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Birgit Vogel, Ridhima Goel, Vijay Kunadian, Deborah N Kalkman, Alaide Chieffo, Yolande Appelman, Roxana Mehran
Coronary revascularization, either percutaneous by stent implantation or surgical, has been established as the treatment of choice for patients with significant coronary stenosis. One of the main targets of coronary revascularization - especially in patients with stable disease - is to alleviate symptoms and thereby improve quality of life. Residual angina after successful coronary revascularization is not uncommon and indeed frustrating for the patient as much as for the treating physician. Several studies have shown worse outcomes in females with regard to post-revascularization morbidity and mortality in percutaneous as well as surgical coronary procedures...
January 11, 2019: International Journal of Cardiology
Alexandra Audemard-Verger, Evangéline Pillebout, Agnès Jamin, Laureline Berthelot, Cédric Aufray, Bruno Martin, Aurélie Sannier, Eric Daugas, Julie Déchanet-Merville, Yolande Richard, Renato Monteiro, Bruno Lucas
OBJECTIVES: Adult immunoglobulin A vasculitis (IgAV) is an immune complex small vessel vasculitis. So far, the involvement of T cells in this pathology has been poorly studied. The aim of this study was to analyze T-cell homeostasis as well as cytokine and chemokine concentrations in the blood and tissues of IgAV patients. METHODS: T cells, cytokine and chemokine concentrations were analyzed in peripheral blood using flow cytometry and multiplex assays. T-cell infiltrates in the kidney and the skin were characterized by immunohistochemistry...
February 8, 2019: Journal of Autoimmunity
Filémon T Tokponnon, Yolande Sissinto, Aurore Hounto Ogouyémi, Adicath Adéola Adéothy, Alioun Adechoubou, Télesphore Houansou, Mariam Oke, Dorothée Kinde-Gazard, Achille Massougbodji, Martin C Akogbeto, Sylvie Cornelie, Vincent Corbel, Tessa B Knox, Abraham Peter Mnzava, Martin J Donnelly, Immo Kleinschmidt, John Bradley
BACKGROUND: Insecticide-based interventions have averted more than 500 million malaria cases since 2000, but insecticide resistance in mosquitoes could bring about a rebound in disease and mortality. This study investigated whether insecticide resistance was associated with increased incidence of clinical malaria. METHODS: In an area of southern Benin with insecticide resistance and high use of insecticide-treated nets (ITNs), malaria morbidity and insecticide resistance were measured simultaneously in 30 clusters (villages or collections of villages) multiple times over the course of 2 years...
February 11, 2019: Malaria Journal
Olga D'Almeida, Omar Mothar, Esther Apraku Bondzie, Yolande Lieumo, Laure Tagne, Sumeet Gupta, Thomas Volkert, Stuart Levine, Jean-Bosco Tagne
BACKGROUND: MicroRNAs are noncoding RNA molecules of ~ 22 nucleotides with diagnostic and therapeutic action [Curr Drug Targets, 2015. 16(12): p. 1381-403], affecting the expression of mRNAs involved in invasion, migration, and development [Oncotarget, 2015. 6(9): p. 6472-98, Cancer Manag Res, 2014. 6: p. 205-16]. miR-200c is part of the miR-200c/141 cluster on chromosome 12p13. Its mechanism of action when encapsulated is critical in lung cancer when patients express changes in miRNAs...
February 11, 2019: BMC Cancer
Marie Bruun, Juha Koikkalainen, Hanneke F M Rhodius-Meester, Marta Baroni, Le Gjerum, Mark van Gils, Hilkka Soininen, Anne M Remes, Päivi Hartikainen, Gunhild Waldemar, Patrizia Mecocci, Frederik Barkhof, Yolande Pijnenburg, Wiesje M van der Flier, Steen G Hasselbalch, Jyrki Lötjönen, Kristian S Frederiksen
BACKGROUND: Diagnosing frontotemporal dementia may be challenging. New methods for analysis of regional brain atrophy patterns on magnetic resonance imaging (MRI) could add to the diagnostic assessment. Therefore, we aimed to develop automated imaging biomarkers for differentiating frontotemporal dementia subtypes from other diagnostic groups, and from one another. METHODS: In this retrospective multicenter cohort study, we included 1213 patients (age 67 ± 9, 48% females) from two memory clinic cohorts: 116 frontotemporal dementia, 341 Alzheimer's disease, 66 Dementia with Lewy bodies, 40 vascular dementia, 104 other dementias, 229 mild cognitive impairment, and 317 subjective cognitive decline...
February 4, 2019: NeuroImage: Clinical
José Bargas, Juan Mena-Segovia, Yoland Smith, J Paul Bolam
This Special Issue of EJN is dedicated to original papers and reviews that arose from presentations given during for the 13th Meeting of the International Basal Ganglia Society (IBAGS) held in Mérida, Mexico in the spring of 2016. The meeting was organised by José Bargas and his team, with over 200 people attending. It consisted of 10 oral sessions and 2 poster sessions (with wine to encourage lively debate). The meeting was preceded by a Clinical Workshop, a Publishing Workshop and a Basic Science Tutorial Session...
February 8, 2019: European Journal of Neuroscience
Yolande Therese Rose Proroga, Andrea Mancusi, Maria Francesca Peruzy, Maria Rosaria Carullo, Angela Michela Immacolata Montone, Andrea Fulgione, Federico Capuano
In order to characterize the most commonly detected Salmonella serotypes, we tested 124 isolates of S. Typhimurium and 89 isolates of the monophasic variant of S. Typhimurium (S. 1,4, [5],12:i:-) for their antimicrobial susceptibility by means of the Kirby-Bauer disk-diffusion method, and for the detection of 19 genes (four Phage Markers (g13, Sieb, eat, g8), ten prophage-related virulence genes (gipA, gtgB, nanH, gogB, grvA, sopE, sspH1, sspH2, sodC1, gtgE), and five plasmid-borne virulence genes (spvC, pefA, mig5, rcK, srgA)) by means of PCR-based assays...
February 5, 2019: Folia Microbiologica
Yolande Lievens, Riccardo Audisio, Ian Banks, Laurence Collette, Cai Grau, Kathy Oliver, Richard Price, Ajay Aggarwal
Surgery and radiotherapy, two locoregional cancer treatments, are essential to help improve cancer outcomes, control, and palliation. The continued evolution in treatment processes, techniques, and technologies-often at substantially increased costs-demands for direction on outcomes that are most valued by patients, and the evidence that is required before clinical adoption of these practices. Three recently introduced frameworks-the European Society for Medical Oncology Magnitude of Clinical Benefit Scale, the American Society of Clinical Oncology Value Framework, and the National Comprehensive Cancer Network Blocks-which all help define the value of oncology treatments, were appraised with a focus on their methods and definition of patient benefit...
February 2019: Lancet Oncology
Bruna Agrillo, Marco Balestrieri, Marta Gogliettino, Gianna Palmieri, Rosalba Moretta, Yolande T R Proroga, Ilaria Rea, Alessandra Cornacchia, Federico Capuano, Giorgio Smaldone, Luca De Stefano
Food packaging is not only a simple protective barrier, but a real "active" component, which is expected to preserve food quality, safety and shelf-life. Therefore, the materials used for packaging production should show peculiar features and properties. Specifically, antimicrobial packaging has recently gained great attention with respect to both social and economic impacts. In this paper, the results obtained by using a polymer material functionalized by a small synthetic peptide as "active" packaging are reported...
January 30, 2019: International Journal of Molecular Sciences
Riad Arabi-Derkawi, Yvonne O'Dowd, Ni Cheng, Loïc Rolas, Tarek Boussetta, Houssam Raad, Viviana Marzaioli, Coralie Pintard, Magali Fasseu, Yolande Kroviarski, Sahra A Belambri, Pham My-Chan Dang, Richard D Ye, Marie-Anne Gougerot-Pocidalo, Jamel El-Benna
Superoxide anion production by the phagocyte NADPH oxidase plays a crucial role in host defenses and inflammatory reaction. The phagocyte NADPH oxidase is composed of cytosolic components (p40phox, p47phox, p67phox, and Rac1/2) and the membrane flavocytochrome b558, which is composed of two proteins: p22phox and gp91phox/NOX2. p22phox plays a crucial role in the stabilization of gp91phox in phagocytes and is also a docking site for p47phox during activation. In the current study, we have used a yeast two-hybrid approach to identify unknown partners of p22phox...
January 21, 2019: Journal of Immunology: Official Journal of the American Association of Immunologists
Mira Choi, Yoland-Marie Anistan, Kai-Uwe Eckardt, Maik Gollasch, Peter Nickel
Microscopic hematuria is a common feature of patients with Alport syndrome, a familial nephropathy due to mutations in COL4A3, COL4A4 or COL4A5. These genes encode for α3, α4, and α5 type IV collagen polypeptide chains (collagen IV α345), crucial for the structural component of the glomerular basement membrane. Even patients with mild phenotype, namely isolated microhematuria (X-linked females with thin basement membrane on electron microscopy or heterozygous carriers of COL4A3 or COL4A4 mutations), can potentially progress to proteinuria and to end-stage renal disease...
January 18, 2019: Nephron
Ngoungoure Madeleine Chantal, Dzeufiet Djomeni Paul Désiré, Bilanda Danielle Caude, Mengue Ngandena Yolande Sandrine, Mbolang Nguegang Lohik, Mballa Marguerite Francine, Dzekui Tchuo Larissa, Kameni Poumeni Mireille, Kamtchouing Pierre
Background Estrogen deficiency in postmenopausal period causes severe neuroendocrine changes in brain which influences memory and other nervous functions. Anthocleista schweinfurthii is used traditionally to treat female infertility and menopause related symptoms. This study was performed to investigate the potential neuroprotective effects of aqueous extract of Anthocleista schweinfurthii on brain in a postmenopause-like model of ovariectomized Wistar rats. Methods Thirty animals were sham-operated or ovariectomized (Ovx) 84 days after surgery, six groups of five rats each were daily treated orally during 28 days with: distilled water for groups 1 (sham-operated) and 2 (Ovx), estradiol valerate (group 3) and the three doses of extracts {groups 4, 5 and 6 (Ovx)}...
January 19, 2019: Journal of Complementary & Integrative Medicine
Martijn H J van den Bosch, Yolande F M Ramos, Wouter den Hollander, Nils Bomer, Rob G H H Nelissen, Judith V M G Bovée, Wim B van den Berg, Peter L E M van Lent, Arjen B Blom, Peter M van der Kraan, Ingrid Meulenbelt
Objectives: Previously, we have shown the involvement of Wnt-activated protein Wnt-1-induced signaling protein 1 (WISP1) in the development of OA in mice. Here, we aimed to characterize the relation between WISP1 expression and human OA and its regulatory epigenetic determinants. Methods: Preserved and lesioned articular cartilage from end-stage OA patients and non-OA-diagnosed individuals was collected. WISP1 expression was determined using immunohistochemistry and damage was classified using Mankin scoring...
January 10, 2019: Rheumatology
Laure Rouch, Philippe Cestac, Olivier Hanon, Jean-Bernard Ruidavets, Virginie Ehlinger, Catherine Gentil, Charlène Cool, Catherine Helmer, Jean-François Dartigues, Béatrice Bouhanick, Bernard Chamontin, Brigitte Sallerin, Bruno Vellas, Jean-Claude Marquié, Yolande Esquirol, Sandrine Andrieu
BACKGROUND: Our objective was to investigate the impact of both prevalent and incident hypertension on cognition in middle-aged individuals followed up for 10 years and to explore the extent to which blood pressure control by antihypertensive drugs could modify this relationship. METHOD: Three thousand, two hundred and one participants from the Vieillissement Santé Travail (Aging, Health and Work) (VISAT) cohort study, aged 32, 42, 52 and 62 years at baseline were followed up 5 and 10 years later...
January 7, 2019: Journal of Hypertension
Wim Coucke, Jelena Vlašić Tanasković, Lobna Bouacida, Sylvia Broeders, Bernard China, Marianne Demarteau, Vanessa Ghislain, Yolande Lenga, Marjan Van Blerk, Nathalie Vandevelde, Hannelien Verbeke, Sandra Wathlet, Mohamed Rida Soumali
Proficiency Testing (PT) External Quality Assessment (EQA) schemes are designed to ascertain the ability of individual laboratories to perform satisfactorily with respect to their peer laboratories or to limits imposed by external sources. Observed deviation of a laboratory result for a PT sample must be entirely attributed to the laboratory and not to the PT provider. To minimize the probability that deviations could be attributed to the PT provider, sample homogeneity should be assured. It is generally required that for quantitative parameters, the standard deviation among PT units should be calculated on the basis of duplicate measurements of at least 10 samples chosen at random, and the standard deviation among PT units should not exceed 0...
February 5, 2019: Analytical Chemistry
Deanne M G Johnston, Ilse Truter, Yoland L Irwin, Panjasaram Naidoo, Barbara C Coetzee, Willem D Basson
OBJECTIVES: The Transnet-Phelophepa Health Care Trains provide primary healthcare services to patients in under-resourced rural communities across South Africa. Selected final-year pharmacy students work on the trains for 1 week. The aim of the study was to determine the experiences and document the work-based activities of pharmacy students engaged in. METHODS: A hyperlink to an online questionnaire was sent to 106 pharmacy students from five Pharmacy Schools (70...
December 28, 2018: International Journal of Pharmacy Practice
Simon Ducharme, Leora Pearl-Dowler, Flora Gossink, Jillian McCarthy, Jimmy Lai, Bradford C Dickerson, Howard Chertkow, Lucile Rapin, Everard Vijverberg, Welmoed Krudop, Annemieke Dols, Yolande Pijnenburg
BACKGROUND: Differentiating early behavioral variant frontotemporal dementia (bvFTD) and primary psychiatric disorders (PPD) is complex and biomarkers have limited accuracy, leading to inaccurate diagnoses. OBJECTIVES: Develop a simple bedside clinical tool to differentiate bvFTD from PPD. METHODS: A checklist of clinical features differentiating bvFTD from PPD was developed based on literature and clinical experience. The checklist was filled prospectively for 29 consecutive patients (Montreal Neurological Hospital) with late-onset (≥ age 40) behavioral changes suggestive of bvFTD...
December 21, 2018: Journal of Alzheimer's Disease: JAD
Yoland Savriama, Sylvain Gerber
Symmetry is a pervasive feature of organismal shape and the focus of a large body of research in Biology. Here, we consider complex patterns of symmetry where a phenotype exhibits a hierarchically structured combination of symmetries. We extend the Procrustes ANOVA for the analysis of nested symmetries and the decomposition of the overall morphological variation into components of symmetry (among-individual variation) and asymmetry (directional and fluctuating asymmetry). We illustrate its use with the Aristotle's lantern, the masticatory apparatus of 'regular' sea urchins, a complex organ displaying bilateral symmetry nested within five-fold rotational symmetry...
December 21, 2018: Scientific Reports
Elisabetta Delibato, Ida Luzzi, Eleonora Pucci, Yolande T R Proroga, Federico Capuano, Dario De Medici
The transmission of enteric pathogens by fresh produce depends on the survival of the bacteria organisms during the product shelf-life. The removal of any potentially hazardous microorganism from the vegetables is therefore dependent on the washing and sanitizing techniques employed by individual households. For this purpose, in this work we investigated the persistence of enteric bacteria, using as model Salmonella enterica serovar Napoli (S. Napoli) and Yersinia enterocolitica, in vegetables stored at refrigeration temperature (4 °C)...
October 2018: Annali Dell'Istituto Superiore di Sanità
Yoland Savriama, Mia Valtonen, Juhana I Kammonen, Pasi Rastas, Olli-Pekka Smolander, Annina Lyyski, Teemu J Häkkinen, Ian J Corfe, Sylvain Gerber, Isaac Salazar-Ciudad, Lars Paulin, Liisa Holm, Ari Löytynoja, Petri Auvinen, Jukka Jernvall
An increasing number of mammalian species have been shown to have a history of hybridization and introgression based on genetic analyses. Only relatively few fossils, however, preserve genetic material, and morphology must be used to identify the species and determine whether morphologically intermediate fossils could represent hybrids. Because dental and cranial fossils are typically the key body parts studied in mammalian palaeontology, here we bracket the potential for phenotypically extreme hybridizations by examining uniquely preserved cranio-dental material of a captive hybrid between grey and ringed seals...
November 2018: Royal Society Open Science
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