along with seven known compounds, 6-[8'Z-pentadecenyl] salicylic acid (15:1 anacardic acid) (2), 6-nonadecenyl salicylic acid (anacardic acid 19:0) (3), 6-pentadecyl salicylic acid (anacardic acid 15:0) (4), masticadienonic acid (5), 3α-hydroxymasticadienonic acid (6), 3-epi-oleanolic acid (7) and β-sitosterol, were isolated from the bark of Amphipterygium adstringens using a bioassay-guided fractionation method. The structure of the new compound (1) was elucidated by spectroscopic data interpretation...
August 2011: Natural Product Research
Ramón E Robles-Zepeda, Carlos A Velázquez-Contreras, Adriana Garibay-Escobar, Juan C Gálvez-Ruiz, Eduardo Ruiz-Bustos
Helicobacter pylori is the major etiologic agent of such gastric disorders as chronic active gastritis and gastric carcinoma. Over the past few years, the appearance of antibiotic-resistant bacteria has led to the development of better treatments, such as the use of natural products. This study evaluated the anti-H. pylori activity of 17 Mexican plants used mainly in the northwestern part of Mexico (Sonora) for the empirical treatment of gastrointestinal disorders. The anti-H. pylori activity of methanolic extracts of the plants was determined by using the broth microdilution method...
October 2011: Journal of Medicinal Food
Hortensia Rosas-Acevedo, Teresa Terrazas, Ma Eva González-Trujano, Yolanda Guzmán, Marcos Soto-Hernández
ETHNOPHARMACOLOGICAL RELEVANCE: The bark of Amphipterygium adstringens (Aa) is commonly mixed or adulterated with the bark of Cyrtocarpa procera (Cp) and sold in Mexican markets. Aa is a well known species in Mexico used as decoction to relieve ulcers. Scientific reports reinforcing the anti-ulcer activity of Aa have been previously described, but those describing the anti-ulcer properties of Cp as a substitute for Aa in folk medicine are scarce. AIM OF THE STUDY: To investigate anatomical and phytochemical differences between these species, as well as to assess the anti-ulcer effect of Cp extracts in comparison to the Aa extracts...
March 8, 2011: Journal of Ethnopharmacology
Israel Castillo-Juárez, Fausto Rivero-Cruz, Heliodoro Celis, Irma Romero
Amphipterygium adstringens (Schltdl.) Standl. (Anacardiaceae) is widely used in traditional Mexican medicine for the treatment of gastritis and ulcers. In this work, we studied the anti-Helicobacter pylori activity of its bark, this Gram-negative bacterium is considered the major etiological agent of chronic active gastritis and peptic ulcer disease, and it is linked to gastric carcinoma. From a bio-guided assay of the fractions obtained form a continuous Soxhlet extraction of the bark, we identified that petroleum ether fraction had significant antimicrobial activity against Helicobacter pylori...
October 8, 2007: Journal of Ethnopharmacology
Hortensia Rosas Acevedo, Maritere Domínguez Rojas, Sandra Díaz Barriga Arceo, Marcos Soto Hernández, Mariano Martínez Vázquez, Teresa Terrazas, Gustavo Valencia del Toro
The bark of Amphipterygium adstringens is widely used in the traditional Mexican medicine for treating ailments such as gastric ulcers, gastritis and stomach cancer. The 6-nonadecyl salicylic acid (anacardic acid) was isolated from the bark of this species. In previous papers have been informed that the anacardic acids possess anti-tumour, antimicrobial, antiacne, antibacterial and many others medicinal properties. Now we describe cytotoxic and genotoxic effects of this compound and its methyl ester. The cytotoxic and genotoxic effects of 6-nonadecyl salicylic acid (6NDSA) and its methyl ester (ME6NDSA) on CD1 male mice were determined with micronucleus assay at 24, 48 and 72h after oral administration of doses of 0...
October 10, 2006: Mutation Research
Myrna Deciga-Campos, Eva González-Trujano, Andrés Navarrete, Rachel Mata
Pain is considered one of the most common complaints worldwide for which patients seek treatment. Conventional analgesic agents have played an important role in modern pain therapy, but they cause several adverse effects. Therefore, the search for new and better analgesics agents continues. The present study was designed to investigate the antinociceptive potential of six Mexican medicinal herbs commonly employed for the treatment of anti-inflammatory diseases and pain. The antinociceptive effect was tested in male mice using the writhing test...
2005: Proceedings of the Western Pharmacology Society
Andrés Navarrete, Iván Oliva, María Elena Sánchez-Mendoza, Jesús Arrieta, Leticia Cruz-Antonio, Gilberto Castañeda-Hernández
This work aimed to study the effect of Cuachalalate methanol extract (CME) on the anti-inflammatory activity and pharmacokinetics of diclofenac sodium, a frequently prescribed non-steroidal anti-inflammatory drug (NSAID). The gastroprotective effect of CME on the gastric injury induced by diclofenac was studied in rats. CME showed a gastroprotective effect of 15.7% at 1 mg kg(-1) and 72.5% at dose of 300 mg kg(-1). Omeprazole, used as anti-ulcer reference drug, showed gastroprotective effects of 50-89.7% at doses tested (1-30 mg kg(-1))...
December 2005: Journal of Pharmacy and Pharmacology
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