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Ruby K Prakasam, Martin Röhlig, Dagmar-C Fischer, Aline Götze, Anselm Jünemann, Heidrun Schumann, Oliver Stachs
Purpose To analyze the use of deviation maps (DevMs) to understand thickness changes of inner retinal layers in optical coherence tomography (OCT) data. To test a new visual analytics (VA) method with reduced complexity of OCT data analysis by comparing the layer thickness of children with type 1 diabetes mellitus (T1DM) to matched controls. METHODS: OCT was performed on unilateral eyes of 26 children with T1DM without diabetic retinopathy and 29 healthy children to obtain macular volume scans...
March 20, 2019: Current Eye Research
Leonardo Horn Iwaya, Simone Fischer-Hübner, Rose-Mharie Åhlfeldt, Leonardo A Martucci
BACKGROUND: Community-based primary care focuses on health promotion, awareness raising, and illnesses treatment and prevention in individuals, groups, and communities. Community Health Workers (CHWs) are the leading actors in such programs, helping to bridge the gap between the population and the health system. Many mobile health (mHealth) initiatives have been undertaken to empower CHWs and improve the data collection process in the primary care, replacing archaic paper-based approaches...
March 20, 2019: JMIR MHealth and UHealth
Thomas Karlas, Tina Weiße, David Petroff, Sebastian Beer, Christine Döhring, Franziska Gnatzy, Dietger Niederwieser, Gerhard Behre, Joachim Mössner, Janett Fischer, Michael Tröltzsch, Johannes Wiegand, Volker Keim, Georg-Nikolaus Franke
In the original article, the affiliations were presented incorrectly. David Petroff is in fact the only author at affiliation 2. All other authors listed as being at affiliation 2 (Tina Weiße, Sebastian Beer, Franziska Gnatzy, Joachim Mössner, Michael Tröltzsch, Johannes Wiegand and Volker Keim) are in fact just at affiliation 1. These have now been corrected in the original article.
March 19, 2019: Bone Marrow Transplantation
Roman Fudim, Michal Szczepek, Johannes Vierock, Arend Vogt, Andrea Schmidt, Gunnar Kleinau, Paul Fischer, Franz Bartl, Patrick Scheerer, Peter Hegemann
The light-driven proton pump Coccomyxa subellipsoidea rhodopsin (CsR) provides-because of its high expression in heterologous host cells-an opportunity to study active proton transport under controlled electrochemical conditions. In this study, solving crystal structure of CsR at 2.0-Å resolution enabled us to identify distinct features of the membrane protein that determine ion transport directivity and voltage sensitivity. A specific hydrogen bond between the highly conserved Arg83 and the nearby nonconserved tyrosine (Tyr14 ) guided our structure-based transformation of CsR into an operational light-gated proton channel (CySeR) that could potentially be used in optogenetic assays...
March 19, 2019: Science Signaling
Michael Woolman, Claudia M Kuzan-Fischer, Isabelle Ferry, Taira Kiyota, Betty Luu, Megan Wu, David G Munoz, Sunit Das, Ahmed Aman, Michael David Taylor, James T Rutka, Howard Joeseph Ginsberg, Arash Zarrine-Afsar
Medulloblastoma (MB) is a pediatric malignant brain tumor comprised of four different subgroups (WNT, SHH, Group 3, Group 4), each of which are a unique biological entity with distinct clinico-pathological, molecular, and prognostic characteristics. While risk stratification of MB patients based on molecular features may offer personalized therapies, conventional subgroup identification methods take too long and are unable to deliver subgroup information intraoperatively. This limitation prevents subgroup-specific adjustment of the extent or the aggressiveness of the tumor resection by the neurosurgeon...
March 19, 2019: Cancer Research
Nadja Rohr, J Barbara Nebe, Fredy Schmidli, Petra Müller, Michael Weber, Horst Fischer, Jens Fischer
OBJECTIVE: The recently developed bioactive glass PC-XG3, which is suitable to coat zirconia implant surfaces with high adhesion strength may reduce the time of osseointegration and the marginal bone loss following implantation. The glass composition has been previously evaluated for cytotoxicity on fibroblast cells, and will now be used to evaluate the cell behavior of osteoblast cells. METHODS: Three different surface morphologies were created with PC-XG3 on zirconia discs...
March 16, 2019: Dental Materials: Official Publication of the Academy of Dental Materials
Laurent Pierot, Mahesh Jarayaman, Istvan Szikora, Joshua Hirsch, Blaise Baxter, Shigeru Miyachi, Jeyaledchumy Mahadevan, Winston Chong, Peter J Mitchell, Alan Coulthard, Howard A Rowley, Pina C Sanelli, Donatella Tampieri, Patrick Brouwer, Jens Fiehler, Naci Kocer, Pedro Vilela, Alex Rovira, Urs Fischer, Valeria Caso, Bart van der Wort, Nobuyuki Sakai, Yuji Matsumaru, Shin-Ichi Yoshimura, Luisa Biscoito, Manuel Pumar, Orlando Diaz, Justin Fraser, Italo Lifante, David S Liebeskind, Raul G Nogueira, Werner Hacke, Michael Brainin, Bernard Yan, Michael Soderman, Allan Taylor, Sirintara Pongpech, Karel Terbrugge
After five positive randomized controlled trials showed benefit of mechanical thrombectomy in the management of acute ischemic stroke with emergent large-vessel occlusion, a multi-society meeting was organized during the 17th Congress of the World Federation of Interventional and Therapeutic Neuroradiology in October 2017 in Budapest, Hungary. This multi-society meeting was dedicated to establish standards of practice in acute ischemic stroke intervention aiming for a consensus on the minimum requirements for centers providing such treatment...
March 20, 2019: Canadian Journal of Neurological Sciences. le Journal Canadien des Sciences Neurologiques
Stefanie Keupp, Rowan Titchener, Thomas Bugnyar, Thomas Mussweiler, Julia Fischer
Humans modulate their self-evaluations and behaviour as a function of conspecific presence and performance. In this study, we tested for the presence of human-like social comparison effects in long-tailed macaques ( Macaca fascicularis). The monkeys' task was to extract food from an apparatus by pulling drawers within reach and we measured latency between drawer pulls. Subjects either worked on the task with a partner who could access the apparatus from an adjacent cage, worked in the absence of a conspecific but with food moving towards the partner's side or worked next to a partner who was denied apparatus access...
March 29, 2019: Biology Letters
Robert E MacLaren, M Dominik Fischer, Cristina Martinez-Fernandez De La Camara
No abstract text is available yet for this article.
March 2019: Human Gene Therapy. Clinical Development
Weijin Li, Sebastian Watzele, Hany A El-Sayed, Yunchang Liang, Gregor Kieslich, Aliaksandr S Bandarenka, Katia Rodewald, Bernhard Rieger, Roland A Fischer
The oxygen evolution reaction (OER) is a key process for renewa-ble energy storage. However, developing non-noble metal OER electrocatalysts with high activity, long durability and scalability remains a major challenge. Herein, high OER activity and stability in alkaline solution were discovered for mixed nickel/cobalt hy-droxide electrocatalysts, which were derived in one-step procedure from oriented surface-mounted metal-organic framework (SURMOF) thin films that had been directly grown layer-by-layer on macro- and microelectrode substrates...
March 19, 2019: Journal of the American Chemical Society
Daniela A Hey, Pauline J Fischer, Walter Baratta, Fritz E Kühn
The dinuclear ruthenium(ii) phosphine complexes Ru2Cl(O2CCHxF3-x)3(PPh3)4(μ-H2O) (x = 0, 1, 2), containing fluoroacetate ligands, were prepared from RuCl2(PPh3)3 and NaO2CCHxF3-x in tBuOH. The X-ray characterization of these complexes reveals a bridging water molecule, stabilized by hydrogen bonds with the fluoroacetate ligands. The isolation of the complex Ru(O2CCF3)2(PPh3)2 is described, starting from RuCl2(PPh3)3 or Ru2Cl(O2CCF3)3(PPh3)4(μ-H2O) and TlO2CCF3, correcting the reported preparation in which Ru2Cl(O2CCF3)3(PPh3)4(μ-H2O) was obtained...
March 19, 2019: Dalton Transactions: An International Journal of Inorganic Chemistry
Andrea Baczako, Tatjana Fischer, Alexander Konstantinow, Thomas Volz
No abstract text is available yet for this article.
March 2019: MMW Fortschritte der Medizin
Anja Lehner, Ingram Schulze-Neick, Marcus Fischer, Silvia Fernandez-Rodriguez, Sarah Ulrich, Nikolaus A Haas, André Jakob
PURPOSE OF THE REVIEW: Targeted pharmacotherapies did improve survival rates, exercise capacity, and quality of life (QoL) of PAH patients. However, these pharmacological interventions are expensive and not always accessible. In addition, not all patients do respond similarly to these medications and many will continue to deteriorate. This review aims to discuss the beneficial role of an artificial right-to-left shunt and highlights current interventional devices and outcomes. RECENT FINDINGS: Since patients with preexisting atrial shunts or patients with Eisenmenger's disease show better survival rates, improved exercise capacity, and QoL, PAH patients clinically do benefit from an atrial septostomy by reducing signs of right heart failure, improving left heart filling, cardiac output, and systemic oxygen transport despite hypoxia...
March 18, 2019: Current Cardiology Reports
Alexandre Bani Sadr, Bastien Gregoire, Jeremie Tordo, Jacques Guyotat, Andre Boibieux, Marc Janier
OBJECTIVE: Currently, the diagnosis of bone flap osteomyelitis (BFO) remains a challenge for medical imaging. The present study aimed to identify predictive scintigraphic patterns of BFO. METHODS: This retrospective study reviewed planar bone scan of patients with suspected BFO between 2010, and 2016. A total of 15 patients were included. Final diagnosis of BFO was obtained by histological and bacteriological documentation. Eight scintigraphic signs potentially helpful were reviewed and correlated with the final diagnosis individually or in combination through Fischer exact test...
March 18, 2019: Annals of Nuclear Medicine
A Luckscheiter, T Lohs, M Fischer, W Zink
BACKGROUND AND OBJECTIVE: Due to multiple factors the performance of preclinical emergency anesthesia is fraught with risks even for experienced emergency physicians. In order to support emergency physicians in monitoring and management of anesthesia, the German practice management guidelines for preclinical emergency anesthesia in adults were published in 2015; however, current data on adherence to the guidelines are not available. MATERIAL AND METHODS: In a retrospective register analysis of preclinical anesthesia from 2015-2017 in Baden-Württemberg, the recorded anesthetic agents, monitoring, airway management and medical disciplines of emergency physicians were analyzed...
March 18, 2019: Der Anaesthesist
Alessandro Valli, Matteo Morotti, Christos E Zois, Patrick K Albers, Tomoyoshi Soga, Katharina Feldinger, Roman Fischer, Martin Frejno, Alan McIntyre, Esther Bridges, Syed Haider, Francesca M Buffa, Dilair Baban, Miguel Rodriguez, Oscar Yanes, Hannah J Whittington, Hannah A Lake, Sevasti Zervou, Craig A Lygate, Benedikt M Kessler, Adrian L Harris
Hypoxia-inducible factor 1α is a key regulator of the hypoxia response in normal and cancer tissues. It is well recognised to regulate glycolysis and is a target for therapy. However, how tumour cells adapt to grow in the absence of HIF1α is poorly understood and important to understand for developing targeted therapies and the flexibility of the metabolic response to hypoxia via alternative pathways. We analysed pathways that allow cells to survive hypoxic stress in the absence of HIF1α, using the HCT116 colon cancer cell line with deleted HIF1α versus control...
March 18, 2019: Molecular Cancer Research: MCR
L Owen, A Fischer
BACKGROUND: Reviews of economic evaluations of public health (PH) interventions assessed by the National Institute for Health and Care Excellence (NICE) in the periods 2005-2010 and 2011-2016 have been undertaken. This study combines these analyses, adds six further guidelines published since then, and thus provides a summary of cost-effectiveness of NICE's PH interventions to the present. METHODS: As in previous studies, economic evaluations carried out between 2005 and 2018 were categorised by the type of economic analysis used to extract and summarise base-case ICERs...
March 15, 2019: Public Health
Marie Agatha Mohn, Besarta Thaqi, Katrin Fischer-Schrader
Nitrate reductase (NR) is important for higher land plants, as it catalyzes the rate-limiting step in the nitrate assimilation pathway, the two-electron reduction of nitrate to nitrite. Furthermore, it is considered to be a major enzymatic source of the important signaling molecule nitric oxide (NO), that is produced in a one-electron reduction of nitrite. Like many other plants, the model plant Arabidopsis thaliana expresses two isoforms of NR (NIA1 and NIA2). Up to now, only NIA2 has been the focus of detailed biochemical studies, while NIA1 awaits biochemical characterization...
March 16, 2019: Plants (Basel, Switzerland)
Yan Zhang, Yu Yang, Xianduo Li, Dongdong Chen, Guanbao Tang, Tongyi Men
Chronic T cell mediated rejection (TCMR), which is characterized by infiltration of the interstitium by T cells and macrophages, still remains a major barrier to the long-term survival of kidney transplantation. Our recent report indicated that thalidomide can attenuate graft arteriosclerosis in an aortic transplant model. In this study, we investigated the effect of thalidomide on chronic TCMR in a rat model of kidney transplantation. Fischer or Lewis kidney allografts were transplanted into Lewis recipient rats...
March 12, 2019: International Immunopharmacology
Jocelyn R Farmer, Zsofia Foldvari, Boglarka Ujhazi, Suk See De Ravin, Karin Chen, Jack J H Bleesing, Catharina Schuetz, Waleed Al-Herz, Roshini Sarah Abraham, Avni Y Joshi, Beatriz T Costa-Carvalho, David Buchbinder, Claire Booth, Andreas Reiff, Polly J Ferguson, Asghar Aghamohammadi, Hassan Abolhassani, Jennifer M Puck, Mehdi Adeli, Caterina Cancrini, Paolo Palma, Alice Bertaina, Franco Locatelli, Gigliola Di Matteo, Raif S Geha, Maria G Kanariou, Evangelia Lycopoulou, Marianna Tzanoudaki, John W Sleasman, Suhag Parikh, Gloria Pinero, Bernard M Fischer, Ghassan Dbaibo, Ekrem Unal, Turkan Patiroglu, Musa Karakukcu, Khulood Khalifa Al-Saad, Meredith A Dilley, Sung-Yun Pai, Cullen M Dutmer, Erwin W Gelfand, Christoph B Geier, Martha M Eibl, Hermann M Wolf, Lauren A Henderson, Melissa M Hazen, Carmem Bonfim, Beata Wolska-Kuśnierz, Manish J Butte, Joseph D Hernandez, Sarah K Nicholas, Polina Stepensky, Shanmuganathan Chandrakasan, Maurizio Miano, Emma Westermann-Clark, Vera Goda, Gergely Kriván, Steven M Holland, Olajumoke Fadugba, Sarah E Henrickson, Ahmet Ozen, Elif Karakoc-Aydiner, Safa Baris, Ayca Kiykim, Robbert Bredius, Birgit Hoeger, Kaan Boztug, Olga Pashchenko, Benedicte Neven, Despina Moshous, Jean-Pierre de Villartay, Ahmed Aziz Bousfiha, Harry R Hill, Luigi D Notarangelo, Jolan E Walter
BACKGROUND: While autoimmunity and hyperinflammation secondary to recombinase activating gene (RAG) deficiency have been associated with delayed diagnosis and even death, our current understanding is limited primarily to small case series. OBJECTIVE: Understand the frequency, severity, and treatment responsiveness of autoimmunity and hyperinflammation in RAG deficiency. METHODS: In reviewing the literature and our own database, we identified 85 patients with RAG deficiency, reported between 2001 and 2016, and compiled the largest case series to date of 63 patients with prominent autoimmune and/or hyperinflammatory pathology...
March 12, 2019: Journal of Allergy and Clinical Immunology in Practice
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