keyword
https://read.qxmd.com/read/37810974/updates-in-pathobiological-aspects-of-anaplastic-large-cell-lymphoma
#1
REVIEW
Rui Wu, Megan S Lim
Anaplastic large cell lymphomas (ALCL) encompass several distinct subtypes of mature T-cell neoplasms that are unified by the expression of CD30 and anaplastic cytomorphology. Identification of the cytogenetic abnormality t(2;5)(p23;q35) led to the subclassification of ALCLs into ALK+ ALCL and ALK- ALCL. According to the most recent World Health Organization (WHO) Classification of Haematolymphoid Tumours as well as the International Consensus Classification (ICC) of Mature Lymphoid Neoplasms, ALCLs encompass ALK+ ALCL, ALK- ALCL, and breast implant-associated ALCL (BI-ALCL)...
2023: Frontiers in Oncology
https://read.qxmd.com/read/37493459/alcl-3-mediated-ring-opening-reactions-of-indoline-2-thiones-with-acyl-cyclopropanes-bi-cyclopropanes-and-spirocyclic-cyclopropanes
#2
JOURNAL ARTICLE
Hao-Jie Ma, Ke Gao, Xue-Long Wang, Jun-Yi Zeng, Yi Yang, Yan Jiang
AlCl3 -mediated nucleophilic ring-opening reactions of indoline-2-thiones with various acyl cyclopropanes, bi-cyclopropanes and spirocyclic cyclopropanes were investigated. A series of ketones functionalized with indolylthio groups were synthesized in yields ranging from moderate to good. Moreover, chemical transformations of 4-indolylthio butan-1-ones to dihydro-2 H -thiepino[2,3- b ]indoles and sulfone were carried out to further expand both synthetic utility and structural complexity.
July 26, 2023: Organic & Biomolecular Chemistry
https://read.qxmd.com/read/36376583/mortality-rate-in-breast-implant-surgery-is-an-additional-procedure-worthwhile-to-mitigate-bia-alcl-risk
#3
JOURNAL ARTICLE
Fabio Santanelli di Pompeo, Michail Sorotos, Mark W Clemens, Guido Paolini, Paolo Anibaldi, Marina Davoli, Giovanni Baglio, Luigi Pinnarelli, Margherita Ferranti, Francesco Cerza, Stefano Domenico Cicala, Guido Firmani
BACKGROUND: Because of poor knowledge of risks and benefits, prophylactic explantation of high BIA-ALCL risk breast implant (BI) is not indicated. Several surgical risks have been associated with BI surgery, with mortality being the most frightening. Primary aim of this study is to assess mortality rate in patients undergoing breast implant surgery for aesthetic or reconstructive indication. MATERIALS AND METHODS: In this retrospective observational cohort study, Breast Implant Surgery Mortality rate (BISM) was calculated as the perioperative mortality rate among 99,690 patients who underwent BI surgery for oncologic and non-oncologic indications...
November 14, 2022: Aesthetic Plastic Surgery
https://read.qxmd.com/read/35434240/history-of-breast-implants-back-to-the-future
#4
REVIEW
Fabio Santanelli di Pompeo, Guido Paolini, Guido Firmani, Michail Sorotos
Modern breast implants are a staple of plastic surgery, finding uses in esthetic and reconstructive procedures. Their history began in the 1960s, with the first generation of smooth devices with thick silicone elastomer, thick silicone gel, and Dacron patches on the back. They presented hard consistency, high capsular contracture rates and the patches increased the risk of rupture. In the same decade, polyurethane coating of implants was implemented. A second generation was introduced in the 1970s with a thinner shell, less viscous gel filler and no patches, but increased silicone bleed-through and rupture rates...
June 2022: JPRAS Open
https://read.qxmd.com/read/34977845/genomic-analysis-of-cutaneous-cd30-positive-lymphoproliferative-disorders
#5
JOURNAL ARTICLE
Farah R Abdulla, Weiwei Zhang, Xiwei Wu, Kord Honda, Hanjun Qin, Hyejin Cho, Christiane Querfeld, Jasmine Zain, Steven Terry Rosen, Wing C Chan, Vishwas Parekh, Joo Y Song
Primary cutaneous CD30+ T-cell lymphoproliferative disorders are the second most common cutaneous lymphomas. According to the World Health Organization, CD30+ T-cell lymphoproliferative disorders include primary cutaneous anaplastic large cell lymphoma (C-ALCL) and lymphomatoid papulosis (LyP) as well as borderline lesions. C-ALCL and LyP are thought to represent two ends of a spectrum of diseases that have different clinical presentations, clinical courses, and prognoses in their classic forms but share the same histology of medium to large CD30+ atypical lymphoid cell infiltrates...
January 2022: JID innovations
https://read.qxmd.com/read/34944796/rna-sequencing-of-primary-cutaneous-and-breast-implant-associated-anaplastic-large-cell-lymphomas-reveals-infrequent-fusion-transcripts-and-upregulation-of-pi3k-akt-signaling-via-neurotrophin-pathway-genes
#6
JOURNAL ARTICLE
Arianna Di Napoli, Davide Vacca, Giorgio Bertolazzi, Gianluca Lopez, Maria Piane, Aldo Germani, Evelina Rogges, Giuseppina Pepe, Fabio Santanelli Di Pompeo, Marzia Salgarello, Vaidehi Jobanputra, Susan Hsiao, Kazimierz O Wrzeszczynski, Emilio Berti, Govind Bhagat
Cutaneous and breast implant-associated anaplastic large-cell lymphomas (cALCLs and BI-ALCLs) are two localized forms of peripheral T-cell lymphomas (PTCLs) that are recognized as distinct entities within the family of ALCL. JAK-STAT signaling is a common feature of all ALCL subtypes, whereas DUSP22/IRF4, TP63 and TYK gene rearrangements have been reported in a proportion of ALK-negative sALCLs and cALCLs. Both cALCLs and BI-ALCLs differ in their gene expression profiles compared to PTCLs; however, a direct comparison of the genomic alterations and transcriptomes of these two entities is lacking...
December 7, 2021: Cancers
https://read.qxmd.com/read/34833432/current-challenges-in-breast-implantation
#7
REVIEW
Zuzanna Pelc, Magdalena Skórzewska, Andrzej Kurylcio, Paweł Olko, Joanna Dryka, Piotr Machowiec, Marcela Maksymowicz, Karol Rawicz-Pruszyński, Wojciech Polkowski
Breast implantation (BI) is the most common plastic surgery worldwide performed among women. Generally, BI is performed both in aesthetic and oncoplastic procedures. Recently, the prevalence of breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) or breast implant illness (BII) has aroused concerns. As a result, several countries, like Australia, Korea or the United Kingdom, introduced national registries dedicated to the safety and quality of BI surgeries. This narrative review aimed to focus on the clinical challenges, management and the current state of knowledge of BI...
November 7, 2021: Medicina
https://read.qxmd.com/read/34526863/when-benign-becomes-cancer-malignant-degeneration-of-chronic-inflammation
#8
REVIEW
Christopher Conlon, Lauren Pupa, Edward M Reece, Carrie K Chu, Jessie Z Yu, Joshua Vorstenbosch, Sebastian Winocour
Chronic inflammation, long implicated in the genesis of malignancy, is now understood to underlie an estimated 25% of all cancers. The most pertinent malignancies, to the plastic surgeon, associated with the degeneration of chronic inflammation include Marjolin's ulcer, breast implant-associated large cell lymphoma, radiation-induced sarcoma, and Kaposi's sarcoma. The cellular and genetic damage incurred by a prolonged inflammatory reaction is controlled by an increasingly understood cytokinetic system. Advances in understanding the chronic inflammatory cascade have yielded new therapeutics and therapeutic targets...
August 2021: Seminars in Plastic Surgery
https://read.qxmd.com/read/34294955/potentiometric-sensing-of-histamine-using-immobilized-enzymes-on-layered-double-hydroxides
#9
JOURNAL ARTICLE
Slah Hidouri, Abdel Hamid Errachid, Joan Baussels, Yaroslav I Korpan, Oscar Ruiz-Sanchez, Zouhair M Baccar
Diamine oxydase and peroxidase have been co-immobilized onto layered double hydroxide (LDH) thin films for the development of real-time histamine biosensors. The chosen LDH materials are Mg2 AlCO3 , Mg4 FeCl and Ca2 AlCl. Prepared bi-enzymatic hybrid nanomaterials are capable of detecting histamine through the electrochemical oxidation of H2 O2 and are used as the sensitive membrane for potentiometric microelectrode. Histamine biosensors developed in this work have fast response of less than 20 s, are sensitive and selective, with a large dynamic range of 10-8 -10-3  M and a limit of detection of less than 10-8  M...
August 2021: Journal of Food Science and Technology
https://read.qxmd.com/read/33146828/il-10-il-13-eotaxin-and-il-10-il-6-ratio-distinguish-breast-implant-associated-anaplastic-large-cell-lymphoma-from-all-types-of-benign-late-seromas
#10
JOURNAL ARTICLE
Arianna Di Napoli, Daniele Greco, Giorgia Scafetta, Francesca Ascenzi, Alessandro Gulino, Luigi Aurisicchio, Fabio Santanelli Di Pompeo, Adriana Bonifacino, Enrico Giarnieri, John Morgan, Rita Mancini, Marshall E Kadin
Breast implant-associated anaplastic large-cell lymphoma (BI-ALCL) is an uncommon peripheral T cell lymphoma usually presenting as a delayed peri-implant effusion. Chronic inflammation elicited by the implant has been implicated in its pathogenesis. Infection or implant rupture may also be responsible for late seromas. Cytomorphological examination coupled with CD30 immunostaining and eventual T-cell clonality assessment are essential for BI-ALCL diagnosis. However, some benign effusions may also contain an oligo/monoclonal expansion of CD30 + cells that can make the diagnosis challenging...
November 4, 2020: Cancer Immunology, Immunotherapy: CII
https://read.qxmd.com/read/32791685/diagnostic-challenges-and-potential-early-indicators-of-breast-periprosthetic-anaplastic-large-cell-lymphoma-a-case-report
#11
JOURNAL ARTICLE
Daniele La Forgia, Annamaria Catino, Alfonso Fausto, Daniela Cutrignelli, Annarita Fanizzi, Gianluca Gatta, Liliana Losurdo, Arianna Maiorella, Marco Moschetta, Cosmo Ressa, Anna Scattone, Aurelio Portincasa
RATIONALE: Anaplastic large T-cell lymphoma (BI-ALCL) is a rare primitive lymphoma described in women with breast implant prostheses, which has been arousing interest in recent years due to its potentially high social impact. The difficult diagnosis associated with the high and increasing number of prosthetic implants worldwide has led to hypothesize an underestimation of the real impact of the disease among prosthesis-bearing women. The aim of this work is to search for specific radiological signs of disease linked to the chronic inflammatory pathogenetic mechanism...
July 24, 2020: Medicine (Baltimore)
https://read.qxmd.com/read/32724469/ph-responsive-dna-nanomicelles-for-chemo-gene-synergetic-therapy-of-anaplastic-large-cell-lymphoma
#12
JOURNAL ARTICLE
Yuwei Li, Shuzhen Yue, Jingyu Cao, Chengzhan Zhu, Yixiu Wang, Xin Hai, Weiling Song, Sai Bi
Chemo-gene therapy is an emerging synergetic modality for the treatment of cancers. Herein, we developed pH-responsive multifunctional DNA nanomicelles (DNMs) as delivery vehicles for controllable release of doxorubicin (Dox) and anaplastic lymphoma kinase (ALK)-specific siRNA for the chemo-gene synergetic therapy of anaplastic large cell lymphoma (ALCL). Methods: DNMs were synthesized by performing in situ rolling circle amplification (RCA) on the amphiphilic primer-polylactide (PLA) micelles, followed by functionalization of pH-responsive triplex DNA via complementary base pairing...
2020: Theranostics
https://read.qxmd.com/read/32491282/anaplastic-large-cell-lymphoma-report-of-two-cases-with-rare-patterns-carcinomatous-and-sarcomatous-in-fine-needle-aspiration-cytology-and-histopathology
#13
JOURNAL ARTICLE
Dilip K Das, Mrinmay K Mallik, Abdullah E Ali, Fatemah Ask Khadom, Bency John, Mamoun Al-Ayanti
Anaplastic large cell lymphoma (ALCL) is a non-Hodgkin lymphoma of T-cell or null-cell lineage with variable cytomorphology. We report two rare ALCL cases with carcinomatous and sarcomatous patterns, respectively, in fine needle aspiration (FNA) cytology and histopathology. The first case was a 56-year-old man with enlarged left inguinal lymph node. FNA smears showed a malignant small round cell tumor with nuclear molding. In addition, there were large bi-nucleated and multinucleated cells with wreath-like arrangement of nuclei...
November 2020: Diagnostic Cytopathology
https://read.qxmd.com/read/32344893/incidence-of-anaplastic-large-cell-lymphoma-and-breast-implant-associated-lymphoma-an-analysis-of-a-certified-tumor-registry-over-17-years
#14
JOURNAL ARTICLE
Lukas Prantl, Michael Gerken, Florian Zeman, Michael Leitzmann, Michael Koller, Monika Klinkhammer-Schalke, Matthias Evert, Britta Kuehlmann, Niklas Biermann
BACKGROUND: Breast-implant-associated anaplastic large cell lymphoma (BI-ALCL) and primary breast ALCL are rare extranodal manifestations of non-Hodgkin lymphoma. The rarity of both diseases, along with unreleased sales data on breast implants and constant updates of classification systems impede the calculation of an exact incidence. METHODS: The database of the Tumor Center Regensburg in Bavaria was searched for patients with CD30-positive and ALK-negative anaplastic large cell lymphoma between 2002 and 2018...
April 25, 2020: Journal of Clinical Medicine
https://read.qxmd.com/read/32315816/b-cell-lymphomas-associated-with-breast-implants-report-of-three-cases-and-review-of-the-literature
#15
REVIEW
Mark G Evans, Roberto N Miranda, Patricia A Young, Linda Pai, Huan-You Wang, Sergej N Konoplev, L Jeffrey Medeiros, Lauren C Pinter-Brown
Since the first reported case in 1997, over 600 women with breast implant-associated anaplastic large cell lymphoma (BI ALCL) have been reported. BI ALCL is a CD30-positive T-cell lymphoma that carries clonal T-cell receptor gene rearrangements, and a subset of cases harbors mutations in the JAK-STAT signaling pathway. Rarely, other histologic types of lymphoma have been reported in association with breast implants, including fewer than 10 cases of B-cell origin. Here, we describe three additional patients with B-cell lymphoma occurring around breast implants...
June 2020: Annals of Diagnostic Pathology
https://read.qxmd.com/read/31863183/lymphomas-arising-in-immune-privileged-sites-insights-into-biology-diagnosis-and-pathogenesis
#16
REVIEW
Rebecca L King, John R Goodlad, Maria Calaminici, Snjezana Dotlic, Santiago Montes-Moreno, Ilske Oschlies, Maurilio Ponzoni, Alexandra Traverse-Glehen, German Ott, Judith A Ferry
Session 2 of the 2018 European Association of Hematopathology/Society for Hematopathology Workshop focused on lymphomas arising in immune-privileged sites: both lymphomas arising in the traditionally described "immune sanctuary" sites of the central nervous system (CNS) and testes, as well as those arising at sites of local immune privilege. Primary CNS large B cell lymphoma and primary testicular large B cell lymphoma were discussed, and the biology of these unique tumors was highlighted by several cases showing the classic mutation profile including MYD88 L265P and CD79B...
May 2020: Virchows Archiv: An International Journal of Pathology
https://read.qxmd.com/read/31774495/gene-alterations-in-epigenetic-modifiers-and-jak-stat-signaling-are-frequent-in-breast-implant-associated-alcl
#17
JOURNAL ARTICLE
Camille Laurent, Alina Nicolae, Cécile Laurent, Fabien Le Bras, Corinne Haioun, Virginie Fataccioli, Nadia Amara, José Adélaïde, Arnaud Guille, Jean-Marc Schiano, Bruno Tesson, Alexandra Traverse-Glehen, Marie-Pierre Chenard, Lénaïg Mescam, Anne Moreau, Catherine Chassagne-Clement, Joan Somja, Frédéric Escudié, Marc André, Nadine Martin, Laetitia Lacroix, François Lemonnier, Anne-Sophie Hamy, Fabien Reyal, Marie Bannier, Lucie Oberic, Nais Prade, François-Xavier Frénois, Asma Beldi-Ferchiou, Marie-Helene Delfau-Larue, Reda Bouabdallah, Daniel Birnbaum, Pierre Brousset, Luc Xerri, Philippe Gaulard
The oncogenic events involved in breast implant-associated anaplastic large cell lymphoma (BI-ALCL) remain elusive. To clarify this point, we have characterized the genomic landscape of 34 BI-ALCLs (15 tumor and 19 in situ subtypes) collected from 54 BI-ALCL patients diagnosed through the French Lymphopath network. Whole-exome sequencing (n = 22, with paired tumor/germline DNA) and/or targeted deep sequencing (n = 24) showed recurrent mutations of epigenetic modifiers in 74% of cases, involving notably KMT2C (26%), KMT2D (9%), CHD2 (15%), and CREBBP (15%)...
January 30, 2020: Blood
https://read.qxmd.com/read/31489733/breast-implant-associated-anaplastic-large-cell-lymphoma-a-rare-case-report-of-lymphoma-in-the-form-of-a-pericapsular-solid-formation
#18
Marco Gardani, Elisa Bellini, Gabriele Villani, Nicola Orsi, Dante Palli
Breast cancer is the most frequently diagnosed cancer in women in the western world and a major cause of premature death. Consequently, breast implants are widely used for breast reconstruction. Despite this, the prevalence of implant complications is low. Given widespread use of breast implants, there is an increased awareness of the risk for developing a breast implant associated- anaplastic large cell Lymphoma (BI-ALCL) although rare. Clinical presentation is variable and may include a palpable mass in the breast or axilla, generalized breast pain, or breast firmness...
September 6, 2019: Breast Journal
https://read.qxmd.com/read/31125630/recurrent-pdl1-expression-and-pdl1-cd274-copy-number-alterations-in-breast-implant-associated-anaplastic-large-cell-lymphomas
#19
JOURNAL ARTICLE
Valentina Tabanelli, Chiara Corsini, Stefano Fiori, Claudio Agostinelli, Angelica Calleri, Stefania Orecchioni, Federica Melle, Giovanna Motta, Anna Rotili, Arianna Di Napoli, Stefano A Pileri
Breast implant-associated anaplastic large-cell lymphoma (BI-ALCL) is a variant of anaplastic large-cell lymphoma arising within seroma effusion associated to breast implants. BI-ALCL is a rare disease, recently recognized as a new provisional entity by the 2017 revised WHO classification. All BI-ALCLs tested so far showed a "triple negative" genetic profile - negative for ALK, DUSP22, and TP63 rearrangements - and were characterized by mutational and gene expression profiles consistent with aberrant activation of the JAK/STAT pathway...
May 21, 2019: Human Pathology
https://read.qxmd.com/read/31110735/brentuximab-vedotin-as-monotherapy-for-unresectable-breast-implant-associated-anaplastic-large-cell-lymphoma
#20
Anthony Stack, Isaac Levy
BI-ALCL is a rare CD30+ T-cell malignancy, which is known to complicate textured breast implants. The CD30-targeting immunoconjugate, brentuximab vedotin, has been suggested for invasive BI-ALCL; however, its efficacy for unresectable BI-ALCL has not been demonstrated. We present a case of unresectable BI-ALCL, which was successfully treated with brentuximab vedotin.
May 2019: Clinical Case Reports
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