Camille Laurent, Alina Nicolae, Cécile Laurent, Fabien Le Bras, Corinne Haioun, Virginie Fataccioli, Nadia Amara, José Adélaïde, Arnaud Guille, Jean-Marc Schiano, Bruno Tesson, Alexandra Traverse-Glehen, Marie-Pierre Chenard, Lénaïg Mescam, Anne Moreau, Catherine Chassagne-Clement, Joan Somja, Frédéric Escudié, Marc André, Nadine Martin, Laetitia Lacroix, François Lemonnier, Anne-Sophie Hamy, Fabien Reyal, Marie Bannier, Lucie Oberic, Nais Prade, François-Xavier Frénois, Asma Beldi-Ferchiou, Marie-Helene Delfau-Larue, Reda Bouabdallah, Daniel Birnbaum, Pierre Brousset, Luc Xerri, Philippe Gaulard
The oncogenic events involved in breast implant-associated anaplastic large cell lymphoma (BI-ALCL) remain elusive. To clarify this point, we have characterized the genomic landscape of 34 BI-ALCLs (15 tumor and 19 in situ subtypes) collected from 54 BI-ALCL patients diagnosed through the French Lymphopath network. Whole-exome sequencing (n = 22, with paired tumor/germline DNA) and/or targeted deep sequencing (n = 24) showed recurrent mutations of epigenetic modifiers in 74% of cases, involving notably KMT2C (26%), KMT2D (9%), CHD2 (15%), and CREBBP (15%)...
January 30, 2020: Blood